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Influenza virus infections lead to thousands of deaths worldwide annually and billions of dollars economic burden. Despite continuing advances in our understanding of the immune evasion mechanism, the disease remains one of the foremost threat for human being. Traditional vaccines (attenuated and inactivated) mainly provide protection by inducing virus neutralizing antibodies, targeting ever changing surface antigens: Haemagultinin (HA) and Neuraminidase (NA). Due to genetic shift and immune selection pressure, prevalence of circulating influenza virus subtypes changes every year. Therefore, mismatch between circulating strain and vaccine strain can critically affect the success rate of these conventional flu vaccines, and requires continuous monitoring of circulating influenza virus subtypes and change in the vaccine formulations accordingly. The collective limitations of existing flu vaccines urgently call for the development of a novel universal vaccines that might provide the required protective immunity to a range of influenza virus subtypes. New approaches are being investigated mainly targeting conserved regions of flu proteins. Some of these approaches include universally conserved epitopes of HA, nucleoprotein (NP), capsid protein (M1) and ion channel protein (M2) that induced strong immune responses in animal models. Some attention and progress appears to be focused on vaccines based on the M2 ectodomain (M2e) employing a variety of constructs, adjuvants and delivery systems, including M2e-hepatitis B core antigen, flagellin constructs, and virus-like particles (VLP). Animal studies with these M2e candidate vaccines demonstrated that these vaccine candidates can prevent severe illness and death but not infection, which may pose difficulties in both the evaluation of clinical efficacy and approval by the regulatory authorities. VLP vaccines appear to be promising, but still are mostly limited to animal studies. The discovery and development of new and improved vaccines have been greatly facilitated by the application of new technologies. The use of nucleic acid-based vaccines, to combine the benefits of in-situ expression of antigens with the safety of inactivated and subunit vaccines, has been a key advancement. Upon their discovery more than 20 years ago, nucleic acid vaccines promised to be a safe and effective mean to mimic immunization with a live organism vaccine, particularly for induction of T cell immunity. In addition, the manufacturing of nucleic acid-based vaccines offered the potential to be relatively simple, inexpensive and generic. Reverse Vaccinology and in-silico designing of vaccines are very innovative approaches and being considered as future of vaccines. Furthermore, various immuno-therapeutic agents also being developed to treat and minimize immuno-pathological damage in patients suffering from life threatening complications. For the treatment of such pathological conditions, various novel approaches such as administration of immune suppressive cytokines, blocking co-stimulatory signals or activating co-inhibitory signal of T cell activation, are being tested both in lab and clinics. The Research Topic on influenza virus vaccine and therapeutics will give an insight in to the current status and future scope of these new innovative approaches and technologies. Moreover, these new methods will also serve as a reference tool for the development of future vaccines against several other pathogens.

T Cell Immunity --- Neutralization antibody --- Influenza Virus --- Vaccine --- Immunotherepy --- adjuvants

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Influenza virus infections lead to thousands of deaths worldwide annually and billions of dollars economic burden. Despite continuing advances in our understanding of the immune evasion mechanism, the disease remains one of the foremost threat for human being. Traditional vaccines (attenuated and inactivated) mainly provide protection by inducing virus neutralizing antibodies, targeting ever changing surface antigens: Haemagultinin (HA) and Neuraminidase (NA). Due to genetic shift and immune selection pressure, prevalence of circulating influenza virus subtypes changes every year. Therefore, mismatch between circulating strain and vaccine strain can critically affect the success rate of these conventional flu vaccines, and requires continuous monitoring of circulating influenza virus subtypes and change in the vaccine formulations accordingly. The collective limitations of existing flu vaccines urgently call for the development of a novel universal vaccines that might provide the required protective immunity to a range of influenza virus subtypes. New approaches are being investigated mainly targeting conserved regions of flu proteins. Some of these approaches include universally conserved epitopes of HA, nucleoprotein (NP), capsid protein (M1) and ion channel protein (M2) that induced strong immune responses in animal models. Some attention and progress appears to be focused on vaccines based on the M2 ectodomain (M2e) employing a variety of constructs, adjuvants and delivery systems, including M2e-hepatitis B core antigen, flagellin constructs, and virus-like particles (VLP). Animal studies with these M2e candidate vaccines demonstrated that these vaccine candidates can prevent severe illness and death but not infection, which may pose difficulties in both the evaluation of clinical efficacy and approval by the regulatory authorities. VLP vaccines appear to be promising, but still are mostly limited to animal studies. The discovery and development of new and improved vaccines have been greatly facilitated by the application of new technologies. The use of nucleic acid-based vaccines, to combine the benefits of in-situ expression of antigens with the safety of inactivated and subunit vaccines, has been a key advancement. Upon their discovery more than 20 years ago, nucleic acid vaccines promised to be a safe and effective mean to mimic immunization with a live organism vaccine, particularly for induction of T cell immunity. In addition, the manufacturing of nucleic acid-based vaccines offered the potential to be relatively simple, inexpensive and generic. Reverse Vaccinology and in-silico designing of vaccines are very innovative approaches and being considered as future of vaccines. Furthermore, various immuno-therapeutic agents also being developed to treat and minimize immuno-pathological damage in patients suffering from life threatening complications. For the treatment of such pathological conditions, various novel approaches such as administration of immune suppressive cytokines, blocking co-stimulatory signals or activating co-inhibitory signal of T cell activation, are being tested both in lab and clinics. The Research Topic on influenza virus vaccine and therapeutics will give an insight in to the current status and future scope of these new innovative approaches and technologies. Moreover, these new methods will also serve as a reference tool for the development of future vaccines against several other pathogens.

T Cell Immunity --- Neutralization antibody --- Influenza Virus --- Vaccine --- Immunotherepy --- adjuvants

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025.85 --- 66.094.8 --- Onderhoud van boeken. Restauratie. Vriesdrogen. Boekbeschadiging --- Neutralization. Removal of acids or bases. Deacidification. Debasification --- 66.094.8 Neutralization. Removal of acids or bases. Deacidification. Debasification --- 025.85 Onderhoud van boeken. Restauratie. Vriesdrogen. Boekbeschadiging

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025.85 --- 66.094.8 --- Onderhoud van boeken. Restauratie. Vriesdrogen. Boekbeschadiging --- Neutralization. Removal of acids or bases. Deacidification. Debasification --- 66.094.8 Neutralization. Removal of acids or bases. Deacidification. Debasification --- 025.85 Onderhoud van boeken. Restauratie. Vriesdrogen. Boekbeschadiging --- Books --- Library materials --- Conservation of library materials --- Preservation of library materials --- Deacidification of books --- Neutralization (Chemistry) --- Paper --- Deacidification --- Conservation and restoration --- Preservation --- Decision making

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This thorough study of the expression of contrast in the world's vowel systems examines phonetic and phonological differences between so-called strong and weak positions, bringing the full range of data from positional neutralization systems to bear on central questions at the interface between phonetics and phonology. The author draws evidence from a diverse array of sources, bringing together cross-linguistic typological surveys, detailed investigations of the diachrony of specific languages (Slavic, Turkic, Uralic, Austronesian, among many others) and original studies in experimental phonetics. Devoted at once to empirical coverage and to theoretical investigation, this is the first work to compile so exhaustive a study of positional neutralization patterns in the languages of the world. On the basis of this catalog of evidence, the author argues for a diachronically oriented approach to the phonetic motivations behind phonological patterns, with phonologization as its central mechanism. Three pairs of traditionally-identified strong and weak positions for the realization of vowel contrasts are selected and examined in detail: stressed and unstressed syllables, domain final and non-final syllables, and domain initial and non-initial syllables. Neutralization patterns in each position are extracted from survey data, and analyzed in light of the phonetic characteristics of each pair of positions. Both the nature of the patterns identified as well as the variety and sources of exceptions have important consequences for formal phonology, phonetics, and historical linguistics as well.

Grammar, Comparative and general --- Neutralization (Linguistics) --- Phonetics. --- Articulatory phonetics --- Orthoepy --- Phonology --- Linguistics --- Speech --- Phonology. --- Philology --- Grammar, Comparative and general Phonology --- phonology.