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Photochemotherapy. --- Photodynamic therapy --- Chemotherapy --- Photosensitization, Biological --- Phototherapy
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This resource brings you the latest advances in photodynamic therapy and offers you a solid understanding of the design, delivery and dosimetry of the three basic ingredients of PDT-photosensitizers, light and oxygen. The book covers novel areas of mechanistic and innovative translational approaches.
Photochemotherapy. --- Photodynamic therapy --- Chemotherapy --- Photosensitization, Biological --- Phototherapy --- Photochemotherapy
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This book is dedicated to a topic related to the effects of photodynamic therapy organized by Biomedicines in 2022 (https://www.mdpi.com/topics/photodynamic_therapy). In medicine, the use of photodynamic therapy for the treatment of oncological and non-oncological diseases has been widely documented and well codified. In dermatology, the use varies from oncological to the treatment of chronic wounds, as well as in cosmetology for photo-rejuvenation. The 19 manuscripts published in this book cover all aspects of this therapy, including the discovery of new natural and synthetic photosensitizers, biomaterials and nanotechnology, in vitro and in vivo studies, and clinical trials.
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Extracorporeal photopheresis (ECP) is the first FDA approved cellular photoimmunotherapy for cancer, namely cutaneous T-cell lymphoma, and has demonstrated efficacy in various diseases that have a suspected involvement of pathogenic T-cells including prevention and treatment of acute and chronic graft-versus-host disease, organ transplant rejection, selected autoimmune diseases and Sezary syndrome. In ECP, patient's blood mononuclear cells are collected, exposed to ultraviolet light in the presence of extracorporeally administered liquid 8-methoxypsoralen and reinfused. Besides its considerable efficacy ECP has an exceptional safety profile, does not cause general immunosuppression and thus, does not increase risk of infectious complications and relapse of malignant disease. Exciting preclinical data and clinical observations provide insight into the mechanisms of action of ECP and support its immunomodulatory role. This book will provide an overview on the historical development of ECP, technical aspects for its use in various patient populations including children and adults, novel research findings both in preclinical models and in various patient cohorts and will stimulate further research in organ, tissue and cell transplantation and autoimmune disorders.
Photochemotherapy. --- Cancer --- Cancer therapy --- Cancer treatment --- Photodynamic therapy --- Chemotherapy --- Photosensitization, Biological --- Phototherapy --- Treatment. --- Therapy
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The fullerene molecule with its unique structure of 60 carbon atoms arranged in a soccer ball structure is a molecule of great potential for a variety of applications and has drawn attention of lots of physicists, chemists and engineers. Recently, these nanostructures have also been studied for their biological activities with a view towards using them for biomedical applications. One of the possible therapies for which fullerenes may have a real medical application is the light based therapy called photodynamic therapy (PDT), which is a non-surgical, minimally invasive approach that has been used in the treatment of solid tumors and many non-malignant diseases.
Photochemotherapy. --- Fullerenes. --- Buckminsterfullerenes --- Buckyballs --- Buckminsterfullerene --- Buckyball --- Fullerene --- Therapy, Photodynamic --- Photodynamic Therapy --- Photochemotherapies --- Photodynamic Therapies --- Therapies, Photodynamic --- Light --- Ultraviolet Therapy --- Photosensitizing Agents --- Carbon --- Photodynamic therapy --- Chemotherapy --- Photosensitization, Biological --- Phototherapy --- biomedical engineering --- fullerene molecule --- engineers --- PDT --- diseases
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eco-friendly nanomaterials --- nanobiosensing --- nanofabrication techniques --- theranostic devices --- nanomaterials for photodynamic therapy --- nanotoxicology --- Nanoscience --- Nanotechnology --- Nanotechnolog --- Nano science --- Nanoscale science --- Nanosciences --- Science
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"Photodynamic therapy (PDT) is currently clinically employed to treat several malignant and nonmalignant diseases. With approvals for various applications by health agencies in Europe, the US, Canada, and Japan, PDT represents the method of choice for treatment of age-related macular degeneration and is appreciated as a minimally invasive therapeutic procedure to treat skin, esophageal, head and neck, lung, and bladder cancers with high cure rates, nearly no side effects, and excellent cosmetic outcomes. Current basic research and clinical studies will help to further integrate PDT as a mainstream procedure for cancer treatment. This book presents an overview of the important medical applications of PDT, including approved treatments, clinical trials, and investigated therapies for cancer and non-malignant diseases."--
Phototherapy. --- Photochemotherapy. --- Photodynamic therapy --- Chemotherapy --- Photosensitization, Biological --- Phototherapy --- Actinotherapy --- Finsen rays --- Finsen therapy --- Light --- Light therapy --- Physical therapy --- Therapeutics, Physiological --- Thermotherapy --- Radiotherapy --- Therapeutic use --- Physiological effect
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Nanomaterials for Photodynamic Therapy takes a unique approach to this area, with a key focus on the use of nanomaterials and nanocarriers for photodynamic therapy (PDT). The book introduces the history and mechanism of action behind PDT, covering the variety of sensitizers currently available. Subsequent chapters review existing and emerging nanomaterials for PDT, including hydrogel nanocomposites, fullerenes, quantum dots, polymeric micelles, and more. Challenges and translational aspects of PDT are also discussed, touching on the issues and hindrances of drug resistant cancers. The book bridges the gap between the physics and clinical aspects of PDT, offering a unique nanomaterials-focused perspective. This book will prove useful for materials scientists, biomedical engineers, electrical and optical engineers, and pharmaceutical scientists interested in cancer treatment.
Nanostructured materials. --- Photochemotherapy. --- Photodynamic therapy --- Chemotherapy --- Photosensitization, Biological --- Phototherapy --- Nanomaterials --- Nanometer materials --- Nanophase materials --- Nanostructure controlled materials --- Nanostructure materials --- Ultra-fine microstructure materials --- Microstructure --- Nanotechnology --- Photochemotherapy --- Nanostructures
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Still, only a tiny fraction of PDT’s potential has been realized in the clinical practice guideline. Nevertheless, multiple contributions from all over the world emphasize the importance of PDT and signal that there is much more to expect!
Medicine --- Pharmaceutical industries --- antibiotic resistance --- virulence factors --- Klebsiella pneumoniae --- photodynamic therapy --- cyanine dyes --- cancer therapy --- irradiation --- antimicrobial photodynamic therapy --- periodontitis --- scaling and root planing --- systematic review --- meta-analysis --- colon carcinoma cells --- stress responses --- candidiasis --- C. albicans --- methylene blue --- tetraether liposomes --- nebulisation --- liposomal stability --- curcumin --- A549 cells --- PDT mechanisms --- new photosensitizers --- PDT tumor treatment --- antimicrobial PDT --- non-oncologic applications of PDT --- PDT in medical devices --- photosensitizers --- liposomes --- stealth liposomes --- thermosensitive liposomes --- tetraether lipids --- cancer --- methicillin-resistant Staphylococcus aureus --- hypericin --- wound infection model --- targeted delivery --- head and neck cancer --- nanoparticles --- 5-aminolevulinic acid --- ALA-based photodynamic therapy --- phototherapy --- extracorporeal --- photopheresis --- chronic graft-versus-host disease --- light --- malignant tumors --- nanomedicine --- natural photosensitizer --- photobiomodulation (PBM) --- photodynamic therapy (PDT) --- porphyrins --- fluorescence lifetime imaging miscroscopy (FLIM) --- antimicrobial photodynamic therapy (aPDT) --- Helicobacter pylori biofilm --- experimental arthritis --- multi-drug resistance --- antibiotic synergy --- dental caries --- oral biofilms --- Fotoenticine --- chlorine --- antimicrobials --- ROS --- combinatory strategies --- multidrug resistance --- wound healing --- low-dose photodynamic therapy --- photosensitizer --- two-photon microscopy --- second-harmonic-generation-to-auto-fluorescence aging index of the dermis --- actinic keratosis --- physcion --- hydroxypropyl-β-cyclodextrin --- low dose photodynamic therapy --- optical coherence tomography --- aggregation-induced emission --- organelles targeting --- hepatocellular carcinoma --- viral inactivation --- photodynamic inactivation --- SARS-CoV-2 pseudovirus --- enveloped virus --- UV-C light --- antimicrobial nanomaterials --- carbon nanotubes --- graphene --- magnetic nanoparticles --- hydrogel --- photothermal therapy --- nanocarrier --- actinic keratoses --- combination --- topical --- systemic --- laser --- n/a
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Photodynamic Therapy in Dermatology is the first book to cover global research on photodynamic therapy (PDT) in the management of skin disease. Although a relatively young procedure, PDT has enjoyed increased popularity during the last ten years. As research has grown, two distinct routes have appeared: the United States model and the European one, each focusing on different uses and photosensitizers. Dr. Gold has assembled the world’s experts on PDT to create a book that concisely covers every use and photosensitizer available around the world and includes comprehensive coverage of both of the FDA-approved photosensitizers in the United States, all the while carefully differentiating between off-label and FDA-approved uses of photodynamic therapy. Photodynamic Therapy in Dermatology emphasizes how to integrate PDT into practice. Toward this end, it is organized by disease category, with each chapter providing a systematic discussion of indications, PDT approaches from country to country, common side effects, prognosis as well as the underlying science. The book will be of value to dermatologists seeking a state-of-the-art review of PDT around the world, the latest in its clinical uses, and guidance on how to incorporate PDT into clinical practice.
Phototherapy. --- Skin -- Diseases -- Photochemotherapy. --- Skin -- Diseases -- Phototherapy. --- Skin Diseases -- diagnosis. --- Skin Diseases -- therapy. --- Photochemotherapy --- Skin --- Dermatology --- Phototherapy --- Skin and Connective Tissue Diseases --- Therapeutics --- Combined Modality Therapy --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Diseases --- Skin Diseases --- Drug Therapy --- Medicine --- Health & Biological Sciences --- Oncology --- Treatment --- Photochemotherapy. --- Dermatology. --- Treatment. --- Photodynamic therapy --- Medicine. --- Medicine & Public Health. --- Chemotherapy --- Photosensitization, Biological
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