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The presence of green and yellow ornamental plants around us, dark spots on our skin, people with brown and blue mosaic irises, and white-spotted dogs and horses are all well-known phenomena of life, and are recognisable genetic mosaics. Although such genetics mosaics live with us (and, in fact, we are all a genetic mosaics), little is known about the genetic bases of their origin. This book provides a general overview of the mechanisms that lead to the formation of different types of mosaics, listing an ample collection of examples to illustrate the impact of the genetic mosaics on our life. The book will appeal to the reader interested in understanding the relationship between genetic events and mosaicism, especially undergraduate and graduate students and medical doctors, as well as experts engaged in horticulture and animal breeding.
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Mammals --- Mosaicism. --- Genetics.
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In his 2006 State of the Union speech, President George W. Bush asked the U.S. Congress to prohibit the ""most egregious abuses of medical research,"" such as the ""creation of animal-human hybrids."" The president's message echoed that of a 2004 report by the President's Council on Bioethics, which recommended that hybrid human-animal embryos be banned by Congress.Discussions of early interspecies research, in which cells or DNA are interchanged between humans and nonhumans at early stages of development, can often devolve into sweeping statements, colorful imagery, and confusing policy. Alth
Mosaicism --- Transgenic animals --- Research --- Government policy
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Skin --- Mosaicism. --- Skin Neoplasms. --- Skin Diseases. --- Nevus. --- Diseases.
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Muscular Dystrophies --- DNA --- Mosaicism --- Prenatal Diagnosis --- genetics --- analysis
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Animal embryology and growth --- Chimera --- Mosaicism --- Chimères (génétique) --- Chimères (génétique) --- Chimera.
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Human reproduction --- Twins --- Parthenogenesis --- Mosaicism --- Mythology --- Reproduction humaine --- Jumeaux --- Parthénogenèse --- Chimères (génétique) --- Mythologie
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This second edition offers a fully revised and updated work on a rapidly growing field of knowledge, and was prepared by two experts whose goal was to explain the molecular basis of mosaic skin disorders in a language that is accessible for practicing physicians and medical students alike. It presents a timely and comprehensive overview of the strikingly manifold patterns and peculiarities of mosaic skin disorders in a straightforward, reader-friendly way that will help physicians to further improve genetic counseling and treatment outcomes. The first two parts of the book are devoted to the mechanisms and patterns of cutaneous mosaicism, and include an explanation of genomic and epigenetic mosaicism and a description of the archetypical segmental patterns including the lines of Blaschko and the flag-like, phylloid and lateralization pattern, the non-segmental pattern of large congenital melanocytic nevi, and the sash-like arrangement as noted in a particular type of cutis tricolor. The concept of lethal mutations surviving as mosaics has now been confirmed by molecular analysis in many sporadically occurring phenotypes. The difference between monoallelic and biallelic traits has deepened our understanding of hereditary mosaics, especially of multiple benign skin tumors. Moreover, recognition of the fundamental difference between the simple segmental and the superimposed types of mosaicism is important for the purpose of genetic counseling. In the third part, the various mosaic skin disorders are examined in depth, including nevi, didymotic disorders, other binary genodermatoses, mosaic manifestations of autosomal skin disorders, and nevoid skin disorders such as phenotypes reflecting functional X-chromosome mosaicism or a superimposed mosaic manifestation of common skin diseases with a polygenic background. Reader-friendly and clearly structured, Mosaicism in Human Skin will appeal to both experienced dermatologists and residents in training, as well as to medical geneticists and pediatricians. .
Paediatrics --- Human genetics --- Pathological dermatology --- Neuropathology --- Ophthalmology --- medische genetica --- hersenen --- dermatologie --- pediatrie --- oftalmologie --- Skin --- Mosaicism. --- Skin Neoplasms. --- Skin Diseases. --- Nevus. --- Diseases.
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'Females are Mosaics' focuses on the X chromosome as a key to female development and the role of X-related factors in the etiology of sex differences in human disease.
X chromosome. --- Mosaicism. --- Sex determination, Genetic. --- Sex-linkage (Genetics) --- Linkage (Genetics) --- Sex chromosomes --- Chromosomal sex determination --- Determination of sex, Genetic --- Genetic determination of sex --- Genotypic sex determination --- Sex --- Sex determination, Genetic --- Gene expression --- Sex determination --- Chromosomal mosaicism --- Chromosome mosaics --- Mosaics (Genetics) --- Mosaics, Chromosome --- Genetics --- Chromosome X --- Cause and determination --- X Chromosome Inactivation --- Genetic Diseases, X-Linked. --- Sex Factors. --- physiology. --- Genetic sex determination.
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