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Metabolomics has been a useful method for various study fields. However, its application in animal science does not seem to be sufficient. Metabolomics will be useful for various studies in animal science: Animal genetics and breeding, animal physiology, animal nutrition, animal products (milk, meat, eggs, and their by-products) and their processing, livestock environment, animal biotechnology, animal behavior, and animal welfare. More application examples and protocols for animal science will promote more motivation to use metabolomics effectively in the study field. Therefore, in this Special Issue, we introduced some research and review articles for “Metabolomic Applications in Anmal Science”. The main methods used were mass spectrometry or nuclear magnetic resonance spectroscopy. Not only a non-targeted, but also a targeted, analysis of metabolites is shown. The topics include dietary and pharmacological interventions and protocols for metabolomic experiments.

albumen --- breed --- chicken --- feed --- metabolome --- yolk --- arachidonic acid --- omega-3 fatty acids --- lipidomics --- mass spectrometry --- dietary fat --- fatty acid metabolism --- pork --- meat --- skeletal muscle --- fiber type --- cooking --- beef --- Wagyu --- Holstein --- captive giraffes --- urine --- metabolomics --- 1H-NMR --- NMR --- metabotype --- transition --- ketosis --- cattle --- chemometrics --- spectral correction --- authentication --- biomarker --- feeding --- meat quality traits --- metabolite --- postmortem aging --- processing --- chickens --- heat stress --- lipid peroxidation --- orotic acid --- feed efficiency --- biomarkers --- SNPs --- GWAS --- RFI --- pigs --- pathways --- metabolic profile --- transition period --- livestock --- methyl donor --- one-carbon metabolism --- negative energy balance --- pasture legumes --- phytoestrogens --- flavonoids --- coumestans --- polyphenols --- proanthocyanidins --- metabolic profiling --- biosynthesis --- linear model --- transcriptomics --- horse --- metabolomic --- metabolism --- exercise --- saliva --- anabolic practices --- testosterone --- plasma --- CE-TOFMS --- intramuscular fat --- meat quality --- porcine

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The book starts with the editors’ preface summarizing the contributions of each of the following thirteen articles dealing with chemical and pharmacological aspects of the molecular modulators of the oxidative stress in regard to various therapeutic approaches in cardiovascular and neurodegenerative diseases, cancer, and diabetes. The seven articles present data from original research studies enlightening the roles and mechanisms of action of small molecular weight compounds (natural and synthetic; ascorbic acid/vitamin C, deferoxamine, N-acetylcysteine, MitoVitE, α-tocopherol, trolox, and ezetimibe) or proteins (SIRT3) in modulation of oxidative stress. In the six review papers, the authors present and discuss the possible therapeutic potential of novel approaches and compounds that are promising and deserve further investigation, in modulation of oxidative stress.

Research & information: general --- Biology, life sciences --- ascorbic acid --- deferoxamine --- N-acetylcysteine --- ischemia/reperfusion --- cardiac fibroblasts --- reactive oxygen species --- photobiomodulation --- reactive oxygen species (ROS) --- nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кB) --- cancer --- diabetes --- wound healing --- glucose --- pentose phosphate pathway --- NADPH --- redox balance --- glycogen --- glycolysis --- stress resistance --- insulin resistance --- immunomodulation --- inflammation --- olive tree --- oxidative stress --- secoirioids --- sirtuin 3 --- high fat diet --- sex differences --- mice --- metabolic stress --- antioxidants --- ADHD --- Nrf2 --- NRF2-KEAP1 --- ROS --- cancer metabolism --- antioxidant --- cancer therapy --- chemoresistance --- radioresistance --- sepsis --- MitoVitE --- mitochondria --- gene expression --- cytokines --- mRNA --- vitamin C --- folic acid --- one-carbon metabolism --- C2C12 cells --- metabolomics --- mass spectrometry --- type 2 diabetes --- dipeptidyl peptidase-4 inhibitors --- biomarkers --- ER stress --- Ezetimibe --- ischemia-reperfusion --- ionizing radiation --- liver --- hydroperoxide --- epigenetics --- miR7/MAFG/Nrf2 axe --- ascorbic acid --- deferoxamine --- N-acetylcysteine --- ischemia/reperfusion --- cardiac fibroblasts --- reactive oxygen species --- photobiomodulation --- reactive oxygen species (ROS) --- nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кB) --- cancer --- diabetes --- wound healing --- glucose --- pentose phosphate pathway --- NADPH --- redox balance --- glycogen --- glycolysis --- stress resistance --- insulin resistance --- immunomodulation --- inflammation --- olive tree --- oxidative stress --- secoirioids --- sirtuin 3 --- high fat diet --- sex differences --- mice --- metabolic stress --- antioxidants --- ADHD --- Nrf2 --- NRF2-KEAP1 --- ROS --- cancer metabolism --- antioxidant --- cancer therapy --- chemoresistance --- radioresistance --- sepsis --- MitoVitE --- mitochondria --- gene expression --- cytokines --- mRNA --- vitamin C --- folic acid --- one-carbon metabolism --- C2C12 cells --- metabolomics --- mass spectrometry --- type 2 diabetes --- dipeptidyl peptidase-4 inhibitors --- biomarkers --- ER stress --- Ezetimibe --- ischemia-reperfusion --- ionizing radiation --- liver --- hydroperoxide --- epigenetics --- miR7/MAFG/Nrf2 axe

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This book is a compilation of articles that brings together current knowledge from an international team of contributors who are dedicated investigators exploring novel strategies for the treatment of glioblastoma. These articles describe some of the latest concepts that will provide students, researchers and clinicians with an overview of the therapeutic approaches being developed in the field of neuro-oncology to combat this deadly disease.

glioblastoma --- glioma --- temozolomide --- radiotherapy --- immunotherapy --- novel therapy --- personalized treatment --- drug repurposing --- invasion --- invadopodia --- ion channels --- gene therapy --- viral vectors --- brain tumor --- nanomedicine --- cancer stem cell --- targeted therapy --- brain cancer --- cell cycle --- differentiation --- proliferation --- RAS --- SRGAP2 --- stem cell --- TP53 --- glioblastoma multiforme --- GBM --- nerve/glial antigen 2 --- NG2 --- CK2 --- CX-4945 --- migration --- CRISPR/Cas9 --- anticancer --- anti-angiogenesis --- thyrointegrin αvβ3 --- PEG --- triazole tetrac --- P-bi-TAT --- P-m-TAT --- tetrac --- one-carbon metabolism --- de novo purine synthesis --- metabolic reprogramming --- metabolic treatment --- vaccine --- immune checkpoint inhibitors --- chimeric antigen receptor (CAR) T cells --- glioblastoma (GB) --- prolyl-oligopeptidase (POP) --- vascular endothelial growth factor (VEGF) --- transforming growth factor-β (TGF-β) --- angiopoietin (Ang) --- endothelial nitric oxide synthase (eNOS) --- newly diagnosed glioblastoma --- recurrent glioblastoma --- new trial design --- drug-inducible gene expression --- Mardepodect --- Regorafenib --- drug targets --- tumor antigens --- renin–angiotensin system --- pluripotent stem cells --- organoids --- cancer stem cells --- cancer stem cell niche --- tumor microenvironment --- n/a --- renin-angiotensin system

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Alcohol is often perceived as an under-rated risk factor for human health. This book corrects these misperceptions and misinformation by providing up to date reviews and publications that consider the impact of alcoholic beverages on human health in the domains of toxicity, carcinogenicity, genotoxicity, foetal toxicity, neurotoxicity, impacts of alcohol on the gastro-intestinal system (including nutrient deficiencies), cardiovascular system, injuries, body weight and communicable diseases. The reprint considers how the impact of alcohol on human health can be mitigated – through, for example, improved labelling on nutrients and health warnings, better policy measures, and actions by alcohol producers on their products through reformulation to lower alcoholic strength.

alcoholism --- evolution --- fermentation --- frugivory --- Homo --- primate --- yeast --- alcohol --- patterns of drinking --- disease --- mortality --- dose response --- monotonous --- protective effects --- curvilinear --- alcohol control policy --- injury --- review --- risk --- morbidity --- policy --- intervention --- public health --- alcohol industry --- Canada --- body weight --- obesity --- eating dietary intake --- drinking pattern --- labelling --- health warning labels --- effectiveness --- implementation --- burden of disease --- death --- disability --- infectious diseases --- non-communicable diseases --- injuries --- global --- no-alcohol products --- low-alcohol products --- production --- consumption --- health impact --- gut --- liver --- cirrhosis --- hepatocellular carcinoma --- microbiome --- acetaldehyde --- oxidative stress --- inflammation --- one carbon metabolism --- lipid metabolism --- DNA damage --- cancer --- carcinogenesis --- communicable diseases --- HIV --- tuberculosis --- pneumonia --- severe acute respiratory syndrome coronavirus 2 --- alcohol drinking --- binge drinking --- cardiovascular diseases --- ischaemic heart disease --- hypertension --- stroke --- fetal --- fetal alcohol spectrum disorder --- pregnancy --- risk assessment --- hepatotoxicity --- dose–response relationship --- margin of exposure --- epidemiological methods --- brain --- addiction --- n/a --- dose-response relationship

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Alcohol is often perceived as an under-rated risk factor for human health. This book corrects these misperceptions and misinformation by providing up to date reviews and publications that consider the impact of alcoholic beverages on human health in the domains of toxicity, carcinogenicity, genotoxicity, foetal toxicity, neurotoxicity, impacts of alcohol on the gastro-intestinal system (including nutrient deficiencies), cardiovascular system, injuries, body weight and communicable diseases. The reprint considers how the impact of alcohol on human health can be mitigated – through, for example, improved labelling on nutrients and health warnings, better policy measures, and actions by alcohol producers on their products through reformulation to lower alcoholic strength.

Public health & preventive medicine --- alcoholism --- evolution --- fermentation --- frugivory --- Homo --- primate --- yeast --- alcohol --- patterns of drinking --- disease --- mortality --- dose response --- monotonous --- protective effects --- curvilinear --- alcohol control policy --- injury --- review --- risk --- morbidity --- policy --- intervention --- public health --- alcohol industry --- Canada --- body weight --- obesity --- eating dietary intake --- drinking pattern --- labelling --- health warning labels --- effectiveness --- implementation --- burden of disease --- death --- disability --- infectious diseases --- non-communicable diseases --- injuries --- global --- no-alcohol products --- low-alcohol products --- production --- consumption --- health impact --- gut --- liver --- cirrhosis --- hepatocellular carcinoma --- microbiome --- acetaldehyde --- oxidative stress --- inflammation --- one carbon metabolism --- lipid metabolism --- DNA damage --- cancer --- carcinogenesis --- communicable diseases --- HIV --- tuberculosis --- pneumonia --- severe acute respiratory syndrome coronavirus 2 --- alcohol drinking --- binge drinking --- cardiovascular diseases --- ischaemic heart disease --- hypertension --- stroke --- fetal --- fetal alcohol spectrum disorder --- pregnancy --- risk assessment --- hepatotoxicity --- dose-response relationship --- margin of exposure --- epidemiological methods --- brain --- addiction --- alcoholism --- evolution --- fermentation --- frugivory --- Homo --- primate --- yeast --- alcohol --- patterns of drinking --- disease --- mortality --- dose response --- monotonous --- protective effects --- curvilinear --- alcohol control policy --- injury --- review --- risk --- morbidity --- policy --- intervention --- public health --- alcohol industry --- Canada --- body weight --- obesity --- eating dietary intake --- drinking pattern --- labelling --- health warning labels --- effectiveness --- implementation --- burden of disease --- death --- disability --- infectious diseases --- non-communicable diseases --- injuries --- global --- no-alcohol products --- low-alcohol products --- production --- consumption --- health impact --- gut --- liver --- cirrhosis --- hepatocellular carcinoma --- microbiome --- acetaldehyde --- oxidative stress --- inflammation --- one carbon metabolism --- lipid metabolism --- DNA damage --- cancer --- carcinogenesis --- communicable diseases --- HIV --- tuberculosis --- pneumonia --- severe acute respiratory syndrome coronavirus 2 --- alcohol drinking --- binge drinking --- cardiovascular diseases --- ischaemic heart disease --- hypertension --- stroke --- fetal --- fetal alcohol spectrum disorder --- pregnancy --- risk assessment --- hepatotoxicity --- dose-response relationship --- margin of exposure --- epidemiological methods --- brain --- addiction