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Book
The Prevention and Treatment of Atherosclerosis
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Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

This special issue of JCM ‘The Prevention and Treatment of Atherosclerosis’ will walk the Readers across novel diagnostic achievements in atherosclerosis and contemporary actions towards optimizing therapy.Everything begins with diagnosis. Accurate diagnostic tools and tests are of utmost importance. Contemporary research on microparticles, non-coding RNAs, proteomic characterization, …, offers detailed molecular characteristics of athero-thrombosis.Prevention is equally important as treatment. The impact of eating habits in prophylaxis of many pathologies, including cardiovascular disease has been documented.Then new pharmacological agents. Managing hypercholesterolemia with PCSK9 inhibitors, shown great potential in efficient lipid lowering to achieve LDL-C treatment goals, as well as reduction in cardiovascular mortality and morbidity.However, therapeutic goals accomplishment requires supervision. Arising number of data support that cardiovascular risk prediction can be improved with imaging modalities displaying atheroma: carotid plaque ultrasonography, coronary calcium score, intravascular ultrasonography, and optical coherent tomography or many others.As atherosclerosis is a progressive disease, it comes the time for more radical management, including endovascular and surgical intervention. There is field for new stent and equipment technologies, new surgical and endovascular techniques, supervision of endovascular procedures with IVUS, OCT, functional flow assessment or cell therapy.From diagnosis to risk stratification, elaborated prevention models, finally to modern and optimized therapeutic intervention.


Book
Diagnosis, Prevention and Treatment for Stroke
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Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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In recent years, there have been outstanding achievements in stroke diagnosis and care. Our better understanding of the pathophysiological mechanisms and the advances in neuro-imaging have enabled us to diagnose stroke syndromes with remarkable precision and uncover underlying vessel pathologies that can be directly correlated to the stroke event. Within a short period of time, mechanical thrombectomy became the standard of care for patients with large vessel occlusions and symptom onset up to 24 hours, while other recent trials also suggest the use of perfusion imaging to guide intravenous thrombolysis in the extended time window. In this Special Issue, we will also extensively discuss relevant topics on secondary stroke prevention, including the prompt use of nonvitamin k oral anticoagulants and the potential effect of reversal agents in patients with intracerebral hemorrhage related to their use. We will also delineate treatment options for stroke patients with indication for long-term anticoagulation and high bleeding risk. Finally, a particular mention will be made for young patients with stroke, the extent of the diagnostic work-up, and the selection of those who would benefit from patent foramen ovale closure.


Book
The Prevention and Treatment of Atherosclerosis
Author:
Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

This special issue of JCM ‘The Prevention and Treatment of Atherosclerosis’ will walk the Readers across novel diagnostic achievements in atherosclerosis and contemporary actions towards optimizing therapy.Everything begins with diagnosis. Accurate diagnostic tools and tests are of utmost importance. Contemporary research on microparticles, non-coding RNAs, proteomic characterization, …, offers detailed molecular characteristics of athero-thrombosis.Prevention is equally important as treatment. The impact of eating habits in prophylaxis of many pathologies, including cardiovascular disease has been documented.Then new pharmacological agents. Managing hypercholesterolemia with PCSK9 inhibitors, shown great potential in efficient lipid lowering to achieve LDL-C treatment goals, as well as reduction in cardiovascular mortality and morbidity.However, therapeutic goals accomplishment requires supervision. Arising number of data support that cardiovascular risk prediction can be improved with imaging modalities displaying atheroma: carotid plaque ultrasonography, coronary calcium score, intravascular ultrasonography, and optical coherent tomography or many others.As atherosclerosis is a progressive disease, it comes the time for more radical management, including endovascular and surgical intervention. There is field for new stent and equipment technologies, new surgical and endovascular techniques, supervision of endovascular procedures with IVUS, OCT, functional flow assessment or cell therapy.From diagnosis to risk stratification, elaborated prevention models, finally to modern and optimized therapeutic intervention.


Book
Diagnosis, Prevention and Treatment for Stroke
Author:
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

In recent years, there have been outstanding achievements in stroke diagnosis and care. Our better understanding of the pathophysiological mechanisms and the advances in neuro-imaging have enabled us to diagnose stroke syndromes with remarkable precision and uncover underlying vessel pathologies that can be directly correlated to the stroke event. Within a short period of time, mechanical thrombectomy became the standard of care for patients with large vessel occlusions and symptom onset up to 24 hours, while other recent trials also suggest the use of perfusion imaging to guide intravenous thrombolysis in the extended time window. In this Special Issue, we will also extensively discuss relevant topics on secondary stroke prevention, including the prompt use of nonvitamin k oral anticoagulants and the potential effect of reversal agents in patients with intracerebral hemorrhage related to their use. We will also delineate treatment options for stroke patients with indication for long-term anticoagulation and high bleeding risk. Finally, a particular mention will be made for young patients with stroke, the extent of the diagnostic work-up, and the selection of those who would benefit from patent foramen ovale closure.


Book
The Prevention and Treatment of Atherosclerosis
Author:
Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

This special issue of JCM ‘The Prevention and Treatment of Atherosclerosis’ will walk the Readers across novel diagnostic achievements in atherosclerosis and contemporary actions towards optimizing therapy.Everything begins with diagnosis. Accurate diagnostic tools and tests are of utmost importance. Contemporary research on microparticles, non-coding RNAs, proteomic characterization, …, offers detailed molecular characteristics of athero-thrombosis.Prevention is equally important as treatment. The impact of eating habits in prophylaxis of many pathologies, including cardiovascular disease has been documented.Then new pharmacological agents. Managing hypercholesterolemia with PCSK9 inhibitors, shown great potential in efficient lipid lowering to achieve LDL-C treatment goals, as well as reduction in cardiovascular mortality and morbidity.However, therapeutic goals accomplishment requires supervision. Arising number of data support that cardiovascular risk prediction can be improved with imaging modalities displaying atheroma: carotid plaque ultrasonography, coronary calcium score, intravascular ultrasonography, and optical coherent tomography or many others.As atherosclerosis is a progressive disease, it comes the time for more radical management, including endovascular and surgical intervention. There is field for new stent and equipment technologies, new surgical and endovascular techniques, supervision of endovascular procedures with IVUS, OCT, functional flow assessment or cell therapy.From diagnosis to risk stratification, elaborated prevention models, finally to modern and optimized therapeutic intervention.

Keywords

Research & information: general --- familial hypercholesterolemia --- genetic screening --- atherosclerosis prevention --- early detection --- atherosclerosis --- cigarette smoking --- miR-27b --- peripheral artery disease --- subclinical atherosclerosis --- SCORE --- Framingham --- QRISK --- PROCAM --- cardiovascular risk --- pulse wave velocity --- intima media thickness --- malondialdehyde low-density lipoprotein --- high-risk plaque --- coronary computed tomography angiography --- statin --- cardiovascular risk factors --- heart failure --- major cardiac and cerebral ischemic events --- degenerative aortic stenosis --- risk stratification --- vascular resistance --- cardiovascular disease --- acute myocardial infarction --- intravascular imaging --- statins --- control-theoretic model --- logistic growth --- coronary artery disease --- fibrin clot --- fibrinolysis --- thromboembolism --- carotid intima-media complex --- carotid plaque --- major adverse cardiac and cerebral events --- prevention --- scores --- vitamin D --- myocardial infarction --- males --- Coronary Artery Surgery Study Score --- familial hypercholesterolemia --- genetic screening --- atherosclerosis prevention --- early detection --- atherosclerosis --- cigarette smoking --- miR-27b --- peripheral artery disease --- subclinical atherosclerosis --- SCORE --- Framingham --- QRISK --- PROCAM --- cardiovascular risk --- pulse wave velocity --- intima media thickness --- malondialdehyde low-density lipoprotein --- high-risk plaque --- coronary computed tomography angiography --- statin --- cardiovascular risk factors --- heart failure --- major cardiac and cerebral ischemic events --- degenerative aortic stenosis --- risk stratification --- vascular resistance --- cardiovascular disease --- acute myocardial infarction --- intravascular imaging --- statins --- control-theoretic model --- logistic growth --- coronary artery disease --- fibrin clot --- fibrinolysis --- thromboembolism --- carotid intima-media complex --- carotid plaque --- major adverse cardiac and cerebral events --- prevention --- scores --- vitamin D --- myocardial infarction --- males --- Coronary Artery Surgery Study Score


Book
Diagnosis, Prevention and Treatment for Stroke
Author:
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

In recent years, there have been outstanding achievements in stroke diagnosis and care. Our better understanding of the pathophysiological mechanisms and the advances in neuro-imaging have enabled us to diagnose stroke syndromes with remarkable precision and uncover underlying vessel pathologies that can be directly correlated to the stroke event. Within a short period of time, mechanical thrombectomy became the standard of care for patients with large vessel occlusions and symptom onset up to 24 hours, while other recent trials also suggest the use of perfusion imaging to guide intravenous thrombolysis in the extended time window. In this Special Issue, we will also extensively discuss relevant topics on secondary stroke prevention, including the prompt use of nonvitamin k oral anticoagulants and the potential effect of reversal agents in patients with intracerebral hemorrhage related to their use. We will also delineate treatment options for stroke patients with indication for long-term anticoagulation and high bleeding risk. Finally, a particular mention will be made for young patients with stroke, the extent of the diagnostic work-up, and the selection of those who would benefit from patent foramen ovale closure.

Keywords

Medicine --- atrial fibrillation --- cerebral infarction --- carotid stenosis --- ultrasonography --- outcomes --- cryptogenic stroke --- neurosonology --- Holter monitoring --- transcranial Doppler --- cervical duplex --- stroke --- hemorrhage --- thrombectomy --- cone-beam computed tomography --- cerebral angiography --- platelet reactivity --- ischemic stroke --- aspirin resistance --- infarction volume --- multiplate --- reperfusion --- therapy --- outcome --- intravenous thrombolysis --- NIHSS --- Barthel index --- functional dependence --- ultrasound --- acute ischemic stroke --- perfusion imaging --- contrast agent --- intracerebral hematoma --- subarachnoid hemorrhage --- large vessel disease --- clinical outcome --- prognosis --- functional magnetic resonance imaging --- neuronal plasticity --- recovery of function --- motor cortex --- ankle-brachial index difference --- inter-ankle blood pressure difference --- peripheral artery disease --- anemia --- blood transfusion --- red blood cells --- outcome assessment --- endothelial progenitor cells --- atherosclerosis --- computed tomography angiography --- atrial fibrillation --- cerebral infarction --- carotid stenosis --- ultrasonography --- outcomes --- cryptogenic stroke --- neurosonology --- Holter monitoring --- transcranial Doppler --- cervical duplex --- stroke --- hemorrhage --- thrombectomy --- cone-beam computed tomography --- cerebral angiography --- platelet reactivity --- ischemic stroke --- aspirin resistance --- infarction volume --- multiplate --- reperfusion --- therapy --- outcome --- intravenous thrombolysis --- NIHSS --- Barthel index --- functional dependence --- ultrasound --- acute ischemic stroke --- perfusion imaging --- contrast agent --- intracerebral hematoma --- subarachnoid hemorrhage --- large vessel disease --- clinical outcome --- prognosis --- functional magnetic resonance imaging --- neuronal plasticity --- recovery of function --- motor cortex --- ankle-brachial index difference --- inter-ankle blood pressure difference --- peripheral artery disease --- anemia --- blood transfusion --- red blood cells --- outcome assessment --- endothelial progenitor cells --- atherosclerosis --- computed tomography angiography


Book
Protective and Detrimental Role of Heme Oxygenase-1
Author:
ISBN: 3039218077 3039218069 Year: 2019 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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The book “Protective and Detrimental Role of Heme Oxygenase-1”, includes a selection of original research papers and reviews aimed at understanding the dual role (protective and detrimental) of HO-1 and the involved signaling pathways. Original research papers and reviews aimed at the identification of natural molecules or new synthetic compounds able to modulate HO-1 activity/expression help make HO-1 a potential therapeutic target for the amelioration of various diseases.


Book
Clinical Research on Diabetic Complications
Author:
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Refrigeration, air conditioning, and heat pumps (RACHP) have an important impact on the final energy uses of many sectors of modern society, such as residential, commercial, industrial, transport, and automotive. Moreover, RACHP also have an important environmental impact due to the working fluids that deplete the stratospheric ozone layer, which are being phased out according to the Montreal Protocol (1989). Last, but not least, high global working potential (GWP), working fluids (directly), and energy consumption (indirectly) are responsible for a non-negligible quota of greenhouse gas (GHG) emissions in the atmosphere, thus impacting climate change.

Keywords

History of engineering & technology --- burnt-out diabetes --- chronic kidney disease (CKD) --- dialysis --- end-stage renal disease (ESRD) --- incident diabetes mellitus (DM) --- insulin resistance --- dementia --- dipeptidyl-peptidase IV inhibitors --- diabetes mellitus --- type 2 --- Alzheimer’s disease --- vascular --- diabetes --- microperimetry --- type 2 diabetes mellitus --- glucose fluctuations --- sarcopenia --- diabetic retinopathy --- type 1 diabetes --- quality of life --- treatment satisfaction --- patient-reported outcomes --- plaque characteristics --- carotid plaque --- echogenic plaque --- diabetic foot syndrome --- vascular disease --- fibroblast growth factor 23 --- Klotho --- inflammation --- dermal electrochemical conductance --- neuropathy --- primary care --- screening --- sudomotor reflex --- prediabetes --- arterial stiffness --- baPWV --- aspirin --- primary prevention --- meta-analysis --- trial sequential analysis --- sCD36 --- type 1 diabetes mellitus --- branched-chain amino acids --- metabolomics --- NMR spectroscopy --- diabetic kidney disease --- reno-cardiovascular protection --- sodium-glucose co-transporter 2 inhibitors --- glucagon-like peptide-1 receptor agonists --- dipeptidyl peptidase 4 inhibitors --- obesity --- bariatric surgery --- diabetic macroangiopathy --- cardiovascular disease --- heart disease --- cerebrovascular disease --- peripheral artery disease --- diabetic foot disease --- diabetic microangiopathy --- diabetic neuropathy


Book
Clinical Research on Diabetic Complications
Author:
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Refrigeration, air conditioning, and heat pumps (RACHP) have an important impact on the final energy uses of many sectors of modern society, such as residential, commercial, industrial, transport, and automotive. Moreover, RACHP also have an important environmental impact due to the working fluids that deplete the stratospheric ozone layer, which are being phased out according to the Montreal Protocol (1989). Last, but not least, high global working potential (GWP), working fluids (directly), and energy consumption (indirectly) are responsible for a non-negligible quota of greenhouse gas (GHG) emissions in the atmosphere, thus impacting climate change.


Book
Clinical Research on Diabetic Complications
Author:
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

Loading...
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Bookmark

Abstract

Refrigeration, air conditioning, and heat pumps (RACHP) have an important impact on the final energy uses of many sectors of modern society, such as residential, commercial, industrial, transport, and automotive. Moreover, RACHP also have an important environmental impact due to the working fluids that deplete the stratospheric ozone layer, which are being phased out according to the Montreal Protocol (1989). Last, but not least, high global working potential (GWP), working fluids (directly), and energy consumption (indirectly) are responsible for a non-negligible quota of greenhouse gas (GHG) emissions in the atmosphere, thus impacting climate change.

Keywords

History of engineering & technology --- burnt-out diabetes --- chronic kidney disease (CKD) --- dialysis --- end-stage renal disease (ESRD) --- incident diabetes mellitus (DM) --- insulin resistance --- dementia --- dipeptidyl-peptidase IV inhibitors --- diabetes mellitus --- type 2 --- Alzheimer’s disease --- vascular --- diabetes --- microperimetry --- type 2 diabetes mellitus --- glucose fluctuations --- sarcopenia --- diabetic retinopathy --- type 1 diabetes --- quality of life --- treatment satisfaction --- patient-reported outcomes --- plaque characteristics --- carotid plaque --- echogenic plaque --- diabetic foot syndrome --- vascular disease --- fibroblast growth factor 23 --- Klotho --- inflammation --- dermal electrochemical conductance --- neuropathy --- primary care --- screening --- sudomotor reflex --- prediabetes --- arterial stiffness --- baPWV --- aspirin --- primary prevention --- meta-analysis --- trial sequential analysis --- sCD36 --- type 1 diabetes mellitus --- branched-chain amino acids --- metabolomics --- NMR spectroscopy --- diabetic kidney disease --- reno-cardiovascular protection --- sodium-glucose co-transporter 2 inhibitors --- glucagon-like peptide-1 receptor agonists --- dipeptidyl peptidase 4 inhibitors --- obesity --- bariatric surgery --- diabetic macroangiopathy --- cardiovascular disease --- heart disease --- cerebrovascular disease --- peripheral artery disease --- diabetic foot disease --- diabetic microangiopathy --- diabetic neuropathy --- burnt-out diabetes --- chronic kidney disease (CKD) --- dialysis --- end-stage renal disease (ESRD) --- incident diabetes mellitus (DM) --- insulin resistance --- dementia --- dipeptidyl-peptidase IV inhibitors --- diabetes mellitus --- type 2 --- Alzheimer’s disease --- vascular --- diabetes --- microperimetry --- type 2 diabetes mellitus --- glucose fluctuations --- sarcopenia --- diabetic retinopathy --- type 1 diabetes --- quality of life --- treatment satisfaction --- patient-reported outcomes --- plaque characteristics --- carotid plaque --- echogenic plaque --- diabetic foot syndrome --- vascular disease --- fibroblast growth factor 23 --- Klotho --- inflammation --- dermal electrochemical conductance --- neuropathy --- primary care --- screening --- sudomotor reflex --- prediabetes --- arterial stiffness --- baPWV --- aspirin --- primary prevention --- meta-analysis --- trial sequential analysis --- sCD36 --- type 1 diabetes mellitus --- branched-chain amino acids --- metabolomics --- NMR spectroscopy --- diabetic kidney disease --- reno-cardiovascular protection --- sodium-glucose co-transporter 2 inhibitors --- glucagon-like peptide-1 receptor agonists --- dipeptidyl peptidase 4 inhibitors --- obesity --- bariatric surgery --- diabetic macroangiopathy --- cardiovascular disease --- heart disease --- cerebrovascular disease --- peripheral artery disease --- diabetic foot disease --- diabetic microangiopathy --- diabetic neuropathy

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