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Sustainability, defined as ‘meeting current needs without compromising the future’, is a widely accepted goal across many sectors of society. Sustainability’s criteria and indicators often only regard sustaining present conditions through increased resilience, intended as a system’s capacity to experience shocks while retaining essentially the same functions and structures. However, new sustainability concepts, sometimes referred to as “sustainagility”, also consider the properties and assets of a system that sustains the ability (agility) of agents to adapt and meet their needs in new ways, preparing for future unpredictability and unforeseen changes. Therefore, resilience must coexist with adaptive capacity for real, long-term sustainability. Consumers are paying increasing attention to the sustainability of the food supply chain; thus, sustainable development is necessary for all food processes. Since the olive oil sector has a well-established historical tradition, any change and innovation that aims to obtain a sustainable development not only needs to be analyzed in terms of environmental, economic, and social aspects, it should also be significantly improved and closely monitored. Thus, this Special Issue is a collection of papers that can increase sustainability knowledge in the olive-oil-processing chain, to take a significant step forward in future developments.

Research & information: general --- extra virgin olive oil --- authentication --- chemometrics --- proton NMR --- carbon NMR --- machine learning --- artificial neural networks --- PLS-DA --- olive leaf polyphenols --- encapsulation --- functional food --- mayonnaise --- alginate/pectin beads --- phenolic extract --- food enrichment --- olive leaves --- organic --- local --- consumer attitude --- up-cycled ingredients --- by-products --- generational differences --- virgin olive oil --- organic production --- harvesting method --- harvesting time --- volatile compounds --- olive by-product --- reactive oxygen species (ROS) --- olive leaf --- pomace --- olive wastewater --- clones --- minor accessions --- olive oil --- quality --- olive landrace --- ripening --- harvest season --- antioxidants --- minor compounds --- oil quality --- circular economy --- environmental impact --- global warming --- valorization of waste --- phenolic compounds --- acidic hydrolysis --- derivative UV spectroscopy --- green chemistry --- screening methods --- health claim --- antioxidant activity --- olive mill wastewaters --- reactive oxygen species --- vascular cells --- breadsticks --- gluten-free --- olive oil by-products --- oxidation stability --- electronic nose --- accelerated shelf-life tests --- transparent plastic material --- metallized material --- brown-amber glass --- oxidation --- stability --- packaging --- olive oil quality --- life cycle assessment --- biocompounds --- shelf life --- environmental sustainability --- biscuits --- gluten-free breadsticks --- salad dressing --- vegan mayonnaise --- waste recovery --- choice experiment (CE) --- extra virgin olive oil (EVOO) --- willingness to pay (WTP) --- country of origin --- organic food --- consumer preferences --- sustainable food system --- authenticity --- biodiversity --- differential scanning calorimetry --- color --- chlorophyll --- geographical origin --- botanical origin --- principal component analysis --- anaerobic codigestion --- biomethane --- life cycle assessment (LCA) --- life cycle costing (LCC) --- olive mill by-products --- olive composition --- olive cultivars --- olive ripening --- PLS regression model --- portable device --- quality parameters --- sustainability --- Olea europaea --- kaolin --- zeolitite --- foliar treatments --- sustainable agriculture --- crop defense --- autochthonous cultivars --- molecular fingerprinting --- polyphenol content --- gene expression --- fruit developmental stages --- n/a --- olive storage duration --- oil chemical composition --- sensory properties

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Sustainability, defined as ‘meeting current needs without compromising the future’, is a widely accepted goal across many sectors of society. Sustainability’s criteria and indicators often only regard sustaining present conditions through increased resilience, intended as a system’s capacity to experience shocks while retaining essentially the same functions and structures. However, new sustainability concepts, sometimes referred to as “sustainagility”, also consider the properties and assets of a system that sustains the ability (agility) of agents to adapt and meet their needs in new ways, preparing for future unpredictability and unforeseen changes. Therefore, resilience must coexist with adaptive capacity for real, long-term sustainability. Consumers are paying increasing attention to the sustainability of the food supply chain; thus, sustainable development is necessary for all food processes. Since the olive oil sector has a well-established historical tradition, any change and innovation that aims to obtain a sustainable development not only needs to be analyzed in terms of environmental, economic, and social aspects, it should also be significantly improved and closely monitored. Thus, this Special Issue is a collection of papers that can increase sustainability knowledge in the olive-oil-processing chain, to take a significant step forward in future developments.

Research & information: general --- extra virgin olive oil --- authentication --- chemometrics --- proton NMR --- carbon NMR --- machine learning --- artificial neural networks --- PLS-DA --- olive leaf polyphenols --- encapsulation --- functional food --- mayonnaise --- alginate/pectin beads --- phenolic extract --- food enrichment --- olive leaves --- organic --- local --- consumer attitude --- up-cycled ingredients --- by-products --- generational differences --- virgin olive oil --- organic production --- harvesting method --- harvesting time --- volatile compounds --- olive by-product --- reactive oxygen species (ROS) --- olive leaf --- pomace --- olive wastewater --- clones --- minor accessions --- olive oil --- quality --- olive landrace --- ripening --- harvest season --- antioxidants --- minor compounds --- oil quality --- circular economy --- environmental impact --- global warming --- valorization of waste --- phenolic compounds --- acidic hydrolysis --- derivative UV spectroscopy --- green chemistry --- screening methods --- health claim --- antioxidant activity --- olive mill wastewaters --- reactive oxygen species --- vascular cells --- breadsticks --- gluten-free --- olive oil by-products --- oxidation stability --- electronic nose --- accelerated shelf-life tests --- transparent plastic material --- metallized material --- brown-amber glass --- oxidation --- stability --- packaging --- olive oil quality --- life cycle assessment --- biocompounds --- shelf life --- environmental sustainability --- biscuits --- gluten-free breadsticks --- salad dressing --- vegan mayonnaise --- waste recovery --- choice experiment (CE) --- extra virgin olive oil (EVOO) --- willingness to pay (WTP) --- country of origin --- organic food --- consumer preferences --- sustainable food system --- authenticity --- biodiversity --- differential scanning calorimetry --- color --- chlorophyll --- geographical origin --- botanical origin --- principal component analysis --- anaerobic codigestion --- biomethane --- life cycle assessment (LCA) --- life cycle costing (LCC) --- olive mill by-products --- olive composition --- olive cultivars --- olive ripening --- PLS regression model --- portable device --- quality parameters --- sustainability --- Olea europaea --- kaolin --- zeolitite --- foliar treatments --- sustainable agriculture --- crop defense --- autochthonous cultivars --- molecular fingerprinting --- polyphenol content --- gene expression --- fruit developmental stages --- olive storage duration --- oil chemical composition --- sensory properties

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In this Special Issue, we have published papers on the health-promoting effects of nutraceuticals from different sources, and their effects in different pathologies. Extracts from plants have been analyzed, for example, extracts from olive leaves, Mikania micrantha, the devil’s claw, raspberries and others, alongside marine phytoplankton, egg-yolk and marketed dietary supplements. The effects of these extracts and dietary supplements have been studied in diseases associated with obesity, and in diseases where inflammation pathways are involved. The effectiveness of resveratrol and curcumin to support the anticancer activity of cisplatin has also been reported, as well as the ability of devil’s claw root extract to stimulate the CB2 receptors in synoviocytes in osteoarthritis patients. The anti-oxidant effect of marine phytoplankton has been studied on muscle damage, both in humans and in an animal model, and the effects of the metabolite of antocianin were analyzed in a mouse model of amyotrophic lateral sclerosis. Finally, reviews on the use of lactoferrin, ω3 and ω6 and abscisic acid have been reported, in addition to the crosstalk between prostate cancer and microbiota inflammation. Although it is not yet possible to draw definitive conclusions on the use of nutraceuticals, several mechanisms of action for many of them have been further clarified.

fertility --- ingredients --- male reproduction --- semen parameters --- supplements --- allithiamine --- garlic --- hyperglycaemia --- advanced glycation end-products --- cytokines --- abscisic acid --- prediabetes --- type 2 diabetes mellitus --- metabolic syndrome --- insulin resistance --- adipocyte browning --- AMP-activated protein kinase --- food supplement --- frambinone --- meal frequency --- open-field test --- elevated plus maze --- sensory motor gating --- pre-pulse inhibition --- c-Fos --- amyotrophic lateral sclerosis --- anti-inflammatory --- antioxidant --- phenolic acid --- neuroprotective --- neurodegeneration --- obesity --- overweight --- beta-glucans --- chitosan --- follow up study --- weight loss programs --- weight gain --- weight loss --- body weight changes --- phytoplankton --- antioxidants --- muscle damage --- muscle recovery --- muscle soreness --- Viburnum opulus --- phenolic compounds --- adipogenesis --- PPARγ --- lipase inhibition --- green tea --- epigallocatechin --- lipid profile --- high-fat diet --- fast food --- osteoarthritis --- nutraceuticals --- polyphenols --- volatile compounds --- β-caryophyllene --- eugenol --- FAAH --- cannabinoid receptors --- phospholipases --- lactoferrin --- bovine milk --- nutraceutical --- human health --- resveratrol --- curcumin --- cisplatin --- head and neck cancer --- cell cycle --- apoptosis --- prostate cancer --- microbiota --- nutraceutical compounds --- fecundation --- inflammation --- cytokine --- growth factors --- metabolomics --- lipidomics --- ω-3PUFAs --- ω-6PUFAs --- endocannabinoids --- CRC --- fatty acids --- Gymnema inodorum --- gymnemic acid --- Mikania micrantha --- anti-hypercholesterolemia --- steatosis --- olive leaf --- macrophages

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Recent years have seen the idea of a close association between nutrition and the modulation of cancer development/progression reinforced. An increasing amount of experimental and epidemiological evidence has been produced supporting the concept that many different bioactive components of food (e.g. polyphenols, mono- and polyunsaturated fatty acids, methyl-group donors, etc.) may be implicated in either the promotion of or the protection against carcinogenesis. At the cellular level, such compounds can have an impact on different but sometimes intertwined processes, such as growth and differentiation, DNA repair, programmed cell death, and oxidative stress. In addition, compelling evidence is starting to build up of the existence of primary epigenetic targets of dietary compounds, such as oncogenic/oncosuppressor miRNAs or DNA-modifying enzymes, which in turn impair gene expression and function. Since there is a growing interest in the study of the biochemical and molecular role played by food components and its impact on cellular processes and/or gene expressions directed towards the fine-tuning of cancer phenotypes, in this Special Issue researchers contributed with either research or review articles presenting the latest findings on the intracellular pathways and mechanisms affected by natural bioactive dietary molecules.

Research & information: general --- Biology, life sciences --- berberine --- signaling pathways --- oncogenic cascades --- TRAIL --- microRNAs --- cancer therapy --- colon cancer cells --- ethanol --- Nrf2 --- HO-1 --- ER stress --- autophagy --- MMPs --- formononetin --- cancer --- preclinical models --- cell signaling --- angiogenesis --- nobiletin --- colorectal cancer --- chemoprevention --- bioactivities --- experimental therapeutics --- HDAC --- multiple myeloma --- oleacein --- breast cancer --- persistent organic pollutants --- breast cancer risk --- breast cancer prognostic --- systematic review --- carrageenan --- invasion --- metastasis --- RacGAP1 --- radiotherapy --- marine sponge --- natural product --- anticancer drug --- oral cancer inhibition --- phytochemicals --- small organic agents --- Piper eriopodon, alkenylphenols --- human cancer cells --- cell death --- apoptosis --- caspase-independent cell death --- XIAP antagonists --- XIAP-BIR3 domain --- Calocedrus formosana --- lung cancer --- yatein --- cell-cycle arrest --- xenograft --- isorhamnetin --- G2/M arrest --- ROS --- AMPK --- pancreatic cancer --- epigallocatechin-3-gallate (EGCG) --- gemcitabine --- glycolysis --- phosphofructokinase --- natural polyphenols --- anticancer activities --- molecular mechanisms --- Streptomyces --- mangrove --- anti-proliferative --- colon cancer --- epithelial mesenchymal transition --- inflammation --- malignant cancer --- natural anti-inflammatory compounds --- pro-resolving lipids --- anticancer drugs --- flavonoids --- natural compounds --- Xenopus laevis --- AOM/DSS model --- melanoma cells --- nicotine --- α9-nAChR --- PD-L1 --- STAT3 --- gigantol --- AKT --- JAK/STAT --- cancer stem cell --- tumor maintenance --- tumor density --- proteomics --- honokiol --- anticancer --- mechanism --- signalling pathway --- uterine sarcoma --- fucoidan --- isobolography --- colchicine alkaloid --- mesoporous silica nanoparticles --- targeted delivery system --- PD-1 immune checkpoint inhibitor and cancer immunotherapy --- glucose transport --- drugs --- innate immunity --- β-glucans --- nutrition --- immunotherapy --- estrogen --- estrogen receptor alpha --- polyphenols --- daidzein --- daidzein metabolites --- paclitaxel --- breast cancer cells --- obesity --- renin–angiotensin system --- eicosapentaenoic acid --- adipocyte inflammation --- olive leaf extract --- oleuropein --- Seahorse analysis --- cancer metabolism --- glycolytic markers --- Malva pseudolavatera Webb &amp --- Berthel. --- acute myeloid leukemia --- reactive oxygen species --- brain cancer --- gliomas --- schwannomas --- malignant tumors of the peripheral nerve sheath (MPNST) --- neurofibromas --- bioavailability --- nanoparticle-based delivery systems --- natural bioactive compound --- gallic acid --- EGFR signaling --- p53 --- EGCG --- non-coding RNAs --- anti-cancer drug --- NSCLC --- EGFR TKI --- FASN inhibitors --- resistance --- n/a --- renin-angiotensin system

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• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Recent years have seen the idea of a close association between nutrition and the modulation of cancer development/progression reinforced. An increasing amount of experimental and epidemiological evidence has been produced supporting the concept that many different bioactive components of food (e.g. polyphenols, mono- and polyunsaturated fatty acids, methyl-group donors, etc.) may be implicated in either the promotion of or the protection against carcinogenesis. At the cellular level, such compounds can have an impact on different but sometimes intertwined processes, such as growth and differentiation, DNA repair, programmed cell death, and oxidative stress. In addition, compelling evidence is starting to build up of the existence of primary epigenetic targets of dietary compounds, such as oncogenic/oncosuppressor miRNAs or DNA-modifying enzymes, which in turn impair gene expression and function. Since there is a growing interest in the study of the biochemical and molecular role played by food components and its impact on cellular processes and/or gene expressions directed towards the fine-tuning of cancer phenotypes, in this Special Issue researchers contributed with either research or review articles presenting the latest findings on the intracellular pathways and mechanisms affected by natural bioactive dietary molecules.

Research & information: general --- Biology, life sciences --- berberine --- signaling pathways --- oncogenic cascades --- TRAIL --- microRNAs --- cancer therapy --- colon cancer cells --- ethanol --- Nrf2 --- HO-1 --- ER stress --- autophagy --- MMPs --- formononetin --- cancer --- preclinical models --- cell signaling --- angiogenesis --- nobiletin --- colorectal cancer --- chemoprevention --- bioactivities --- experimental therapeutics --- HDAC --- multiple myeloma --- oleacein --- breast cancer --- persistent organic pollutants --- breast cancer risk --- breast cancer prognostic --- systematic review --- carrageenan --- invasion --- metastasis --- RacGAP1 --- radiotherapy --- marine sponge --- natural product --- anticancer drug --- oral cancer inhibition --- phytochemicals --- small organic agents --- Piper eriopodon, alkenylphenols --- human cancer cells --- cell death --- apoptosis --- caspase-independent cell death --- XIAP antagonists --- XIAP-BIR3 domain --- Calocedrus formosana --- lung cancer --- yatein --- cell-cycle arrest --- xenograft --- isorhamnetin --- G2/M arrest --- ROS --- AMPK --- pancreatic cancer --- epigallocatechin-3-gallate (EGCG) --- gemcitabine --- glycolysis --- phosphofructokinase --- natural polyphenols --- anticancer activities --- molecular mechanisms --- Streptomyces --- mangrove --- anti-proliferative --- colon cancer --- epithelial mesenchymal transition --- inflammation --- malignant cancer --- natural anti-inflammatory compounds --- pro-resolving lipids --- anticancer drugs --- flavonoids --- natural compounds --- Xenopus laevis --- AOM/DSS model --- melanoma cells --- nicotine --- α9-nAChR --- PD-L1 --- STAT3 --- gigantol --- AKT --- JAK/STAT --- cancer stem cell --- tumor maintenance --- tumor density --- proteomics --- honokiol --- anticancer --- mechanism --- signalling pathway --- uterine sarcoma --- fucoidan --- isobolography --- colchicine alkaloid --- mesoporous silica nanoparticles --- targeted delivery system --- PD-1 immune checkpoint inhibitor and cancer immunotherapy --- glucose transport --- drugs --- innate immunity --- β-glucans --- nutrition --- immunotherapy --- estrogen --- estrogen receptor alpha --- polyphenols --- daidzein --- daidzein metabolites --- paclitaxel --- breast cancer cells --- obesity --- renin-angiotensin system --- eicosapentaenoic acid --- adipocyte inflammation --- olive leaf extract --- oleuropein --- Seahorse analysis --- cancer metabolism --- glycolytic markers --- Malva pseudolavatera Webb &amp --- Berthel. --- acute myeloid leukemia --- reactive oxygen species --- brain cancer --- gliomas --- schwannomas --- malignant tumors of the peripheral nerve sheath (MPNST) --- neurofibromas --- bioavailability --- nanoparticle-based delivery systems --- natural bioactive compound --- gallic acid --- EGFR signaling --- p53 --- EGCG --- non-coding RNAs --- anti-cancer drug --- NSCLC --- EGFR TKI --- FASN inhibitors --- resistance