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Sleeping is a fundamental behavior that occupies almost a third of our lives. Its physiological importance is therefore easily understood. Scientific evidence of the role of quality sleep for healthy cognitive aging is accumulating. Many studies have shown the association between sleep dysfunction and Alzheimer's disease (AD). Interestingly, a significant aspect of AD is that its primary pathophysiological sign is detected post-mortem before the age of 35 years in the locus coeruleus (LC) which is a small brainstem nucleus essential for sleep regulation. Thus, there are some reasons to establish early associations between sleep and AD via the LC. However, the link between variability in sleep quality and variability in LC characteristics remains poorly understood in humans. Therefore, it seems appropriate to first study the link between sleep and LC characteristics such as its reactivity. In this context, we postulate that a greater LC reactivity during wakefulness is associated with a better sleep, during youth as well as throughout the aging process. To test this hypothesis, young (18-29 years, n = 13) and older subjects (53-69 years, n = 14) were recruited. On the one hand, we worked with electroencephalography to characterize sleep, on the other hand, we used ultra-high field MRI (7 Tesla) to assess LC reactivity. The aim of this thesis was to highlight a link between sleep and LC reactivity during an auditory oddball task. Our results suggested for the first time in humans, a link which seems to change over the life course. Thus, in the youth, sleep seems to be more stable when the LC is more reactive, at least when this reactivity is assessed via an auditory oddball task.
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Transcranial magnetic stimulation (TMS) is being increasingly used in neuroscience and clinics. Modern advances include but are not limited to the combination of TMS with precise neuronavigation as well as the integration of TMS into a multimodal environment, e.g., by guiding the TMS application using complementary techniques such as functional magnetic resonance imaging (fMRI), electroencephalography (EEG), diffusion tensor imaging (DTI), or magnetoencephalography (MEG). Furthermore, the impact of stimulation can be identified and characterized by such multimodal approaches, helping to shed light on the basic neurophysiology and TMS effects in the human brain. Against this background, the aim of this Special Issue was to explore advancements in the field of TMS considering both investigations in healthy subjects as well as patients.
Medical equipment & techniques --- brain stimulation --- fiber tractography --- glioblastoma multiforme --- gray matter --- language mapping --- navigated transcranial magnetic stimulation --- Autism spectrum disorder --- evoked and induced gamma oscillations --- EEG --- TMS --- oddball task --- reaction time --- aberrant and repetitive behaviors --- repetition suppression --- neuroplasticity --- transcranial magnetic stimulation --- paired associative stimulation --- nTMS --- intensive care --- motor mapping --- ICU --- neurocritical care --- neuromonitoring --- functional mapping --- motor evoked potentials --- aging --- excitability --- connectivity --- plasticity --- brain tumor --- bilingual --- language --- preoperative mapping --- case report --- CD73 --- adenosine --- A2AR --- A1R --- neuroinflammation --- theta-burst stimulation --- rTMS --- purinergic signaling --- electric field --- eloquent cortex --- motor threshold --- neuronavigation --- presurgical evaluation --- chronic pain --- low back pain --- repetitive transcranial magnetic stimulation --- neuromodulation --- dorsolateral prefrontal cortex --- primary motor cortex --- picture naming --- bihemispheric --- action naming --- object naming --- memory --- hippocampus --- brain networks --- non-invasive brain stimulation --- mild cognitive impairment --- Alzheimer’s disease --- stroke --- aphasia --- iTBS --- fMRI --- rehabilitation --- alpha oscillations --- functional connectivity --- source reconstruction --- MEG --- EEG state-dependent TMS --- n/a --- Alzheimer's disease
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Transcranial magnetic stimulation (TMS) is being increasingly used in neuroscience and clinics. Modern advances include but are not limited to the combination of TMS with precise neuronavigation as well as the integration of TMS into a multimodal environment, e.g., by guiding the TMS application using complementary techniques such as functional magnetic resonance imaging (fMRI), electroencephalography (EEG), diffusion tensor imaging (DTI), or magnetoencephalography (MEG). Furthermore, the impact of stimulation can be identified and characterized by such multimodal approaches, helping to shed light on the basic neurophysiology and TMS effects in the human brain. Against this background, the aim of this Special Issue was to explore advancements in the field of TMS considering both investigations in healthy subjects as well as patients.
brain stimulation --- fiber tractography --- glioblastoma multiforme --- gray matter --- language mapping --- navigated transcranial magnetic stimulation --- Autism spectrum disorder --- evoked and induced gamma oscillations --- EEG --- TMS --- oddball task --- reaction time --- aberrant and repetitive behaviors --- repetition suppression --- neuroplasticity --- transcranial magnetic stimulation --- paired associative stimulation --- nTMS --- intensive care --- motor mapping --- ICU --- neurocritical care --- neuromonitoring --- functional mapping --- motor evoked potentials --- aging --- excitability --- connectivity --- plasticity --- brain tumor --- bilingual --- language --- preoperative mapping --- case report --- CD73 --- adenosine --- A2AR --- A1R --- neuroinflammation --- theta-burst stimulation --- rTMS --- purinergic signaling --- electric field --- eloquent cortex --- motor threshold --- neuronavigation --- presurgical evaluation --- chronic pain --- low back pain --- repetitive transcranial magnetic stimulation --- neuromodulation --- dorsolateral prefrontal cortex --- primary motor cortex --- picture naming --- bihemispheric --- action naming --- object naming --- memory --- hippocampus --- brain networks --- non-invasive brain stimulation --- mild cognitive impairment --- Alzheimer’s disease --- stroke --- aphasia --- iTBS --- fMRI --- rehabilitation --- alpha oscillations --- functional connectivity --- source reconstruction --- MEG --- EEG state-dependent TMS --- n/a --- Alzheimer's disease
Choose an application
Transcranial magnetic stimulation (TMS) is being increasingly used in neuroscience and clinics. Modern advances include but are not limited to the combination of TMS with precise neuronavigation as well as the integration of TMS into a multimodal environment, e.g., by guiding the TMS application using complementary techniques such as functional magnetic resonance imaging (fMRI), electroencephalography (EEG), diffusion tensor imaging (DTI), or magnetoencephalography (MEG). Furthermore, the impact of stimulation can be identified and characterized by such multimodal approaches, helping to shed light on the basic neurophysiology and TMS effects in the human brain. Against this background, the aim of this Special Issue was to explore advancements in the field of TMS considering both investigations in healthy subjects as well as patients.
Medical equipment & techniques --- brain stimulation --- fiber tractography --- glioblastoma multiforme --- gray matter --- language mapping --- navigated transcranial magnetic stimulation --- Autism spectrum disorder --- evoked and induced gamma oscillations --- EEG --- TMS --- oddball task --- reaction time --- aberrant and repetitive behaviors --- repetition suppression --- neuroplasticity --- transcranial magnetic stimulation --- paired associative stimulation --- nTMS --- intensive care --- motor mapping --- ICU --- neurocritical care --- neuromonitoring --- functional mapping --- motor evoked potentials --- aging --- excitability --- connectivity --- plasticity --- brain tumor --- bilingual --- language --- preoperative mapping --- case report --- CD73 --- adenosine --- A2AR --- A1R --- neuroinflammation --- theta-burst stimulation --- rTMS --- purinergic signaling --- electric field --- eloquent cortex --- motor threshold --- neuronavigation --- presurgical evaluation --- chronic pain --- low back pain --- repetitive transcranial magnetic stimulation --- neuromodulation --- dorsolateral prefrontal cortex --- primary motor cortex --- picture naming --- bihemispheric --- action naming --- object naming --- memory --- hippocampus --- brain networks --- non-invasive brain stimulation --- mild cognitive impairment --- Alzheimer's disease --- stroke --- aphasia --- iTBS --- fMRI --- rehabilitation --- alpha oscillations --- functional connectivity --- source reconstruction --- MEG --- EEG state-dependent TMS --- brain stimulation --- fiber tractography --- glioblastoma multiforme --- gray matter --- language mapping --- navigated transcranial magnetic stimulation --- Autism spectrum disorder --- evoked and induced gamma oscillations --- EEG --- TMS --- oddball task --- reaction time --- aberrant and repetitive behaviors --- repetition suppression --- neuroplasticity --- transcranial magnetic stimulation --- paired associative stimulation --- nTMS --- intensive care --- motor mapping --- ICU --- neurocritical care --- neuromonitoring --- functional mapping --- motor evoked potentials --- aging --- excitability --- connectivity --- plasticity --- brain tumor --- bilingual --- language --- preoperative mapping --- case report --- CD73 --- adenosine --- A2AR --- A1R --- neuroinflammation --- theta-burst stimulation --- rTMS --- purinergic signaling --- electric field --- eloquent cortex --- motor threshold --- neuronavigation --- presurgical evaluation --- chronic pain --- low back pain --- repetitive transcranial magnetic stimulation --- neuromodulation --- dorsolateral prefrontal cortex --- primary motor cortex --- picture naming --- bihemispheric --- action naming --- object naming --- memory --- hippocampus --- brain networks --- non-invasive brain stimulation --- mild cognitive impairment --- Alzheimer's disease --- stroke --- aphasia --- iTBS --- fMRI --- rehabilitation --- alpha oscillations --- functional connectivity --- source reconstruction --- MEG --- EEG state-dependent TMS
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