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The Mongolian gerbil brain lies in the anatomy of the blood vessels supplying blood to the brain. In all mammals, there is a special mechanism that compensates for the decreased blood flow to the brain in the case of development of stroke. This mechanism is missing in the gerbil and therefore makes the Mongolian gerbil a unique model for stroke. Dr. Mayevsky adopted the gerbil as a model for stroke and his laboratory uniquely studied the mitochondria in the gerbil brain under various pathophysiological conditions. This book describes the history of the Mongolian gerbil in research, the brain energy metabolism and mitochondrial function and brain real-time monitoring systems used in gerbils, as well as the brain vasculature of the Mongolian gerbil. Further, the book includes chapters on brain multisite recording under brain perturbations, multiparametric responses to brain activation, and the effect of neuroprotectants on the gerbil brain. This is an ideal book for research teams researching stroke and epilepsy.
Neurosciences. --- Nervous system --- Physiology. --- Medical sciences. --- Drug development. --- Medicine --- Biology --- Neuroscience. --- Neurological Disorders. --- Animal Physiology. --- Preclinical Research. --- Biomedical Research. --- Diseases. --- Research. --- Research.
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The Mongolian gerbil brain lies in the anatomy of the blood vessels supplying blood to the brain. In all mammals, there is a special mechanism that compensates for the decreased blood flow to the brain in the case of development of stroke. This mechanism is missing in the gerbil and therefore makes the Mongolian gerbil a unique model for stroke. Dr. Mayevsky adopted the gerbil as a model for stroke and his laboratory uniquely studied the mitochondria in the gerbil brain under various pathophysiological conditions. This book describes the history of the Mongolian gerbil in research, the brain energy metabolism and mitochondrial function and brain real-time monitoring systems used in gerbils, as well as the brain vasculature of the Mongolian gerbil. Further, the book includes chapters on brain multisite recording under brain perturbations, multiparametric responses to brain activation, and the effect of neuroprotectants on the gerbil brain. This is an ideal book for research teams researching stroke and epilepsy.
Neurosciences. --- Nervous system --- Physiology. --- Medical sciences. --- Drug development. --- Medicine --- Biology --- Neuroscience. --- Neurological Disorders. --- Animal Physiology. --- Preclinical Research. --- Biomedical Research. --- Diseases. --- Research. --- Mongolian gerbil.
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Papers related to any fields of medicine that present an interdisciplinary dimension.
internal medicine --- clinical and preclinical research --- progress in medicine --- Medicine --- Medicine. --- Europe. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Council of Europe countries --- Eastern Hemisphere --- Eurasia --- Human medicine --- Health Workforce --- Medicine - General
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This book provides conceptual information on the various processes involved in meta-analysis. It examines the importance of meta-analysis for the analyses of clinical data to draw a valid conclusion using suitable software. The initial sections of the book introduce meta-analysis, how to perform a systematic literature review (SLR), quality assessment of studies, extraction, and analysis of data. The subsequent section of the book contains information on advanced topics including, meta-regression, network meta-analysis, issues, mistakes, and future perspectives. In summary, the book provides a statistical method for combining the results of different studies on the same topic and resolving conflicts among studies. This book is written with the intent to allow a wide range of readers including students, researchers, and health care professionals, including physicians, nurses, pharmacists, and paramedical, and is also helpful for a beginner who would like to do a meta-analysis.
Pharmacology. --- Medical sciences. --- Drug development. --- Biologicals. --- Biopharmaceutics. --- Preclinical Research. --- Biologics. --- Pharmacology --- Pharmacy --- Biologics --- Biological products --- Medical supplies --- Development of drugs --- Drugs --- New drug development --- Basic medical sciences --- Basic sciences, Medical --- Biomedical sciences --- Health sciences --- Preclinical sciences --- Sciences, Medical --- Life sciences --- Medicine --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Development --- Physiological effect
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This Open Access book is a guide to good, responsible research at each step of the process of research discovery, so that a researcher at the beginning of a scientific career has a clear pathway to doing good research and producing reliable results. The textbook will give context to the practices described in the European Code of Conduct for Research Integrity, guided by the fundamental principles or research integrity – reliability, honesty, respect, and accountability. The chapters in the book follow the good practices outlined in the Code, give practical advice and address basic principles. In this way, the book is applicable to different research fields. It directs readers to various sources for further and updated information, particularly drawing from the resources available at The Embassy of Good Science, the European platform for research integrity and ethics.
Medicine—Research. --- Biology—Research. --- Clinical medicine—Research. --- Medical sciences. --- Drug development. --- Bioethics. --- Medical Ethics. --- Biomedical Research. --- Clinical Research. --- Preclinical Research. --- Biomedical ethics --- Clinical ethics --- Ethics, Medical --- Health care ethics --- Medical care --- Medicine --- Bioethics --- Professional ethics --- Nursing ethics --- Social medicine --- Biology --- Life sciences --- Life sciences ethics --- Science --- Development of drugs --- Drugs --- New drug development --- Pharmacology --- Pharmacy --- Basic medical sciences --- Basic sciences, Medical --- Biomedical sciences --- Health sciences --- Preclinical sciences --- Sciences, Medical --- Moral and ethical aspects --- Development --- Research --- Moral and ethical aspects.
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This detailed book explores protocols for a wide array of preclinical pharmacology and toxicology evaluations to be applied to chemical drugs and their development through in vitro, involving tissues and cell lines, and in vivo models, using animals as experimental systems, utilized to conduct pharmacological research. Written for the Springer Protocols Handbooks series, the methodologies included in this collection have been standardized by the authors through extensive use in the lab so that they are ready to be applied in the labs of readers around the world. Authoritative and practical, Bioassays in Experimental and Preclinical Pharmacology aims to assist undergraduate and postgraduate students, research scholars, scientists, and other academicians performing research in the vital field of drug discovery.
Farmacologia experimental --- Farmacologia clínica --- Bioassaigs --- Assaigs biològics --- Proves biològiques --- Química analítica qualitativa --- Efecte dels medicaments en els éssers humans --- Efectes dels medicaments en els éssers humans --- Farmacologia --- Medicina clínica --- Assaigs clínics de medicaments --- Placebos --- Farmacoepidemiologia --- Efecte dels medicaments sobre els diferents sistemes orgànics dels animals --- Efectes dels medicaments sobre els diferents sistemes orgànics dels animals --- Experimentació humana en medicina --- Pharmacology. --- Medical sciences. --- Drug development. --- Toxicology. --- Pharmacovigilance. --- Preclinical Research. --- Drug Safety and Pharmacovigilance. --- Pharmacoepidemiology --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Development of drugs --- Drugs --- New drug development --- Pharmacy --- Basic medical sciences --- Basic sciences, Medical --- Biomedical sciences --- Health sciences --- Preclinical sciences --- Sciences, Medical --- Life sciences --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Toxicology --- Development --- Physiological effect
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This book highlights recent research investigating psychological and neural mechanisms contributing to dysfunctional cognition in people with schizophrenia. The work on cognition in schizophrenia from the past 20 years is highlighted, and emphasis throughout the book is placed on utilizing the Research Domain Criterion framework. Thus, the book also covers animals work relevant to schizophrenia that assesses behaviors utilizing the same framework, enabling mechanistic studies and highlighting potential biomarkers of function. The book also includes important areas of research in the field of cognitive function in schizophrenia that have received less attention, such as cognitive side-effects of current treatments and olfactory-based cognition. Altogether, the book provides a translational perspective of the most-up-to-date research on cognition in schizophrenia to-date, but with identification of novel directions for research initiatives.
Medicine—Research. --- Biology—Research. --- Medical sciences. --- Drug development. --- Pharmacology. --- Genetics—Research. --- Clinical medicine—Research. --- Biochemical markers. --- Translational Research. --- Preclinical Research. --- Genetics Research. --- Clinical Research. --- Biomarkers. --- Biologic markers --- Biological markers --- Biomarkers --- Markers, Biochemical --- Biochemistry --- Indicators (Biology) --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Development of drugs --- New drug development --- Pharmacology --- Basic medical sciences --- Basic sciences, Medical --- Biomedical sciences --- Health sciences --- Preclinical sciences --- Sciences, Medical --- Life sciences --- Medicine --- Physiological effect --- Development --- Schizophrenia. --- Dementia praecox --- Schizophrenic disorders --- Psychoses --- Schizotypal personality disorder --- Biology --- Genetics --- Clinical medicine --- Research. --- Genetic research --- Biological research --- Biomedical research --- Health Workforce
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This up-to-date and unique monograph covers the different aspects of pharmaceutical validation, calibration, qualification and documentation. It discusses the various methods and processes under all these heads. It includes eight major sections and exhaustively covers each topic.The book includes interesting and timely topics like the ‘Validation of herbals’ considering the increasing reliance on herbal medicines. It includes a section of validation of dosage forms, which is an essential topic for any pharmaceutical scientist. The chapters provide lucid illustrations, figures, flowcharts and other diagrams to facilitate understanding. A final section on 'expert opinion' provides a rundown about the global scenario to the readers. The book serves as a complete reference material for students, researchers and industry experts in the field of pharmaceutical sciences, medicinal chemistry and pharmacology.
Pharmacy. --- Pharmacology. --- Medical sciences. --- Drug development. --- Pharmaceutical chemistry. --- Toxicology. --- Pharmacovigilance. --- Preclinical Research. --- Pharmaceutics. --- Drug Safety and Pharmacovigilance. --- Pharmacoepidemiology --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Chemistry --- Development of drugs --- New drug development --- Pharmacy --- Basic medical sciences --- Basic sciences, Medical --- Biomedical sciences --- Health sciences --- Preclinical sciences --- Sciences, Medical --- Life sciences --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Materia medica --- Toxicology --- Development --- Physiological effect --- Calibration. --- Pharmaceutical technology Quality control. --- Pharmaceutical technology Standards. --- Physical measurements --- Standardization
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The Handbook of Bioethical Decisions is aimed at addressing and analyzing the most important ethical concerns and moral quandaries arisen in biomedical and scientific research. As such, it identifies and problematizes on a comprehensive range of ethical issues researchers must deal with in different critical contexts. Thus, the Handbook, Vol. I, may be helpful for them to make decisions and deliberate in complex practical scenarios. In this fashion, the volume reunites different points of view to give readers room enough to get a better knowledge and take their own position on pressing bioethical issues of the day. Consequently, this work seeks to engender dense ethical epistemology scientists can count on when conducting latest generation biomedical research. By bringing together an impressive array of contributions on the most important elements and categories for “at the bench” bioethical decisions as well as offering chapters by some of the most world renowned and prominent experts in bioethics, the Handbook, Vol. I, is a paradigmatic text in its area and a valuable resource for courses on bioethics, and biomedical research, as well as courses that discuss ethics and the biosciences at different professional levels, biomedical industry, pharmacological companies and the public sphere in general. .
Bioethics --- Decision making. --- Biology --- Biomedical ethics --- Life sciences --- Life sciences ethics --- Science --- Moral and ethical aspects --- Bioethics. --- Medicine—Research. --- Biology—Research. --- Biomedical engineering. --- Medical sciences. --- Drug development. --- Clinical medicine—Research. --- Environment. --- Biomedical Research. --- Biomedical Engineering and Bioengineering. --- Preclinical Research. --- Clinical Research. --- Environmental Sciences. --- Balance of nature --- Bionomics --- Ecological processes --- Ecological science --- Ecological sciences --- Environment --- Environmental biology --- Oecology --- Environmental sciences --- Population biology --- Development of drugs --- Drugs --- New drug development --- Pharmacology --- Pharmacy --- Basic medical sciences --- Basic sciences, Medical --- Biomedical sciences --- Health sciences --- Preclinical sciences --- Sciences, Medical --- Medicine --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Ecology --- Development
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This book provides an overview of Data Monitoring Committees - what was done in the past, what is currently being done, and thoughts on improvements for the future. Previous works focused primarily on large cardiovascular studies (where DMCs originated more than 30 years ago) but updated references are needed that discuss smaller, more flexible studies in areas such as oncology. The authors have attended ~800 DMC meetings from ~200 distinct studies across all areas of clinical studies (oncology, rheumatology, rare diseases, cardiology, immunology, etc.) This wide range of expertise will be used, as well as the expertise that comes from working with virtually every large biotech/pharma and CRO for DMC work. The reader of the book will know when DMCs are needed or helpful, how to form the DMC, how to work with external CROs and with sponsor teams and the DMC to create needed DMC outputs, how the DMC meetings are conducted, and - especially for DMC members - what are considerations within the Closed Session to review safety/efficacy outputs to assess risk/benefit to make appropriate recommendations that protect the patient safety and trial integrity. This is a practical hands-on book on how to decide if a DMC is necessary, how to form the DMC, how to smoothly create the necessary materials for the DMC and have smooth running DMC meetings. There is no specialized training in school about how DMCs work - frequently people may have been in industry for many years without ever needing to work with a DMC. This book is the helpful reference for those new to these DMCs. The DMC work is critical to be correctly implemented as the implications of it are so great. This book provides the following: Thorough instructions on the steps needed to form and implement a Data Monitoring Committee for clinical trial evaluation; Includes practical and hands-on information on DMC implementation; Discusses a wide range of clinical trial – by phase and therapeutic area.
Pharmacology. --- Medical sciences. --- Drug development. --- Medicine—Research. --- Biology—Research. --- Pharmaceutical chemistry. --- Biometry. --- Toxicology. --- Preclinical Research. --- Biomedical Research. --- Pharmaceutics. --- Biostatistics. --- Medical Toxicology. --- Biological statistics --- Biology --- Biometrics (Biology) --- Biostatistics --- Biomathematics --- Statistics --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Chemistry --- Development of drugs --- New drug development --- Pharmacology --- Pharmacy --- Basic medical sciences --- Basic sciences, Medical --- Biomedical sciences --- Health sciences --- Preclinical sciences --- Sciences, Medical --- Life sciences --- Medicine --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Poisoning --- Poisons --- Statistical methods --- Development --- Physiological effect --- Toxicology
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