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Reflecting significant advances in microtubule research during the past decade, a prominent group of contributors present reviews dealing with three central topics--the biochemistry and assembly of tubulin dimer; associated proteins and regulation of microtubule function; and microtubule organization and function in the cell.
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reviews. The SAR data are discussed in light of the structural information available for each agent. The second chapter focuses on the total synthesis of the marine sponge-derived polyketide discodermolide. A comprehensive survey of the synthetic chemistry efforts of several groups over a 14-year period is provided together with a compa- son of the different approaches. The third chapter describes a comprehensive study of the mechanisms of activity of microtubules stabilizing drugs. Thermodynamic, kinetic, structural and fu- tional data on microtubules stabilizing drugs are discussed in an interdisciplinary manner to generate a time-resolved picture of the interaction of the drugs with different tubulin forms. The fourth and fifth chapters review the efforts and achievements made in the characterization of the structure of the complexes of tubulin with microtubules stabilizing agents by NMR (Chapter 4) and EM (Chapter 5). Especially evident is the discrepancy of the results obtained for epothilones, where the two techniques deliver radically different structures of the bound drug. Both NMR and EM models are, however, able to explain a consistent set of SAR data. The authors of the two chapters discuss critically the advantages and limitations of each methodology.
Tubulins --- Stabilizing agents --- Microtubules
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"This book brings together current information on the families that make up the kinesin superfamily of molecular motors in one comprehensive text; an ideal reference for researchers looking to make comparisons between different families, for specific information on a family, or simply for an overview of the kinesin superfamily. Information is clearly structured and grouped according to individual families and organized in a standardized way, allowing the reader to search and retrieve information on this large superfamily of molecular motors and understand how its individual members carry out a diverse variety of cellular functions. Features: The first book dedicated to the entire kinesin superfamily Enables a fuller understanding of this family of proteins which is becoming an increasing focus of research due to its involvement in diseases such as cancer, neuropathies and ciliopathies. Written in a manner accessible to a range of researchers in the life and medical sciences, including biophysicists, biochemists, and medical researchers"--
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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
Alzheimer --- dementia --- microtubules --- neurodegeneration --- tau --- tauopathies
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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
Science: general issues --- Neurosciences --- Alzheimer --- dementia --- microtubules --- neurodegeneration --- tau --- tauopathies --- Alzheimer --- dementia --- microtubules --- neurodegeneration --- tau --- tauopathies
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Histology. Cytology --- Microtubules --- Microtubules. --- PATHOLOGY --- EVOLUTION --- MECHANISMS --- MITOSIS --- TRANSPORT PROPERTIES --- AXONES --- SECRETION --- MOTION --- SHAPES --- CELLS --- TOXIC SUBSTANCES --- PHYSIOLOGY --- ASSEMBLING --- BIOSYNTHESIS --- COMPOSITION --- STRUCTURES --- MICROTUBULES --- COMPONENTS
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Cytoskeletal proteins. --- Dynein. --- Adenosine triphosphatase --- Microtubules --- Structural proteins --- Proteins
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