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This Special Issue on “Blood-Derived Products for Tissue Repair and Regeneration” reveals the evolution and diversity of platelet rich plasma (PRP) technologies, which includes experimental research on novel formulations, the creation of combination therapies, and the exploration of potential modifiers of PRPs, as well as efficacy of PRP therapies in clinical veterinary and human applications. Scientist and clinicians are now starting to develop different treatments based on their reinterpretation of the traditional roles of platelets and plasma, and the current Issue has provided a forum for sharing research and ways of understanding the associated medicinal benefits from different points of view. The research interest in this area has covered different medical disciplines, such as ophthalmology, dentistry, orthopedics, and sports medicine.

n/a --- biomaterial --- redifferentiation --- regenerative medicine --- skeletal muscle regeneration --- furcation defects --- Platelet-Rich Plasma (PRP) --- PRP --- fracture --- fibrin sealant --- periodontal surgery --- bone regeneration --- serum derived from plasma rich in growth factors (s-PRGF) --- cartilage repair --- myofibroblasts --- autologous platelet concentrates --- burns --- satellite cells --- articular cartilage --- stem cell niche --- wound healing --- quantification --- growth factors --- biologics --- platelet rich plasma --- meniscus --- adipose tissue --- Carprofen --- platelet-rich fibrin --- platelets --- hyperacute serum --- bone defects --- serum eye drops --- corneal epithelial defect --- fibrosis --- dog --- myoblasts --- differentiation --- chronic meniscal lesion --- horizontal meniscal tear --- PRGF --- collagen hydrogels --- periodontal defects --- bone grafting material --- composition --- cell therapy --- bone healing --- tissue healing --- trephination --- plasma rich plasma (PRP) --- bone repair --- plasma rich in growth factors --- knee arthrosis --- meniscus tear --- cornea regeneration --- wrist osteoarthritis --- periosteal sheet --- Platelet-Poor Plasma (PPP) --- platelet-rich plasma --- microfat --- bone grafting --- hyaluronic acid (NaHA) --- periodontal regeneration --- meniscus repair --- photobiomodulation therapy --- growth --- myogenesis --- blood derived products --- low-level laser therapy

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The papers collected in this Special Issue entitled “Electrospun Nanomaterials: Applications in Food, Environmental Remediation, and Bioengineering” illustrate the high diversity and potential for implementation of electrospun nanofibers in these fields, including the covering of a wide number of subtopics. Examples of these applications have included bioactive scaffolds, wound healing dressings, compound protective nanoreservoirs and sustained and controlled release systems. An important driver of these applications results from advances in materials science and new nanofiber manufacturing processes. Definitely, such pieces of fundamental research will contribute to the promotion of electrospinning as a focal point in the future development of technological applications at the interface of biological systems, which promise long-term benefits for both health and the environment.

electrospinning --- curcumin --- PLA/PEG/curcumin nanofiber --- drug release --- porous nanofiber --- polycaprolactone --- nanofibers --- COOH plasma --- cell adhesion and spreading --- cell viability --- freeze–thawed platelet-rich plasma immobilization --- piezoelectricity --- scaffold --- polyvinylidene fluoride --- polyvinylidene fluoride-trifluoroethylene --- tissue engineering --- osteoblast --- neuron --- stem cell --- aligned fiber --- HDPAF --- micro-nanofibers --- β-carotene --- thermoprotection --- photoprotection --- antibacterial effect --- centella --- propolis --- hinokitiol --- biodegradable polymer --- PHBH --- nanofiber --- food packaging --- functional membrane --- biomaterials --- polymers --- PMVE/MA --- nanoparticles --- nanoencapsulation --- antibiotics --- electrospun nanofibers --- polyethylene oxide nanofibers PEO-NFs --- microbial fuel cells --- honey --- food industry --- recovered energy (Erec) --- chitosan --- chitin nanofibrils --- hemostatic material --- hemorrhage --- photoactive nanoparticles --- cadmium selenide --- cellulose acetate --- electrospun fibers --- solar thermal --- n/a --- freeze-thawed platelet-rich plasma immobilization

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The papers collected in this Special Issue entitled “Electrospun Nanomaterials: Applications in Food, Environmental Remediation, and Bioengineering” illustrate the high diversity and potential for implementation of electrospun nanofibers in these fields, including the covering of a wide number of subtopics. Examples of these applications have included bioactive scaffolds, wound healing dressings, compound protective nanoreservoirs and sustained and controlled release systems. An important driver of these applications results from advances in materials science and new nanofiber manufacturing processes. Definitely, such pieces of fundamental research will contribute to the promotion of electrospinning as a focal point in the future development of technological applications at the interface of biological systems, which promise long-term benefits for both health and the environment.

Technology: general issues --- electrospinning --- curcumin --- PLA/PEG/curcumin nanofiber --- drug release --- porous nanofiber --- polycaprolactone --- nanofibers --- COOH plasma --- cell adhesion and spreading --- cell viability --- freeze-thawed platelet-rich plasma immobilization --- piezoelectricity --- scaffold --- polyvinylidene fluoride --- polyvinylidene fluoride-trifluoroethylene --- tissue engineering --- osteoblast --- neuron --- stem cell --- aligned fiber --- HDPAF --- micro-nanofibers --- β-carotene --- thermoprotection --- photoprotection --- antibacterial effect --- centella --- propolis --- hinokitiol --- biodegradable polymer --- PHBH --- nanofiber --- food packaging --- functional membrane --- biomaterials --- polymers --- PMVE/MA --- nanoparticles --- nanoencapsulation --- antibiotics --- electrospun nanofibers --- polyethylene oxide nanofibers PEO-NFs --- microbial fuel cells --- honey --- food industry --- recovered energy (Erec) --- chitosan --- chitin nanofibrils --- hemostatic material --- hemorrhage --- photoactive nanoparticles --- cadmium selenide --- cellulose acetate --- electrospun fibers --- solar thermal --- electrospinning --- curcumin --- PLA/PEG/curcumin nanofiber --- drug release --- porous nanofiber --- polycaprolactone --- nanofibers --- COOH plasma --- cell adhesion and spreading --- cell viability --- freeze-thawed platelet-rich plasma immobilization --- piezoelectricity --- scaffold --- polyvinylidene fluoride --- polyvinylidene fluoride-trifluoroethylene --- tissue engineering --- osteoblast --- neuron --- stem cell --- aligned fiber --- HDPAF --- micro-nanofibers --- β-carotene --- thermoprotection --- photoprotection --- antibacterial effect --- centella --- propolis --- hinokitiol --- biodegradable polymer --- PHBH --- nanofiber --- food packaging --- functional membrane --- biomaterials --- polymers --- PMVE/MA --- nanoparticles --- nanoencapsulation --- antibiotics --- electrospun nanofibers --- polyethylene oxide nanofibers PEO-NFs --- microbial fuel cells --- honey --- food industry --- recovered energy (Erec) --- chitosan --- chitin nanofibrils --- hemostatic material --- hemorrhage --- photoactive nanoparticles --- cadmium selenide --- cellulose acetate --- electrospun fibers --- solar thermal

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Carpal tunnel syndrome (CTS) is a very common median nerve compression neuropathy at wrist level. It causes unplesant symptoms to patient as well as a financial burden for society. Conservative treatment helps with mild and transient symptoms, but often this syndrome requires surgical treatment. Surgical decompression of the median nerve is one of the most common surgical operations. If the symptom persists for a long time and treatment is delayed, this can result in a lack of sensation in the median area in addition to thenar atrophy and weakness of the thumb opposition. There are many impressive things behind CTS that we do not know yet; anatomical causes, links to other diseases and medication, occupational exposures and predisposing lifestyle risk factors. Diagnostics and differential diagnostics of CTS have their own challenges. Conservative treatment practices of CTS are diverse and unambiguous best practice is not clear. Clinical symptoms, electromyography (EMG) finding, and possible differential diagnostic challenges should be considered when deciding on surgery. Surgical treatment varies somewhat from hospital to hospital and from country to country. When the CTS diagnosis and treatment is done too late for nerves to recover or there is perioperative complication, some late reconstructive surgeries might be needed. These nerve surgery techniques can be done by experienced hand surgeons. The quality of care, complications, and cost effectiveness of different methods require further research. This Special Issue will present the latest research on this interesting and clinically significant syndrome.

Medicine --- carpal tunnel syndrome --- support vector machine --- machine learning --- tablet app --- screening --- manual dexterity --- drawing --- nerve --- pain --- mobility --- ESWT --- corticosteroid --- gabapentin --- Kinesio taping --- orthoses --- platelet-rich plasma --- neurodynamic techniques --- ultrasound --- splint --- entrapment neuropathy --- conditioned pain modulation --- temporal summation --- pain measurement --- pressure pain threshold --- central sensitization --- central sensitization inventory --- neuropathy --- revision carpal tunnel release --- neurolysis --- body mass index --- waist circumference --- waist-to-hip ratio --- obesity --- median nerve --- diabetic neuropathy --- diabetes --- nerve conduction study --- electrophysiological severity classification --- electrodiagnosis --- X-rays --- ultrasonography --- diabetes mellitus --- peripheral nerve ultrasound --- carpal tunnel release --- wide-awake anesthesia --- local anesthesia --- WALANT --- nerve compression --- carpal tunnel surgery --- ulnar nerve entrapment --- cubital tunnel syndrome --- psychotropic drugs --- psychological health --- socioeconomical factors --- national quality register --- median neuropathy --- median nerve entrapment --- neuralgic amyotrophy --- pronator syndrome --- trends --- Japan --- n/a

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Recently, stem cells have been drawing increasing interest in basic and translational research that aims to understand stem cell biology and generate new therapies for various disorders. Many stem cells can be cultured in 2D relatively easily using tissue culture plastic. However, many of these cultures do not represent the natural conditions of stem cells in the body. In the body, microenvironments include numerous supporting cells and molecules. Therefore, researchers and clinicians have sought ideal stem cell preparations for basic research and clinical applications, which may be attainable through 3D culture of stem cells. The 3D cultures mimic the conditions of the natural environment of stem cells better, as cells in 3D cultures exhibit many unique and desirable characteristics that could be beneficial for therapeutic interventions. 3D stem cell cultures may employ supporting structures, such as various matrices or scaffolds, in addition to stem cells, to support complex structures. This book brings together recent research on 3D cultures of various stem cells to increase the basic understanding of stem cell culture techniques and also to highlight stem cell preparations for possible novel therapeutic applications.

hematopoiesis --- hematopoietic stem cells --- stem cell culture --- 2D culture --- 3D culture --- embryonic stem cells --- three-dimensional --- self-assembling scaffold --- pluripotency --- culture conditions --- expansion --- growth --- niche --- human cortical progenitors --- silicon pillars --- cell growth --- hiPSC-derived neural progenitors --- cerebral cortex --- carcinogen --- protein phosphatase 2A (PP2A) --- intestinal tumor --- intestinal organoid --- Lgr5+ crypt stem cell --- mouse embryonic stem cell --- differentiation protocol --- ureteric bud progenitor cells --- 3D kidney organoids --- intestinal organoids --- canine intestine --- differentiation --- organoid culture --- induced pluripotent stem cells --- neurospheres --- neurite outgrowth --- neurotoxicity --- hBM-MSCs --- cytokines --- tenogenic markers --- cyclic strain --- 3D microenvironment --- PLGA carriers --- bioreactor --- cardiac microtissues --- iPSC-derived cardiomyocytes --- cardiac fibroblasts --- cardiac fibrosis --- cardiac rhythm --- TGF-β signalling --- drug screening --- in vitro model --- stem cell --- 3D --- culture condition --- regenerative medicine --- scaffold --- organoid --- adipose tissue-derived mesenchymal stem cells --- stromal vascular fraction --- platelet rich plasma --- platelet concentrates --- veterinary regenerative medicine