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This book covers the most recent research trends and applications of Pharmaceutical Analytical Chemistry. The included topics range from the adulteration of dietary supplements, to the determination of drugs in biological samples with the aim to investigate their pharmacokinetic properties.

Research & information: general --- growth hormone --- long-acting Fc-fusion recombinant human growth hormone --- method validation --- cell-based bioassay --- reporter gene assay --- pharmacokinetics --- tissue distribution --- alnustone --- rats --- LC-MS/MS --- inflammatory bowel disease --- fixed-dose combination --- biomimetic chromatography --- thiopurine immunosuppressants --- folic acid --- doxorubicin --- hernandezine --- pharmacokinetic study --- drug-drug interaction --- gardneramine --- monoterpenoid indole alkaloid --- memantine --- rimantadine --- amantadine --- zone fluidics --- o-phthalaldehyde --- derivatization --- stopped-flow --- quality control --- anwuligan --- rat --- optode --- polyhexamethylene biguanide hydrochloride --- lactone-rhodamine B --- contact-lens detergent --- dietary supplement --- adulteration --- low-field NMR --- multivariate analysis --- steroids --- Partial Least Squares regression --- in vitro permeability --- predictive model --- ketamine --- norketamine --- high throughput bar adsorptive microextraction --- LVI-GC-MS(SIM) --- urine --- baricitinib --- UPLC-MS/MS --- irbersartan --- growth hormone --- long-acting Fc-fusion recombinant human growth hormone --- method validation --- cell-based bioassay --- reporter gene assay --- pharmacokinetics --- tissue distribution --- alnustone --- rats --- LC-MS/MS --- inflammatory bowel disease --- fixed-dose combination --- biomimetic chromatography --- thiopurine immunosuppressants --- folic acid --- doxorubicin --- hernandezine --- pharmacokinetic study --- drug-drug interaction --- gardneramine --- monoterpenoid indole alkaloid --- memantine --- rimantadine --- amantadine --- zone fluidics --- o-phthalaldehyde --- derivatization --- stopped-flow --- quality control --- anwuligan --- rat --- optode --- polyhexamethylene biguanide hydrochloride --- lactone-rhodamine B --- contact-lens detergent --- dietary supplement --- adulteration --- low-field NMR --- multivariate analysis --- steroids --- Partial Least Squares regression --- in vitro permeability --- predictive model --- ketamine --- norketamine --- high throughput bar adsorptive microextraction --- LVI-GC-MS(SIM) --- urine --- baricitinib --- UPLC-MS/MS --- irbersartan

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Derivatization is one of the most widely used sample pretreatment techniques in Analytical Chemistry and Chemical Analysis. Reagent-based or reagent-less schemes offer improved detectability of target compounds, modification of the chromatographic properties and/or the stabilization of sensitive compounds until analysis. Either coupled with separation techniques or as a “stand alone” analytical procedure, derivatization offers endless possibilities in all aspects of analytical applications.

tyrosine kinase inhibitors --- chloranilic acid --- charge-transfer reaction --- 96-microwell spectrophotometric assay --- high-throughput pharmaceutical analysis --- biogenic amines --- Lycium barbarum L. --- HPLC --- derivatization --- amino acids --- esterification --- GC–MS --- pentafluoropropionic anhydride --- stability --- toluene --- pigment --- linseed oil --- derivatisation --- quantification --- P/S ratio --- A/P ratio --- ∑D --- GC-MS --- ureide --- BSTFA --- creatine --- creatinine --- silylation --- TMS --- validation --- low-molecular-weight thiols --- human serum albumin --- α-lipoic acid --- blood plasma --- monobromobimane --- reduction --- sodium borohydride --- high-performance liquid chromatography --- fluorescence detection --- taurine --- glutamine --- clams --- high-resolution mass spectrometry --- nerve agents --- methylation --- chemical warfare agents --- sarin --- Novichoks --- 2-naphthalenethiol --- sulforaphane --- HPLC-UV/Vis --- pharmacokinetics --- acetonitrile-related adducts --- acetylenic lipids --- double and triple bond localization --- in-source derivatization --- mass spectrometry --- acetazolamide --- carbonic anhydrase --- enhancement --- inhibition --- pentafluorobenzyl bromide --- chiral metabolomics --- rice water --- d-amino acids --- enantiomer separation --- dimethyl labeling --- homocysteine thiolactone --- homocysteine --- zone fluidics --- o-phthalaldehyde --- fluorosurfactant-modified gold nanoparticles

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Derivatization is one of the most widely used sample pretreatment techniques in Analytical Chemistry and Chemical Analysis. Reagent-based or reagent-less schemes offer improved detectability of target compounds, modification of the chromatographic properties and/or the stabilization of sensitive compounds until analysis. Either coupled with separation techniques or as a “stand alone” analytical procedure, derivatization offers endless possibilities in all aspects of analytical applications.

Research & information: general --- Chemistry --- Analytical chemistry --- tyrosine kinase inhibitors --- chloranilic acid --- charge-transfer reaction --- 96-microwell spectrophotometric assay --- high-throughput pharmaceutical analysis --- biogenic amines --- Lycium barbarum L. --- HPLC --- derivatization --- amino acids --- esterification --- GC–MS --- pentafluoropropionic anhydride --- stability --- toluene --- pigment --- linseed oil --- derivatisation --- quantification --- P/S ratio --- A/P ratio --- ∑D --- GC-MS --- ureide --- BSTFA --- creatine --- creatinine --- silylation --- TMS --- validation --- low-molecular-weight thiols --- human serum albumin --- α-lipoic acid --- blood plasma --- monobromobimane --- reduction --- sodium borohydride --- high-performance liquid chromatography --- fluorescence detection --- taurine --- glutamine --- clams --- high-resolution mass spectrometry --- nerve agents --- methylation --- chemical warfare agents --- sarin --- Novichoks --- 2-naphthalenethiol --- sulforaphane --- HPLC-UV/Vis --- pharmacokinetics --- acetonitrile-related adducts --- acetylenic lipids --- double and triple bond localization --- in-source derivatization --- mass spectrometry --- acetazolamide --- carbonic anhydrase --- enhancement --- inhibition --- pentafluorobenzyl bromide --- chiral metabolomics --- rice water --- d-amino acids --- enantiomer separation --- dimethyl labeling --- homocysteine thiolactone --- homocysteine --- zone fluidics --- o-phthalaldehyde --- fluorosurfactant-modified gold nanoparticles --- tyrosine kinase inhibitors --- chloranilic acid --- charge-transfer reaction --- 96-microwell spectrophotometric assay --- high-throughput pharmaceutical analysis --- biogenic amines --- Lycium barbarum L. --- HPLC --- derivatization --- amino acids --- esterification --- GC–MS --- pentafluoropropionic anhydride --- stability --- toluene --- pigment --- linseed oil --- derivatisation --- quantification --- P/S ratio --- A/P ratio --- ∑D --- GC-MS --- ureide --- BSTFA --- creatine --- creatinine --- silylation --- TMS --- validation --- low-molecular-weight thiols --- human serum albumin --- α-lipoic acid --- blood plasma --- monobromobimane --- reduction --- sodium borohydride --- high-performance liquid chromatography --- fluorescence detection --- taurine --- glutamine --- clams --- high-resolution mass spectrometry --- nerve agents --- methylation --- chemical warfare agents --- sarin --- Novichoks --- 2-naphthalenethiol --- sulforaphane --- HPLC-UV/Vis --- pharmacokinetics --- acetonitrile-related adducts --- acetylenic lipids --- double and triple bond localization --- in-source derivatization --- mass spectrometry --- acetazolamide --- carbonic anhydrase --- enhancement --- inhibition --- pentafluorobenzyl bromide --- chiral metabolomics --- rice water --- d-amino acids --- enantiomer separation --- dimethyl labeling --- homocysteine thiolactone --- homocysteine --- zone fluidics --- o-phthalaldehyde --- fluorosurfactant-modified gold nanoparticles

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Flow analysis is an automatic, precise and fast way to perform analytical tests. Flow instruments are used for clinical and pharmaceutical analyses, quality control of industrial products, monitoring of environmental pollution and many other fields. The book presents the latest methodological, technical and instrumental achievements in flow analysis. It shows new possibilities for the miniaturization and full mechanization of flow systems, together with examples of their interesting application. The proposed solutions contribute to reducing the amount of used reagents and waste, as well as increasing the safety of working with hazardous reagents, resulting in modern devices operating in accordance with the principles of green chemistry. A number of innovative methods of processing and measuring analytical samples have also been described. The book very well reflects the current state of flow analysis and development directions.

cholesterol --- serum samples --- lab-on-valve --- automation --- enzymatic reaction --- neonicotinoid --- thiacloprid --- solid-phase spectroscopy --- optosensor --- luminescence --- bioaccessibility --- dog food --- dog nutrition --- dynamic extraction --- flow analysis --- kinetic profile --- zinc --- nuclear waste --- spent nuclear fuel --- ß-emitting nuclides --- 90Sr --- flow injection --- ICP-DRC-MS --- flow synthesis --- flow reactors --- flow-injection analysis --- flow techniques --- radionuclides --- radiochemical separation --- environmental monitoring --- nuclear emergency preparedness --- radioactive waste characterization --- medical isotope production --- titration --- Fe(III), Fe(II) determination --- speciation analysis --- Lab-In-Syringe --- automation of sample pretreatment --- potentials and troubles --- system setup and operation modes --- tips and tricks in method development --- 3D printing of instrument elements --- histidine --- random human urine --- zone fluidics --- o-phthalaldehyde --- derivatization --- stopped-flow --- fluorimetry --- SI-LAV --- mono-segmented flow --- in-line dilution --- in-line single-standard calibration --- in-line standard addition --- albumin --- glucose --- creatinine --- flow method --- chitosan --- catalyst particles --- micron-size --- sampling study --- p-nitrophenol reduction --- preconcentration --- evaporation --- sequential injection analysis --- paired emitter–detector diode detector --- contactless conductivity detector --- flow-based analysis --- simultaneous detection --- sequential detection --- flow chemistry