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This Book presents original research articles published in the Special Issue entitled “Green Nanotechnology: The Latest Innovations, Knowledge Gaps, and Future Perspectives”. It proposes pioneering and innovative applications, products, technologies, and processes in several green nanotechnology-related fields (e.g., drug delivery systems, antifouling nanoadditives, and coatings for optical applications), as well as identifying some knowledge gaps on this domain. Research on the sustainable production of nanomaterials based on safe-by-design approaches and (eco)toxicological assessments of novel nanomaterials is also provided. Future perspectives are also highlighted in the Editorial and across the original articles.

Technology: general issues --- carvacrol --- stearic acid --- beeswax --- carnauba wax --- nanostructured lipid carriers --- crystallinity --- cationic surfactants --- microemulsion --- mesoporous silica --- encapsulation --- ecotoxicity --- Perna perna --- biofouling --- nanotechnology --- toxicity --- silver nanoparticles --- gemini surfactant --- green synthesis --- black nickel coatings --- electrochemical testing --- electrodeposition --- hull cell --- nanostructured coatings --- green nanotechnology --- green chemistry --- safe-by-design --- sustainability --- nanomaterials --- nanoparticles --- nanoecotoxicology --- environmental risk assessment

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This Book presents original research articles published in the Special Issue entitled “Green Nanotechnology: The Latest Innovations, Knowledge Gaps, and Future Perspectives”. It proposes pioneering and innovative applications, products, technologies, and processes in several green nanotechnology-related fields (e.g., drug delivery systems, antifouling nanoadditives, and coatings for optical applications), as well as identifying some knowledge gaps on this domain. Research on the sustainable production of nanomaterials based on safe-by-design approaches and (eco)toxicological assessments of novel nanomaterials is also provided. Future perspectives are also highlighted in the Editorial and across the original articles.

Technology: general issues --- carvacrol --- stearic acid --- beeswax --- carnauba wax --- nanostructured lipid carriers --- crystallinity --- cationic surfactants --- microemulsion --- mesoporous silica --- encapsulation --- ecotoxicity --- Perna perna --- biofouling --- nanotechnology --- toxicity --- silver nanoparticles --- gemini surfactant --- green synthesis --- black nickel coatings --- electrochemical testing --- electrodeposition --- hull cell --- nanostructured coatings --- green nanotechnology --- green chemistry --- safe-by-design --- sustainability --- nanomaterials --- nanoparticles --- nanoecotoxicology --- environmental risk assessment

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The use of lipid-based nanosystems, including lipid nanoparticles (solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC)), nanoemulsions, and liposomes, among others, is widespread. Several researchers have described the advantages of different applications of these nanosystems. For instance, they can increase the targeting and bioavailability of drugs, improving therapeutic effects. Their use in the cosmetic field is also promising, owing to their moisturizing properties and ability to protect labile cosmetic actives. Thus, it is surprising that only a few lipid-based nanosystems have reached the market. This can be explained by the strict regulatory requirements of medicines and the occurrence of unexpected in vivo failure, which highlights the need to conduct more preclinical studies.Current research is focused on testing the in vitro, ex vivo, and in vivo efficacy of lipid-based nanosystems to predict their clinical performance. However, there is a lack of method validation, which compromises the comparison between different studies.This book brings together the latest research and reviews that report on in vitro, ex vivo, and in vivo preclinical studies using lipid-based nanosystems. Readers can find up-to-date information on the most common experiments performed to predict the clinical behavior of lipid-based nanosystems. A series of 15 research articles and a review are presented, with authors from 15 different countries, which demonstrates the universality of the investigations that have been carried out in this area.

Technology: general issues --- nanostructured lipid carriers (NLC) --- formulation optimization --- rivastigmine --- quality by design (QbD) --- nasal route --- nose-to-brain --- N-alkylisatin --- liposome --- urokinase plasminogen activator --- PAI-2 --- SerpinB2 --- breast cancer --- liposomes --- target delivery nanosystem --- FZD10 protein --- colon cancer therapy --- supersaturation --- silica-lipid hybrid --- spray drying --- lipolysis --- lipid-based formulation --- fenofibrate --- mesoporous silica --- oral drug delivery --- hyaluronic acid --- drug release --- light activation --- stability --- mobility --- biocorona --- dissolution enhancement --- phospholipids --- solid dosage forms --- porous microparticles --- nanoemulsion(s) --- phase-behavior --- DoE --- D-optimal design --- vegetable oils --- non-ionic surfactants --- efavirenz --- flaxseed oil --- nanostructured lipid carriers --- nanocarrier --- docohexaenoic acid --- neuroprotection --- neuroinflammation --- fluconazole --- Box‒Behnken design --- nanotransfersome --- ulcer index --- zone of inhibition --- rheological behavior --- ex vivo permeation --- nanomedicine --- cancer --- doxorubicin --- melanoma --- drug delivery --- ultrasound contrast agents --- phospholipid coating --- ligand distribution --- cholesterol --- acoustic response --- microbubble --- lipid phase --- dialysis --- ammonia --- intoxication --- cyanocobalamin --- vitamin B12 --- atopic dermatitis --- psoriasis --- transferosomes --- lipid vesicles --- skin topical delivery --- oligonucleotide --- self-emulsifying drug delivery systems --- hydrophobic ion pairing --- intestinal permeation enhancers --- Caco-2 monolayer --- clarithromycin --- solid lipid nanoparticles --- optimization --- permeation --- pharmacokinetics --- follicular targeting --- dexamethasone --- alopecia areata --- lipomers --- lipid polymer hybrid nanocapsules --- biodistribution --- skin --- ethyl cellulose --- n/a

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The use of lipid-based nanosystems, including lipid nanoparticles (solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC)), nanoemulsions, and liposomes, among others, is widespread. Several researchers have described the advantages of different applications of these nanosystems. For instance, they can increase the targeting and bioavailability of drugs, improving therapeutic effects. Their use in the cosmetic field is also promising, owing to their moisturizing properties and ability to protect labile cosmetic actives. Thus, it is surprising that only a few lipid-based nanosystems have reached the market. This can be explained by the strict regulatory requirements of medicines and the occurrence of unexpected in vivo failure, which highlights the need to conduct more preclinical studies.Current research is focused on testing the in vitro, ex vivo, and in vivo efficacy of lipid-based nanosystems to predict their clinical performance. However, there is a lack of method validation, which compromises the comparison between different studies.This book brings together the latest research and reviews that report on in vitro, ex vivo, and in vivo preclinical studies using lipid-based nanosystems. Readers can find up-to-date information on the most common experiments performed to predict the clinical behavior of lipid-based nanosystems. A series of 15 research articles and a review are presented, with authors from 15 different countries, which demonstrates the universality of the investigations that have been carried out in this area.

Technology: general issues --- nanostructured lipid carriers (NLC) --- formulation optimization --- rivastigmine --- quality by design (QbD) --- nasal route --- nose-to-brain --- N-alkylisatin --- liposome --- urokinase plasminogen activator --- PAI-2 --- SerpinB2 --- breast cancer --- liposomes --- target delivery nanosystem --- FZD10 protein --- colon cancer therapy --- supersaturation --- silica-lipid hybrid --- spray drying --- lipolysis --- lipid-based formulation --- fenofibrate --- mesoporous silica --- oral drug delivery --- hyaluronic acid --- drug release --- light activation --- stability --- mobility --- biocorona --- dissolution enhancement --- phospholipids --- solid dosage forms --- porous microparticles --- nanoemulsion(s) --- phase-behavior --- DoE --- D-optimal design --- vegetable oils --- non-ionic surfactants --- efavirenz --- flaxseed oil --- nanostructured lipid carriers --- nanocarrier --- docohexaenoic acid --- neuroprotection --- neuroinflammation --- fluconazole --- Box‒Behnken design --- nanotransfersome --- ulcer index --- zone of inhibition --- rheological behavior --- ex vivo permeation --- nanomedicine --- cancer --- doxorubicin --- melanoma --- drug delivery --- ultrasound contrast agents --- phospholipid coating --- ligand distribution --- cholesterol --- acoustic response --- microbubble --- lipid phase --- dialysis --- ammonia --- intoxication --- cyanocobalamin --- vitamin B12 --- atopic dermatitis --- psoriasis --- transferosomes --- lipid vesicles --- skin topical delivery --- oligonucleotide --- self-emulsifying drug delivery systems --- hydrophobic ion pairing --- intestinal permeation enhancers --- Caco-2 monolayer --- clarithromycin --- solid lipid nanoparticles --- optimization --- permeation --- pharmacokinetics --- follicular targeting --- dexamethasone --- alopecia areata --- lipomers --- lipid polymer hybrid nanocapsules --- biodistribution --- skin --- ethyl cellulose

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This book focuses on how nanoscale systems can be used to deliver molecules to help with cancer management. It provides a broad overview of some of the key strategies for nanocarrier design. These strategies are brought together by the wide compositional variety of these systems and the diversity of molecules that may be carried. Additionally, functionalization strategies, codelivery, and combination with other treatment modalities highlight a very active research field.

nanostructured lipid carriers --- doxorubicin --- mucositis --- cell internalization --- albumin --- BSA --- CPP --- gold nanorods --- gold nanoprisms --- arginine-rich peptide --- glutathione --- nanoparticles --- oxidative stress --- breast cancer --- gastric cancer --- nanoparticle --- fucoidan --- d-alpha-tocopherylpoly (ethylene glycol) succinate --- combination chemotherapy --- G-quadruplex --- nucleolin --- DNA nanocages --- intracellular localization --- cancer targeting --- molecular dynamics simulations --- mesoporous silica nanoparticles --- radiotherapy --- immunotherapy --- tumor microenvironment --- abscopal effect --- magnetofection in vivo --- magnetic nanoparticles --- iron oxide --- gene delivery --- gene vectors --- codelivery nanocarriers --- photodynamic therapy --- anticancer therapies --- combination therapy --- phthalocyanine --- uterine cervical neoplasms --- photochemotherapy --- in vitro --- in vivo --- nanocarrier --- polyplexes --- siRNA delivery --- glioblastoma therapy --- amphiphilic poly(α)glutamate --- P-selectin --- prodrug --- drug delivery --- targeted therapy --- chemotherapy --- prostate cancer --- prostate-specific membrane antigen --- targeted delivery --- encapsulation --- cabazitaxel --- nanocarriers --- nanosystems --- radiosensitizer --- hypoxia --- synergism --- cancer --- photothermal therapy --- combined antitumor effect --- oxygenation --- hydrogel --- hypoxic tumor --- n/a