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The next frontier in pharmacology is the development of multi-target strategies in which pathological processes are controlled by pharmacologically manipulating them at many different points at once. Designing multi-target strategies will require deep understanding of the complex physiology that underlies pathological processes. It will also require the development of single drugs with multiple targets, or combinations of drugs with compatible pharmacokinetics that work synergistically to maximize desirable effects while minimizing unwanted side effects. This e-Book contains ten original articles, each addressing a different aspect of this challenge. Together they open new perspectives and show the way forward in the development of multi-target therapeutics.

systems biology --- computer modeling --- drug repurposing --- synergy --- drug discovery --- drug combination --- high throughput screening --- multidrug therapeutics --- polypharmacy --- multifactorial process --- systems biology --- computer modeling --- drug repurposing --- synergy --- drug discovery --- drug combination --- high throughput screening --- multidrug therapeutics --- polypharmacy --- multifactorial process

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The next frontier in pharmacology is the development of multi-target strategies in which pathological processes are controlled by pharmacologically manipulating them at many different points at once. Designing multi-target strategies will require deep understanding of the complex physiology that underlies pathological processes. It will also require the development of single drugs with multiple targets, or combinations of drugs with compatible pharmacokinetics that work synergistically to maximize desirable effects while minimizing unwanted side effects. This e-Book contains ten original articles, each addressing a different aspect of this challenge. Together they open new perspectives and show the way forward in the development of multi-target therapeutics.

systems biology --- computer modeling --- drug repurposing --- synergy --- drug discovery --- drug combination --- high throughput screening --- multidrug therapeutics --- polypharmacy --- multifactorial process