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The impact of fat intake on hypercholesterolemia and related atherosclerotic cardiovascular diseases has been studied for decades. However, the current evidence base suggests that fatty acids also influences cardiometabolic diseases through other mechanisms including effects on glucose metabolism, body fat distribution, blood pressure, inflammation, and heart rate. Furthermore, studies evaluating single fatty acids have challenged the simplistic view of shared health effects within fatty acid groups categorized by degree of saturation. In addition, investigations of endogenous fatty acid metabolism, including genetic studies of fatty acid metabolizing enzymes, and the identification of novel metabolically derived fatty acids have further increased the complexity of fatty acids’ health impacts. This Special Issue aims to include original research and up-to-date reviews on genetic and dietary modulation of fatty acids, and the role and function of dietary and metabolically derived fatty acids in cardiometabolic health.

coronary artery disease --- n-6 fatty acids --- ischemic heart disease --- n-3 fatty acids --- body weight --- alternatively activated macrophages --- type 2 cytokines --- children --- medium-chain triglyceride --- fat --- omega-3 PUFA --- substitution models --- obesity --- EETs --- arachidonic acid --- blood pressure --- Genome-wide association study (GWAS) --- antioxidant --- Mediterranean diet --- Insulin sensitivity --- PUFA --- n-3 PUFA --- long-chain triglyceride --- fish oil --- omega 3 --- CAD --- adipose tissue --- FADS --- blood lipids --- hemodynamics --- genotype --- erucic acid --- klotho --- CYP450 eicosanoids --- cardiometabolic disease --- fibrosis --- desaturase --- EEQs --- cohort study --- lipid metabolism --- fatty acid --- metabolic disease --- epidemiology --- omega-3 --- inflammation --- docosapentaenoic acid --- omega-6 PUFA --- type 2 diabetes mellitus --- diet --- CKD --- human --- perivascular adipose tissue --- seafood --- cardiovascular disease --- prospective cohort study --- linoleic acid --- low-fat diet --- conjugated fatty acids --- furan fatty acids --- unsaturated fat --- statins --- fish --- cholesterol ester --- CHD --- COPD

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The first national conference with international participation, “Fundamental aspects of atherosclerosis: scientific research for improving the technologies of personalized medicine”, was held in Novosibirsk on 15 October, 2021. The purpose of this conference was to disseminate the latest basic and clinical findings in the fields of etiology, clinical characteristics, and modern diagnostics and treatments of atherosclerosis among various relevant specialists. The conference was intended for practicing cardiologists, primary care physicians, medical geneticists, and physician–scientists. The conference included plenary sessions, specialty sessions, satellite symposia, an open competition for young scientists.

metalloproteinases --- calcification --- atherosclerosis --- multiplex assay --- coronary heart disease --- aspirin --- resistance --- non-sensitivity --- antiplatelet --- light transmission aggregometry --- Plateletworks® --- familial hypercholesterolemia --- targeted sequencing technologies --- multiplex ligation-dependent probe amplification --- LDLR --- APOB --- ABCG5 --- APOC3 --- LPL --- SREBF1 --- rare variants --- coronary atherosclerosis --- ischemic heart disease --- saturated fatty acids --- monounsaturated fatty acids --- polyunsaturated fatty acids --- oxidative stress --- superoxide dismutase --- catalase --- glutathione peroxidase --- cumulative LDL-C level --- prognosis --- DNA methylation --- epigenetic age --- myocardial infarction --- acute coronary syndrome --- population --- nested case-control --- HAPIEE project --- HAPIEE study --- atrial fibrillation --- arterial hypertension --- obesity --- diabetes mellitus --- aging --- determinants --- prevalence --- Russian population cohort --- Cox regression analysis --- adiponectin --- leptin --- interleukin-6 --- epicardial adipose tissue --- perivascular adipose tissue --- circulating biochemical markers --- coronary atherosclerosis presence and severity --- integrated biomarker (i-BIO) --- validation --- visual markers --- lipoprotein(a) --- immune cells blood count --- n/a