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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

antibiotic resistance --- antibiotic inactivation --- multi-drug-resistance --- cell wall alteration --- efflux pumps --- ribosome --- bacteria

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Science: general issues --- antibiotic resistance --- antibiotic inactivation --- multi-drug-resistance --- cell wall alteration --- efflux pumps --- ribosome --- bacteria

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ATP-Binding Cassette Transporters --- Drug Resistance, Multiple. --- Ovarian Neoplasms --- P-Glycoprotein --- Heat-Shock Proteins --- Multi-Drug Resistance --- Multidrug Resistance --- Multiple Drug Resistance --- Resistance, Multiple Drug --- P-Glycoproteins --- Genes, MDR --- Multidrug Resistance-Associated Proteins --- chemistry. --- drug therapy. --- analysis. --- Theses --- ATP Binding Cassette Transporter, Sub-Family B --- ATP-Binding Cassette, Sub-Family B, Member 1 --- ATP Binding Cassette Transporter, Subfamily B --- ATP Binding Cassette Transporter, Subfamily B, Member 1 --- Drug Resistance, Multiple --- ABCB1 Protein --- ATP Binding Cassette Transporter, Sub-Family B, Member 1 --- CD243 Antigen --- PGY-1 Protein --- MDR1 Protein --- Multidrug Resistance Protein 1 --- Antigen, CD243 --- P Glycoprotein --- PGY 1 Protein --- Rhodamine 123 --- chemistry --- drug therapy --- analysis

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This book provides new structural, biochemical, and clinical information on ABC transporters. The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins. The first ABC transporter was discovered in 1973 and was named P-glycoprotein. It elicits resistance to cytotoxic drugs, chiefly in human tumours, within which chemotherapy failure is observed in about 50% of cases. Together with its complex pharmacology, and even a suspected role in Alzheimer’s disease, this ABC transporter still eludes a clinical solution to its multidrug resistance property. ABC transporters are integral membrane active proteins and they belong to one of the largest protein families across all species. Their myriad roles encompass the import or export of a diverse range of allocrites, including ion, nutrients, peptides, polysaccharides, lipids, and xenobiotics. They are of major medical importance with many members elaborating multidrug resistance in bacteria, fungi, yeast, parasites, and humans. Other ABC transporters are involved in a number of inherited diseases, including cystic fibrosis, macular degeneration, gout, and several other metabolic disorders.

Cytology --- Biology --- Health & Biological Sciences --- Multidrug resistance. --- ATP-binding cassette transporters. --- ABC proteins --- ABC transporters --- ATP-binding cassette proteins --- Multi-drug resistance --- Multiple drug resistance --- Pleiotropic drug resistance --- Carrier proteins --- Membrane proteins --- Drug resistance --- Cell membranes. --- Biochemistry. --- Drug interactions. --- Membrane Biology. --- Biological and Medical Physics, Biophysics. --- Biochemistry, general. --- Drug Resistance. --- Interactions, Drug --- Drugs --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Side effects --- Composition --- Cell membranes . --- Biophysics. --- Biological physics. --- Drug resistance. --- Resistance to drugs --- Pharmacology --- Biological physics --- Physics

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This Special Issue is intended as a platform for interactive material science articles with an emphasis on the preparation, functionalization chemistry, and characterization of nanocarbon compounds, as well as all aspects of physical properties of functionalized, conjugated, or hybrid nanocarbon materials, and their associated applications. Some recent advances in the field are here collected, providing new ideas for discussion of researchers working in this multidisciplinary scenario.

graphene oxide --- thermal conductivity --- vacancy defect --- omeprazole --- liquid chromatography --- tandem mass spectrometry --- saliva --- GO-Tabs --- Tri[60]fullerenyl stereoisomers --- cis-cup-form of 3D-stereoisomers --- tris(diphenylaminofluorene) --- 3D-configurated nanostructures --- intramolecular energy transfer for singlet oxygen production --- intramolecular electron transfer for superoxide radical production --- graphene-based materials --- nanoporous graphene --- epitaxial graphene --- molecular modeling --- filled carbon nanotubes --- lithium-ion batteries --- hybrid nanomaterials --- anode material --- carbon nanotube yarns --- carbon nanotube --- functionalization --- electrical conductivity --- annealing --- acid treatment --- carbon fibers --- surface treatment --- grafting --- graphene aerogel --- carbon nanostructures --- carbon nanohybrids --- cancer therapy --- multi-drug resistance