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Irving Langmuir coined the name “plasma” to describe an ionized gas back in 1927. Just over 90 years later, plasma technology is becoming increasingly important in our daily life. For example, in the medical field and dentistry, plasma is used as a method of disinfection and sterilization. Moreover, additional potential novel applications of this technology in different forms of therapy have been proposed. In the agricultural sector, plasma technology could contribute to higher crop yields by enhancing seed germination and the growth of plants, as well as the preservation of foods by disinfection. Plasma technology could also be utilized in environmental applications, including water treatment and remediation, as well as treatment of exhaust gases. Although recent extensive studies have uncovered the broad potential of plasma technology, its mechanisms of action remain unclear. Therefore, further studies aimed at elucidating the molecular mechanisms of plasma technology are required. This book is composed of original articles and reviews investigating the molecular mechanisms of plasma biology. Relevant areas of study include applications in plasma medicine, plasma agriculture, as well as plasma chemistry. Studies on potential therapeutic approaches using plasma itself and plasma-treated solutions are also included.

Technology: general issues --- cold jet atmospheric pressure plasma --- reactive oxygen and nitrogen species --- backbone cleavage --- hydroxylation --- carbonyl formation --- cold atmospheric plasma --- autophagy --- silymarin nanoemulsion --- PI3K/mTOR pathway --- wound healing --- oncology --- regenerative medicine --- plasma --- atmospheric pressure plasma jets --- large-scale imaging --- machine learning --- cancer treatment --- cellular imaging --- reactive oxygen species --- mesoporous silica nanoparticles --- biomaterials --- bone regeneration --- cytotoxicity --- proliferation --- osteogenic differentiation --- plasma-activated medium --- TRAIL --- DR5 --- apoptosis --- ROS/RNS --- atmospheric-pressure plasma --- titanium --- amine --- mesenchymal stem cells --- antibiotic resistant bacteria --- antibiotic resistance gene --- disinfection --- E. coli --- inactivation --- sterilization --- cell migration --- endothelial cells VEGF --- gynaecological oncology --- vulva cancer --- risk factors --- plasma tissue interaction --- premalignant lesions --- cancer development --- patient stratification --- individualised profiling --- predictive preventive personalised medicine (PPPM/3PM) --- treatment --- Candida albicans --- cold plasma treatment --- genome --- hydrolytic enzyme activity --- carbon assimilation --- drug susceptibility --- malignant melanoma --- acidification --- nitrite --- acidified nitrite --- nitration --- membrane damage --- CAP --- cancer --- cold atmospheric pressure plasma --- hydrogen peroxide --- hypochlorous acid --- moDCs --- peroxynitrite --- RNS --- ROS --- non-thermal plasma --- biological activity --- breast cancer --- solution plasma process --- aqueous solutions --- chitin --- chitosan --- degradation --- deacetylation --- non-thermal atmospheric pressure plasma --- Pectobacteriaceae --- Dickeya spp. --- Pectobacterium spp. --- antibacterial --- plant protection --- agriculture --- selective cancer treatment --- reaction network --- mathematical modeling --- Mdm2-p53 --- plasma treatment --- molecular dynamic (MD) simulations --- cold jet atmospheric pressure plasma --- reactive oxygen and nitrogen species --- backbone cleavage --- hydroxylation --- carbonyl formation --- cold atmospheric plasma --- autophagy --- silymarin nanoemulsion --- PI3K/mTOR pathway --- wound healing --- oncology --- regenerative medicine --- plasma --- atmospheric pressure plasma jets --- large-scale imaging --- machine learning --- cancer treatment --- cellular imaging --- reactive oxygen species --- mesoporous silica nanoparticles --- biomaterials --- bone regeneration --- cytotoxicity --- proliferation --- osteogenic differentiation --- plasma-activated medium --- TRAIL --- DR5 --- apoptosis --- ROS/RNS --- atmospheric-pressure plasma --- titanium --- amine --- mesenchymal stem cells --- antibiotic resistant bacteria --- antibiotic resistance gene --- disinfection --- E. coli --- inactivation --- sterilization --- cell migration --- endothelial cells VEGF --- gynaecological oncology --- vulva cancer --- risk factors --- plasma tissue interaction --- premalignant lesions --- cancer development --- patient stratification --- individualised profiling --- predictive preventive personalised medicine (PPPM/3PM) --- treatment --- Candida albicans --- cold plasma treatment --- genome --- hydrolytic enzyme activity --- carbon assimilation --- drug susceptibility --- malignant melanoma --- acidification --- nitrite --- acidified nitrite --- nitration --- membrane damage --- CAP --- cancer --- cold atmospheric pressure plasma --- hydrogen peroxide --- hypochlorous acid --- moDCs --- peroxynitrite --- RNS --- ROS --- non-thermal plasma --- biological activity --- breast cancer --- solution plasma process --- aqueous solutions --- chitin --- chitosan --- degradation --- deacetylation --- non-thermal atmospheric pressure plasma --- Pectobacteriaceae --- Dickeya spp. --- Pectobacterium spp. --- antibacterial --- plant protection --- agriculture --- selective cancer treatment --- reaction network --- mathematical modeling --- Mdm2-p53 --- plasma treatment --- molecular dynamic (MD) simulations

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• Reference Manager
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Irving Langmuir coined the name “plasma” to describe an ionized gas back in 1927. Just over 90 years later, plasma technology is becoming increasingly important in our daily life. For example, in the medical field and dentistry, plasma is used as a method of disinfection and sterilization. Moreover, additional potential novel applications of this technology in different forms of therapy have been proposed. In the agricultural sector, plasma technology could contribute to higher crop yields by enhancing seed germination and the growth of plants, as well as the preservation of foods by disinfection. Plasma technology could also be utilized in environmental applications, including water treatment and remediation, as well as treatment of exhaust gases. Although recent extensive studies have uncovered the broad potential of plasma technology, its mechanisms of action remain unclear. Therefore, further studies aimed at elucidating the molecular mechanisms of plasma technology are required. This book is composed of original articles and reviews investigating the molecular mechanisms of plasma biology. Relevant areas of study include applications in plasma medicine, plasma agriculture, as well as plasma chemistry. Studies on potential therapeutic approaches using plasma itself and plasma-treated solutions are also included.

Technology: general issues --- cold jet atmospheric pressure plasma --- reactive oxygen and nitrogen species --- backbone cleavage --- hydroxylation --- carbonyl formation --- cold atmospheric plasma --- autophagy --- silymarin nanoemulsion --- PI3K/mTOR pathway --- wound healing --- oncology --- regenerative medicine --- plasma --- atmospheric pressure plasma jets --- large-scale imaging --- machine learning --- cancer treatment --- cellular imaging --- reactive oxygen species --- mesoporous silica nanoparticles --- biomaterials --- bone regeneration --- cytotoxicity --- proliferation --- osteogenic differentiation --- plasma-activated medium --- TRAIL --- DR5 --- apoptosis --- ROS/RNS --- atmospheric-pressure plasma --- titanium --- amine --- mesenchymal stem cells --- antibiotic resistant bacteria --- antibiotic resistance gene --- disinfection --- E. coli --- inactivation --- sterilization --- cell migration --- endothelial cells VEGF --- gynaecological oncology --- vulva cancer --- risk factors --- plasma tissue interaction --- premalignant lesions --- cancer development --- patient stratification --- individualised profiling --- predictive preventive personalised medicine (PPPM/3PM) --- treatment --- Candida albicans --- cold plasma treatment --- genome --- hydrolytic enzyme activity --- carbon assimilation --- drug susceptibility --- malignant melanoma --- acidification --- nitrite --- acidified nitrite --- nitration --- membrane damage --- CAP --- cancer --- cold atmospheric pressure plasma --- hydrogen peroxide --- hypochlorous acid --- moDCs --- peroxynitrite --- RNS --- ROS --- non-thermal plasma --- biological activity --- breast cancer --- solution plasma process --- aqueous solutions --- chitin --- chitosan --- degradation --- deacetylation --- non-thermal atmospheric pressure plasma --- Pectobacteriaceae --- Dickeya spp. --- Pectobacterium spp. --- antibacterial --- plant protection --- agriculture --- selective cancer treatment --- reaction network --- mathematical modeling --- n/a --- Mdm2–p53 --- plasma treatment --- molecular dynamic (MD) simulations --- Mdm2-p53

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In the last decade, research on cold atmospheric plasma (CAP) has significantly advanced our understanding of the effect of CAP on cancer cells and their potential for cancer treatment. This effect is due to the reactive oxygen and nitrogen species (RONS) created by plasma. This has been demonstrated for different cancer cell lines and the first clinical trials showed promising results. In addition, plasma could be combined with other treatments—such as immunotherapy—to boost its anticancer activity. The addition of new research tools to study the response of cancer cells to CAP—such as 3D in vitro, in ovo, and in vivo models and in silico approaches—as well as the use of -OMICS technologies could aid in unravelling the underlying mechanisms of CAP in cancer treatment. In order to progress towards widespread clinical application of CAP, an integrated study of the multidimensional effect of CAP in cancer treatment is essential. In this book, reviews and original research papers are published that provide new insights into the mechanisms of cold atmospheric plasma in cancer treatment, based on in vitro and in vivo experiments, clinical studies, as well as computer modeling.

cell adhesion --- plasma medicine --- oncology --- cold atmospheric plasma --- selectivity --- plasma-treated liquid --- dielectric barrier discharge --- pancreatic cancer --- pancreatic stellate cells --- immunogenic cell death --- dendritic cells --- cell communication --- extracellular matrix (ECM) --- reactive oxygen and nitrogen species (ROS) --- tumour microenvironment (TME) --- extracellular vesicles --- communication junctions --- three-dimensional in vitro culture models --- apoptosis --- breast cancer --- genome-wide expression --- reactive oxygen species --- anticancer drugs --- screening --- tumor spheroids --- combination therapy --- kINPen --- reactive oxygen and nitrogen species --- ROS --- cancer --- non-thermal atmospheric pressure plasma (NTP) --- indirect treatment --- plasma-treated phosphate-buffered saline --- electroporation --- electric pulses --- pulsed electric field amplitude --- melanoma --- long-lived reactive species --- bone cancer --- osteosarcoma --- reactive species --- plasma-activated liquid --- Ringer’s saline --- organotypic model --- nonthermal biocompatible plasma --- soft jet plasma --- human glioblastoma --- p38/MAPK pathway --- tissue penetration --- non-thermal plasma --- non-invasive plasma treatment (NIPP) --- cervical intraepithelial neoplasia (CIN) --- Raman imaging --- Raman microspectroscopy --- Plasma lipid interactions --- cold physical plasma --- radiation therapy --- radio-frequency discharge --- PARP-inhibitor --- olaparib --- DNA-damage --- gold quantum dots --- plasma --- nanomaterials --- cellular uptake --- invasiveness --- cold atmospheric pressure plasma --- plasma-activated Ringer’s lactate solution --- ovarian cancer --- cytotoxicity --- plasma-activated liquids --- multicellular tumor spheroids --- long-lived reactive oxygen and nitrogen species --- high frequency electrosurgery --- plasma treatment --- cold atmospheric plasma (CAP) --- free radicals --- cancer selectivity --- cervical cancer treatment --- cervical intraepithelial neoplasia --- cholangiocarcinoma --- cold plasma --- innovative therapy --- tumor cells --- macrophages --- plasma selectivity --- plasma jet --- n/a --- Ringer's saline --- plasma-activated Ringer's lactate solution