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This book is devoted to new developments in measurement technologies for upstream and downstream bioprocessing. The recent advances in biotechnology and bioprocessing have generated a number of new biological products that require more qualified analytical technologies for diverse process analytical needs. These includes especially fast and sensitive measurement technology that, early in the process train, can inform on critical process parameters related to process economy and product quality and that can facilitate ambitions of designing efficient integrated end-to-end bioprocesses. This book covers these topics as well as analytical monitoring methods based either on real-time or in-line sensor technology, on simple and compact bioanalytical devices, or on the use of advanced data prediction methods.

Technology: general issues --- lactate biosensor --- enzyme electrode --- off-line monitoring --- screen-printing --- at-line measurement --- in-line monitoring --- cell viability --- prediction --- chromatogram fingerprinting --- filamentous fungi --- Penicillium chrysogenum --- Trichoderma reesei Rut-C30 --- HPLC-SEC --- AAV-adeno-associated virus --- insect cell-baculovirus --- cell culture monitoring --- digital holographic microscopy --- process analytical technology --- pH --- pCO2 --- off-gas measurement --- carbon dioxide --- cell culture --- reference --- CHO --- automated sampling --- bioprocess --- amino acids --- vitamins --- Raman spectroscopy --- mammalian cell culture --- high-throughput --- scale-down technologies --- cation exchange chromatography --- monitoring --- PAT --- IgG titer --- real-time --- on-line --- nanoplasmonic --- AAV—adeno-associated virus --- gene therapy --- dielectric spectroscopy --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book is devoted to new developments in measurement technologies for upstream and downstream bioprocessing. The recent advances in biotechnology and bioprocessing have generated a number of new biological products that require more qualified analytical technologies for diverse process analytical needs. These includes especially fast and sensitive measurement technology that, early in the process train, can inform on critical process parameters related to process economy and product quality and that can facilitate ambitions of designing efficient integrated end-to-end bioprocesses. This book covers these topics as well as analytical monitoring methods based either on real-time or in-line sensor technology, on simple and compact bioanalytical devices, or on the use of advanced data prediction methods.

lactate biosensor --- enzyme electrode --- off-line monitoring --- screen-printing --- at-line measurement --- in-line monitoring --- cell viability --- prediction --- chromatogram fingerprinting --- filamentous fungi --- Penicillium chrysogenum --- Trichoderma reesei Rut-C30 --- HPLC-SEC --- AAV-adeno-associated virus --- insect cell-baculovirus --- cell culture monitoring --- digital holographic microscopy --- process analytical technology --- pH --- pCO2 --- off-gas measurement --- carbon dioxide --- cell culture --- reference --- CHO --- automated sampling --- bioprocess --- amino acids --- vitamins --- Raman spectroscopy --- mammalian cell culture --- high-throughput --- scale-down technologies --- cation exchange chromatography --- monitoring --- PAT --- IgG titer --- real-time --- on-line --- nanoplasmonic --- AAV—adeno-associated virus --- gene therapy --- dielectric spectroscopy --- n/a