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Mucoadhesive polymers are widely used in the design of dosage forms for transmucosal drug delivery to the eye, respiratory, gastrointestinal and reproductive tracts. These routes of drug administration offer a number of advantages including improved drug bioavailability, reduced frequency of administration, and the avoidance for the use of injections.

chitosan --- maltodextrin --- Caco-2 cells --- alkyl lactate --- mucosal drug delivery --- thermogelling polymers --- buccal mucosa drug delivery --- drug delivery --- triple co-culture model --- oral lichen planus --- mucoadhesive polymers --- cyclodextrins --- paediatric --- mucoadhesion --- nanoparticles --- pectin --- furosemide --- oral lyophilisates --- films --- wound healing --- pluronic f127 --- interpolymer complexes --- transmucosal permeations --- Alzheimer’s disease --- biocompatibility --- poly (vinylpyrrolidone) --- mucosal membranes --- scanning electron microscopic images --- pioglitazone --- hydrogel --- resuspendibility --- thermoresponsive polymers --- mucoadhesive microspheres --- trimethyl chitosan --- Candida albicans --- xanthan gum --- omeprazole --- texture profile analysis --- acrylated chitosan --- mucoadhesive --- clotrimazole --- clobetasol --- Carbopol® --- hydroxypropyl cellulose --- electrospinning --- chitosan derivatives --- in vitro permeability --- l-arginine --- resveratrol --- cytotoxicity --- retention --- thiolated hyaluronic acid --- Carbopol --- mucoadhesive polymer --- rheology --- Eudragit® E PO --- detachment force --- chitosan-catechol --- controlled release --- PLGA-PEG --- liposphere --- gellan gum --- storage and loss moduli --- thiolated chitosan --- interpolyelectrolyte complex --- poly(2-ethyl-2-oxazoline)

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Recent technological advancements, socio-economic trends, and population lifestyle modifications throughout the world indicate the need for foods with increased health benefits. The clear relationship between the food that we eat and our well-being is widely recognized. Today, foods are not only intended to satisfy hunger and provide necessary nutrients: they can also confer additional health benefits, such as preventing nutrition-related diseases and improving physical and mental well-being. This book provides a comprehensive overview of developments in the field of functional foods and food supplements. Readers will discover new food matrices as innovative natural sources of bioactive compounds endowed with health-promoting properties. Studies on chemical, technological, and nutritional characteristics of healthy food ingredients, analytical methods for monitoring their quality, and innovative formulation strategies are included.

Cucurbita plants --- cucurbits --- pumpkin --- phytochemical composition --- food industry --- polysaccharides --- Lentinus edodes --- antioxidant --- cytotoxicity --- processing --- mushrooms --- LAB (lactic acid bacteria) --- fermenting --- dietary fiber --- mushroom --- Agaricus bisporus --- dietary fiber ingredient --- chemical composition --- functional properties --- optimization --- central composite design --- botanicals --- food supplements --- nutritional claims --- functional food --- resveratrol --- pioglitazone hydrochloride --- fatty acid --- meat quality --- antioxidant ability --- yellow-feathered broiler chicken --- pomegranate peels --- anti-tyrosinase activity --- waste recovery --- green extraction --- lactobacilli effervescent tablets --- Chinese ginseng --- Polygonatum sibiricum --- lactobacilli viability --- antibacterial activity --- organoleptic assessment --- storage stability --- ellagic acid --- oral administration --- bioavailability --- microformulations --- nanoformulations --- solubility enhancement --- ‘Cobrançosa’ and ‘Galega Vulgar’ olive cultivars --- phenolic compounds --- oleuropein --- verbascoside --- hydroxytyrosol --- ripening stage --- maturity index --- berry fruit --- antioxidant activity --- anthocyanins --- HPLC fingerprint --- underrated species --- multipurpose tree --- natural food preservative --- Eucalyptus globulus essential oil --- eucalyptol --- antioxidant effect --- vapor phase --- Orangina fruit juice --- functional foods --- dietary supplements --- food bioactive compounds --- formulations --- biological activities --- quality control

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Mitochondria are subcellular organelles evolved by the endosymbiosis of bacteria with eukaryotic cells. They are the main source of ATP in the cell and engaged in other aspects of cell metabolism and cell function, including the regulation of ion homeostasis, cell growth, redox status, and cell signaling. Due to their central role in cell life and death, mitochondria are also involved in the pathogenesis and progression of human diseases/conditions, including neurodegenerative and cardiovascular disorders, cancer, diabetes, inflammation, and aging. However, despite the increasing number of studies, precise mechanisms whereby mitochondria are involved in the regulation of basic physiological functions, as well as their role in the cell under pathophysiological conditions, remain unknown. A lack of in-depth knowledge of the regulatory mechanisms of mitochondrial metabolism and function, as well as interplay between the factors that transform the organelle from its role in pro-survival to pro-death, have hindered the development of new mitochondria-targeted pharmacological and conditional approaches for the treatment of human diseases. This book highlights the latest achievements in elucidating the role of mitochondria under physiological conditions, in various cell/animal models of human diseases, and in patients.

hypoglycemia --- sodium dichloroacetate --- pyruvate dehydrogenase kinase --- pyruvate dehydrogenase --- oxidative stress --- neuron death --- cholangiocellular carcinoma --- mitochondria --- energy metabolism --- oxidative phosphorylation --- 4-HNE --- DRP1 --- ERK1/2 --- hippocampus --- JNK --- mitochondrial dynamics --- PKA --- protein phosphatases --- TUNEL --- DDE --- high-fat diet --- mitochondrial UCP2 --- ROS --- antioxidant system --- uncoupling protein --- mitochondria: energy metabolism --- lipid handling --- fatty acid oxidation --- potassium channel --- reactive oxygen species --- antioxidants --- life span --- aging --- BKCa channels --- pravastatin --- gemfibrozil --- liver --- colon --- mitochondrial function --- cyclosporin A --- mitochondria calcium buffering --- mitochondria bioenergetics --- mitochondria permeability transition pore --- inorganic phosphate --- hepatic fibrogenesis --- HtrA2/Omi --- reactive oxygen species stress --- mitochondrial homeostasis --- complex I (CI) deficiency --- metabolome and proteome profiling --- reactive oxygen species (ROS) --- respirasome assembly --- electron tunneling (ET) --- perilipin 5 --- lipid droplet --- H9c2 cardiomyoblasts --- adenine nucleotide translocase --- respiratory supercomplexes --- ETC complexes --- dentate granule cell --- epilepsy --- hyperforin --- LONP1 --- neuroprotection --- pilocarpine --- seizure --- siRNA --- cardioprotection --- mitochondrial permeability transition pores --- mitochondrial connexin 43 --- cardiolipin --- iron overload --- hepcidin --- transferrin --- ferritin --- ZIP --- inflammation --- mtDNA --- mitochondrial dysfunction --- muscle aging --- physical performance --- LHON --- Siberian population --- ancient mutation --- specific genetic background --- apoptosis --- human amniotic membrane --- mitochondrial cell death --- BAX --- BCL-2 --- tensile strength --- mitochondrial gene expression --- mtDNA transcription --- mtRNA --- post-transcriptional mtRNA processing --- dsRNA --- innate immunity --- interferon response --- amino acid neurotransmitter --- cerebellar amino acid metabolism --- hypoxia --- 2-oxoglutarate dehydrogenase --- tricarboxylic acid cycle --- heart --- cytoskeletal proteins --- mitochondrial interactions --- plectin --- tubulin beta --- signaling --- GW9662 --- ischemia reperfusion injury --- Langendorff --- myocardial --- pioglitazone --- redox state --- rosiglitazone --- TZD --- uncoupling --- ADP/ATP carrier --- KmADP --- dextran --- morphology --- cardiomyocytes --- telomere length --- telomerase activity --- development --- regeneration --- intranuclear mitochondria --- healthy cells --- electron and confocal microscopy --- signaling pathways --- ion homeostasis --- human diseases