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Materia medica, Vegetable --- Drugs --- Plants, Medicinal --- Congresses --- congresses --- Pharmacology --- Textbooks & monographs 1891-2000 --- Textbooks & monographs 1891-2000. --- Pharmaceutical Preparations --- congresses. --- Congresses. --- DRUGS --- NATURAL PRODUCTS --- MODIFICATION --- THERAPY --- LIVER --- NEOLIGNANS --- INDIA --- MEDICINAL PLANTS --- DIMERIC COMPOUNDS --- SAPONINS --- SESQUITERPENOIDS --- ALKALOIDS --- ANTIBIOTICS --- ANTI TUMOUR DRUGS --- CLINICAL MEDICINE --- SCREENING --- PHARMACOLOGY --- PLANTS --- SYNTHESIS --- DISEASES

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This Special Issue is focused on natural polyphenols and their synthetic bioactive analogues. It is composed of one review on aza- and azo-stilbenes as bioisosteric analogs of the stilbenoid resveratrol and four original articles, including studies on synthetic (bisphenol neolignans inspired by honokiol, multicomponent synthesis of polyphenols), and natural polyphenols (polyphenols from Tamarix ramosissima and Melanoleuca styphelioides) as antiproliferative, anti-Alzheimer’s, antioxidant, antimicrobial, or anti-inflammatory agents.

Research & information: general --- Melaleuca styphelioides --- polyphenols --- LC/MS-MS --- anti-oxidant activity --- anti-inflammatory activity --- keratinocytes --- Tamarix ramosissima --- polyphenolics --- antioxidant activity --- antimicrobial activity --- isorhamnetin --- hispidulin --- cirsimaritin --- multicomponent reactions --- β-amyloid proteins --- Alzheimer’s disease --- Ugi reaction --- β-lactams --- trans-resveratrol --- aza-stilbene --- azo-stilbene --- bio-isosterism --- structure-activity relationship --- honokiol --- bisphenol neolignans --- Suzuki–Miyaura cross-coupling --- antitumor activity --- apoptosis --- n/a --- Alzheimer's disease --- Suzuki-Miyaura cross-coupling

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Lignans are a class of natural products found mainly in plants. They have a wide variety of structures and exhibit a range of potent biological activities. Lignans are also well-known components of a number of widely eaten foods and are frequently studied for their dietary impact. Owing to these factors, lignans have been extensively studied by scientists from a large number of disciplines. This collection of research and review articles describes topics ranging in scope from the recent isolation and structural elucidation of new lignans, strategies towards the chemical synthesis of lignans, assessment of their biological activities and potential for further therapeutic development. Research showing the impact of lignans in the food and agricultural industries is also presented.

taste-active compound --- heilaohu --- 9-norlignans --- antioxidant activity --- drug-like --- human health --- chemometrics --- lignan --- bitterness --- red-flowered Chinese magnolia vine --- antioxidant --- ruminant --- secoisolariciresinol diglucoside --- quantification --- intermolecular interactions --- cattle --- anti-inflammatory activity --- acyl-Claisen --- LOX --- seed --- food groups --- microtubules --- anti-proliferative --- acetylcholinesterase inhibitors --- flax --- arylnaphthalene lignan --- epiboly --- aryldihydronaphthalene lignan --- multiple bioactive components --- enterolignan --- total synthesis --- genetic --- synthesis --- cultivated --- cell cycle --- chronic diseases --- national databases --- oxidation --- chemical components --- molecular dynamics --- COX --- lignans --- hydroxycinnamic acid --- chemical structures --- Chinese magnolia vine --- stereoselective synthesis --- sPLA2 --- Bursera fagaroides --- in silico studies --- antibacterial activity --- semisynthesis --- dibenzyl butyrolactones --- flavonoid glycoside --- lignan glycoside --- chemical characterization --- hydroxymatairesinol --- podophyllotoxin --- Lespedeza cuneata --- Bursera --- oak ageing --- Schisandrae Chinensis Fructus --- F-actin --- cultivar --- UHPLC-MS/MS --- bioactivity --- podophyllotoxin-type lignans --- harmonized databases --- graph theory --- antioxidants --- health promotion --- simultaneous quantitation --- natural products --- dietary intake --- cell migration --- Lignan --- chemical space --- diet --- Lauraceae --- pharmacokinetic --- cytotoxicity --- tujia ethnomedicine --- flavonolignans --- flavonol --- adipocyte and osteoblast differentiation --- Burseraceae --- environment --- dietary lignans --- phytochemical analysis --- Schisandra chinensis --- animal health --- neolignans --- Schisandra rubriflora --- cancer --- norlignans --- wild