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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- Neurology & clinical neurophysiology --- Epidemiology --- prevalence --- population-based study --- risk factors --- neurological disorders

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Clinical Genomics provides an overview of the various next-generation sequencing (NGS) technologies that are currently used in clinical diagnostic laboratories. It presents key bioinformatic challenges and the solutions that must be addressed by clinical genomicists and genomic pathologists, such as specific pipelines for identification of the full range of variants that are clinically important. This book is also focused on the challenges of diagnostic interpretation of NGS results in a clinical setting.

Genomics. --- Medical genetics. --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Genome research --- Genomes --- Molecular genetics --- Genetic aspects --- Research --- Community Health Planning --- Public Health --- Biostatistics --- Health Education --- Health Promotion --- Community Health Systems --- Population-Based Planning --- Community Health Plannings --- Community Health System --- Health Planning, Community --- Health Plannings, Community --- Health System, Community --- Health Systems, Community --- Planning, Community Health --- Planning, Population-Based --- Plannings, Community Health --- Plannings, Population-Based --- Population Based Planning --- Population-Based Plannings --- System, Community Health --- Systems, Community Health --- Promotional Items --- Health Campaigns --- Promotion of Health --- Wellness Programs --- Campaign, Health --- Campaigns, Health --- Health Campaign --- Health Promotions --- Item, Promotional --- Items, Promotional --- Program, Wellness --- Programs, Wellness --- Promotion, Health --- Promotional Item --- Promotions, Health --- Wellness Program --- Preventive Health Services --- Preventive Medicine --- Education, Community Health --- Health Education, Community --- Community Health Education --- Education, Health --- Health --- Biological Statistics --- Biological Statistic --- Statistic, Biological --- Statistics, Biological --- Community Health --- Environment, Preventive Medicine & Public Health --- Environment, Preventive Medicine and Public Health --- Health, Community --- Health, Public --- Education, Public Health Professional --- education

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This progressive resource brings the innovative power of narrative medicine to the forefront of community public health care. Chapters describe community involvement across a continuum of control, from health consultants describing problems and suggesting solutions to health committees designing programs and evaluating results. Narrative strategies to this end, including authentic dialogue and community mapping, are examined in the context of public health and fleshed out with examples of different levels of participation by community members. From the respectful collaboration modeled here, the principles of community public health care can potentially expand beyond the immediate community into other social domains on a greater scale. Included in the coverage: Narratives, local knowledge, and world entry. Community and narratives. What is dialogue? Storylines, causes, and locus of interventions. Community mapping tells a story. The politics of storytelling. Narrative Medicine and Community-Based Health Care and Planning  gives health psychologists, sociologists, social workers, and public health administrators realistic practical insights for tapping into the unique resources communities and clients have to offer. This is the next step in the evolution of public health, toward large-scale improvements in care delivery, access to and relevance of services, and patient and community outcomes.

Psychology. --- Rehabilitation. --- Social medicine. --- Social service. --- Health psychology. --- Health Psychology. --- Social Work and Community Development. --- Medical Sociology. --- Health psychology --- Health psychology, Clinical --- Psychology, Clinical health --- Psychology, Health --- Salutogenesis --- Benevolent institutions --- Philanthropy --- Relief stations (for the poor) --- Social service agencies --- Social welfare --- Social work --- Medical care --- Medical sociology --- Medicine --- Medicine, Social --- Behavioral sciences --- Mental philosophy --- Mind --- Science, Mental --- Social aspects --- Narrative Medicine. --- Community Health Services. --- Community Health Planning. --- Community Participation. --- Social Medicine. --- Clinical psychology --- Medicine and psychology --- Human services --- Public health --- Public welfare --- Sociology --- Medical ethics --- Medical sociologists --- Human biology --- Philosophy --- Soul --- Mental health --- Public Health --- Community Involvement --- Public Participation --- Community Action --- Consumer Involvement --- Consumer Participation --- Action, Community --- Actions, Community --- Community Actions --- Community Involvements --- Consumer Involvements --- Involvement, Community --- Involvement, Consumer --- Involvements, Community --- Participation, Community --- Participation, Consumer --- Participation, Public --- Political Activism --- Delivery of Health Care --- Patient Care Planning --- Community Health Systems --- Population-Based Planning --- Community Health Plannings --- Community Health System --- Health Planning, Community --- Health Plannings, Community --- Health System, Community --- Health Systems, Community --- Planning, Community Health --- Planning, Population-Based --- Plannings, Community Health --- Plannings, Population-Based --- Population Based Planning --- Population-Based Plannings --- System, Community Health --- Systems, Community Health --- Community Healthcare --- Health Services, Community --- Services, Community Health --- Community Health Care --- Care, Community Health --- Community Health Service --- Community Healthcares --- Health Care, Community --- Health Service, Community --- Healthcare, Community --- Healthcares, Community --- Service, Community Health --- Public Health Administration --- Social Work --- Community Health Planning --- Medicine, Narrative --- Community health services. --- Neighborhood health centers --- Regional medical programs --- Psychology, clinical.

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Melanoma is a very aggressive tumor which is derived from the transformation of pigment-producing cells termed the melanocytes. This cancer type accounts for most of the deaths associated with skin cancer as well as its incidence and is in constant evolution. Because of the rapid and very high metastatic potential of this tumor, melanoma prognosis has been quite poor for a long time. In the past decade, groundbreaking discoveries in the melanoma research field have led to the development of two main treatment strategies: combination therapies targeting specific kinases or combination therapies focused on immune checkpoint inhibitors (ICIs). These treatment approaches have become the standard of care in most cancer centers and significantly improved the prognosis and overall survival of advanced melanoma patients. Nevertheless, many patients do not benefit from or even respond to these treatments. It is therefore essential to better comprehend the phenomenon of drug resistance, immune escape mechanisms, as well as to search for alternative treatment strategies. In addition, strong predictive biomarkers are desperately needed to improve clinical efficacy. The aim of this Special Issue is to present recent advances in the field of melanoma research, in which the abovementioned areas represent the primary focus, and other relevant themes are also discussed.

Public health & preventive medicine --- melanoma --- targeted therapies --- BRAF --- druggable mutations --- real-time PCR --- NGS assay --- immune escape --- microRNA --- transporter associated with antigen processing --- incidence --- population-based study --- epidemiology --- Spain --- skin cancer --- single-cell transcriptome sequencing --- treatment response --- pseudotime analysis --- treatment --- ubiquitination --- miRNAs --- embryogenesis --- melanoblasts --- melanoblast --- NF1 --- transcriptome --- RNAseq --- Trp-1 --- metastasis --- animal models --- lung --- mice

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Melanoma is a very aggressive tumor which is derived from the transformation of pigment-producing cells termed the melanocytes. This cancer type accounts for most of the deaths associated with skin cancer as well as its incidence and is in constant evolution. Because of the rapid and very high metastatic potential of this tumor, melanoma prognosis has been quite poor for a long time. In the past decade, groundbreaking discoveries in the melanoma research field have led to the development of two main treatment strategies: combination therapies targeting specific kinases or combination therapies focused on immune checkpoint inhibitors (ICIs). These treatment approaches have become the standard of care in most cancer centers and significantly improved the prognosis and overall survival of advanced melanoma patients. Nevertheless, many patients do not benefit from or even respond to these treatments. It is therefore essential to better comprehend the phenomenon of drug resistance, immune escape mechanisms, as well as to search for alternative treatment strategies. In addition, strong predictive biomarkers are desperately needed to improve clinical efficacy. The aim of this Special Issue is to present recent advances in the field of melanoma research, in which the abovementioned areas represent the primary focus, and other relevant themes are also discussed.

Public health & preventive medicine --- melanoma --- targeted therapies --- BRAF --- druggable mutations --- real-time PCR --- NGS assay --- immune escape --- microRNA --- transporter associated with antigen processing --- incidence --- population-based study --- epidemiology --- Spain --- skin cancer --- single-cell transcriptome sequencing --- treatment response --- pseudotime analysis --- treatment --- ubiquitination --- miRNAs --- embryogenesis --- melanoblasts --- melanoblast --- NF1 --- transcriptome --- RNAseq --- Trp-1 --- metastasis --- animal models --- lung --- mice