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This Special Issue explored different topics concerning recent progress in the synthesis and characterization of suitable innovative macromolecular systems, proposed as carriers of specific antimicrobial molecules, to be employed in the biomedical and pharmaceutical fields. Many infectious diseases are induced by omnipresent micro-organisms, including bacteria, viruses, protozoa, fungi, and algae, and, consequently, are very common, accounting for a significant share of the global disease burden. Unfortunately, antimicrobial resistance, adverse effects, and the high cost of antimicrobials are crucial health challenges worldwide. One of the common efforts in addressing this issue lies in improving the existing antimicrobial delivery systems. In this regard, nanoparticles as well as three-dimensional hydrophilic systems represent valuable tools able to ensure excellent performances. Biocompatible polymeric particles, entrapping these bioactive molecules, are capable of releasing them over a desired period of time, thereby decreasing the frequency of their administration. At the same time, these systems are able to protect antimicrobial drugs from degradation, enhancing their bioavailability. This Special Issue serves to highlight and capture the contemporary progress recorded in this field.

film nanocomposite --- essential oil --- supercritical CO2 --- long-term package --- hybrid nanoparticles --- biocompatible polymer --- antimicrobial amphiphiles --- dynamic light scattering --- scanning electron microscopy --- cell viability from counting of colony-forming unities --- antimicrobial activity of nanoparticles --- Escherichia coli --- Staphylococcus aureus --- Candida albicans --- hydrogel --- polyvinyl alcohol --- aliphatic dicarboxylic acids --- sustained release --- linezolid --- equilibrium swelling ratio --- accumulative release --- thermogravimetric analysis --- gram-negative bacteria --- multidrug resistance --- polymer therapeutics --- colistin --- polymyxin B --- nanoliposomes --- MDR-Bacteria --- chitosan --- nanotechnologies --- plant extracts --- agro-food-wastes --- antimicrobial agents --- polymeric nanocarriers --- mixed polymeric micelles --- drug delivery --- antibiotics --- Pluronic F127 --- antimicrobial agent --- polymeric nanomaterial --- self-assembly --- antimicrobial peptide --- silver nanoparticle --- anti-biofilm --- wound healing --- bromelain --- nisin --- bioactivity --- biomedicine --- carrier --- n/a

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Nanomedicine represents one of the most investigated areas in the last two decades in the field of pharmaceutics. Several nanovectors have been developed and a growing number of products have been approved. It is well known that many biomaterials are able to self-organize under controlled conditions giving rise nanostructures. Polymers, lipids, inorganic materials, peptides and proteins, and surfactants are examples of such biomaterials and the self-assembling property can be exploited to design nanovectors that are useful for drug delivery. The self-organization of nanostructures is an attractive approach to preparing nanovectors, avoiding complex and high-energy-consuming preparation methods, and, in some cases, facilitating drug loading procedures. Moreover, preparations based on these biocompatible and pharmaceutical grade biomaterials allow an easy transfer from the lab to the industrial scale. This book reports ten different works, and a review, aiming to cover multiple strategies and pharmaceutical applications in the field of self-organizing nanovectors for drug delivery.

chitosan --- encapsulation --- gold nanoparticles --- pH/redox-responsive --- bolaform amphiphilic lipids --- irradiation cycles --- drug delivery --- caries prevention --- bolalipids --- nanocage --- natural extracts --- astaxanthin --- eukaryotic vaults --- nanoparticles --- amphiphilic random copolymers --- zoledronic acid --- triggered release --- nanohydrogels --- doxorubicin --- vapor nanobubbles --- curcumin --- gold reduction --- diffusion barrier --- liposomes --- hyaluronan --- laser treatment --- nanoparticle --- mixed polymeric micelles --- protein self-assembly --- squalene --- antimicrobial photodynamic therapy --- self-assembly --- hydrogel --- C-peptide --- polyelectrolyte complexes --- siRNA delivery --- drug delivery system --- biofilms --- pulmonary surfactant --- multidrug resistance --- drug delivery systems --- nano-assemblies --- photo-thermal therapy --- anticancer --- polypeptides --- graphene quantum dots --- nanovesicles --- aerogel --- resveratrol --- intracellular therapy --- Oral antimicrobials --- syringeable implant --- trehalose --- betulinic acid --- in situ gelling systems --- autophagy induction --- chorioallantoic membrane model --- controlled release --- diabetes --- oxidative stress --- localized heating effect