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Pharmaceutical Preparations --- analysis --- Drugs --- Pharmaceutical chemistry --- Médicaments --- Chimie pharmaceutique --- Analysis --- Yearbooks. --- Analyse --- Pharmaceutical Preparations - analysis --- Atenolol --- Camphre --- Chloroquine --- Cholecalciferol --- Cimetidine --- Disopyramide (phosphate) --- Indomethacine --- Ketofifene --- Melphalan --- Moxalactam (disodium) --- Oxyphenbutazone --- Pentazocine --- Phenytoine --- Pyridoxine --- Reserpine --- Saccharine --- Salicylamide --- Sulfadadiazine argent --- Sulindac --- Tetracycline (chlorhydrate --- Tolbutamide --- Vitamine d3 --- CHLORTHALIDONE --- IMIPRAMINE HCl --- CISPLATIN --- ANALYTICAL PROFILE --- TRIPELENNAMINE HCl --- XYLOMETAZOLINE HCl --- MEFLOQUINE HCl --- ACIDE IOPOANOIQUE --- LIDOCAINE --- LIDOCAINE HCl --- BENPERIDOL --- HYDRATE DE TERPINE --- ATROPINE --- ISOPROTERENOL --- WARFARIN --- NALOXONE HCl --- DIFLUNISAL --- BACLOFEN --- ACETAMINOPHEN --- HALOTHANE --- Bacitracine --- Bretylium --- Carbamazepine --- Ccyproheptadine --- Cefaclor --- Cefamandole --- Dibenzepine --- Digoxine --- Doxorubicine --- Fluphenazine --- Gentamicine (sulfate) --- Griseofulvine --- Haloperidol --- Khellin --- Lorazepam --- Methadone --- Methoxsalen --- Monographies medicaments --- Nadolol --- Nitrazepam --- Nitroglycerin --- Trifluoroperazine --- Acide ascorbique --- Acide flufenamique --- Aminophylline --- Captopril --- Cefotaxime --- Cefoxitine sodium --- Clofibrate --- Clotrimazole --- Dopamine chlorhydrate --- Ergonovine maleate --- Hexestrol --- Mestranol --- Noscapine --- Penicilline-g benzathine --- Phenylbutazone --- Sulfadiazine --- Amantadine --- Amikacine sulfate --- Benzocaine --- Dibucaine --- Dibucaine chlorhydrate --- Dioctylsulfosuccinate de sodium --- Estrone --- Etomidate --- Heparine sodium --- Hydrocortisone --- Isopropamide --- Metoprolol tartrate --- Phenylpropanolamine chlorhydrate --- Pilocarpine --- Pyrazinamide --- Pyrimethamine --- Quinine chlorhydrate --- Quinine sulfate --- Rutine --- Trimipramine maleate --- AMILORIDE CHLORHYDRATE --- AMINOGLUTETHIMIDE --- CAFEINE --- COCAINE CHLORHYDRATE --- EPHEDRINE CHLORHYDRATE --- OESTRADIOL --- GUANABENZ ACETATE --- IODAMIDE --- LITHIUM CARBONATE --- MAPROTILINE CHLORHYDRATE --- PENICILLIN G --- POTASSIUM --- PIROXICAM --- RANITIDINE --- STRYCHNINE --- VIDARABINE --- ZOMEPIRAC --- SODIUM --- CHLORAMPHENICOL --- LIDOCAINE CHLORHYDRATE --- SODIUM NITROPRUSSIATE --- Acide aminosalicylique --- Azathioprine --- Benzoate de benzyle --- Chlorhydrate d'emetine --- Chlorhydrate de clindamycine --- Chlorhydrate de methylphenidate --- Colchicine --- Cyanocobalamine --- Glibenclamide --- Heroine --- Hydrochlorothiazide --- Ketoprofen --- Nabinole --- Natamycine --- Oxytocine --- Penicillamine --- Phosphate de codeine

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Mitochondria are subcellular organelles evolved by the endosymbiosis of bacteria with eukaryotic cells. They are the main source of ATP in the cell and engaged in other aspects of cell metabolism and cell function, including the regulation of ion homeostasis, cell growth, redox status, and cell signaling. Due to their central role in cell life and death, mitochondria are also involved in the pathogenesis and progression of human diseases/conditions, including neurodegenerative and cardiovascular disorders, cancer, diabetes, inflammation, and aging. However, despite the increasing number of studies, precise mechanisms whereby mitochondria are involved in the regulation of basic physiological functions, as well as their role in the cell under pathophysiological conditions, remain unknown. A lack of in-depth knowledge of the regulatory mechanisms of mitochondrial metabolism and function, as well as interplay between the factors that transform the organelle from its role in pro-survival to pro-death, have hindered the development of new mitochondria-targeted pharmacological and conditional approaches for the treatment of human diseases. This book highlights the latest achievements in elucidating the role of mitochondria under physiological conditions, in various cell/animal models of human diseases, and in patients.

Medicine --- hypoglycemia --- sodium dichloroacetate --- pyruvate dehydrogenase kinase --- pyruvate dehydrogenase --- oxidative stress --- neuron death --- cholangiocellular carcinoma --- mitochondria --- energy metabolism --- oxidative phosphorylation --- 4-HNE --- DRP1 --- ERK1/2 --- hippocampus --- JNK --- mitochondrial dynamics --- PKA --- protein phosphatases --- TUNEL --- DDE --- high-fat diet --- mitochondrial UCP2 --- ROS --- antioxidant system --- uncoupling protein --- mitochondria: energy metabolism --- lipid handling --- fatty acid oxidation --- potassium channel --- reactive oxygen species --- antioxidants --- life span --- aging --- BKCa channels --- pravastatin --- gemfibrozil --- liver --- colon --- mitochondrial function --- cyclosporin A --- mitochondria calcium buffering --- mitochondria bioenergetics --- mitochondria permeability transition pore --- inorganic phosphate --- hepatic fibrogenesis --- HtrA2/Omi --- reactive oxygen species stress --- mitochondrial homeostasis --- complex I (CI) deficiency --- metabolome and proteome profiling --- reactive oxygen species (ROS) --- respirasome assembly --- electron tunneling (ET) --- perilipin 5 --- lipid droplet --- H9c2 cardiomyoblasts --- adenine nucleotide translocase --- respiratory supercomplexes --- ETC complexes --- dentate granule cell --- epilepsy --- hyperforin --- LONP1 --- neuroprotection --- pilocarpine --- seizure --- siRNA --- cardioprotection --- mitochondrial permeability transition pores --- mitochondrial connexin 43 --- cardiolipin --- iron overload --- hepcidin --- transferrin --- ferritin --- ZIP --- inflammation --- mtDNA --- mitochondrial dysfunction --- muscle aging --- physical performance --- LHON --- Siberian population --- ancient mutation --- specific genetic background --- apoptosis --- human amniotic membrane --- mitochondrial cell death --- BAX --- BCL-2 --- tensile strength --- mitochondrial gene expression --- mtDNA transcription --- mtRNA --- post-transcriptional mtRNA processing --- dsRNA --- innate immunity --- interferon response --- amino acid neurotransmitter --- cerebellar amino acid metabolism --- hypoxia --- 2-oxoglutarate dehydrogenase --- tricarboxylic acid cycle --- heart --- cytoskeletal proteins --- mitochondrial interactions --- plectin --- tubulin beta --- signaling --- GW9662 --- ischemia reperfusion injury --- Langendorff --- myocardial --- pioglitazone --- redox state --- rosiglitazone --- TZD --- uncoupling --- ADP/ATP carrier --- KmADP --- dextran --- morphology --- cardiomyocytes --- telomere length --- telomerase activity --- development --- regeneration --- intranuclear mitochondria --- healthy cells --- electron and confocal microscopy --- signaling pathways --- ion homeostasis --- human diseases