Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book compiles four review articles and four research papers that highlight recent developments in the field of peptide nucleic acid (PNA) chemistry and biomedicine. The review articles encompass a variety of fields related to PNA, emphasizing the versatility of this DNA mimic. Two excellent reviews detail the use of PNA for molecular diagnostics of miRNAs and genetic point mutations (SNPs). Another review provides a comprehensive analysis of the various approaches for gene editing using chemically modified PNA molecules. Lastly, PNA molecules are elegantly described as effective (antisense) antimicrobial agents in the final review. The high binding affinity of PNA to complementary DNA and RNA is highlighted in three research articles. Two articles show how PNA molecules act as splice modulating and RNA masking molecules, separately. In another contribution, the high affinity and achiral characteristics of PNAs are used to developed a stable L-DNA-based catalytic hairpin assembly. Lastly, chemically-modified PNA molecules are shown to be superior probes for SNP detection. Altogether, these studies illustrate how PNA molecules may be useful for a variety of biomedical applications as either therapeutic or diagnostic agents.

RNA structure --- strand invasion --- antisense --- PNA --- exon skipping --- exon inclusion --- oligonucleotides --- peptide nucleic acid (PNA) --- antibacterials --- RNA --- PNA transporters --- conjugates --- bacterial resistance --- peptide nucleic acids --- triplex --- gene editing --- structure --- recombination --- repair --- nanoparticles --- β-thalassemia --- cystic fibrosis --- peptide nucleic acid --- tolane --- single nucleotide polymorphism --- influenza virus --- drug resistance --- peptide nucleic acids (PNAs) --- single-nucleotide polymorphism (SNP) --- polymerase chain reaction (PCR) --- cancer. --- catalytic hairpin assembly (CHA) --- strand-displacement reaction --- l-DNA --- microRNA --- fluorescence --- templated reactions --- light-triggered --- electrochemical biosensors --- colorimetric detection --- Peptide nucleic acids --- PNA-masking --- microRNAs --- miR-145-5p --- miRNA targeting --- delivery --- CFTR --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Over the last few decades, the study of microbial biofilms has been gaining interest among the scientific community. These microbial communities comprise cells adhered to surfaces that are surrounded by a self-produced exopolymeric matrix that protects biofilm cells against different external stresses. Biofilms can have a negative impact on different sectors within society, namely in agriculture, food industries, and veterinary and human health. As a consequence of their metabolic state and matrix protection, biofilm cells are very difficult to tackle with antibiotics or chemical disinfectants. Due to this problem, recent advances in the development of antibiotic alternatives or complementary strategies to prevent or control biofilms have been reported. This book includes different strategies to prevent biofilm formation or to control biofilm development and includes full research articles, reviews, a communication, and a perspective.

Technology: general issues --- antibiofilm --- antimicrobial agent --- bacteria --- fungi --- polymicrobial biofilm --- microalga --- free fatty acids --- encapsulation --- biofilm --- chronic wounds --- host response --- S100A8/A9 --- dental plaque --- quorum sensing --- microbial resistance --- bacterial adhesion --- blocking effect --- hydrodynamics --- parallel plate flow cell --- carbon nanotubes --- poly(dimethylsiloxane) --- adhesion --- Escherichia coli --- Biofilm --- Public Engagement --- Outreach --- Control Strategies --- Oral Biofilm --- TiO2 nanofibers --- electrospinning --- biofilm prevention and control --- multidrug-resistant bacteria --- biomedical application --- biofilms --- biofilm inhibition --- dental implants --- peri-implantitis --- polyether-ether-ketone --- Pseudomonas aeruginosa --- Candida albicans --- mixed-species biofilm analysis --- flow cytometry --- bacteriophage therapy --- prosthesis related infections --- hardware infections --- left ventricular assist devices --- Acinetobacter baumannii --- antibiotic resistance --- antibiotic tolerance --- persister --- intraspecies community --- EPS matrix --- peptide nucleic acid-fluorescence in situ hybridization --- urinary tract infections --- catheter-associated urinary tract infections --- confocal laser scanning microscopy --- recalcitrance --- biofilm control --- Klebsiella pneumoniae --- KPC and OXA-48-like carbapenemases --- Galleria mellonella infection model --- linear oligoethyleneimine hydrochloride --- bacteriophage --- endotracheal tube --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Over the last few decades, the study of microbial biofilms has been gaining interest among the scientific community. These microbial communities comprise cells adhered to surfaces that are surrounded by a self-produced exopolymeric matrix that protects biofilm cells against different external stresses. Biofilms can have a negative impact on different sectors within society, namely in agriculture, food industries, and veterinary and human health. As a consequence of their metabolic state and matrix protection, biofilm cells are very difficult to tackle with antibiotics or chemical disinfectants. Due to this problem, recent advances in the development of antibiotic alternatives or complementary strategies to prevent or control biofilms have been reported. This book includes different strategies to prevent biofilm formation or to control biofilm development and includes full research articles, reviews, a communication, and a perspective.

Technology: general issues --- antibiofilm --- antimicrobial agent --- bacteria --- fungi --- polymicrobial biofilm --- microalga --- free fatty acids --- encapsulation --- biofilm --- chronic wounds --- host response --- S100A8/A9 --- dental plaque --- quorum sensing --- microbial resistance --- bacterial adhesion --- blocking effect --- hydrodynamics --- parallel plate flow cell --- carbon nanotubes --- poly(dimethylsiloxane) --- adhesion --- Escherichia coli --- Biofilm --- Public Engagement --- Outreach --- Control Strategies --- Oral Biofilm --- TiO2 nanofibers --- electrospinning --- biofilm prevention and control --- multidrug-resistant bacteria --- biomedical application --- biofilms --- biofilm inhibition --- dental implants --- peri-implantitis --- polyether-ether-ketone --- Pseudomonas aeruginosa --- Candida albicans --- mixed-species biofilm analysis --- flow cytometry --- bacteriophage therapy --- prosthesis related infections --- hardware infections --- left ventricular assist devices --- Acinetobacter baumannii --- antibiotic resistance --- antibiotic tolerance --- persister --- intraspecies community --- EPS matrix --- peptide nucleic acid-fluorescence in situ hybridization --- urinary tract infections --- catheter-associated urinary tract infections --- confocal laser scanning microscopy --- recalcitrance --- biofilm control --- Klebsiella pneumoniae --- KPC and OXA-48-like carbapenemases --- Galleria mellonella infection model --- linear oligoethyleneimine hydrochloride --- bacteriophage --- endotracheal tube --- antibiofilm --- antimicrobial agent --- bacteria --- fungi --- polymicrobial biofilm --- microalga --- free fatty acids --- encapsulation --- biofilm --- chronic wounds --- host response --- S100A8/A9 --- dental plaque --- quorum sensing --- microbial resistance --- bacterial adhesion --- blocking effect --- hydrodynamics --- parallel plate flow cell --- carbon nanotubes --- poly(dimethylsiloxane) --- adhesion --- Escherichia coli --- Biofilm --- Public Engagement --- Outreach --- Control Strategies --- Oral Biofilm --- TiO2 nanofibers --- electrospinning --- biofilm prevention and control --- multidrug-resistant bacteria --- biomedical application --- biofilms --- biofilm inhibition --- dental implants --- peri-implantitis --- polyether-ether-ketone --- Pseudomonas aeruginosa --- Candida albicans --- mixed-species biofilm analysis --- flow cytometry --- bacteriophage therapy --- prosthesis related infections --- hardware infections --- left ventricular assist devices --- Acinetobacter baumannii --- antibiotic resistance --- antibiotic tolerance --- persister --- intraspecies community --- EPS matrix --- peptide nucleic acid-fluorescence in situ hybridization --- urinary tract infections --- catheter-associated urinary tract infections --- confocal laser scanning microscopy --- recalcitrance --- biofilm control --- Klebsiella pneumoniae --- KPC and OXA-48-like carbapenemases --- Galleria mellonella infection model --- linear oligoethyleneimine hydrochloride --- bacteriophage --- endotracheal tube