Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Nanovesicles are highly-promising systems for the delivery and/or targeting of drugs, biomolecules and contrast agents. Despite the fact that initial studies in this area were performed on phospholipid vesicles, there is an ever-increasing interest in the use of other molecules to obtain smart vesicular carriers focusing on strategies for targeted delivery. These systems can be obtained using newly synthesized smart molecules, or by intelligent design of opportune carriers to achieve specific delivery to the site of action.

n/a --- protein corona --- buspirone --- drug delivery --- Plectranthus ecklonii --- antiproliferative activity --- pancreatic ductal adenocarcinoma --- tetraethyl orthosilicate --- cancer therapy --- nanoparticles --- cationic liposomes --- Ibuprofen --- SBA-15 --- gastrointestinal stability --- mesoporous silica nanoparticles --- Parvifloron D --- anti-tumor drugs --- liposomes --- gingiva mesenchymal stromal cells --- soy lecithin liposomes --- MCM-41 --- lipophilic compound --- multifunctional liposomes --- caryophyllene sesquiterpene --- drug loading --- lamellarity --- hCMEC/D3 cells --- gold shell --- magnetic/plasmonic nanoparticles --- pH-sensitive niosomes --- hot flushes --- nasal delivery system --- andrographolide --- brain delivery --- pancreatic cancer --- Pain --- exosomes --- NSAIDs --- freeze-drying --- manganese ferrite --- surfactant --- cytotoxicity --- paclitaxel --- ovariectomized rat --- PAMPA --- uptake and safety --- nanovesicular nasal carrier --- Stober’s synthesis --- Analgesia --- protocells --- nanocochleates --- squamous cell carcinoma --- Stober's synthesis

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Brain diseases currently affect one in six people worldwide; they include a wide range of neurological diseases, from Alzheimer’s and Parkinson’s diseases to epilepsy, brain injuries, brain cancer, neuroinfections, and strokes. The treatment of these diseases is complex and limited due to the presence of the blood–brain barrier (BBB), which covers the entirety of the brain. The BBB not only has the function of protecting the brain from harmful substances; it is also a metabolic barrier and a transport regulator of nutrients/serum factors/neurotoxins. Knowing these characteristics when it comes to the treatment of brain diseases makes it easier to understand the lack of efficacy of therapeutic drugs, resulting from the innate resistance of the BBB to permeation. To overcome this limitation, drug delivery systems based on nanotechnology/microtechnology have been developed. Brain-targeted drug delivery enables targeted therapy with a higher therapeutic efficacy and fewer side effects because it targets moieties present in the drug delivery systems.

Technology: general issues --- drug delivery into the brain --- transendothelium based on receptor-mediated transcytosis --- immunotherapy --- Alzheimer’s disease --- anti-tau and anti-receptor bispecific monoclonal antibodies --- Alzheimer’s disease-relevant tau species --- temporal-spatial pathological Aβ and tau distribution --- interactions between Aβ and tau --- tau clearance in microglia --- tau clearance in neurons --- liposome --- nanoparticle --- seizure --- laser --- ultrasound --- naringenin --- nanostructured lipid carrier --- intranasal delivery --- central composite rotatable design --- depression --- pomegranate seed oil --- nasal delivery system --- memory impairment --- movement impairment --- delivery to brain --- improved memory --- phospholipid oily gel --- high-grade glioma --- diffuse midline glioma --- glioblastoma --- IL-13Rα2 --- IL-13 --- immunotoxin --- targeted therapy --- GB-13 --- IL13.E13K-PE4E --- receptor expression --- acetaminophen --- blood–brain barrier --- claudin-5 --- CNS drug delivery --- opioids --- tight junction --- microdialysis --- cerebral open flow microperfusion --- electrochemical biosensors --- macromolecules --- tolcapone --- microparticles --- nanoparticles --- PLGA --- Parkinson’s disease --- nose to brain delivery --- gene therapy --- polyplexes --- hyaluronidase --- glycol chitosan --- brain cancer --- chemoattractant --- CXCL --- CXCR --- glioblastoma multiforme --- 3D cell culture systems --- non-human primate --- convection-enhanced delivery --- neurosurgery --- optogenetics --- blood-brain barrier --- brain targeted therapy --- drug delivery --- cerebrospinal fluid microcirculation --- brain biodistribution --- n/a --- Alzheimer's disease --- Alzheimer's disease-relevant tau species --- Parkinson's disease