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Core Concepts in Parenchymal Kidney Disease provides comprehensive and state-of-the-art information on the diagnosis, treatment, classification and pathogenesis of glomerular and tubulointerstitial diseases.  Chapters feature various clinical scenarios and are authored by a team of renowned experts in the field.  Experienced clinicians and trainees alike will find this authoritative reference to be a valuable resource and contribution to the literature.

Kidney glomerulus --- Kidney tubules --- Kidneys --- Kidney diseases --- Nephritis --- Nephropathy --- Renal diseases --- Nephron --- Renal tubules --- Tubules, Kidney --- Diseases. --- Kidney Failure, Chronic. --- Medicine. --- Internal medicine. --- Nephrology. --- Medicine & Public Health. --- Internal Medicine.

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Ubiquitination is a biological process mediated by ubiquitin itself, the E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme, E3 ubiquitin ligase, and deubiquitinating enzyme, respectively. Currently, these multiple biological steps are revealed to participate in various life phenomena, such as cell proliferation, regulation of cell surface proteins expression, and mitochondrial function, which are profoundly related to human health and diseases. Although clinical applications targeting ubiquitination are still limited compared to those directed toward kinase systems such as tyrosine kinases, multiple enzymatic consequences should be future therapeutic implications. This Special Issue of IJMS entitled “Ubiquitination in Health and Disease” successfully published15 distinguished manuscripts, with a total of 66 international authors and. This book provides the latest and most useful information for researchers and scientists in this field.

Humanities --- Social interaction --- deubiquitinase --- degradation --- therapeutic target --- cancer --- hematopoiesis --- hematopoietic stem cells --- immune response --- regulation of gene expression --- ubiquitin system --- genetic diseases --- ubiquitin ligase --- deubiquitinases --- monoubiquitin signaling --- vesicular trafficking --- protein complex formation --- inflammation --- inhibitor --- innate immune --- interferon --- LUBAC --- NF-κB --- ubiquitin --- Parkinson’s disease --- dopa-responsive dystonia --- tyrosine hydroxylase --- α-synuclein --- fatty acid-binding protein 3 --- ubiquitination --- proteasomal degradation --- ubiquitin-proteasome system --- mitochondria --- E3 ubiquitin ligase --- MITOL/MARCH5 --- salt-sensitive hypertension --- Nedd4L/Nedd4-2 --- epithelial sodium channel --- aldosterone sensitive distal nephron --- excitation-transcription coupling --- RNF183 --- RNF186 --- RNF182 --- RNF152 --- RING finger --- mTOR --- endoplasmic reticulum stress --- osmotic stress --- ubiquitin code --- virus infection --- virus-host interaction --- tau protein --- semisynthesis --- disulfide-coupling --- polyubiquitin --- fibrils --- aggregation --- neurodegeneration --- deubiquitination --- inhibitors --- protein quality control --- proteolysis --- protein stabilization --- regulatory T cells --- mesenchymal stem cell --- cortical bone derived stem cell --- myocardial infarction --- blood pressure --- renal salt reabsorption --- vascular function --- ubiquitin proteasome system --- ubiquitin–proteasome pathway --- cilia --- ciliogenesis --- differentiation --- proliferation --- ciliopathy --- E3s --- DUBs --- UPS --- neurodegenerative disease --- immune-related diseases

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This reprint combines recent original manuscripts and reviews covering the multiple functions of peroxisome proliferator-activated receptors in physiology and pathophysiology. Potential applications and limitations of PPAR agonists and antagonists are discussed. All original contributions were published in Cells.

peroxisome-proliferator activated receptors --- tumor angiogenesis --- tumor progression --- metastasis formation --- endothelial cells --- RNA sequencing --- PPARs --- toxicology --- pharmacology --- ligand --- vascular --- coronary artery --- lipidomics --- eicosanoids --- inflammation --- CYP450 --- peroxisome proliferator-activated receptor --- angiogenesis --- proliferation --- metastasis --- immortality --- resistance to cell death --- growth suppressors --- immune system --- cellular metabolism --- PPAR --- nuclear receptors --- addiction --- alcohol --- nicotine --- opioids --- psychostimulants --- animal models --- human studies --- Alzheimer’s --- risk factors --- PPARα --- lipids --- fatty acids --- modulators --- cognition --- sex --- therapy --- hypertrophic adipocytes --- PPARG isoforms --- PPARG splicing --- dominant-negative isoform --- in vitro adipocytes --- adipogenesis --- hypertrophic obesity --- insulin-resistance --- peroxisome proliferator-activated receptors (PPARs) --- synthetic agonists --- non-alcoholic fatty liver disease (NAFLD) --- non-alcoholic steatohepatitis (NASH) --- fibrosis --- Sirtuin1 --- peroxisome proliferator-activated receptor-γ coactivator-1α --- peroxisome proliferator activated receptors --- obesity --- metabolic syndrome --- vitamin B12 --- folate --- fetal programming --- inherited metabolic disorders --- PGC-1α, disease --- kidney --- cancer --- AKI --- CKD --- nephron --- PKD --- cilia --- cystogenesis --- ligands --- Alzheimer’s disease (AD)

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This reprint combines recent original manuscripts and reviews covering the multiple functions of peroxisome proliferator-activated receptors in physiology and pathophysiology. Potential applications and limitations of PPAR agonists and antagonists are discussed. All original contributions were published in Cells.

Medicine --- Physiology --- peroxisome-proliferator activated receptors --- tumor angiogenesis --- tumor progression --- metastasis formation --- endothelial cells --- RNA sequencing --- PPARs --- toxicology --- pharmacology --- ligand --- vascular --- coronary artery --- lipidomics --- eicosanoids --- inflammation --- CYP450 --- peroxisome proliferator-activated receptor --- angiogenesis --- proliferation --- metastasis --- immortality --- resistance to cell death --- growth suppressors --- immune system --- cellular metabolism --- PPAR --- nuclear receptors --- addiction --- alcohol --- nicotine --- opioids --- psychostimulants --- animal models --- human studies --- Alzheimer’s --- risk factors --- PPARα --- lipids --- fatty acids --- modulators --- cognition --- sex --- therapy --- hypertrophic adipocytes --- PPARG isoforms --- PPARG splicing --- dominant-negative isoform --- in vitro adipocytes --- adipogenesis --- hypertrophic obesity --- insulin-resistance --- peroxisome proliferator-activated receptors (PPARs) --- synthetic agonists --- non-alcoholic fatty liver disease (NAFLD) --- non-alcoholic steatohepatitis (NASH) --- fibrosis --- Sirtuin1 --- peroxisome proliferator-activated receptor-γ coactivator-1α --- peroxisome proliferator activated receptors --- obesity --- metabolic syndrome --- vitamin B12 --- folate --- fetal programming --- inherited metabolic disorders --- PGC-1α, disease --- kidney --- cancer --- AKI --- CKD --- nephron --- PKD --- cilia --- cystogenesis --- ligands --- Alzheimer’s disease (AD) --- peroxisome-proliferator activated receptors --- tumor angiogenesis --- tumor progression --- metastasis formation --- endothelial cells --- RNA sequencing --- PPARs --- toxicology --- pharmacology --- ligand --- vascular --- coronary artery --- lipidomics --- eicosanoids --- inflammation --- CYP450 --- peroxisome proliferator-activated receptor --- angiogenesis --- proliferation --- metastasis --- immortality --- resistance to cell death --- growth suppressors --- immune system --- cellular metabolism --- PPAR --- nuclear receptors --- addiction --- alcohol --- nicotine --- opioids --- psychostimulants --- animal models --- human studies --- Alzheimer’s --- risk factors --- PPARα --- lipids --- fatty acids --- modulators --- cognition --- sex --- therapy --- hypertrophic adipocytes --- PPARG isoforms --- PPARG splicing --- dominant-negative isoform --- in vitro adipocytes --- adipogenesis --- hypertrophic obesity --- insulin-resistance --- peroxisome proliferator-activated receptors (PPARs) --- synthetic agonists --- non-alcoholic fatty liver disease (NAFLD) --- non-alcoholic steatohepatitis (NASH) --- fibrosis --- Sirtuin1 --- peroxisome proliferator-activated receptor-γ coactivator-1α --- peroxisome proliferator activated receptors --- obesity --- metabolic syndrome --- vitamin B12 --- folate --- fetal programming --- inherited metabolic disorders --- PGC-1α, disease --- kidney --- cancer --- AKI --- CKD --- nephron --- PKD --- cilia --- cystogenesis --- ligands --- Alzheimer’s disease (AD)

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Long-term exposure to environmental toxicants is estimated to account for 70–90% of the risks of acquiring chronic ailments. Presently, chronic kidney disease and infertility affect a significant proportion of the world population, while research data indicate that exposure to toxic metals may contribute to the looming statistics. Alarming evidence suggests that exposure to the heavy metal cadmium may affect every stage of life, and exposure in early life may determine susceptibility to certain diseases in adulthood. Prevention of these outcomes requires avoidance of further environmental contamination, minimization of exposure, and reduction of toxic metals in food crops to the lowest achievable levels.

Public health & preventive medicine --- Trace elements --- hair --- children --- hazardous waste incinerator --- Constantí (Catalonia, Spain) --- blood lead level --- boatyard --- childhood --- lead poisoning --- fishing community --- lead weights --- β2-microglobulin --- cadmium --- creatinine clearance --- glomerular filtration --- N-acetyl-β-d-glucosaminidase --- nephron mass --- nephrotoxicity --- trace elements --- autopsy tissues --- temporal trends --- creatinine excretion --- glomerular filtration rate --- lead --- kidney --- endocytosis --- metallothionein --- flow cytometry --- proximal tubule epithelial cells --- OGTT --- minimal model --- glucose response mechanism --- genotoxicity --- aluminum chloride --- rats --- food --- farmer --- PTWI (provisional tolerable monthly intake) --- TWI (tolerable weekly intake) --- Monte Carlo simulation --- mercury --- obesogen --- lipid profiles --- hyperlipidemia --- elevated liver enzymes --- hexavalent chromium [Cr(VI)] --- mitochondrial fragmentation --- dynamin-related protein 1 (Drp1) --- mitochondrial respiratory chain complex I (MRCC I) --- reactive oxygen species (ROS) --- blood lead --- cellular immunity --- phagocytosis --- humoral munity --- immunosuppression --- insulin --- diabetes --- hyperglycemia --- hyperinsulinemia --- lipogenic --- β-cell toxicity --- stroke --- cerebrovascular accident --- heavy metal --- rare earth element --- case-control study --- mortality --- lifetime cadmium intake --- renal diseases --- urinary cadmium --- a follow-up study --- diet --- kidney function --- chronic kidney disease --- threshold limit --- tolerable intake level --- heavy metals --- birth weight --- preterm birth --- diet pattern --- Mediterranean diet --- pregnancy --- toxic metals --- reproduction --- testicular and ovarian structure --- Trace elements --- hair --- children --- hazardous waste incinerator --- Constantí (Catalonia, Spain) --- blood lead level --- boatyard --- childhood --- lead poisoning --- fishing community --- lead weights --- β2-microglobulin --- cadmium --- creatinine clearance --- glomerular filtration --- N-acetyl-β-d-glucosaminidase --- nephron mass --- nephrotoxicity --- trace elements --- autopsy tissues --- temporal trends --- creatinine excretion --- glomerular filtration rate --- lead --- kidney --- endocytosis --- metallothionein --- flow cytometry --- proximal tubule epithelial cells --- OGTT --- minimal model --- glucose response mechanism --- genotoxicity --- aluminum chloride --- rats --- food --- farmer --- PTWI (provisional tolerable monthly intake) --- TWI (tolerable weekly intake) --- Monte Carlo simulation --- mercury --- obesogen --- lipid profiles --- hyperlipidemia --- elevated liver enzymes --- hexavalent chromium [Cr(VI)] --- mitochondrial fragmentation --- dynamin-related protein 1 (Drp1) --- mitochondrial respiratory chain complex I (MRCC I) --- reactive oxygen species (ROS) --- blood lead --- cellular immunity --- phagocytosis --- humoral munity --- immunosuppression --- insulin --- diabetes --- hyperglycemia --- hyperinsulinemia --- lipogenic --- β-cell toxicity --- stroke --- cerebrovascular accident --- heavy metal --- rare earth element --- case-control study --- mortality --- lifetime cadmium intake --- renal diseases --- urinary cadmium --- a follow-up study --- diet --- kidney function --- chronic kidney disease --- threshold limit --- tolerable intake level --- heavy metals --- birth weight --- preterm birth --- diet pattern --- Mediterranean diet --- pregnancy --- toxic metals --- reproduction --- testicular and ovarian structure