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Sensory hair cells are the specialized mechanosensory receptors found in vertebrate auditory, vestibular, and lateral line organs that transduce vibratory and acoustic stimuli into the sensations of hearing and balance. Hair cells can be damaged due to such factors as aging, ototoxic chemicals, acoustic trauma, infection, or genetic factors. Loss of these hair cells lead to deficits in hearing and balance, and in mammals, such deficits are permanent. In contrast, non-mammalian vertebrates exhibit the capability to regenerate missing hair cells. Researchers have been examining the process of hair cell death and regeneration in animal models in an attempt to find ways of either preventing hair cell loss or stimulating the production of new hair cells in mammals, with the ultimate goal of finding new therapeutics for human sensorineural hearing and balance deficits. This has led to a wide array of research on sensory hair cells- such as understanding the factors that cause hair cell loss and finding agents that protect them from damage, elucidating the cell signaling pathways activated during hair cell death, examining the genes and cellular pathways that are regulated during the process of hair cell death and regeneration, and characterizing the functional sensory loss and recovery following acoustic or ototoxic insults to the inner ear. This research has involved cell and developmental biologists, physiologists, geneticists, bioinformaticians, and otolaryngologists. In this Research Topic, we have collated reviews of the past progress of hair cell death and regeneration studies and original research articles advancing sensory hair cell death and regeneration research into the future.

Regeneration --- Neuromast --- ototoxicity --- Hair cells --- auditory --- Cell Death --- Cochlea --- Otoprotection --- Otic development --- Hearing Loss

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Scientific and societal concern about the effects of underwater sound on marine ecosystems is growing. While iconic megafauna was of initial concern, more and more taxa are being included. Some countries have joined in multi-national initiatives to measure, monitor and mitigate environmental impacts of ocean noise at large, trans-boundary spatial scales. Approaches to regulating ocean noise change as new scientific evidence becomes available, but may also differ by country. The OCEANOISE conference series has provided a platform for the exchange of scientific results, management approaches, research needs, stakeholder concerns, etc. Attendees have represented various sectors, including academia, offshore industry, defence, NGOs, consultants and government regulators. The published articles in the Special Issue cover a range of topics and applications central to ocean noise.

Acústica submarina --- military aircraft --- noise pollution --- ocean noise --- Endangered species --- human health --- animal behavior --- vessel noise --- radiated noise levels --- monopole source levels --- propagation loss --- animat --- air gun --- impact assessment --- marine vibroseis --- marine mammal --- sound propagation --- underwater noise modeling and mapping --- underwater noise effects --- ocean noise regulations --- underwater acoustics --- underwater sound impacts --- marine conservation --- coastal areas --- fish --- anthropogenic noise --- passive acoustic monitoring --- protected species --- reproduction --- underwater noise --- sound propagation modelling --- multivariate mixture model --- acoustic zone --- ship noise --- Australian EEZ --- source levels --- marine shipping --- automated identification system --- sound mapping --- management --- anthropogenic sound --- seismic surveys --- electromagnetic surveys --- behavioral response studies --- severity scoring of responses --- controlled exposure experiments --- cetaceans --- Physeter macrocephalus --- continuous naval sonar --- marine soundscape --- wind noise --- whale song --- fish chorus --- marine mammal conservation --- behavioral disturbance --- hearing impairment --- auditory masking --- seismic airgun source --- particle motion --- ground motion --- geophysical instruments --- bioacoustics of marine mammals --- underwater acoustic propagation --- animal communication --- acoustic propagation --- whistle detection --- time difference of arrival --- underwater acoustic --- underwater sound sensing --- ocean sound measurement --- seismic interface waves --- dispersion --- water-particle velocity --- seabed vibration --- permanent threshold shift --- synaptopathy --- neuropathy --- auditory brainstem response --- behavioral thresholds --- sea lice --- Lepeophtheirus salmonis --- acoustic trauma --- transmission electron microscopy --- scanning electron microscopy --- ocean noise mitigation --- ocean noise regulation --- small vessel source levels --- acoustic techniques --- hydrophone-based observations --- shallow water --- pinnipeds --- apple snail --- Pomacea maculata --- invasive species --- plague --- mitigation method --- salmon --- Salmo salar --- scanning electron microcopy --- otolith organ --- lateral line --- histopathology --- vaterite --- neuromast

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• Reference Manager
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Scientific and societal concern about the effects of underwater sound on marine ecosystems is growing. While iconic megafauna was of initial concern, more and more taxa are being included. Some countries have joined in multi-national initiatives to measure, monitor and mitigate environmental impacts of ocean noise at large, trans-boundary spatial scales. Approaches to regulating ocean noise change as new scientific evidence becomes available, but may also differ by country. The OCEANOISE conference series has provided a platform for the exchange of scientific results, management approaches, research needs, stakeholder concerns, etc. Attendees have represented various sectors, including academia, offshore industry, defence, NGOs, consultants and government regulators. The published articles in the Special Issue cover a range of topics and applications central to ocean noise.

Acústica submarina --- military aircraft --- noise pollution --- ocean noise --- Endangered species --- human health --- animal behavior --- vessel noise --- radiated noise levels --- monopole source levels --- propagation loss --- animat --- air gun --- impact assessment --- marine vibroseis --- marine mammal --- sound propagation --- underwater noise modeling and mapping --- underwater noise effects --- ocean noise regulations --- underwater acoustics --- underwater sound impacts --- marine conservation --- coastal areas --- fish --- anthropogenic noise --- passive acoustic monitoring --- protected species --- reproduction --- underwater noise --- sound propagation modelling --- multivariate mixture model --- acoustic zone --- ship noise --- Australian EEZ --- source levels --- marine shipping --- automated identification system --- sound mapping --- management --- anthropogenic sound --- seismic surveys --- electromagnetic surveys --- behavioral response studies --- severity scoring of responses --- controlled exposure experiments --- cetaceans --- Physeter macrocephalus --- continuous naval sonar --- marine soundscape --- wind noise --- whale song --- fish chorus --- marine mammal conservation --- behavioral disturbance --- hearing impairment --- auditory masking --- seismic airgun source --- particle motion --- ground motion --- geophysical instruments --- bioacoustics of marine mammals --- underwater acoustic propagation --- animal communication --- acoustic propagation --- whistle detection --- time difference of arrival --- underwater acoustic --- underwater sound sensing --- ocean sound measurement --- seismic interface waves --- dispersion --- water-particle velocity --- seabed vibration --- permanent threshold shift --- synaptopathy --- neuropathy --- auditory brainstem response --- behavioral thresholds --- sea lice --- Lepeophtheirus salmonis --- acoustic trauma --- transmission electron microscopy --- scanning electron microscopy --- ocean noise mitigation --- ocean noise regulation --- small vessel source levels --- acoustic techniques --- hydrophone-based observations --- shallow water --- pinnipeds --- apple snail --- Pomacea maculata --- invasive species --- plague --- mitigation method --- salmon --- Salmo salar --- scanning electron microcopy --- otolith organ --- lateral line --- histopathology --- vaterite --- neuromast --- military aircraft --- noise pollution --- ocean noise --- Endangered species --- human health --- animal behavior --- vessel noise --- radiated noise levels --- monopole source levels --- propagation loss --- animat --- air gun --- impact assessment --- marine vibroseis --- marine mammal --- sound propagation --- underwater noise modeling and mapping --- underwater noise effects --- ocean noise regulations --- underwater acoustics --- underwater sound impacts --- marine conservation --- coastal areas --- fish --- anthropogenic noise --- passive acoustic monitoring --- protected species --- reproduction --- underwater noise --- sound propagation modelling --- multivariate mixture model --- acoustic zone --- ship noise --- Australian EEZ --- source levels --- marine shipping --- automated identification system --- sound mapping --- management --- anthropogenic sound --- seismic surveys --- electromagnetic surveys --- behavioral response studies --- severity scoring of responses --- controlled exposure experiments --- cetaceans --- Physeter macrocephalus --- continuous naval sonar --- marine soundscape --- wind noise --- whale song --- fish chorus --- marine mammal conservation --- behavioral disturbance --- hearing impairment --- auditory masking --- seismic airgun source --- particle motion --- ground motion --- geophysical instruments --- bioacoustics of marine mammals --- underwater acoustic propagation --- animal communication --- acoustic propagation --- whistle detection --- time difference of arrival --- underwater acoustic --- underwater sound sensing --- ocean sound measurement --- seismic interface waves --- dispersion --- water-particle velocity --- seabed vibration --- permanent threshold shift --- synaptopathy --- neuropathy --- auditory brainstem response --- behavioral thresholds --- sea lice --- Lepeophtheirus salmonis --- acoustic trauma --- transmission electron microscopy --- scanning electron microscopy --- ocean noise mitigation --- ocean noise regulation --- small vessel source levels --- acoustic techniques --- hydrophone-based observations --- shallow water --- pinnipeds --- apple snail --- Pomacea maculata --- invasive species --- plague --- mitigation method --- salmon --- Salmo salar --- scanning electron microcopy --- otolith organ --- lateral line --- histopathology --- vaterite --- neuromast