Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Mitogen-activated protein kinases (MAPK) are a large family of enzymes that function as signal transducers to regulate a diverse range of physiological responses. However, signaling via extracellular signal-regulated kinase (ERK), c-Jun amino terminal kinase (JNK), and p38 MAPK also underpin many disease processes. This Special Issue provides new insights into how MAPK signaling contributes to specific pathological processes across a range of conditions, including disorders of lung development, type 2 diabetes, proliferative skin diseases, cardiovascular diseases, and neurological diseases.

Research & information: general --- Biology, life sciences --- Rabdosia inflexa --- inflammation --- gastric ulcer --- cytokines --- MAPK --- NF-κB --- extracellular signal-regulated kinases 1/2 --- hyperoxia --- bronchopulmonary dysplasia --- HPAECs --- angiogenesis --- cell cycle --- SIRT1 --- oxidative stress --- psoriasis --- antimicrobial peptide --- cecropin A --- tight junction protein --- MEK/ERK signaling --- porcine intestinal epithelial cell --- extracellular signal-regulated kinase 5 (ERK5) --- Kv4.2 --- PC12 cells --- infantile myofibromatosis --- receptor tyrosine kinases --- platelet-derived growth factor receptor --- protein kinase inhibitors --- sunitinib --- erlotinib --- FR180204 --- U0126 --- targeted therapy --- apoptosis --- ERK1/2 --- JNKs --- mitochondrial dysfunction --- neurodegeneration --- neuro-inflammation --- p38 MAPKs --- Parkinson's disease --- mitogen-activated protein kinases (MAPKs) --- MAPK kinetics --- osteoclast differentiation --- bone remodeling --- DAPK --- ERK --- p38 --- JNK --- mitogen-activated protein kinase pathway (MAPK pathway) --- protein tyrosine phosphatase interacting protein 51 (PTPIP51) --- protein-protein interaction (PPI) --- cancer signaling --- SR --- CR --- Compatibility --- T2DM --- metabolic profiling --- MAPK/PI3K/Akt signaling pathway --- reactive oxygen species --- PTPN6 --- SRC --- DOK4 --- MKK4 --- MKK7 --- p53 --- DUSP1 --- SIRT2 --- atherosclerosis --- aortic valve sclerosis --- aortic valve stenosis --- naphthalimide-metal complex conjugates --- N-heterocyclic carbene --- mitochondria --- ROS --- p38 MAPK --- cancer --- FGF-induced signaling --- FRS2 --- phosphorylation --- downregulation --- Rabdosia inflexa --- inflammation --- gastric ulcer --- cytokines --- MAPK --- NF-κB --- extracellular signal-regulated kinases 1/2 --- hyperoxia --- bronchopulmonary dysplasia --- HPAECs --- angiogenesis --- cell cycle --- SIRT1 --- oxidative stress --- psoriasis --- antimicrobial peptide --- cecropin A --- tight junction protein --- MEK/ERK signaling --- porcine intestinal epithelial cell --- extracellular signal-regulated kinase 5 (ERK5) --- Kv4.2 --- PC12 cells --- infantile myofibromatosis --- receptor tyrosine kinases --- platelet-derived growth factor receptor --- protein kinase inhibitors --- sunitinib --- erlotinib --- FR180204 --- U0126 --- targeted therapy --- apoptosis --- ERK1/2 --- JNKs --- mitochondrial dysfunction --- neurodegeneration --- neuro-inflammation --- p38 MAPKs --- Parkinson's disease --- mitogen-activated protein kinases (MAPKs) --- MAPK kinetics --- osteoclast differentiation --- bone remodeling --- DAPK --- ERK --- p38 --- JNK --- mitogen-activated protein kinase pathway (MAPK pathway) --- protein tyrosine phosphatase interacting protein 51 (PTPIP51) --- protein-protein interaction (PPI) --- cancer signaling --- SR --- CR --- Compatibility --- T2DM --- metabolic profiling --- MAPK/PI3K/Akt signaling pathway --- reactive oxygen species --- PTPN6 --- SRC --- DOK4 --- MKK4 --- MKK7 --- p53 --- DUSP1 --- SIRT2 --- atherosclerosis --- aortic valve sclerosis --- aortic valve stenosis --- naphthalimide-metal complex conjugates --- N-heterocyclic carbene --- mitochondria --- ROS --- p38 MAPK --- cancer --- FGF-induced signaling --- FRS2 --- phosphorylation --- downregulation

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The Book covers this whole field, from the discovery of structurally new and bioactive natural products (including biomacromolecules), from marine macro-/micro-organisms, to the pharmacodynamics, pharmacokinetics, metabolisms, and mechanisms of marine-derived lead compounds, both in vitro and in vivo, along with the synthesis and/or structural optimization of marine-derived lead compounds and their structure–activity relationships. Taken together, this Special Issue reprint not only provides inspiration for the discovery of marine-derived novel bioactive compounds, but also sheds light on the further research and development of marine candidate drugs.

Medicine --- Antarctic krill (Euphausia superba) --- peptide --- antioxidant activity --- stability --- oyster --- plasma --- peptidome --- antimicrobial peptides --- cytotoxicity --- actinomycete --- piericidins --- absolute configuration --- Pestalotiopsis heterocornis --- heterocornols --- anti-inflammatory activity --- sponge-derived fungus --- sclerotides --- lipodepsipeptide --- Aspergillus sclerotiorum --- nasopharyngeal carcinoma --- AChE inhibitory --- vascular endothelial cell --- flavonoid --- oxidized low-density lipoprotein --- Nrf2 --- apoptosis --- butyrolactone I --- food allergy --- metabolism --- pharmacokinetics --- actinomycin X2 --- microbial pigments --- dyeing --- silk --- antibacterial properties --- PD-L1 --- virtual screening --- pharmacophore modeling --- ADME --- molecular dynamics --- xanthones --- ascidian-derived fungus --- Diaporthe sp. --- anti-glioma activity --- antiaging --- Sonneratia apetala --- signaling pathway --- Caenorhabditis elegans --- mutants --- coral-derived fungi --- Aspergillus hiratsukae --- meroterpenoids --- antibacterial activity --- cytotoxic activity --- deep-sea-derived fungus --- Aspergillus puniceus --- isoquinoline alkaloid --- protein tyrosine phosphatase inhibitor --- antibacterial --- Aspergillus sp. --- geodin --- semisynthesize --- insecticidal activity --- Arca inflata --- antitumor peptide --- MAPK signaling --- calmodulin --- colorectal cancer --- methicillin-resistant Staphylococcus aureus --- actinomycin D --- Streptomyces parvulus --- mechanism --- mangrove endophytic Pestalotiopsis --- Sdy-1 --- antitumor activity --- Wnt signaling --- β-catenin --- eremophilane sesquiterpenoids --- mangrove-derived fungus --- Penicillium sp. --- Oceanapia --- sponge --- secondary metabolites --- biological activities --- drug design --- anticancer --- cyclic pentapeptide --- galaxamide analogues --- skipjack tuna (Katsuwonus pelamis) muscle --- angiotensin-I-converting enzyme (ACE) peptide --- molecular docking --- nitric oxide (NO) --- endothelin-1 (ET-1) --- Trichoderma longibrachiatum --- sesquiterpene glycoside --- antimicrobial activity --- marine fungi --- Aspergillus unguis --- depsides --- depsidones --- osteoclast differentiation --- soft-coral-derived fungus --- pyranodipyran derivatives --- tyrosyl DNA phosphodiesterase 1 inhibitory activities --- fluorescent properties --- butenolides --- enantiomers --- Aspergillus terreus --- pancreatic lipase --- NAFLD --- fucoxanthin --- adenosine monophosphate-activated protein kinase (AMPK) --- nuclear factor erythroid-2-related factor 2-mediated (Nrf2) --- Toll-like receptor 4-mediated (TLR4) --- Aspergillus flavipes HN4-13 --- emodin --- macroporous resin XAD-16 --- adsorption kinetics and isotherms --- enrichment --- tetramic acid derivatives --- deep-sea fungus --- clavipitacae --- Lecanicillium fusisporum --- chronic kidney disease --- fucoidan --- cognitive dysfunction --- neuroinflammation --- oxidative stress --- GSK3β-Nrf2-HO-1 signaling --- microglial polarization --- deep-sea actinomycetes --- aromatic acids --- oximes --- antihyperlipidemic --- phycocyanin --- microbiota --- transcriptome --- IL-17 pathway --- Hahella --- prodiginine --- chejuenlide --- genome mining --- LC-MS/MS --- CDK4/6 --- marine compounds --- pharmacophore construction --- ADMET --- mm-pbsa --- Antarctic krill (Euphausia superba) --- peptide --- antioxidant activity --- stability --- oyster --- plasma --- peptidome --- antimicrobial peptides --- cytotoxicity --- actinomycete --- piericidins --- absolute configuration --- Pestalotiopsis heterocornis --- heterocornols --- anti-inflammatory activity --- sponge-derived fungus --- sclerotides --- lipodepsipeptide --- Aspergillus sclerotiorum --- nasopharyngeal carcinoma --- AChE inhibitory --- vascular endothelial cell --- flavonoid --- oxidized low-density lipoprotein --- Nrf2 --- apoptosis --- butyrolactone I --- food allergy --- metabolism --- pharmacokinetics --- actinomycin X2 --- microbial pigments --- dyeing --- silk --- antibacterial properties --- PD-L1 --- virtual screening --- pharmacophore modeling --- ADME --- molecular dynamics --- xanthones --- ascidian-derived fungus --- Diaporthe sp. --- anti-glioma activity --- antiaging --- Sonneratia apetala --- signaling pathway --- Caenorhabditis elegans --- mutants --- coral-derived fungi --- Aspergillus hiratsukae --- meroterpenoids --- antibacterial activity --- cytotoxic activity --- deep-sea-derived fungus --- Aspergillus puniceus --- isoquinoline alkaloid --- protein tyrosine phosphatase inhibitor --- antibacterial --- Aspergillus sp. --- geodin --- semisynthesize --- insecticidal activity --- Arca inflata --- antitumor peptide --- MAPK signaling --- calmodulin --- colorectal cancer --- methicillin-resistant Staphylococcus aureus --- actinomycin D --- Streptomyces parvulus --- mechanism --- mangrove endophytic Pestalotiopsis --- Sdy-1 --- antitumor activity --- Wnt signaling --- β-catenin --- eremophilane sesquiterpenoids --- mangrove-derived fungus --- Penicillium sp. --- Oceanapia --- sponge --- secondary metabolites --- biological activities --- drug design --- anticancer --- cyclic pentapeptide --- galaxamide analogues --- skipjack tuna (Katsuwonus pelamis) muscle --- angiotensin-I-converting enzyme (ACE) peptide --- molecular docking --- nitric oxide (NO) --- endothelin-1 (ET-1) --- Trichoderma longibrachiatum --- sesquiterpene glycoside --- antimicrobial activity --- marine fungi --- Aspergillus unguis --- depsides --- depsidones --- osteoclast differentiation --- soft-coral-derived fungus --- pyranodipyran derivatives --- tyrosyl DNA phosphodiesterase 1 inhibitory activities --- fluorescent properties --- butenolides --- enantiomers --- Aspergillus terreus --- pancreatic lipase --- NAFLD --- fucoxanthin --- adenosine monophosphate-activated protein kinase (AMPK) --- nuclear factor erythroid-2-related factor 2-mediated (Nrf2) --- Toll-like receptor 4-mediated (TLR4) --- Aspergillus flavipes HN4-13 --- emodin --- macroporous resin XAD-16 --- adsorption kinetics and isotherms --- enrichment --- tetramic acid derivatives --- deep-sea fungus --- clavipitacae --- Lecanicillium fusisporum --- chronic kidney disease --- fucoidan --- cognitive dysfunction --- neuroinflammation --- oxidative stress --- GSK3β-Nrf2-HO-1 signaling --- microglial polarization --- deep-sea actinomycetes --- aromatic acids --- oximes --- antihyperlipidemic --- phycocyanin --- microbiota --- transcriptome --- IL-17 pathway --- Hahella --- prodiginine --- chejuenlide --- genome mining --- LC-MS/MS --- CDK4/6 --- marine compounds --- pharmacophore construction --- ADMET --- mm-pbsa

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The Book covers this whole field, from the discovery of structurally new and bioactive natural products (including biomacromolecules), from marine macro-/micro-organisms, to the pharmacodynamics, pharmacokinetics, metabolisms, and mechanisms of marine-derived lead compounds, both in vitro and in vivo, along with the synthesis and/or structural optimization of marine-derived lead compounds and their structure–activity relationships. Taken together, this Special Issue reprint not only provides inspiration for the discovery of marine-derived novel bioactive compounds, but also sheds light on the further research and development of marine candidate drugs.

Medicine --- Antarctic krill (Euphausia superba) --- peptide --- antioxidant activity --- stability --- oyster --- plasma --- peptidome --- antimicrobial peptides --- cytotoxicity --- actinomycete --- piericidins --- absolute configuration --- Pestalotiopsis heterocornis --- heterocornols --- anti-inflammatory activity --- sponge-derived fungus --- sclerotides --- lipodepsipeptide --- Aspergillus sclerotiorum --- nasopharyngeal carcinoma --- AChE inhibitory --- vascular endothelial cell --- flavonoid --- oxidized low-density lipoprotein --- Nrf2 --- apoptosis --- butyrolactone I --- food allergy --- metabolism --- pharmacokinetics --- actinomycin X2 --- microbial pigments --- dyeing --- silk --- antibacterial properties --- PD-L1 --- virtual screening --- pharmacophore modeling --- ADME --- molecular dynamics --- xanthones --- ascidian-derived fungus --- Diaporthe sp. --- anti-glioma activity --- antiaging --- Sonneratia apetala --- signaling pathway --- Caenorhabditis elegans --- mutants --- coral-derived fungi --- Aspergillus hiratsukae --- meroterpenoids --- antibacterial activity --- cytotoxic activity --- deep-sea-derived fungus --- Aspergillus puniceus --- isoquinoline alkaloid --- protein tyrosine phosphatase inhibitor --- antibacterial --- Aspergillus sp. --- geodin --- semisynthesize --- insecticidal activity --- Arca inflata --- antitumor peptide --- MAPK signaling --- calmodulin --- colorectal cancer --- methicillin-resistant Staphylococcus aureus --- actinomycin D --- Streptomyces parvulus --- mechanism --- mangrove endophytic Pestalotiopsis --- Sdy-1 --- antitumor activity --- Wnt signaling --- β-catenin --- eremophilane sesquiterpenoids --- mangrove-derived fungus --- Penicillium sp. --- Oceanapia --- sponge --- secondary metabolites --- biological activities --- drug design --- anticancer --- cyclic pentapeptide --- galaxamide analogues --- skipjack tuna (Katsuwonus pelamis) muscle --- angiotensin-I-converting enzyme (ACE) peptide --- molecular docking --- nitric oxide (NO) --- endothelin-1 (ET-1) --- Trichoderma longibrachiatum --- sesquiterpene glycoside --- antimicrobial activity --- marine fungi --- Aspergillus unguis --- depsides --- depsidones --- osteoclast differentiation --- soft-coral-derived fungus --- pyranodipyran derivatives --- tyrosyl DNA phosphodiesterase 1 inhibitory activities --- fluorescent properties --- butenolides --- enantiomers --- Aspergillus terreus --- pancreatic lipase --- NAFLD --- fucoxanthin --- adenosine monophosphate-activated protein kinase (AMPK) --- nuclear factor erythroid-2-related factor 2-mediated (Nrf2) --- Toll-like receptor 4-mediated (TLR4) --- Aspergillus flavipes HN4-13 --- emodin --- macroporous resin XAD-16 --- adsorption kinetics and isotherms --- enrichment --- tetramic acid derivatives --- deep-sea fungus --- clavipitacae --- Lecanicillium fusisporum --- chronic kidney disease --- fucoidan --- cognitive dysfunction --- neuroinflammation --- oxidative stress --- GSK3β-Nrf2-HO-1 signaling --- microglial polarization --- deep-sea actinomycetes --- aromatic acids --- oximes --- antihyperlipidemic --- phycocyanin --- microbiota --- transcriptome --- IL-17 pathway --- Hahella --- prodiginine --- chejuenlide --- genome mining --- LC-MS/MS --- CDK4/6 --- marine compounds --- pharmacophore construction --- ADMET --- mm-pbsa

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Structural and Functional Analysis of Extracts in Plants collects 1 editorial, 3 reviews, and 26 research articles reporting recent research findings which cover several aspects of plant-derived bioactive compounds, to correlate extraction techniques with the chemical composition of extracts and their bioactivity for identifying molecules that might be used as active substances in a wide variety of areas.This book is a valuable resource for members of the scientific community wishing to further explore plants and the therapeutic applications of their bioactive compounds. It will appeal to scholars, teachers and scientists involved in plant product research, and facilitate the development of innovative new drugs.

hierarchical cluster analysis --- principal component analysis --- ultrasound-assisted extraction --- triterpenic acid --- Ziziphus jujuba --- water-pepper --- FRAP --- DPPH --- polarity-based solvent extraction --- α-amylase inhibition --- circular economy --- green biorefinery --- polyunsaturated fatty acids --- phytochemicals --- amino acids --- food and feed --- UHPLC-ESI-ORBITRAP-MS/MS --- Bergenia emeiensis --- polysaccharides --- optimization --- RSM --- acrylamide-induced damage --- Sorbus commixta fruit --- anti-melanoma activity --- caspase-3 --- polyphenolic compounds --- depression --- antioxidant --- cytokines --- anti-inflammatory --- cytotoxicity --- medicinal mushroom --- Psilocybe natalensis --- coak oak --- chlorophyll --- terpenes --- lupeol --- cuticular permeance --- Suaeda vermiculata --- halophyte --- aqueous-ethanolic extract --- liver toxicity --- hepatoprotective --- liver disorders --- mass spectrometry --- LC-MS --- HepG-2 --- HepG-2/ADR --- zebrafish --- toxicity --- embryotoxicity --- medicinal plant --- animal model --- Crocus sativus --- in vivo --- carrageenan --- analgesic --- antidepressant --- anticoagulant --- adipogenesis --- AMPK --- anti-obesity --- triglycerides --- UCP1 --- Anacardiaceae --- design of experiments (DOEs) --- flavonoids --- green extraction --- HPLC-DAD --- LC-MS/MS --- tannins --- ultrasound assisted-extraction (UAE) --- compact mass spectrometry --- cleansing properties --- detergent plants --- phytochemical --- tissue culture --- Arbutus pavarii --- antibacterial activity --- MRSA --- time–kill curves --- ultrahigh-performance liquid chromatography --- mass spectrometry (UHPLC- ESI-MS/MS) --- Trigonella stellata --- caffeic acid --- osteoporosis --- osteoblast --- osteoclast --- BMP --- Euphorbia cuneata --- Euphorbiaceae --- lipopolysaccharide --- oxidative stress --- NF-κB --- lung injury --- pachycereus weberi --- escontria chiotilla --- antioxidant activity --- phenolic compounds --- betalains --- food composition --- food analysis --- Scrophularia buergeriana --- S. koraiensis --- S. takesimensis --- harpagoside --- osteoclast differentiation --- RANKL --- Araucaria angustifolia --- bioactive compounds --- cysteine protease inhibitor --- functional food --- insecticide --- plant extracts --- termites --- tumor cells --- pine nuts --- urban pest --- polyphenols --- fruit development --- natural food colorant --- Sambucus canadensis --- Japanese knotweed --- Reynoutria --- Polygonum --- Polygonaceae --- anthraquinones --- emodin --- physcion --- HPTLC --- HPTLC-MS --- densitometry --- carrot juices --- carotenoids --- high-speed juicer --- low-speed juicer --- food processing --- extraction --- glucosinolates --- kale (Brassica oleracea var. acephala) --- phenolics --- candelilla plant --- antioxidant properties --- antimicrobial activity --- candelilla cultivation --- candelilla wax --- polysterols --- saponins --- therapeutic properties --- sage --- stirring and heating extraction --- mechanochemical extraction --- antiproliferative activity --- mutagenicity --- anticoagulant activity --- Rosmarinus officinalis --- hydroalcoholic extract --- Sam-Myo-Whan --- traditional medicine --- gouty arthritis --- inflammation --- monosodium urate --- Underutilized Mexican plants --- Cactus fruits --- Antioxidant activities --- Antiproliferative properties --- n/a --- time-kill curves