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In recent years, the advances and abilities of computer software have substantially increased the number of scientific publications that seek to introduce new probabilistic modelling frameworks, including continuous and discrete approaches, and univariate and multivariate models. Many of these theoretical and applied statistical works are related to distributions that try to break the symmetry of the normal distribution and other similar symmetric models, mainly using Azzalini's scheme. This strategy uses a symmetric distribution as a baseline case, then an extra parameter is added to the parent model to control the skewness of the new family of probability distributions. The most widespread and popular model is the one based on the normal distribution that produces the skewed normal distribution. In this Special Issue on symmetric and asymmetric distributions, works related to this topic are presented, as well as theoretical and applied proposals that have connections with and implications for this topic. Immediate applications of this line of work include different scenarios such as economics, environmental sciences, biometrics, engineering, health, etc. This Special Issue comprises nine works that follow this methodology derived using a simple process while retaining the rigor that the subject deserves. Readers of this Issue will surely find future lines of work that will enable them to achieve fruitful research results.

Humanities --- Social interaction --- positive and negative skewness --- ordering --- fitting distributions --- Epsilon-skew-Normal --- Epsilon-skew-Cauchy --- bivariate densities --- generalized Cauchy distributions --- asymmetric bimodal distribution --- bimodal --- maximum likelihood --- slashed half-normal distribution --- kurtosis --- likelihood --- EM algorithm --- flexible skew-normal distribution --- skew Birnbaum–Saunders distribution --- bimodality --- maximum likelihood estimation --- Fisher information matrix --- maximum likelihood estimates --- type I and II censoring --- skewness coefficient --- Weibull censored data --- truncation --- half-normal distribution --- probabilistic distribution class --- normal distribution --- identifiability --- moments --- power-normal distribution --- positive and negative skewness --- ordering --- fitting distributions --- Epsilon-skew-Normal --- Epsilon-skew-Cauchy --- bivariate densities --- generalized Cauchy distributions --- asymmetric bimodal distribution --- bimodal --- maximum likelihood --- slashed half-normal distribution --- kurtosis --- likelihood --- EM algorithm --- flexible skew-normal distribution --- skew Birnbaum–Saunders distribution --- bimodality --- maximum likelihood estimation --- Fisher information matrix --- maximum likelihood estimates --- type I and II censoring --- skewness coefficient --- Weibull censored data --- truncation --- half-normal distribution --- probabilistic distribution class --- normal distribution --- identifiability --- moments --- power-normal distribution

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• Reference Manager
• EndNote
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In recent years, the advances and abilities of computer software have substantially increased the number of scientific publications that seek to introduce new probabilistic modelling frameworks, including continuous and discrete approaches, and univariate and multivariate models. Many of these theoretical and applied statistical works are related to distributions that try to break the symmetry of the normal distribution and other similar symmetric models, mainly using Azzalini's scheme. This strategy uses a symmetric distribution as a baseline case, then an extra parameter is added to the parent model to control the skewness of the new family of probability distributions. The most widespread and popular model is the one based on the normal distribution that produces the skewed normal distribution. In this Special Issue on symmetric and asymmetric distributions, works related to this topic are presented, as well as theoretical and applied proposals that have connections with and implications for this topic. Immediate applications of this line of work include different scenarios such as economics, environmental sciences, biometrics, engineering, health, etc. This Special Issue comprises nine works that follow this methodology derived using a simple process while retaining the rigor that the subject deserves. Readers of this Issue will surely find future lines of work that will enable them to achieve fruitful research results.

Humanities --- Social interaction --- positive and negative skewness --- ordering --- fitting distributions --- Epsilon-skew-Normal --- Epsilon-skew-Cauchy --- bivariate densities --- generalized Cauchy distributions --- asymmetric bimodal distribution --- bimodal --- maximum likelihood --- slashed half-normal distribution --- kurtosis --- likelihood --- EM algorithm --- flexible skew-normal distribution --- skew Birnbaum–Saunders distribution --- bimodality --- maximum likelihood estimation --- Fisher information matrix --- maximum likelihood estimates --- type I and II censoring --- skewness coefficient --- Weibull censored data --- truncation --- half-normal distribution --- probabilistic distribution class --- normal distribution --- identifiability --- moments --- power-normal distribution

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The field of design and health, formerly known as the domain of healthcare design professionals, has now reached a turning point with the proliferation of a plethora of non-invasive wearable technologies, to provide the objective and near-real-time measurement of the impact of many features of the built environment on aspects of health, wellbeing and performance. In turn, new materials and the Internet of Things are allowing the development of smart buildings, which can interact with occupants to optimize their health, wellbeing, performance and overall experience. Companies that have previously focused on positioning themselves as “green” are now turning to positioning themselves in the marketplace as both green and healthy. This Special Issue will include articles that address new cutting edge technologies and materials at the interface between design and health, and review some of the latest findings related to studies which use these technologies. This SI will also suggest exciting future directions for the field. It will include articles which focus on the objective data gathered to document the effects of the built environment on health. Importantly, it will focus on the use of innovative methods of measurement, such as state-of-the-art wearable and environmental sensors, quantifying some aspects of health, such as stress and relaxation responses, activity, posture, sleep quality, cognitive performance and wellbeing outcomes. It will also examine the impacts of different elements of the built environment on these health and wellbeing outcomes. The published articles will focus on the design interventions informed by these measurements, along with innovative integrated building materials that can shape the design of built environments for better health, productivity, and performance. It will also address the return on investment (ROI) of such design interventions. This Special Issue will provide both the foundational knowledge and fundamentals for characterizing human health and wellbeing in the built environment, as well as the emerging trends and design methods for innovations in this field.

Research & information: general --- lifestyle --- mood states --- perceived restorativeness scale --- positive and negative affect schedule --- quality of life --- resilience --- restorative outcome scale --- Shinrin-yoku --- stress coping --- subjective vitality scale --- open spaces 2 --- CKD 3 --- renal function --- exercise --- obesity --- urban environment --- walkability --- active transportation --- college students --- supportive soundscape --- sonic environment --- nursing homes --- ageing --- dementia --- green spaces --- cardiovascular risk factors --- gender --- hypercholesterolemia --- hypertension --- diabetes --- bamboo forest therapy --- psychological responses --- physiological responses --- immune system --- violent crime --- urban parks --- greenspace --- green space --- scoping review --- systematic review --- literature review --- urban --- landscape --- brain --- visual --- green --- contemplative --- mental health --- well-being --- FAA --- EEG --- UGS --- depression --- human health --- built environment --- urban open space --- forest healing --- wellbeing --- psychology --- physiology

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The field of design and health, formerly known as the domain of healthcare design professionals, has now reached a turning point with the proliferation of a plethora of non-invasive wearable technologies, to provide the objective and near-real-time measurement of the impact of many features of the built environment on aspects of health, wellbeing and performance. In turn, new materials and the Internet of Things are allowing the development of smart buildings, which can interact with occupants to optimize their health, wellbeing, performance and overall experience. Companies that have previously focused on positioning themselves as “green” are now turning to positioning themselves in the marketplace as both green and healthy. This Special Issue will include articles that address new cutting edge technologies and materials at the interface between design and health, and review some of the latest findings related to studies which use these technologies. This SI will also suggest exciting future directions for the field. It will include articles which focus on the objective data gathered to document the effects of the built environment on health. Importantly, it will focus on the use of innovative methods of measurement, such as state-of-the-art wearable and environmental sensors, quantifying some aspects of health, such as stress and relaxation responses, activity, posture, sleep quality, cognitive performance and wellbeing outcomes. It will also examine the impacts of different elements of the built environment on these health and wellbeing outcomes. The published articles will focus on the design interventions informed by these measurements, along with innovative integrated building materials that can shape the design of built environments for better health, productivity, and performance. It will also address the return on investment (ROI) of such design interventions. This Special Issue will provide both the foundational knowledge and fundamentals for characterizing human health and wellbeing in the built environment, as well as the emerging trends and design methods for innovations in this field.

Research & information: general --- lifestyle --- mood states --- perceived restorativeness scale --- positive and negative affect schedule --- quality of life --- resilience --- restorative outcome scale --- Shinrin-yoku --- stress coping --- subjective vitality scale --- open spaces 2 --- CKD 3 --- renal function --- exercise --- obesity --- urban environment --- walkability --- active transportation --- college students --- supportive soundscape --- sonic environment --- nursing homes --- ageing --- dementia --- green spaces --- cardiovascular risk factors --- gender --- hypercholesterolemia --- hypertension --- diabetes --- bamboo forest therapy --- psychological responses --- physiological responses --- immune system --- violent crime --- urban parks --- greenspace --- green space --- scoping review --- systematic review --- literature review --- urban --- landscape --- brain --- visual --- green --- contemplative --- mental health --- well-being --- FAA --- EEG --- UGS --- depression --- human health --- built environment --- urban open space --- forest healing --- wellbeing --- psychology --- physiology --- lifestyle --- mood states --- perceived restorativeness scale --- positive and negative affect schedule --- quality of life --- resilience --- restorative outcome scale --- Shinrin-yoku --- stress coping --- subjective vitality scale --- open spaces 2 --- CKD 3 --- renal function --- exercise --- obesity --- urban environment --- walkability --- active transportation --- college students --- supportive soundscape --- sonic environment --- nursing homes --- ageing --- dementia --- green spaces --- cardiovascular risk factors --- gender --- hypercholesterolemia --- hypertension --- diabetes --- bamboo forest therapy --- psychological responses --- physiological responses --- immune system --- violent crime --- urban parks --- greenspace --- green space --- scoping review --- systematic review --- literature review --- urban --- landscape --- brain --- visual --- green --- contemplative --- mental health --- well-being --- FAA --- EEG --- UGS --- depression --- human health --- built environment --- urban open space --- forest healing --- wellbeing --- psychology --- physiology

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Even in ancient times, semi-solid preparations for cutaneous application, popularly known as ointments, played an important role in human society. An advanced scientific investigation of “ointments” as dosage forms was initiated in the 1950s. It was only from then on that the intensive physico-chemical characterization of ointments as well as the inclusion of dermatological aspects led to a comprehensive understanding of the various interactions between the vehicle, the active ingredient and the skin. From then on, many researchers were involved in optimizing semi-solid formulations with respect to continuously changing therapeutic and patient needs. Aspects that have been dealt with were the optimization of dermato-biopharmaceutical properties and many different issues related to patient compliance, such as skin tolerance, applicability, and cosmetic appeal. Moreover, processing technology has been improved and analytical techniques were developed and refined in order to enable the improved characterization of the formulation itself as well as its interaction with the skin. This Special Issue serves to highlight and capture the contemporary progress and current research on semi-solid formulations as dermal drug delivery systems. We invite articles on all aspects of semi-solid formulations, highlighting the research currently undertaken to improve and better understand these complex drug delivery systems with respect to their formulation, processing and characterization issues.

dermal drug delivery --- diffusion cell --- Franz diffusion --- Skin-PAMPA --- Strat-M® membrane --- nanocarrier --- nonivamide --- methyl cellulose --- skin penetration --- substantivity --- thermogel --- tacrolimus formulation --- nanogels --- drug delivery --- human excised skin --- Jurkat cells --- in situ hydrogel-forming powder --- nitric oxide-releasing formulation --- S-nitrosoglutathione (GSNO) --- antibacterial --- wound dressing --- wound healing --- dermal delivery --- porcine skin --- in vitro permeation --- methadone --- pain --- in vitro --- permeation --- niacinamide --- solvent --- PAMPA --- skin --- curcumin --- deformable liposomes --- liposome surface charge --- hydrogel --- chitosan --- wound therapy --- IVRT --- metronidazole --- topical cream --- semisolid dosage forms --- sameness --- FDA’s SUPAC-SS guidance --- acceptance criteria --- positive and negative controls --- discriminatory ability --- Amphotericin B --- Sepigel 305® --- Leishmania infantum --- cutaneous leishmaniasis --- topical treatment --- birch bark extract --- oleogels --- hydrogen bonding --- triterpene --- rheology --- gel strength --- eosinophilic esophagitis --- budesonide --- xanthan gum --- guar gum --- mucoadhesion --- esophagus permeability --- rheological characterization --- pediatric medicine --- compounded preparation --- non-ionic emulsifiers --- intercellular lipids --- confocal Raman spectroscopy (CRS) --- polyethylene glycol alkyl ethers --- polyethylene glycol sorbitan fatty acid esters --- n/a --- FDA's SUPAC-SS guidance