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Book
Actinomycetes : The Antibiotics Producers
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Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Beyond being the most important natural compound source, actinomycetes are the origin of up to two-thirds of all clinically used antibiotics. Currently, new antimicrobials are urgently needed, as infections caused by antibiotic-resistant pathogens are on the rise. In the identification of new antibiotics, many scientists are currently investigating biosynthetic aspects of antibiotic production in actinomycetes. Since the emergence of next-generation sequencing technologies, the field of antibiotics research has experienced a remarkable revival. These bacteria have the potential to produce more antibiotics than previously thought possible. Some antibiotics are produced in standard media, while others require the presence of a specific signaling molecule in the medium. Others, however, are only produced when the native regulation of the biosynthesis gene cluster is overruled. This book covers topics in the field of antibiotic-producing actinomycetes. The following tops are addressed: - Approaches to access novel antibiotic producers for novel natural compounds - Omics and genome mining approaches for the discovery of novel natural compounds - Analyses and genetic engineering of antibiotic biosynthesis - Regulation of the secondary metabolism in actinomycetes

Keywords

Research & information: general --- Biology, life sciences --- Streptomyces --- biogeography --- comparative genomics --- diversification --- secondary metabolite biosynthetic gene clusters --- SMGC --- natural products --- streptomyces --- rishirilide --- biosynthesis --- polyketides --- polynucleotide phosphorylase --- ribonuclease --- regulation --- promoter --- RNA decay --- polyadenylation --- (p)ppGpp --- antibiotic --- antibiotics --- geomicrobiology --- Illumina sequencing --- microbiome diversity --- Actinobacteria --- Cave microbiology --- secondary metabolite --- rare Actinobacteria --- Amycolatopsis --- unculturability --- siderophore --- glycopeptide antibiotics --- dbv cluster --- regulatory genes --- StrR --- LAL --- LuxR solo --- dalbavancin --- A40926 --- Streptomyces lividans --- secretion pathways --- secretory proteins --- signal peptides --- actinomycetes --- teicoplanin --- van resistance genes --- Streptomyces tsukubaensis --- tacrolimus --- FK506 --- omics --- screening --- secondary metabolism --- differentiation --- elicitors --- morphology --- liquid cultures --- metagenomics --- rare actinomycetes --- dereplication --- metabolomics --- genome mining --- secondary metabolites --- novel compounds --- physicochemical screening --- physical and chemical properties --- structural diversity --- biological activity --- Actinoallomurus --- antibiotics polyethers --- lysolipin --- minimal PKS II --- cyclases --- benz[a]naphthacene quinone --- tridecaketide --- aromatic polyketide --- pentacyclic angular polyphenol --- extended polyketide chain --- actinobacteria --- β-lactamase --- resistance --- β-lactamase inhibitor --- polyketide synthases --- acyltransferases --- engineering --- new bioactive compounds --- symbiosis --- drug discovery --- chemical ecology --- culture-based approaches --- strain --- specialized metabolites --- biosynthetic gene cluster --- n/a


Book
Actinomycetes : The Antibiotics Producers
Authors: ---
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Beyond being the most important natural compound source, actinomycetes are the origin of up to two-thirds of all clinically used antibiotics. Currently, new antimicrobials are urgently needed, as infections caused by antibiotic-resistant pathogens are on the rise. In the identification of new antibiotics, many scientists are currently investigating biosynthetic aspects of antibiotic production in actinomycetes. Since the emergence of next-generation sequencing technologies, the field of antibiotics research has experienced a remarkable revival. These bacteria have the potential to produce more antibiotics than previously thought possible. Some antibiotics are produced in standard media, while others require the presence of a specific signaling molecule in the medium. Others, however, are only produced when the native regulation of the biosynthesis gene cluster is overruled. This book covers topics in the field of antibiotic-producing actinomycetes. The following tops are addressed: - Approaches to access novel antibiotic producers for novel natural compounds - Omics and genome mining approaches for the discovery of novel natural compounds - Analyses and genetic engineering of antibiotic biosynthesis - Regulation of the secondary metabolism in actinomycetes

Keywords

Streptomyces --- biogeography --- comparative genomics --- diversification --- secondary metabolite biosynthetic gene clusters --- SMGC --- natural products --- streptomyces --- rishirilide --- biosynthesis --- polyketides --- polynucleotide phosphorylase --- ribonuclease --- regulation --- promoter --- RNA decay --- polyadenylation --- (p)ppGpp --- antibiotic --- antibiotics --- geomicrobiology --- Illumina sequencing --- microbiome diversity --- Actinobacteria --- Cave microbiology --- secondary metabolite --- rare Actinobacteria --- Amycolatopsis --- unculturability --- siderophore --- glycopeptide antibiotics --- dbv cluster --- regulatory genes --- StrR --- LAL --- LuxR solo --- dalbavancin --- A40926 --- Streptomyces lividans --- secretion pathways --- secretory proteins --- signal peptides --- actinomycetes --- teicoplanin --- van resistance genes --- Streptomyces tsukubaensis --- tacrolimus --- FK506 --- omics --- screening --- secondary metabolism --- differentiation --- elicitors --- morphology --- liquid cultures --- metagenomics --- rare actinomycetes --- dereplication --- metabolomics --- genome mining --- secondary metabolites --- novel compounds --- physicochemical screening --- physical and chemical properties --- structural diversity --- biological activity --- Actinoallomurus --- antibiotics polyethers --- lysolipin --- minimal PKS II --- cyclases --- benz[a]naphthacene quinone --- tridecaketide --- aromatic polyketide --- pentacyclic angular polyphenol --- extended polyketide chain --- actinobacteria --- β-lactamase --- resistance --- β-lactamase inhibitor --- polyketide synthases --- acyltransferases --- engineering --- new bioactive compounds --- symbiosis --- drug discovery --- chemical ecology --- culture-based approaches --- strain --- specialized metabolites --- biosynthetic gene cluster --- n/a


Book
Actinomycetes : The Antibiotics Producers
Authors: ---
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

Loading...
Export citation

Choose an application

Bookmark

Abstract

Beyond being the most important natural compound source, actinomycetes are the origin of up to two-thirds of all clinically used antibiotics. Currently, new antimicrobials are urgently needed, as infections caused by antibiotic-resistant pathogens are on the rise. In the identification of new antibiotics, many scientists are currently investigating biosynthetic aspects of antibiotic production in actinomycetes. Since the emergence of next-generation sequencing technologies, the field of antibiotics research has experienced a remarkable revival. These bacteria have the potential to produce more antibiotics than previously thought possible. Some antibiotics are produced in standard media, while others require the presence of a specific signaling molecule in the medium. Others, however, are only produced when the native regulation of the biosynthesis gene cluster is overruled. This book covers topics in the field of antibiotic-producing actinomycetes. The following tops are addressed: - Approaches to access novel antibiotic producers for novel natural compounds - Omics and genome mining approaches for the discovery of novel natural compounds - Analyses and genetic engineering of antibiotic biosynthesis - Regulation of the secondary metabolism in actinomycetes

Keywords

Research & information: general --- Biology, life sciences --- Streptomyces --- biogeography --- comparative genomics --- diversification --- secondary metabolite biosynthetic gene clusters --- SMGC --- natural products --- streptomyces --- rishirilide --- biosynthesis --- polyketides --- polynucleotide phosphorylase --- ribonuclease --- regulation --- promoter --- RNA decay --- polyadenylation --- (p)ppGpp --- antibiotic --- antibiotics --- geomicrobiology --- Illumina sequencing --- microbiome diversity --- Actinobacteria --- Cave microbiology --- secondary metabolite --- rare Actinobacteria --- Amycolatopsis --- unculturability --- siderophore --- glycopeptide antibiotics --- dbv cluster --- regulatory genes --- StrR --- LAL --- LuxR solo --- dalbavancin --- A40926 --- Streptomyces lividans --- secretion pathways --- secretory proteins --- signal peptides --- actinomycetes --- teicoplanin --- van resistance genes --- Streptomyces tsukubaensis --- tacrolimus --- FK506 --- omics --- screening --- secondary metabolism --- differentiation --- elicitors --- morphology --- liquid cultures --- metagenomics --- rare actinomycetes --- dereplication --- metabolomics --- genome mining --- secondary metabolites --- novel compounds --- physicochemical screening --- physical and chemical properties --- structural diversity --- biological activity --- Actinoallomurus --- antibiotics polyethers --- lysolipin --- minimal PKS II --- cyclases --- benz[a]naphthacene quinone --- tridecaketide --- aromatic polyketide --- pentacyclic angular polyphenol --- extended polyketide chain --- actinobacteria --- β-lactamase --- resistance --- β-lactamase inhibitor --- polyketide synthases --- acyltransferases --- engineering --- new bioactive compounds --- symbiosis --- drug discovery --- chemical ecology --- culture-based approaches --- strain --- specialized metabolites --- biosynthetic gene cluster --- Streptomyces --- biogeography --- comparative genomics --- diversification --- secondary metabolite biosynthetic gene clusters --- SMGC --- natural products --- streptomyces --- rishirilide --- biosynthesis --- polyketides --- polynucleotide phosphorylase --- ribonuclease --- regulation --- promoter --- RNA decay --- polyadenylation --- (p)ppGpp --- antibiotic --- antibiotics --- geomicrobiology --- Illumina sequencing --- microbiome diversity --- Actinobacteria --- Cave microbiology --- secondary metabolite --- rare Actinobacteria --- Amycolatopsis --- unculturability --- siderophore --- glycopeptide antibiotics --- dbv cluster --- regulatory genes --- StrR --- LAL --- LuxR solo --- dalbavancin --- A40926 --- Streptomyces lividans --- secretion pathways --- secretory proteins --- signal peptides --- actinomycetes --- teicoplanin --- van resistance genes --- Streptomyces tsukubaensis --- tacrolimus --- FK506 --- omics --- screening --- secondary metabolism --- differentiation --- elicitors --- morphology --- liquid cultures --- metagenomics --- rare actinomycetes --- dereplication --- metabolomics --- genome mining --- secondary metabolites --- novel compounds --- physicochemical screening --- physical and chemical properties --- structural diversity --- biological activity --- Actinoallomurus --- antibiotics polyethers --- lysolipin --- minimal PKS II --- cyclases --- benz[a]naphthacene quinone --- tridecaketide --- aromatic polyketide --- pentacyclic angular polyphenol --- extended polyketide chain --- actinobacteria --- β-lactamase --- resistance --- β-lactamase inhibitor --- polyketide synthases --- acyltransferases --- engineering --- new bioactive compounds --- symbiosis --- drug discovery --- chemical ecology --- culture-based approaches --- strain --- specialized metabolites --- biosynthetic gene cluster


Book
Genome Mining and Marine Microbial Natural Products
Authors: --- ---
ISBN: 3039280910 3039280902 Year: 2020 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Two review papers, eight research articles, and one brief report were published in this Special Issue. They showed the rich resources that are present within the genomes of marine microorganisms and discussed the use of recently developed tools and technologies to exploit this genetic richness. Examples include the rational supply of precursors according to the relevant biosynthetic pathway and stress driven discovery together with the use of histone deacetylase inhibitors to facilitate the discovery of new bioactive molecules with potential biopharmaceutical applications. We believe that the content of this Special Issue reflects the current state-of-the-art research in this area and highlights the interesting strategies that are being employed to uncover increasing numbers of exciting novel compounds for drug discovery from marine genetic resources.


Book
Genome Mining and Synthetic Biology in Marine Natural Products Discovery
Author:
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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In recent years, marine genomics has become a growning rapidly field, helped by the large amount of information that is becoming available to the international scientific community. Taking into account the current excitement in the field of marine biotechnology, this Special Issue entitled “Genome Mining and Synthetic Biology in Marine Natural Product Discovery” aims to to assess the impact of these molecular approaches on the discovery of bioactive compounds from marine organisms. The term “genome mining” is used to identify all bioinformatic investigations aimed at detecting the biosynthetic pathways of bioactive natural products and their possible functional and chemical interactions. Several studies are now reporting on marine organisms. Oceans cover nearly 70% of the Earth’s surface and host a huge ecological, chemical, and biological diversity. The natural conditions of the sea favor, in marine organisms, the production of a large variety of novel molecules with great pharmaceutical potential. Marine organisms are unique in their structural and functional features compared to terrestrial ones. Innovation in this field is very rapid, as revealed by the funding of several Seventh Framework Programme (FP7) and Horizon 2020 projects under the topic “Blue Growth”, with the urgent goal of discovering new drugs.


Book
Actinobacteria and Myxobacteria : Important Resources for Novel Antibiotics
Author:
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Bacterial infections cause millions of deaths globally, particularly in children and the elderly, and four of the 10 leading causes of death are infectious diseases in low- and middle-income countries. The continuous use of antibiotics has resulted in multi-resistant bacterial strains all over the world, such as Community-associated Methicillin-resistant Staphylococcus aureus (MRSA), extended-spectrum β-lactamases (ESBLs), and, as expected, hospitals have become breeding grounds for human-associated microorganisms, especially in critical care units.


Book
Genome Mining and Synthetic Biology in Marine Natural Products Discovery
Author:
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

In recent years, marine genomics has become a growning rapidly field, helped by the large amount of information that is becoming available to the international scientific community. Taking into account the current excitement in the field of marine biotechnology, this Special Issue entitled “Genome Mining and Synthetic Biology in Marine Natural Product Discovery” aims to to assess the impact of these molecular approaches on the discovery of bioactive compounds from marine organisms. The term “genome mining” is used to identify all bioinformatic investigations aimed at detecting the biosynthetic pathways of bioactive natural products and their possible functional and chemical interactions. Several studies are now reporting on marine organisms. Oceans cover nearly 70% of the Earth’s surface and host a huge ecological, chemical, and biological diversity. The natural conditions of the sea favor, in marine organisms, the production of a large variety of novel molecules with great pharmaceutical potential. Marine organisms are unique in their structural and functional features compared to terrestrial ones. Innovation in this field is very rapid, as revealed by the funding of several Seventh Framework Programme (FP7) and Horizon 2020 projects under the topic “Blue Growth”, with the urgent goal of discovering new drugs.


Book
Actinobacteria and Myxobacteria : Important Resources for Novel Antibiotics
Author:
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Bacterial infections cause millions of deaths globally, particularly in children and the elderly, and four of the 10 leading causes of death are infectious diseases in low- and middle-income countries. The continuous use of antibiotics has resulted in multi-resistant bacterial strains all over the world, such as Community-associated Methicillin-resistant Staphylococcus aureus (MRSA), extended-spectrum β-lactamases (ESBLs), and, as expected, hospitals have become breeding grounds for human-associated microorganisms, especially in critical care units.


Book
Genome Mining and Synthetic Biology in Marine Natural Products Discovery
Author:
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

In recent years, marine genomics has become a growning rapidly field, helped by the large amount of information that is becoming available to the international scientific community. Taking into account the current excitement in the field of marine biotechnology, this Special Issue entitled “Genome Mining and Synthetic Biology in Marine Natural Product Discovery” aims to to assess the impact of these molecular approaches on the discovery of bioactive compounds from marine organisms. The term “genome mining” is used to identify all bioinformatic investigations aimed at detecting the biosynthetic pathways of bioactive natural products and their possible functional and chemical interactions. Several studies are now reporting on marine organisms. Oceans cover nearly 70% of the Earth’s surface and host a huge ecological, chemical, and biological diversity. The natural conditions of the sea favor, in marine organisms, the production of a large variety of novel molecules with great pharmaceutical potential. Marine organisms are unique in their structural and functional features compared to terrestrial ones. Innovation in this field is very rapid, as revealed by the funding of several Seventh Framework Programme (FP7) and Horizon 2020 projects under the topic “Blue Growth”, with the urgent goal of discovering new drugs.


Book
Methods in enzymology.
Author:
ISSN: 00766879 ISBN: 0123745918 9780123745910 9786612120947 1282120948 0080923364 Year: 2009 Volume: 459 Publisher: Amsterdam [Netherlands] ; Boston [Mass.] : Academic Press/Elsevier,

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Abstract

Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been

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