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Cancer is the second leading cause of death worldwide, and was accountable for an estimated 9.6 million deaths in 2018. Nowadays, about 1 in 6 deaths in the world is due to cancer. Another major global public health issue is HIV. Over 70 million people have been infected with the HIV virus and about 35 million people have died of HIV-related illness, since the start of the epidemic. We have been fighting against these two serious diseases by finding successful treatments. The discovery of effective drugs is important for fighting cancer and HIV. Natural products, which are secondary metabolites produced by various living organisms, have been playing a principal role in drug discovery and developments, because of their structural and biological diversity. Many clinically used drugs have come from natural products; for example, more than 60% of anticancer drugs currently in clinical use are derived from natural sources. This Special Issue aims to collect original research and review articles focusing on notable and recent contributions to the discovery and development of novel anticancer and anti-HIV drug candidates from natural sources. Up-to-date knowledge from various research fields is welcome. This could be of great interest for scientists working in different research areas, such as natural product chemistry, including isolation and structural elucidation; phytochemistry; medicinal chemistry, including chemically modified natural compounds with improved biological activity; pharmacology; molecular biology; mechanisms of action study using natural products or related compounds; pharmacognosy, etc. Biological studies of natural extracts without an appropriate chemical characterization may not be considered.

Research & information: general --- natural phaeosphaeride A --- antitumor activity --- human tumor cell lines --- HEF cell line --- acute toxicity --- aspidosperma-type --- monoterpenoid indole alkaloids --- antiproliferative activity --- tubulin inhibitor --- Bousigonia mekongensis --- ursolic acid --- DOTA --- triterpenoids --- cytotoxicity --- diterpenoid alkaloids --- human tumor cells --- lipojesaconitine --- delcosine --- delpheline --- kobusine --- pseudokobusine --- BRAF inhibitor --- Mentha aquatica var. Kenting Water Mint --- essential oil --- chemoprevention --- two-stage skin carcinogenesis --- melanoma --- curcumin analog --- apoptosis --- oxidative stress --- drug–drug interaction --- tamoxifen --- taxol --- cisplatin --- Artemisia absinthium L. --- antioxidants --- total phenolic content --- melanoma and breast cancer cell line --- HaCaT cells --- inflammation --- breast cancer --- cell cycle --- flavonoids --- reactive oxygen species --- tumor suppression --- antiretroviral agents --- anti-HIV --- marine metabolites --- natural products --- drug development --- Ivalin --- Carpesium divaricatum --- hepatocellular carcinoma --- mitochondria-mediated apoptosis --- NF-κB --- Hernandia nymphaeifolia --- butanolides --- lignan glycosides --- coumarins --- antiangiogenic --- cancer --- natural agents --- chemistry --- medicine --- cancer stem cell --- cervical cancer --- pterostilbene --- resveratrol --- caffeic acid --- cancer multidrug resistance --- P-glycoprotein --- phenolic acid --- oxypeucedanin --- Angelica dahurica --- antiproliferation --- G2/M phase cell cycle arrest --- p53 --- SK-Hep-1 --- hepatoma cells --- allyl isothiocyanate --- benzyl isothiocyanate --- sulforaphane --- phenethyl isothiocyanate --- bladder cancer --- quercetin --- oral squamous cell carcinoma cells --- metastasis --- cell cycle arrest --- epithelial-to-mesenchymal transition --- matrix metalloproteinase --- transforming growth factor-β1 --- β-lapachone --- natural phaeosphaeride A --- antitumor activity --- human tumor cell lines --- HEF cell line --- acute toxicity --- aspidosperma-type --- monoterpenoid indole alkaloids --- antiproliferative activity --- tubulin inhibitor --- Bousigonia mekongensis --- ursolic acid --- DOTA --- triterpenoids --- cytotoxicity --- diterpenoid alkaloids --- human tumor cells --- lipojesaconitine --- delcosine --- delpheline --- kobusine --- pseudokobusine --- BRAF inhibitor --- Mentha aquatica var. Kenting Water Mint --- essential oil --- chemoprevention --- two-stage skin carcinogenesis --- melanoma --- curcumin analog --- apoptosis --- oxidative stress --- drug–drug interaction --- tamoxifen --- taxol --- cisplatin --- Artemisia absinthium L. --- antioxidants --- total phenolic content --- melanoma and breast cancer cell line --- HaCaT cells --- inflammation --- breast cancer --- cell cycle --- flavonoids --- reactive oxygen species --- tumor suppression --- antiretroviral agents --- anti-HIV --- marine metabolites --- natural products --- drug development --- Ivalin --- Carpesium divaricatum --- hepatocellular carcinoma --- mitochondria-mediated apoptosis --- NF-κB --- Hernandia nymphaeifolia --- butanolides --- lignan glycosides --- coumarins --- antiangiogenic --- cancer --- natural agents --- chemistry --- medicine --- cancer stem cell --- cervical cancer --- pterostilbene --- resveratrol --- caffeic acid --- cancer multidrug resistance --- P-glycoprotein --- phenolic acid --- oxypeucedanin --- Angelica dahurica --- antiproliferation --- G2/M phase cell cycle arrest --- p53 --- SK-Hep-1 --- hepatoma cells --- allyl isothiocyanate --- benzyl isothiocyanate --- sulforaphane --- phenethyl isothiocyanate --- bladder cancer --- quercetin --- oral squamous cell carcinoma cells --- metastasis --- cell cycle arrest --- epithelial-to-mesenchymal transition --- matrix metalloproteinase --- transforming growth factor-β1 --- β-lapachone

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This theme issue is to celebrate Professor Robert Verpoorte’s 75th birthday. Prof. Verpoorte has been working in Leiden University over 40 years. There is no need to dwell upon the contributions of Dr. Verpoorte to plant-derived natural products research during his whole life. Dr. Verpoorte was a highly productive scientist throughout his academic career, with over 800 scientific publications in the form of research papers, books, and book chapters. His research interests are very diverse, cover- ing numerous topics related to plant-based natural products such as plant cell biotech- nology, biosynthesis, metabolomics, genetic engineering, and green technology, as well as the isolation of new biologically active compounds. He has left indelible footprints in all these fields, and he is widely recognised as a pioneer in the work of the biosynthesis of indole alkaloids, NMR-based metabolomics, and green technology in natural products production. As close friends and colleagues who have been in nearly daily contact with him over the last 20 years viewing all of these remarkable scientific contributions, we felt compelled to recognize this by the publication of a Special Issue of this journal dedicated to him.Thus, this Special Issue has now finally been released with the help of many of his colleagues and former students as a token of our gratitude to his impressive work.The Special Issue covers five main natural products topics: (1) chemical profiling and metabolomics, (2) separation/isolation and identification of plant specialized metabolites, (3) pharmacognosy of natural products to identify bioactive molecules from natural prod- ucts, (4) novel formulation of natural products, and (5) overview of natural products as a source of bioactive molecules.

Research & information: general --- natural extract --- glycerin --- chemical profiling --- centrifugal partition chromatography --- 13C nuclear magnetic resonance --- cosmetic industry --- Psychotria malayana Jack --- type 2 diabetes --- α-glucosidase inhibitors --- LC-MS --- metabolomics --- molecular docking --- colorectal cancer --- HCT 116 --- telomerase --- telomerase inhibitor --- berberine --- downregulation --- cell cycle arrest --- telomere erosion --- molecular imaging --- direct analysis in real-time mass spectrometry --- ephedra alkaloids --- ephedrine --- methylephedrine --- Ephedra sinica --- natural products --- dereplication --- databases --- spectroscopy --- taxonomy --- molecular structures --- lignans --- secoisolariciresinol --- RNA interference --- flax --- osmotic stress --- 1H-NMR --- ionic liquids --- oxypeucedanin hydrate --- byakangelicin --- A. dahurica --- back-extraction --- enrichment --- plum brandy --- GC-FID-MS --- enzyme inhibition assay --- antibacterial assay --- effect-directed analysis --- bioassay --- botanicals --- health food --- protein tyrosine phosphatases (PTPs) --- PTP-MEG2 --- phloridzin --- glucose-uptake --- Eleutherococcus senticosus --- fruits --- eleutherosides --- nutri-pharmacological --- herbs --- inflammation --- docking --- NuBBE database --- chalcones --- Nacobbus aberrans --- nematicidal activity --- α-terthienyl --- stigmasterol --- quercetagetin derivatives --- 9-O-angeloyl-retronecine N-oxide --- alkaloid --- Solanaceae --- tropane --- indole --- pyrrolidine --- Datura --- terpenoid --- signaling --- chemical cue --- kairomone --- potentiation --- cytotoxic activity --- NMR --- Ononis diffusa --- Ononis variegata --- oxylipins --- toronjil --- Mexican agastache --- aromatic plants --- weld --- Reseda luteola L. --- natural yellow dye --- μ-analysis --- micro-extraction of wool --- UHPLC --- fingerprinting --- flavones --- structure elucidation --- n/a

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• Reference Manager
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This theme issue is to celebrate Professor Robert Verpoorte’s 75th birthday. Prof. Verpoorte has been working in Leiden University over 40 years. There is no need to dwell upon the contributions of Dr. Verpoorte to plant-derived natural products research during his whole life. Dr. Verpoorte was a highly productive scientist throughout his academic career, with over 800 scientific publications in the form of research papers, books, and book chapters. His research interests are very diverse, cover- ing numerous topics related to plant-based natural products such as plant cell biotech- nology, biosynthesis, metabolomics, genetic engineering, and green technology, as well as the isolation of new biologically active compounds. He has left indelible footprints in all these fields, and he is widely recognised as a pioneer in the work of the biosynthesis of indole alkaloids, NMR-based metabolomics, and green technology in natural products production. As close friends and colleagues who have been in nearly daily contact with him over the last 20 years viewing all of these remarkable scientific contributions, we felt compelled to recognize this by the publication of a Special Issue of this journal dedicated to him.Thus, this Special Issue has now finally been released with the help of many of his colleagues and former students as a token of our gratitude to his impressive work.The Special Issue covers five main natural products topics: (1) chemical profiling and metabolomics, (2) separation/isolation and identification of plant specialized metabolites, (3) pharmacognosy of natural products to identify bioactive molecules from natural prod- ucts, (4) novel formulation of natural products, and (5) overview of natural products as a source of bioactive molecules.

natural extract --- glycerin --- chemical profiling --- centrifugal partition chromatography --- 13C nuclear magnetic resonance --- cosmetic industry --- Psychotria malayana Jack --- type 2 diabetes --- α-glucosidase inhibitors --- LC-MS --- metabolomics --- molecular docking --- colorectal cancer --- HCT 116 --- telomerase --- telomerase inhibitor --- berberine --- downregulation --- cell cycle arrest --- telomere erosion --- molecular imaging --- direct analysis in real-time mass spectrometry --- ephedra alkaloids --- ephedrine --- methylephedrine --- Ephedra sinica --- natural products --- dereplication --- databases --- spectroscopy --- taxonomy --- molecular structures --- lignans --- secoisolariciresinol --- RNA interference --- flax --- osmotic stress --- 1H-NMR --- ionic liquids --- oxypeucedanin hydrate --- byakangelicin --- A. dahurica --- back-extraction --- enrichment --- plum brandy --- GC-FID-MS --- enzyme inhibition assay --- antibacterial assay --- effect-directed analysis --- bioassay --- botanicals --- health food --- protein tyrosine phosphatases (PTPs) --- PTP-MEG2 --- phloridzin --- glucose-uptake --- Eleutherococcus senticosus --- fruits --- eleutherosides --- nutri-pharmacological --- herbs --- inflammation --- docking --- NuBBE database --- chalcones --- Nacobbus aberrans --- nematicidal activity --- α-terthienyl --- stigmasterol --- quercetagetin derivatives --- 9-O-angeloyl-retronecine N-oxide --- alkaloid --- Solanaceae --- tropane --- indole --- pyrrolidine --- Datura --- terpenoid --- signaling --- chemical cue --- kairomone --- potentiation --- cytotoxic activity --- NMR --- Ononis diffusa --- Ononis variegata --- oxylipins --- toronjil --- Mexican agastache --- aromatic plants --- weld --- Reseda luteola L. --- natural yellow dye --- μ-analysis --- micro-extraction of wool --- UHPLC --- fingerprinting --- flavones --- structure elucidation --- n/a