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The possibility that morphine and other opioids may modulate tumour growth and metastasis has been researched for many years. The recent past has seen multiple clinical studies attempting to document whether limiting the perioperative use of morphine is beneficial for cancer surgery patients. Furthermore, a lot of exciting new data has been generated in vitro, but also in preclinical and clinical studies, that indirectly shed light on the effect of opioids on cancer. This book combines chapters written by qualified experts around the world whose research encompasses the effect of morphine or other opioids on tumour growth and metastasis. This includes clinicians, researchers working on animal models and studying the effect of morphine on tumours, and most importantly the mechanism for this effect, and lastly cell biologists. Current investigations and cross talk between basic science and clinical trials will refine our understanding of the multiple levels of actions of morphine and other opioids on tumour growth and metastasis, and result in improved guidelines for patient care. This book will be of interest to clinicians, especially those dealing with cancer patients and their pain management, as well as students, teachers and scientists in the fields of anaesthesiology, oncology, tumour biology, immunology, opioid pharmacology.

Morphine -- Therapeutic use. --- Morphine. --- Opioids. --- Metastasis --- Growth Substances --- Therapeutics --- Morphinans --- Biological Science Disciplines --- Neoplastic Processes --- Neoplasms --- Phenanthrenes --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Pathologic Processes --- Opiate Alkaloids --- Natural Science Disciplines --- Heterocyclic Compounds with 4 or More Rings --- Heterocyclic Compounds, Bridged-Ring --- Physiological Effects of Drugs --- Heterocyclic Compounds --- Pathological Conditions, Signs and Symptoms --- Disciplines and Occupations --- Diseases --- Pharmacologic Actions --- Polycyclic Hydrocarbons, Aromatic --- Alkaloids --- Chemicals and Drugs --- Chemical Actions and Uses --- Polycyclic Compounds --- Morphine --- Growth Inhibitors --- Pharmacology --- Neoplasm Metastasis --- Drug Therapy --- Medicine --- Health & Biological Sciences --- Oncology --- Metastasis. --- Cancer --- Chemotherapy. --- Cancer metastasis --- Dissemination of cancer --- Metastases --- Metastatic cancer --- Neoplasm metastasis --- Spread of cancer --- Tumor dissemination --- Tumor metastasis --- Tumor spread --- Morphia --- Dissemination --- Medicine. --- Pharmacy. --- Cancer research. --- Pharmacology. --- Oncology. --- Pain medicine. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Pain Medicine. --- Antineoplastic agents --- Pathology --- Cancer invasiveness --- Cancer of unknown primary origin --- Narcotics --- Opium --- Treatment --- Toxicology. --- Oncology  . --- Tumors --- Chemicals --- Poisoning --- Poisons --- Chemistry --- Drugs --- Materia medica --- Toxicology --- Algiatry --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Pharmacy --- Cancer research --- Physiological effect

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Depression, Mental --- Hypericum perforatum --- Depressive Disorder --- Xanthenes --- Plant Extracts --- Perylene --- Depression --- Benz(a)Anthracenes --- Mood Disorders --- Behavioral Symptoms --- Plant Preparations --- Pharmaceutical Preparations --- Heterocyclic Compounds, 3-Ring --- Phenalenes --- Polycyclic Hydrocarbons, Aromatic --- Chemicals and Drugs --- Behavior --- Biological Products --- Mental Disorders --- Heterocyclic Compounds --- Psychiatry and Psychology --- Polycyclic Compounds --- Hydrocarbons, Aromatic --- Behavior and Behavior Mechanisms --- Complex Mixtures --- Hydrocarbons, Cyclic --- Hydrocarbons --- Organic Chemicals --- Psychiatric Disorders, Individual --- Psychiatry --- Health & Biological Sciences --- Alternative treatment --- Therapeutic use --- Pharmaceutical Preparations. --- Psychiatry. --- Organic Chemical --- Chemical, Organic --- Chemicals, Organic --- Hydrocarbon --- Saturated Hydrocarbons --- Unsaturated Hydrocarbons --- Hydrocarbons, Saturated --- Hydrocarbons, Unsaturated --- Cyclic Hydrocarbons --- Hydrocarbons, Polycyclic --- Polycyclic Hydrocarbons --- Complex Extracts --- Crude Extracts --- Extracts, Complex --- Extracts, Crude --- Complex Extract --- Complex Mixture --- Crude Extract --- Mixtures, Complex --- Extract, Complex --- Extract, Crude --- Mixture, Complex --- Behavior And Behavior Mechanism --- Aromatic Hydrocarbon --- Aromatic Hydrocarbons --- Hydrocarbon, Aromatic --- Compounds, Polycyclic --- Psychiatrists --- Psychiatrist --- Heterocyclic Compound --- Compound, Heterocyclic --- Compounds, Heterocyclic --- Behavior Disorders --- Diagnosis, Psychiatric --- Mental Disorders, Severe --- Psychiatric Diagnosis --- Mental Illness --- Psychiatric Diseases --- Psychiatric Disorders --- Psychiatric Illness --- Illness, Mental --- Mental Disorder --- Mental Disorder, Severe --- Mental Illnesses --- Psychiatric Disease --- Psychiatric Disorder --- Psychiatric Illnesses --- Severe Mental Disorder --- Severe Mental Disorders --- Mentally Ill Persons --- Biologic Drugs --- Biologic Medicines --- Biologic Pharmaceuticals --- Biologic Products --- Biological Drugs --- Biological Medicines --- Biologicals --- Biopharmaceuticals --- Products, Biological --- Biologic --- Biologic Drug --- Biologic Product --- Biological --- Biological Drug --- Biological Medicine --- Biological Product --- Biologics --- Biopharmaceutical --- Natural Product --- Natural Products --- Drug, Biologic --- Drug, Biological --- Drugs, Biologic --- Drugs, Biological --- Medicine, Biological --- Medicines, Biologic --- Medicines, Biological --- Pharmaceuticals, Biologic --- Product, Biologic --- Product, Biological --- Product, Natural --- Biological Factors --- Acceptance Process --- Acceptance Processes --- Behaviors --- Process, Acceptance --- Processes, Acceptance --- Pharmaceutic Preparations --- Pharmaceutical Products --- Pharmaceuticals --- Preparations, Pharmaceutical --- Drug --- Drugs --- Pharmaceutical --- Pharmaceutical Preparation --- Pharmaceutical Product --- Preparation, Pharmaceutical --- Preparations, Pharmaceutic --- Product, Pharmaceutical --- Products, Pharmaceutical --- Pharmacology --- Drug Dosage Calculations --- Polycyclic Aromatic Hydrocarbon --- Polynuclear Aromatic Hydrocarbon --- Polynuclear Aromatic Hydrocarbons --- Aromatic Hydrocarbon, Polycyclic --- Aromatic Hydrocarbon, Polynuclear --- Aromatic Hydrocarbons, Polycyclic --- Aromatic Hydrocarbons, Polynuclear --- Aromatic Polycyclic Hydrocarbons --- Hydrocarbon, Polycyclic Aromatic --- Hydrocarbon, Polynuclear Aromatic --- Hydrocarbons, Aromatic Polycyclic --- Hydrocarbons, Polycyclic Aromatic --- Hydrocarbons, Polynuclear Aromatic --- Fused-Ring Compounds --- Bridged-Ring Compounds --- Oxabenzochrysenones --- Phenylphenalenones --- Fused Heterocyclic Compounds, Three-Ring --- Heterocyclic Cpds, 3 Ring --- Three Ring Heterocyclic Compounds --- 3-Ring Heterocyclic Compounds --- Fused Heterocyclic Compounds, Three Ring --- Heterocyclic Compounds, 3 Ring --- Herbal Preparation --- Plant Preparation --- Herbal Preparations --- Preparation, Plant --- Behavioral Symptom --- Symptom, Behavioral --- Symptoms, Behavioral --- Affective Disorders --- Affective Disorder --- Disorder, Affective --- Disorder, Mood --- Disorders, Affective --- Disorders, Mood --- Mood Disorder --- Benz(b)Phenanthrenes --- Naphthanthracenes --- Emotional Depression --- Depressive Symptoms --- Depression, Emotional --- Depressive Symptom --- Symptom, Depressive --- Peri-Dinaphthalene --- Perilene --- Peri Dinaphthalene --- Herbal Medicines --- Plant Extract --- Extract, Plant --- Extracts, Plant --- Medicines, Herbal --- Materia Medica --- Phytotherapy --- Plants, Medicinal --- Herbal Medicine --- Xanthene --- Depression, Endogenous --- Depression, Neurotic --- Depression, Unipolar --- Depressive Syndrome --- Melancholia --- Neurosis, Depressive --- Unipolar Depression --- Depressions, Endogenous --- Depressions, Neurotic --- Depressions, Unipolar --- Depressive Disorders --- Depressive Neuroses --- Depressive Neurosis --- Depressive Syndromes --- Disorder, Depressive --- Disorders, Depressive --- Endogenous Depression --- Endogenous Depressions --- Melancholias --- Neuroses, Depressive --- Neurotic Depression --- Neurotic Depressions --- Syndrome, Depressive --- Syndromes, Depressive --- Unipolar Depressions --- Common Saint Johnswort --- Klamath weed --- Perforate Saint Johnswort --- Saint Johns-wort, Common --- Saint Johnswort, Common --- St. Johnswort, Common --- Tipton's weed --- Hypericum --- Depressive Disorder. --- Xanthenes. --- Plant Extracts. --- Perylene. --- Depression. --- Benz(a)Anthracenes. --- Mood Disorders. --- Behavioral Symptoms. --- Plant Preparations. --- Heterocyclic Compounds, 3-Ring. --- Phenalenes. --- Polycyclic Aromatic Hydrocarbons. --- Behavior. --- Biological Products. --- Mental Disorders. --- Heterocyclic Compounds. --- Polycyclic Compounds. --- Hydrocarbons, Aromatic. --- Behavior and Behavior Mechanisms. --- Complex Mixtures. --- Hydrocarbons, Cyclic. --- Hydrocarbons. --- Organic Chemicals. --- Alternative treatment. --- Therapeutic use.