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This Special Issue presents studies on the genotoxicity of nanomaterials. Although nanomaterials provide multiple benefits in a wide range of applications, challenges remain in addressing strong concerns about their risks to the environment and human health. As a result of inconsistencies among published results and diverging conclusions, the understanding of nanomaterial exposure and toxicity remains unclear. Determining whether these materials cause DNA damage—the first step in carcinogenesis—must be a priority in testing. In this book, readers will find recent publications on the genotoxic response to a broad range of nanomaterials, the impact of physico-chemical characteristics, safe-by-design and new developed tools.

Humanities --- Social interaction --- graphene oxide --- reduced graphene oxide --- micronucleus --- oxidative stress --- safer-by-design --- tungsten --- nanoparticles --- tritiated particles --- in vitro testing --- cytotoxicity --- micronuclei formation --- DNA damage --- epigenetics --- DNA methylation --- BEAS-2B cells. --- polystyrene nanoparticles --- nanoplastics --- genotoxicity --- Hs27 human fibroblasts --- comet assay --- FPG enzyme --- TiO2NP --- SiO2NP --- ZnONP --- CeO2NP --- AgNP --- multi-walled carbon nanotubes (MWCNT) --- titanium dioxide nanoparticles --- lincomycin --- human amniotic cells --- in vitro genotoxicity --- apoptosis --- nanotoxicology --- metal oxides --- high throughput screening --- micronucleus assay --- nanomaterial --- aluminum --- oral route --- gut --- liver --- V79 cells --- Hprt --- advanced in vitro model --- hepatotoxicity --- liver spheroids --- 3D culture --- HepG2 --- nongenotoxic silver nanoparticles --- genotoxic --- cytotoxic --- antioxidant activity --- silver ions --- Allium cepa --- metal/coating agent ratio --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This Special Issue presents studies on the genotoxicity of nanomaterials. Although nanomaterials provide multiple benefits in a wide range of applications, challenges remain in addressing strong concerns about their risks to the environment and human health. As a result of inconsistencies among published results and diverging conclusions, the understanding of nanomaterial exposure and toxicity remains unclear. Determining whether these materials cause DNA damage—the first step in carcinogenesis—must be a priority in testing. In this book, readers will find recent publications on the genotoxic response to a broad range of nanomaterials, the impact of physico-chemical characteristics, safe-by-design and new developed tools.

Humanities --- Social interaction --- graphene oxide --- reduced graphene oxide --- micronucleus --- oxidative stress --- safer-by-design --- tungsten --- nanoparticles --- tritiated particles --- in vitro testing --- cytotoxicity --- micronuclei formation --- DNA damage --- epigenetics --- DNA methylation --- BEAS-2B cells. --- polystyrene nanoparticles --- nanoplastics --- genotoxicity --- Hs27 human fibroblasts --- comet assay --- FPG enzyme --- TiO2NP --- SiO2NP --- ZnONP --- CeO2NP --- AgNP --- multi-walled carbon nanotubes (MWCNT) --- titanium dioxide nanoparticles --- lincomycin --- human amniotic cells --- in vitro genotoxicity --- apoptosis --- nanotoxicology --- metal oxides --- high throughput screening --- micronucleus assay --- nanomaterial --- aluminum --- oral route --- gut --- liver --- V79 cells --- Hprt --- advanced in vitro model --- hepatotoxicity --- liver spheroids --- 3D culture --- HepG2 --- nongenotoxic silver nanoparticles --- genotoxic --- cytotoxic --- antioxidant activity --- silver ions --- Allium cepa --- metal/coating agent ratio --- graphene oxide --- reduced graphene oxide --- micronucleus --- oxidative stress --- safer-by-design --- tungsten --- nanoparticles --- tritiated particles --- in vitro testing --- cytotoxicity --- micronuclei formation --- DNA damage --- epigenetics --- DNA methylation --- BEAS-2B cells. --- polystyrene nanoparticles --- nanoplastics --- genotoxicity --- Hs27 human fibroblasts --- comet assay --- FPG enzyme --- TiO2NP --- SiO2NP --- ZnONP --- CeO2NP --- AgNP --- multi-walled carbon nanotubes (MWCNT) --- titanium dioxide nanoparticles --- lincomycin --- human amniotic cells --- in vitro genotoxicity --- apoptosis --- nanotoxicology --- metal oxides --- high throughput screening --- micronucleus assay --- nanomaterial --- aluminum --- oral route --- gut --- liver --- V79 cells --- Hprt --- advanced in vitro model --- hepatotoxicity --- liver spheroids --- 3D culture --- HepG2 --- nongenotoxic silver nanoparticles --- genotoxic --- cytotoxic --- antioxidant activity --- silver ions --- Allium cepa --- metal/coating agent ratio

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Personalised medicine is the next step in healthcare, especially when applied to genetically diverse diseases such as cancers. Naturally, a host of methods need to evolve alongside this, in order to allow the practice and implementation of individual treatment regimens. One of the major tasks for the development of personalised treatment of cancer is the identification and validation of a comprehensive, robust, and reliable panel of biomarkers that guide the clinicians to provide the best treatment to patients. This is indeed important with regards to radiotherapy; not only do biomarkers allow for the assessment of treatability, tumour response, and the radiosensitivity of healthy tissue of the treated patient. Furthermore, biomarkers should allow for the evaluation of the risks of developing adverse late effects as a result of radiotherapy such as second cancers and non-cancer effects, for example cardiovascular injury and cataract formation. Knowledge of all of these factors would allow for the development of a tailored radiation therapy regime. This Special Issue of the Journal of Personalised Medicine covers the topic of Radiation Response Biomarkers in the context of individualised cancer treatments, and offers an insight into some of the further evolution of radiation response biomarkers, their usefulness in guiding clinicians, and their application in radiation therapy.

carbon-ion radiotherapy --- head-and-neck tumors --- squamous cell carcinoma --- radiosensitivity --- relative biological effectiveness --- lung cancer --- radiotherapy --- radiotherapy monitoring --- radiation-induced lung injury --- RILI --- pneumonitis --- radiation-induced lung fibrosis --- RILF --- circulating biomarkers --- microRNA --- micronuclei --- uterine cervical cancer --- cGAS --- STING --- abscopal effect --- immunotherapy --- PBMCS --- micronucleus assay --- biological dosimetry --- human blood --- genotoxicity tests --- ionizing radiation --- biomarkers --- dicentric assay --- gamma H2AX foci assay --- health surveillance analyses --- clonogenic assays --- methods --- plating --- cancer --- radiation --- head and neck cancer --- exosomes --- serum --- metabolomics --- GC/MS --- biodosimetry --- chromosome aberrations --- normal tissue toxicity --- predictive tests --- normal tissue --- biomarker --- protein --- immune infiltrate --- stroma --- tumour microenvironment --- proteomics --- telomeres --- chromosomal instability --- inversions --- prostate cancer --- IMRT --- machine learning --- individual radiosensitivity --- late effects --- personalized medicine --- liquid biopsy --- circulating tumour cells --- extracellular vesicles --- microRNAs --- immune system --- inflammation --- n/a