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This book collects multidisciplinary research articles focused on Clostridioides difficile infection. The contributions collected here shed some light on grey areas of our knowledge of Clostridioides difficile, including regional Clostridioides difficile phenotypic and genotypic patterns, the Clostridioides difficile infection clinical course and the mortality rate in different settings and patient case-mix, the levels of Clostridioides difficile toxins in patients' sera, and novel, promising therapeutic approaches. This collection serves as a valuable reservoir of knowledge for scientists and researchers in the field of infectious diseases.

Clostridioides difficile infection --- co–morbidities --- mortality --- malignancy --- outcome --- risk factors --- C. difficile infection --- molecular analysis --- toxin production --- antibiotic resistance --- microbiome --- C. difficile --- hamsters --- bovine immunoglobulins --- 16S rRNA --- next generation sequencing --- Clostridioides difficile --- Charlson comorbidity index --- Child–Pugh score --- Clostridioides difficile associated disease --- CDI --- nonalcoholic fatty liver disease --- NAFLD --- NASH --- recurrent disease --- antibacterial --- Clostridioides (Clostridium) difficile --- peptidomimetic --- triazole --- baicalin --- gut dysbiosis --- mouse model --- spores --- anti-spore --- spore germination --- nanomaterial --- teicoplanin --- spore --- antibiotics --- multi-step algorithm --- multiplex “real-time” PCR --- PCR capillary-based electrophoresis ribotyping --- Clostridium difficile --- TcdA --- TcdB --- toxin --- toxemia --- plasma --- method --- quantification --- CDI severity --- n/a --- co-morbidities --- Child-Pugh score --- multiplex "real-time" PCR