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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- Neurology & clinical neurophysiology --- Chronic pain --- neuropathic pain --- inflammatory pain --- visceral pain --- pain treatment --- analgesics

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This text presents cutting-edge topics on and the diagnostic and therapeutic approaches for tear film abnormities, including dry eye disease and Meibomian gland dysfunction. A new management algorithm for Meibomian gland dysfunction, therapeutic eye drops and intense pulsed lasers for dry eye disease, and topical and systemic agents for neuropathic ocular pain are proposed in this issue.

Medicine --- cross-sectional study --- dry eye disease --- systemic comorbidity --- graves’ ophthalmopathy --- inflammation --- meibomian glands --- morphological changes --- meibomian gland dysfunction --- ocular surface disease --- dry eye symptoms --- questionnaire --- Bangladesh --- global health --- epidemiology --- aqueous-deficient dry eye --- meibomian gland --- intense pulsed light --- severe keratitis --- hyaluronan --- hylan A --- multicenter --- randomized trial --- gabapentin --- dry eye --- neuropathic pain --- diabetes --- neuropathic keratopathy --- neuropathy --- nerve growth --- neurotrophic --- Houttuynia --- ultrasonic atomization --- meibography --- meiboscore --- TRPM8 agonist --- cryosim-3 --- fatty acids --- vitamin D --- brief-type self-administered diet history questionnaire --- Japanese --- cross-sectional study --- dry eye disease --- systemic comorbidity --- graves’ ophthalmopathy --- inflammation --- meibomian glands --- morphological changes --- meibomian gland dysfunction --- ocular surface disease --- dry eye symptoms --- questionnaire --- Bangladesh --- global health --- epidemiology --- aqueous-deficient dry eye --- meibomian gland --- intense pulsed light --- severe keratitis --- hyaluronan --- hylan A --- multicenter --- randomized trial --- gabapentin --- dry eye --- neuropathic pain --- diabetes --- neuropathic keratopathy --- neuropathy --- nerve growth --- neurotrophic --- Houttuynia --- ultrasonic atomization --- meibography --- meiboscore --- TRPM8 agonist --- cryosim-3 --- fatty acids --- vitamin D --- brief-type self-administered diet history questionnaire --- Japanese

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This text presents cutting-edge topics on and the diagnostic and therapeutic approaches for tear film abnormities, including dry eye disease and Meibomian gland dysfunction. A new management algorithm for Meibomian gland dysfunction, therapeutic eye drops and intense pulsed lasers for dry eye disease, and topical and systemic agents for neuropathic ocular pain are proposed in this issue.

cross-sectional study --- dry eye disease --- systemic comorbidity --- graves’ ophthalmopathy --- inflammation --- meibomian glands --- morphological changes --- meibomian gland dysfunction --- ocular surface disease --- dry eye symptoms --- questionnaire --- Bangladesh --- global health --- epidemiology --- aqueous-deficient dry eye --- meibomian gland --- intense pulsed light --- severe keratitis --- hyaluronan --- hylan A --- multicenter --- randomized trial --- gabapentin --- dry eye --- neuropathic pain --- diabetes --- neuropathic keratopathy --- neuropathy --- nerve growth --- neurotrophic --- Houttuynia --- ultrasonic atomization --- meibography --- meiboscore --- TRPM8 agonist --- cryosim-3 --- fatty acids --- vitamin D --- brief-type self-administered diet history questionnaire --- Japanese

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The Essential Charcot Neuroarthropathy: Biomechanics, Pathophysiology, and MRI Findings provides a comprehensive analysis of Charcot neuroarthropathy (or Charcot Foot) in diabetic patients. All aspects are covered, including epidemiology, biomechanics, pathophysiology, socioeconomic impacts, radiological findings, and differential diagnosis, with an emphasis on MRI. Chapters address the challenges of pre-and-post surgical management of Charcot neuroarthropathy and the role of unconventional imaging modalities in diagnosis. The book presents an analysis of the normal biomechanics of the ankle and foot, the biomechanical derangements of the ankle-foot unit (including abnormal gait) caused by diabetes Type II, and more. Finally, there is also a reference of the pathophysiology of diabetes-induced peripheral neuropathy and its direct link with the development of Charcot neuroarthropathy foot. Diabetes-induced Charcot foot is frequently misunderstood, misinterpreted and misdiagnosed which can lead to confusion and detrimental management with reported high morbidity.

Charcot joints. --- Diabetes --- Diabetic Foot --- Arthropathy, Neurogenic --- Complications. --- Charcot's Joint --- Arthropathies, Neurogenic --- Charcot Joint --- Charcots Joint --- Joint, Charcot's --- Neurogenic Arthropathies --- Neurogenic Arthropathy --- Diabetic Feet --- Foot Ulcer, Diabetic --- Feet, Diabetic --- Foot, Diabetic --- Charcot's joint --- Neuro-arthropathy --- Neurogenic arthropathy --- Neuropathic joint --- Joints --- Complications and sequelae --- Diseases --- Diabetes Complications

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Marine Drugs is glad to announce its first Special Issue book on “ion channels” related research: Under the great stewardship of the Guest Editor, Dr. Jean-Marc Sabatier, four advanced research articles and three comprehensive review papers were collected in the Special Issue “Ion Channels as Marine Drug Targets”. Join us to explore the advanced research outcomes in this field: α-Conotoxin RgIA and a potent analog, RgIA4, in treatment of pain; botulinum toxin-chitosan nanoparticles in treatment of atrial fibrillation; 27-amino acid (aa)-long δ-conotoxin TxVIA that modulates mammalian CaV3.x; first venomics study of Conus tulipa venom; review on marine toxins targeting Kv1 channels; review on synthetic approaches to zetekitoxin AB; and review on marine natural products and drug resistance in latent tuberculosis. The second edition of this Special Issue is open for submissions, we look forward to your contribution.

Medicine --- conotoxin --- Conus tulipa --- intraspecific variation --- venomics --- transcriptomics --- proteomics --- conantokins --- net hunting strategy --- nirvana cabal --- ion channel modulators --- marine anti-TB compounds --- PZA --- MTB --- latent TB --- sponges --- nicotinic --- chemotherapy --- paclitaxel --- taxane --- neuropathic pain --- α9α10 --- saxitoxin --- zetekitoxin AB --- voltage-gated sodium channel --- guanidine alkaloid --- bioactives --- conotoxins 2 --- Kv1 --- marine toxins --- modulators --- potassium channels --- sea anemone toxins --- TxVIA --- mammalian NaV channel --- selective inhibitor --- T-type CaV3.2 --- botulinum toxin A1 --- chitosan nanoparticles --- antiarrhythmics --- pharmacological models of arrhythmia --- electrically induced arrhythmia --- conotoxin --- Conus tulipa --- intraspecific variation --- venomics --- transcriptomics --- proteomics --- conantokins --- net hunting strategy --- nirvana cabal --- ion channel modulators --- marine anti-TB compounds --- PZA --- MTB --- latent TB --- sponges --- nicotinic --- chemotherapy --- paclitaxel --- taxane --- neuropathic pain --- α9α10 --- saxitoxin --- zetekitoxin AB --- voltage-gated sodium channel --- guanidine alkaloid --- bioactives --- conotoxins 2 --- Kv1 --- marine toxins --- modulators --- potassium channels --- sea anemone toxins --- TxVIA --- mammalian NaV channel --- selective inhibitor --- T-type CaV3.2 --- botulinum toxin A1 --- chitosan nanoparticles --- antiarrhythmics --- pharmacological models of arrhythmia --- electrically induced arrhythmia