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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

quality --- breeding --- omics analyses --- vaccinium --- rubus --- fragaria --- postharvest --- nutraceutical

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Science: general issues --- Botany & plant sciences --- quality --- breeding --- omics analyses --- vaccinium --- rubus --- fragaria --- postharvest --- nutraceutical

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Diet therapy --- Functional foods. --- Homeopathy. --- Dietary Supplements. --- Probiotics. --- Probiotic --- Pediococcus pentosaceus --- Prebiotics --- Dietary Supplementations --- Food Supplementations --- Herbal Supplements --- Nutraceuticals --- Nutriceuticals --- Food Supplements --- Neutraceuticals --- Dietary Supplement --- Food Supplement --- Herbal Supplement --- Neutraceutical --- Nutraceutical --- Nutriceutical --- Supplement, Food --- Supplement, Herbal --- Supplementations, Dietary --- Supplements, Dietary --- Supplements, Food --- Supplements, Herbal --- Functional Food --- Homoeopathy --- Materia Medica --- Designer foods --- Medicinal food --- Medicinal foods --- Neutriceuticals --- Pharmafoods --- Food

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Functional foods --- Functional foods. --- Food Science & Technology. --- Nutrition Science. --- Nutraceutical Industry. --- Dietary Supplements. --- Food, Fortified. --- Herbal Medicine. --- Designer foods --- Medicinal food --- Medicinal foods --- Neutraceuticals --- Neutriceuticals --- Nutraceuticals --- Nutriceuticals --- Pharmafoods --- Food --- Hawaiian Herbal Medicine --- La au Lapa au --- La'au Lapa'au --- Laau Lapaau --- Herbalism --- Medicine, Herbal --- Hawaiian Herbal Medicines --- Herbal Medicine, Hawaiian --- Herbal Medicines, Hawaiian --- Medicine, Hawaiian Herbal --- Medicines, Hawaiian Herbal --- Naturopathy --- Enriched Food --- Food, Supplemented --- Enriched Foods --- Food, Enriched --- Foods, Enriched --- Foods, Fortified --- Foods, Supplemented --- Fortified Food --- Fortified Foods --- Supplemented Food --- Supplemented Foods --- Biofortification --- Dietary Supplementations --- Food Supplementations --- Herbal Supplements --- Food Supplements --- Dietary Supplement --- Food Supplement --- Herbal Supplement --- Neutraceutical --- Nutraceutical --- Nutriceutical --- Supplement, Food --- Supplement, Herbal --- Supplementations, Dietary --- Supplements, Dietary --- Supplements, Food --- Supplements, Herbal --- Functional Food --- Agriculture Sciences --- Engineering --- Health Sciences --- Food Science and Technology --- Physiology

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Natural products or organic compounds isolated from natural sources as primary or secondary metabolites have inspired numerous drugs. It is not an overstatement that the majority of medicines in clinics, even in the 21st century, have been derived from natural resources despite the decline of industry research into natural products due to a variety of drawbacks. Saffron crocus, considered to be the most valuable spice by weight, and its bioactive constituents, have been studied for the treatment of a wide range of pathologies, including neuropsychiatric and neurodegenerative disorders, cancer, diabetes, and even cardiovascular diseases. In this book on the chemistry, pharmacology, and therapeutic potential of Crocus sativus L. extract and its constituents, we aimed to assess new advances in the understanding of the therapeutic action of saffron and its constituents in targeting different pathologies. In this context, eight original research articles covering recent advances in the therapeutic actions of saffron and its ingredients in different diseases are reported. Two studies reporting novel methods regarding the bioanalysis of saffron extracts have been included. The collection is completed with two very interesting reviews reporting advances in the fields of schizophrenia and cancer. In conclusion, in this book, we are delighted to have received several contributions that we hope will provide new and interesting information for the scientific community on the chemistry, pharmacology, and therapeutic potential of Crocus sativus L. extract and its constituents.

Medicine --- saffron --- affron® --- depression --- anxiety --- antioxidant --- crocins --- glucose --- β-pancreatic cells --- insulin --- pck1 --- neuroprotective activity --- P2X7 receptor --- fraction --- flumazenil --- rat --- Crocus sativus --- cancer --- anticancer activity --- chemoprevention --- clinical trials --- patents --- anesthetic ketamine --- memory --- Crocus sativus L. --- schizophrenia --- crocetin --- pubertal testis --- X-rays --- radiotherapy --- fertility preservation --- SIRT1 --- HuR --- oxidative stress --- autophagy --- crocin --- picrocrocin --- safranal --- dietary supplement --- nutraceutical --- Crocus sativus L. (Iridaceae) --- reversed-phase UPLC --- metabolomics --- HR MS --- inflammatory bowel disease --- gut microbiota --- colitis --- cytokines --- colorectal cancer --- HCT116 --- MLH1 --- MSH3 --- DNA damage and repair --- apoptosis --- saffron --- affron® --- depression --- anxiety --- antioxidant --- crocins --- glucose --- β-pancreatic cells --- insulin --- pck1 --- neuroprotective activity --- P2X7 receptor --- fraction --- flumazenil --- rat --- Crocus sativus --- cancer --- anticancer activity --- chemoprevention --- clinical trials --- patents --- anesthetic ketamine --- memory --- Crocus sativus L. --- schizophrenia --- crocetin --- pubertal testis --- X-rays --- radiotherapy --- fertility preservation --- SIRT1 --- HuR --- oxidative stress --- autophagy --- crocin --- picrocrocin --- safranal --- dietary supplement --- nutraceutical --- Crocus sativus L. (Iridaceae) --- reversed-phase UPLC --- metabolomics --- HR MS --- inflammatory bowel disease --- gut microbiota --- colitis --- cytokines --- colorectal cancer --- HCT116 --- MLH1 --- MSH3 --- DNA damage and repair --- apoptosis