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Solvents are ubiquitous throughout the chemical industry and are found in many consumer products. As a result, interest in solvents and their environmental impact has been steadily increasing. However, in order to achieve maximum integration of new green solvents into the relevant chemical sectors, clarification of the social, economic, and environmental implications of solvent substitution are needed. This book explores the solvent life cycle, highlighting the challenges faced at various points, from production, through the supply-chain and downstream use to end-of-life treatment. It also discusses the potential benefits that a green chemistry and bio-based economy approach could bring. The current state-of-the-art of green solvents is evaluated along these lines, in addition to reviewing their applications with an appreciation of sustainability criteria. Providing a critical assessment on emerging solvents and featuring case studies and perspectives from different sectors, this is an important reference for academics and industrialists working with solvents, as well as policy-makers involved in bio-based initiatives.

Chemistry --- groene chemie --- duurzaamheid --- oplosmiddelen

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Solvent systems are integral to drug development and pharmaceutical technology. This single topic encompasses numerous allied subjects running the gamut from recrystallization solvents to biorelevant media. The goal of this contribution to the AAPS Biotechnology: Pharmaceutical Aspects series is to generate both a practical handbook as well as a reference allowing the reader to make effective decisions concerning the use of solvents and solvent systems. To this end, the monograph was created by inviting recognized experts from a number of fields to author relevant sections. Specifically, 15 chapters have been designed covering the theoretical background of solubility, the effect of ionic equilibria and pH on solubilization, the use of solvents to effect drug substance crystallization and polymorph selection, the use of solvent systems in high throughput screening and early discovery, solvent use in preformulation, the use of solvents in bio-relevant dissolution and permeation experiments, solvents and their use as toxicology vehicles, solubilizing media and excipients in oral and parenteral formulation development, specialized vehicles for protein formulation and solvent systems for topical and pulmonary drug administration. The chapters are organized such that useful decision trees are included together with the scientific underpinning for their application. In addition, trends in the use of solvent systems and a balance of current views make this monograph useful to both the novice and experienced researcher and to scientists at all developmental stages from early discovery to late pharmaceutical operations.

Pharmacology. Therapy --- farmacologie --- biogeneesmiddelen --- toxicologie --- oplosmiddelen

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Pharmacology. Therapy --- farmacologie --- biogeneesmiddelen --- toxicologie --- oplosmiddelen

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CFO Techniques: A Hands-on Guide to Keeping Your Business Solvent and Successful is a comprehensive and instructive working manual for multitasking chief financial officers and controllers working in the fast-paced commercial environment. Every senior financial professional with an ever-broadening span of control will benefit from this complete outline of the core activities with specific descriptions of individual tasks comprising the daily agenda of a successful CFO or controller. It covers everything from traditional responsibilities like budgeting and financial reporting, to more innovative tasks like performance analytics and business strategy development. While emphasizing specific guidelines on what it takes to excel as a company's head of finance, the book refrains from overwhelming dryness by using cultural references, real-life examples, and a casual tone. With its bite-sized, easy-to-read chapters, CFO Techniques serves as both an invaluable desktop reference handbook and a good bedtime read. Whether you need a quick recommendation on treasury procedures, adhering to GAAP, keeping funds safe from embezzlers, or advice on dealing with the CEO, you will find the answers in this book. Guides you through CFO/controller core responsibilities, function by function Serves as a reference manual on financial matters specific to the small and mid-size commercial environment Goes beyond finance and accounting, addressing the administrative and behavioral issues all CFOs occasionally must address 

Business management --- management --- bedrijfskunde --- handelswetenschappen --- oplosmiddelen

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After a basic introduction spanning the principles of stereoselective transformations, kinetics and enzyme properties, the different types of reactions are explained. Special techniques, such as the use of enzymes in organic solvents, immobilization techniques and the use of modified enzymes, are also treated. This new edition features an improved didactic style and includes new developments, such as dynamic resolution, stereo-inversion and enantio-convergent processes.

Organic chemistry --- biotransformatie --- organische chemie --- oplosmiddelen --- enzymen