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MicroRNAs. --- Neoplasms --- genetics. --- Micro RNA --- MicroRNA --- Primary MicroRNA --- Primary miRNA --- miRNAs --- pre-miRNA --- pri-miRNA --- RNA, Small Temporal --- Small Temporal RNA --- miRNA --- stRNA --- MicroRNA, Primary --- RNA, Micro --- Temporal RNA, Small --- miRNA, Primary --- pre miRNA --- pri miRNA --- RNA, Small Interfering --- Cancer --- Genetic aspects. --- Radiotherapy. --- Cancer genetics --- Cancer genes --- Treatment

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This book tells the story of the discovery of microRNA (miRNA) quantum code, the basic theory of biological data science for medical investigation with miRNA, to its implementation. It explains the use of a new algorithm called the miRNA entangling target sorter (METS), based on the quantum computation algorithm, to give the etiologic analysis for diseases such as cancer, infectious diseases, and age-related disorders. Providing detailed descriptions to make the METS algorithm simple to grasp, it also explains the accumulated cutting-edged data for human diseases utilizing artificial intelligence (AI) for quantum miRNA language (miRNA qubit) (MIRAI). Further, it describes a discovery story for quantum miRNA surveillance against tumors and quantum miRNA immunity against viruses. Since this is a multidisciplinary field of study, crucial details on physics, mathematics, computer science, data science, virology, immunology, oncology, pathology, and biology are supplied. This book will support professional advancement for scientists, clinicians, educators, students, and science enthusiasts. The reader's knowledge of the subject and its practical medical applications will be enriched by the wealth of informative figures and supporting data.

Medical microbiology. --- Virology. --- Oncogenic viruses. --- Immunology. --- Oncology. --- Pathology. --- Medical Microbiology. --- Tumour Virus Infections. --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Tumors --- Immunobiology --- Life sciences --- Serology --- Cancer-causing viruses --- Cancer viruses --- Oncoviruses (Oncogenic viruses) --- Tumor viruses --- Tumorigenic viruses --- Viruses --- Viral carcinogenesis --- Microbiology --- MicroRNA. --- Quantum biochemistry. --- Quantum computing. --- Computation, Quantum --- Computing, Quantum --- Information processing, Quantum --- Quantum computation --- Quantum information processing --- Electronic data processing --- Biochemistry, Quantum --- Biology, Quantum --- Quantum biology --- Biochemistry --- Quantum chemistry --- Micro RNA --- miRNA (MicroRNA) --- pre-miRNA (Pre-MicroRNA) --- pri-miRNA (Primary MicroRNA) --- Primary MicroRNA --- Primary miRNA --- Small temporal RNA --- stRNA (Small temporal RNA) --- Antisense RNA --- Non-coding RNA --- MicroRNAs --- MicroRNA --- miRNAs --- pre-miRNA --- pri-miRNA --- RNA, Small Temporal --- Small Temporal RNA --- miRNA --- stRNA --- MicroRNA, Primary --- RNA, Micro --- Temporal RNA, Small --- miRNA, Primary --- pre miRNA --- pri miRNA --- RNA, Small Interfering

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This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well as improved health span and life span. The use of exosomes from body fluids to define specific biomarkers for various tumors may also clear the path to patient-targeted treatments by developing exosome-derived microRNA based cancer therapeutics. It is essential reading for graduate students, research fellow and biomedical researchers in academia or the pharmaceutical or biotech industries.

Stem cells. --- MicroRNA. --- Life sciences. --- Cancer research. --- Geriatrics. --- Cell physiology. --- Regenerative medicine. --- Tissue engineering. --- Life Sciences. --- Stem Cells. --- Regenerative Medicine/Tissue Engineering. --- Cell Physiology. --- Cancer Research. --- Geriatrics/Gerontology. --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Biomedical engineering --- Regenerative medicine --- Tissue culture --- Medicine --- Regeneration (Biology) --- Cell function --- Cytology --- Physiology --- Gerontology --- Older people --- Cancer research --- Biosciences --- Sciences, Life --- Science --- Diseases --- Health and hygiene --- Micro RNA --- miRNA (MicroRNA) --- pre-miRNA (Pre-MicroRNA) --- pri-miRNA (Primary MicroRNA) --- Primary MicroRNA --- Primary miRNA --- Small temporal RNA --- stRNA (Small temporal RNA) --- Antisense RNA --- Non-coding RNA --- Oncology. --- Tumors

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RNA interference has become a key method in the suppression of gene expression and the development of therapeutic agents, yet there is still the problem of delivery, stability, and the danger of off-target effects such as the silencing of unwanted genes and activation of innate immunity. In siRNA and miRNA Gene Silencing: From Bench to Bedside, expert researchers explore the most recent advances in siRNA design, expression, delivery, in vivo imaging, and methods to minimize siRNA's unwanted effects and promote successful use in patients. As part of the highly successful Methods in Molecular Biology™ series, the chapters focus on their respective subjects with easy-to-use, up-to-date information, including several step-by-step laboratory protocols on topics such as new delivery formulations and strategies with promising applications in vitro and in vivo, validated therapeutic target genes, and components of miRNA function, biogenesis, and interference with virus infection. Comprehensive and cutting-edge, siRNA and miRNA Gene Silencing: From Bench to Bedside offers an excellent collection of chapters to aid all those with an interest in RNAi, gene regulation, and new therapies.

RNA, Small Interfering --- MicroRNAs --- Gene Silencing. --- RNA, Small Interfering. --- Small interfering RNA --- Gene silencing. --- Petits ARN interférents --- Inactivation génétique --- therapeutic use. --- MicroRNA. --- Small interfering RNA. --- Antisense RNA. --- Gene silencing --- RNA, Antisense --- RNA, Small Untranslated --- Epigenesis, Genetic --- RNA --- Antisense Elements (Genetics) --- RNA, Untranslated --- Gene Expression Regulation --- Gene Silencing --- Nucleic Acids, Nucleotides, and Nucleosides --- Genetic Processes --- Nucleic Acids --- Chemicals and Drugs --- Genetic Phenomena --- Phenomena and Processes --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Petits ARN interférents --- Inactivation génétique --- Genetic Concepts --- Genetic Phenomenon --- Genetic Process --- Concept, Genetic --- Concepts, Genetic --- Genetic Concept --- Phenomena, Genetic --- Phenomenon, Genetic --- Process, Genetic --- Processes, Genetic --- Acids, Nucleic --- Gene Inactivation --- Inactivation, Gene --- Silencing, Gene --- Micro RNA --- MicroRNA --- Primary MicroRNA --- Primary miRNA --- miRNAs --- pre-miRNA --- pri-miRNA --- RNA, Small Temporal --- Small Temporal RNA --- miRNA --- stRNA --- MicroRNA, Primary --- RNA, Micro --- Temporal RNA, Small --- miRNA, Primary --- pre miRNA --- pri miRNA --- Short Hairpin RNA --- Short Interfering RNA --- Small Hairpin RNA --- Small Interfering RNA --- piRNA --- scnRNA --- shRNA --- tasiRNA --- Piwi-Interacting RNA --- RNA, Piwi-Interacting --- RNA, Scan --- Repeat-Associated siRNA --- Scan RNA --- Small Scan RNA --- Trans-Acting siRNA --- siRNA --- siRNA, Repeat-Associated --- siRNA, Trans-Acting --- Hairpin RNA, Short --- Hairpin RNA, Small --- Interfering RNA, Short --- Interfering RNA, Small --- Piwi Interacting RNA --- RNA, Piwi Interacting --- RNA, Short Hairpin --- RNA, Short Interfering --- RNA, Small Hairpin --- RNA, Small Scan --- Repeat Associated siRNA --- Scan RNA, Small --- Trans Acting siRNA --- siRNA, Repeat Associated --- siRNA, Trans Acting --- Expression Regulation, Gene --- Regulation, Gene Action --- Regulation, Gene Expression --- Gene Action Regulation --- Regulation of Gene Expression --- Noncoding RNA --- RNA, Non-Coding --- RNA, Non-Peptide-Coding --- RNA, Non-Protein-Coding --- RNA, Noncoding --- RNA, Nontranslated --- npcRNA --- Non-Coding RNA --- Non-Peptide-Coding RNA --- Non-Protein-Coding RNA --- Nontranslated RNA --- RNA, Non Coding --- RNA, Non Peptide Coding --- RNA, Non Protein Coding --- Untranslated RNA --- Anti-Sense Elements --- Anti-Sense Probes --- Antisense Probes --- Anti Sense Elements --- Anti Sense Probes --- Elements, Anti-Sense --- Probes, Anti-Sense --- Probes, Antisense --- Gene Products, RNA --- Non-Polyadenylated RNA --- RNA, Non-Polyadenylated --- Ribonucleic Acid --- Acid, Ribonucleic --- Non Polyadenylated RNA --- RNA Gene Products --- RNA, Non Polyadenylated --- Epigenetic Process --- Epigenetics Processes --- Epigenetic Processes --- Genetic Epigenesis --- Process, Epigenetic --- Processes, Epigenetic --- Processes, Epigenetics --- Short Noncoding RNA --- Small Non-Coding RNA --- Small Non-Messenger RNA --- Small Non-Protein-Coding RNA --- Small Noncoding RNA --- Small Untranslated RNA --- sncRNA --- sncRNAs --- Non-Coding RNA, Small --- Non-Messenger RNA, Small --- Non-Protein-Coding RNA, Small --- Noncoding RNA, Short --- Noncoding RNA, Small --- RNA, Short Noncoding --- RNA, Small Non-Coding --- RNA, Small Non-Messenger --- RNA, Small Non-Protein-Coding --- RNA, Small Noncoding --- Small Non Coding RNA --- Small Non Messenger RNA --- Small Non Protein Coding RNA --- Untranslated RNA, Small --- Anti-Sense RNA --- Antisense RNA --- Anti Sense RNA --- RNA, Anti-Sense --- Gene inactivation --- Complementary RNA --- piRNA (Piwi-interacting RNA) --- Piwi-interacting RNA --- Piwi protein-interacting RNA --- rasiRNA (Repeat-associated small interfering RNA) --- Repeat-associated siRNA --- Repeat-associated small interfering RNA --- scnRNA (Small scan RNA) --- Short hairpin RNA --- Short interfering RNA --- shRNA (Short hairpin RNA) --- siRNA (Small interfering RNA) --- Small hairpin RNA --- Small scan RNA --- tasiRNA (Trans-acting small interfering RNA) --- Trans-acting siRNA --- Trans-acting small interfering RNA --- miRNA (MicroRNA) --- pre-miRNA (Pre-MicroRNA) --- pri-miRNA (Primary MicroRNA) --- Small temporal RNA --- stRNA (Small temporal RNA) --- Biochemistry. --- Human genetics. --- Gene expression. --- Biochemistry, general. --- Human Genetics. --- Gene Expression. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Genes --- Genetic regulation --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Composition --- Expression

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This book describes translational cancer therapeutics and the way forward from clinical and molecular diagnosis to treatment. In addition, genomics alterations, microRNAs, and long non-coding RNAs translate precision medicine for the individualistic therapy of cancer patients. It describes the involvement of various pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK) modulations of medicines. Indeed, the role of bioinformatics and biostatistics, considering the extensive data analysis serving precision medicine approaches, has also been entertained in the present book. Therefore, intended book demonstrates the successful medical evidence for the use of precision medicine in the treatment of cancer and its future clinical perspectives. It fills the gaps in cancer biology and precision medicine with its up-to-date content and well-designed chapters. It will serve as a valuable resource for science, medical students, and interdisciplinary researchers. It is a very welcome addition for the scientific community, research centers, and university-industry research collaborators to find out a complete capsular package about cancer drug targets, precision, and personalized medicine (including an introduction to cancer cell signaling, genomic alterations, miRNA targeting, pharmacogenetics, biomarkers, and metabolomics in precision medicine, etc.) at a single platform.

Precision Medicine. --- Pharmacogenetics. --- Pharmacogenomic Variants. --- MicroRNAs --- RNA, Long Noncoding. --- Biomarkers. --- Neoplasms --- Medical Oncology. --- therapy. --- Clinical Oncology --- Oncology, Medical --- Oncology, Clinical --- Biochemical Marker --- Biologic Marker --- Biologic Markers --- Clinical Marker --- Immune Marker --- Immune Markers --- Immunologic Marker --- Laboratory Marker --- Marker, Biochemical --- Marker, Biological --- Marker, Clinical --- Marker, Immunologic --- Marker, Laboratory --- Marker, Serum --- Marker, Surrogate --- Serum Marker --- Surrogate End Point --- Surrogate End Points --- Surrogate Endpoint --- Surrogate Endpoints --- Surrogate Marker --- Viral Marker --- Biochemical Markers --- Biological Markers --- Biomarker --- Clinical Markers --- Immunologic Markers --- Laboratory Markers --- Markers, Biochemical --- Markers, Biological --- Markers, Clinical --- Markers, Immunologic --- Markers, Laboratory --- Markers, Serum --- Markers, Surrogate --- Markers, Viral --- Serum Markers --- Surrogate Markers --- Viral Markers --- Biological Marker --- End Point, Surrogate --- End Points, Surrogate --- Endpoint, Surrogate --- Endpoints, Surrogate --- Marker, Biologic --- Marker, Immune --- Marker, Viral --- Markers, Biologic --- Markers, Immune --- Molecular Probes --- Endophenotypes --- LINC RNA --- LincRNAs --- Long Intergenic Non-Protein Coding RNA --- Long Non-Coding RNA --- Long Non-Protein-Coding RNA --- Long Noncoding RNA --- Long ncRNA --- Long ncRNAs --- RNA, Long Non-Translated --- lncRNA --- LincRNA --- RNA, Long Untranslated --- Long Intergenic Non Protein Coding RNA --- Long Non Coding RNA --- Long Non Protein Coding RNA --- Long Non-Translated RNA --- Long Untranslated RNA --- Non-Coding RNA, Long --- Non-Protein-Coding RNA, Long --- Non-Translated RNA, Long --- Noncoding RNA, Long --- RNA, Long Non Translated --- RNA, Long Non-Coding --- RNA, Long Non-Protein-Coding --- Untranslated RNA, Long --- ncRNA, Long --- ncRNAs, Long --- Micro RNA --- MicroRNA --- Primary MicroRNA --- Primary miRNA --- miRNAs --- pre-miRNA --- pri-miRNA --- RNA, Small Temporal --- Small Temporal RNA --- miRNA --- stRNA --- MicroRNA, Primary --- RNA, Micro --- Temporal RNA, Small --- miRNA, Primary --- pre miRNA --- pri miRNA --- RNA, Small Interfering --- Pharmacogenetic Variants --- Pharmacokinetic Genetic Variants --- Genetic Variant, Pharmacokinetic --- Genetic Variants, Pharmacokinetic --- Pharmacogenetic Variant --- Pharmacogenomic Variant --- Pharmacokinetic Genetic Variant --- Variant, Pharmacogenetic --- Variant, Pharmacogenomic --- Variants, Pharmacogenetic --- Variants, Pharmacogenomic --- Pharmacogenetics --- Precision Medicine --- P Health --- P-Health --- Personalized Medicine --- Theranostics --- Individualized Medicine --- Predictive Medicine --- Medicine, Individualized --- Medicine, Personalized --- Medicine, Precision --- Medicine, Predictive --- Theranostic --- Pharmacogenomic Variants --- Patient-Specific Modeling --- Pharmacogenomics --- Drug Resistance --- Toxicology --- Cancer. --- Cancer—Genetic aspects. --- Oncology. --- Therapeutics. --- Cancer Biology. --- Cancer Genetics and Genomics. --- Medical treatment --- Therapy --- Treatment of diseases --- Treatments for diseases --- Clinical medicine --- Tumors --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors