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L’objectif de ce travail est l’étude de l’effet de l’organisation des pores dans des gels de silice synthétisés via le procédé sol-gel sur l’encapsulation et le relargage de biomolécules. Trois différents objectifs ont été envisagés via trois séries de synthèses de gels de silice : •Tester la reproductibilité d’une installation de quatre réacteurs hydrothermaux •Voir les effets de différents précurseurs de silice sur l’organisation des pores •Analyser l’influence de la quantité et le temps d’addition de l’expanseur micellaire Trois des quatre réacteurs hydrothermaux présentent une reproductibilité adéquate. Les trois échantillons de silice synthétisés à partir de précurseurs différents présentent trois morphologies différentes avec des pores désorganisés. Le temps d’addition de l’expanseur micellaire a une influence sur l’organisation des pores. Les gels de silice ont été caractérisés par analyses FTIR, adsorption-désorption d’azote, analyses thermogravimétriques (TGA) et par microscopie électronique à transmission (TEM). L’ibuprofen a été choisi comme biomolécule modèle pour l’encapsulation dans les gels de silice et le relargage. Il a été encapsulé dans trois différents échantillons pour pouvoir analyser les effets du précurseur de silice sur la cinétique de relargage. En comparant avec la littérature, une faible quantité d’ibuprofen a pu être encapsulée. L’ibuprofen présente un relargage très rapide (burst) la première heure et est totalement relargué après 19 heures. Pour la création de films de silice, deux différentes stratégies ont été utilisées : •Films de silice via dip coating •Dispersion dans trois différents polymères De très fins films ont été obtenus avec la première technique tandis que des gels avec une épaisseur plus importante ont été obtenus avec la deuxième stratégie. L’épaisseur des films a été estimée via une différence de poids pour les films réalisés par dip coating, et avec un micromètre électronique pour les films silice-polymère Nos résultats très prometteurs aident à ouvrir des nouvelles perspectives dans le domaine des biomatériaux, et plus spécifiquement dans le domaine de la biofonctionnalisation des matrices pour la reconstruction osseuse.
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Mesoporous materials are capturing great interest thanks to their exceptional surface area, uniform and tunable pore size, ease surface functionalization, thus enabling broad series of intervention in the field of nanomedicine. Since many years, these aspects foster a deep investigation on mesoporous nanoparticles, to design and fabricate biocompatible, smart and stimuli-responsive nanotools for controlled drug- or gene-delivery, theranostics applications, in particular for cancer therapy, and tissue engineering. This Book is thus dedicated to the most recent advances in the field, collecting research papers and reviews. It spans from the synthesis and characterization of the mesoporous material, especially those made of silica, silicon and bioactive glasses, to their functionalization with smart gate-keepers, reporter molecules or targeting ligands, up to their in-vitro applications in the nanomedicine field.
polyurethane --- injectable hydrogels --- ion/drug delivery --- mesoporous bioactive glasses --- tissue regeneration --- mesoporous silica --- therapeutic biomolecules --- proteins --- peptides --- nucleic acids --- glycans --- nanoporous silicon --- gold nanoparticles --- drug delivery --- cancer cells --- theranostics --- mesoporous silica nanoparticles --- core-shell --- surface functionalization --- cell targeting --- size-dependent delivery --- antitumoral microRNA (miRNA) --- confocal microscopy --- tumor targeting --- stimuli responsive --- multimodal decorations --- targeted and controlled cargo release --- cancer therapy and diagnosis --- alginate–poloxamer copolymer --- silk fibroin --- dual network hydrogel --- mesoporous bioactive glass --- insulin-like growth factor-1 --- electrostatic gating --- nanofluidic diffusion --- controlled drug release --- silicon membrane --- smart drug delivery --- three-dimensional porous scaffolds --- electron beam melting --- selective laser sintering --- stereolithography --- electrospinning --- two-photon polymerization --- osteogenesis --- antibiotics --- anti-inflammatory --- n/a --- alginate-poloxamer copolymer
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This Book presents original research articles published in the Special Issue entitled “Green Nanotechnology: The Latest Innovations, Knowledge Gaps, and Future Perspectives”. It proposes pioneering and innovative applications, products, technologies, and processes in several green nanotechnology-related fields (e.g., drug delivery systems, antifouling nanoadditives, and coatings for optical applications), as well as identifying some knowledge gaps on this domain. Research on the sustainable production of nanomaterials based on safe-by-design approaches and (eco)toxicological assessments of novel nanomaterials is also provided. Future perspectives are also highlighted in the Editorial and across the original articles.
Technology: general issues --- carvacrol --- stearic acid --- beeswax --- carnauba wax --- nanostructured lipid carriers --- crystallinity --- cationic surfactants --- microemulsion --- mesoporous silica --- encapsulation --- ecotoxicity --- Perna perna --- biofouling --- nanotechnology --- toxicity --- silver nanoparticles --- gemini surfactant --- green synthesis --- black nickel coatings --- electrochemical testing --- electrodeposition --- hull cell --- nanostructured coatings --- green nanotechnology --- green chemistry --- safe-by-design --- sustainability --- nanomaterials --- nanoparticles --- nanoecotoxicology --- environmental risk assessment --- carvacrol --- stearic acid --- beeswax --- carnauba wax --- nanostructured lipid carriers --- crystallinity --- cationic surfactants --- microemulsion --- mesoporous silica --- encapsulation --- ecotoxicity --- Perna perna --- biofouling --- nanotechnology --- toxicity --- silver nanoparticles --- gemini surfactant --- green synthesis --- black nickel coatings --- electrochemical testing --- electrodeposition --- hull cell --- nanostructured coatings --- green nanotechnology --- green chemistry --- safe-by-design --- sustainability --- nanomaterials --- nanoparticles --- nanoecotoxicology --- environmental risk assessment
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This Book presents original research articles published in the Special Issue entitled “Green Nanotechnology: The Latest Innovations, Knowledge Gaps, and Future Perspectives”. It proposes pioneering and innovative applications, products, technologies, and processes in several green nanotechnology-related fields (e.g., drug delivery systems, antifouling nanoadditives, and coatings for optical applications), as well as identifying some knowledge gaps on this domain. Research on the sustainable production of nanomaterials based on safe-by-design approaches and (eco)toxicological assessments of novel nanomaterials is also provided. Future perspectives are also highlighted in the Editorial and across the original articles.
Technology: general issues --- carvacrol --- stearic acid --- beeswax --- carnauba wax --- nanostructured lipid carriers --- crystallinity --- cationic surfactants --- microemulsion --- mesoporous silica --- encapsulation --- ecotoxicity --- Perna perna --- biofouling --- nanotechnology --- toxicity --- silver nanoparticles --- gemini surfactant --- green synthesis --- black nickel coatings --- electrochemical testing --- electrodeposition --- hull cell --- nanostructured coatings --- green nanotechnology --- green chemistry --- safe-by-design --- sustainability --- nanomaterials --- nanoparticles --- nanoecotoxicology --- environmental risk assessment
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This Book presents original research articles published in the Special Issue entitled “Green Nanotechnology: The Latest Innovations, Knowledge Gaps, and Future Perspectives”. It proposes pioneering and innovative applications, products, technologies, and processes in several green nanotechnology-related fields (e.g., drug delivery systems, antifouling nanoadditives, and coatings for optical applications), as well as identifying some knowledge gaps on this domain. Research on the sustainable production of nanomaterials based on safe-by-design approaches and (eco)toxicological assessments of novel nanomaterials is also provided. Future perspectives are also highlighted in the Editorial and across the original articles.
carvacrol --- stearic acid --- beeswax --- carnauba wax --- nanostructured lipid carriers --- crystallinity --- cationic surfactants --- microemulsion --- mesoporous silica --- encapsulation --- ecotoxicity --- Perna perna --- biofouling --- nanotechnology --- toxicity --- silver nanoparticles --- gemini surfactant --- green synthesis --- black nickel coatings --- electrochemical testing --- electrodeposition --- hull cell --- nanostructured coatings --- green nanotechnology --- green chemistry --- safe-by-design --- sustainability --- nanomaterials --- nanoparticles --- nanoecotoxicology --- environmental risk assessment
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Mesoporous materials are capturing great interest thanks to their exceptional surface area, uniform and tunable pore size, ease surface functionalization, thus enabling broad series of intervention in the field of nanomedicine. Since many years, these aspects foster a deep investigation on mesoporous nanoparticles, to design and fabricate biocompatible, smart and stimuli-responsive nanotools for controlled drug- or gene-delivery, theranostics applications, in particular for cancer therapy, and tissue engineering. This Book is thus dedicated to the most recent advances in the field, collecting research papers and reviews. It spans from the synthesis and characterization of the mesoporous material, especially those made of silica, silicon and bioactive glasses, to their functionalization with smart gate-keepers, reporter molecules or targeting ligands, up to their in-vitro applications in the nanomedicine field.
Technology: general issues --- polyurethane --- injectable hydrogels --- ion/drug delivery --- mesoporous bioactive glasses --- tissue regeneration --- mesoporous silica --- therapeutic biomolecules --- proteins --- peptides --- nucleic acids --- glycans --- nanoporous silicon --- gold nanoparticles --- drug delivery --- cancer cells --- theranostics --- mesoporous silica nanoparticles --- core-shell --- surface functionalization --- cell targeting --- size-dependent delivery --- antitumoral microRNA (miRNA) --- confocal microscopy --- tumor targeting --- stimuli responsive --- multimodal decorations --- targeted and controlled cargo release --- cancer therapy and diagnosis --- alginate-poloxamer copolymer --- silk fibroin --- dual network hydrogel --- mesoporous bioactive glass --- insulin-like growth factor-1 --- electrostatic gating --- nanofluidic diffusion --- controlled drug release --- silicon membrane --- smart drug delivery --- three-dimensional porous scaffolds --- electron beam melting --- selective laser sintering --- stereolithography --- electrospinning --- two-photon polymerization --- osteogenesis --- antibiotics --- anti-inflammatory --- polyurethane --- injectable hydrogels --- ion/drug delivery --- mesoporous bioactive glasses --- tissue regeneration --- mesoporous silica --- therapeutic biomolecules --- proteins --- peptides --- nucleic acids --- glycans --- nanoporous silicon --- gold nanoparticles --- drug delivery --- cancer cells --- theranostics --- mesoporous silica nanoparticles --- core-shell --- surface functionalization --- cell targeting --- size-dependent delivery --- antitumoral microRNA (miRNA) --- confocal microscopy --- tumor targeting --- stimuli responsive --- multimodal decorations --- targeted and controlled cargo release --- cancer therapy and diagnosis --- alginate-poloxamer copolymer --- silk fibroin --- dual network hydrogel --- mesoporous bioactive glass --- insulin-like growth factor-1 --- electrostatic gating --- nanofluidic diffusion --- controlled drug release --- silicon membrane --- smart drug delivery --- three-dimensional porous scaffolds --- electron beam melting --- selective laser sintering --- stereolithography --- electrospinning --- two-photon polymerization --- osteogenesis --- antibiotics --- anti-inflammatory
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Mesoporous materials are capturing great interest thanks to their exceptional surface area, uniform and tunable pore size, ease surface functionalization, thus enabling broad series of intervention in the field of nanomedicine. Since many years, these aspects foster a deep investigation on mesoporous nanoparticles, to design and fabricate biocompatible, smart and stimuli-responsive nanotools for controlled drug- or gene-delivery, theranostics applications, in particular for cancer therapy, and tissue engineering. This Book is thus dedicated to the most recent advances in the field, collecting research papers and reviews. It spans from the synthesis and characterization of the mesoporous material, especially those made of silica, silicon and bioactive glasses, to their functionalization with smart gate-keepers, reporter molecules or targeting ligands, up to their in-vitro applications in the nanomedicine field.
Technology: general issues --- polyurethane --- injectable hydrogels --- ion/drug delivery --- mesoporous bioactive glasses --- tissue regeneration --- mesoporous silica --- therapeutic biomolecules --- proteins --- peptides --- nucleic acids --- glycans --- nanoporous silicon --- gold nanoparticles --- drug delivery --- cancer cells --- theranostics --- mesoporous silica nanoparticles --- core-shell --- surface functionalization --- cell targeting --- size-dependent delivery --- antitumoral microRNA (miRNA) --- confocal microscopy --- tumor targeting --- stimuli responsive --- multimodal decorations --- targeted and controlled cargo release --- cancer therapy and diagnosis --- alginate–poloxamer copolymer --- silk fibroin --- dual network hydrogel --- mesoporous bioactive glass --- insulin-like growth factor-1 --- electrostatic gating --- nanofluidic diffusion --- controlled drug release --- silicon membrane --- smart drug delivery --- three-dimensional porous scaffolds --- electron beam melting --- selective laser sintering --- stereolithography --- electrospinning --- two-photon polymerization --- osteogenesis --- antibiotics --- anti-inflammatory --- n/a --- alginate-poloxamer copolymer
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With pore sizes up to 100 nm, the term "nanoporous" covers a wide range of material classes. A broad field of applications has arisen from the diversity of unique structures and properties of nanoporous materials. Recent research spans the range from fundamental studies of the behavior of atoms and molecules in confined space, creative synthetic pathways for novel materials, to applications in high-performance technologies. This Special Issue collects current studies about the progress in the development, characterization, and application of nanoporous materials, including (but not restricted to) mesoporous silica, carbon and metal oxides, porous coordination polymers, metal organic frameworks (MOFs), and covalent organic frameworks (COFs), as well as materials exhibiting hierarchical porosity. Their functionalities show promise for fields such as energy storage/conversion (e.g., photocatalysis and battery electrodes), sensing, catalysis, and their sorption properties for N2, CO2, NOx, or H2O, to name just a few.
History of engineering & technology --- mesoporous silica --- organocatalysis --- host-guest materials --- magic-angle spinning NMR (MAS-NMR) --- nanoporous metal foam --- nanoshell --- buckling --- free vibration --- strain gradient theory --- first-order shear deformation theory --- SERS --- near-infrared --- crystal silicon photoluminescence --- porous silicon photonic crystals --- hot-spots --- mesoporous films --- direct growth --- esterification --- material formation --- porous organic polymers --- amine modification --- CO2 separation --- adsorption mechanism --- chemisorption of CO2 --- Birnessite --- nanoporous metal oxides --- impedance spectroscopy --- perovskite solar cell --- electron selective layer --- pinhole --- mesoporous TiO2 --- evaporation-induced self-assembly --- dip coating --- mesoporous silica --- organocatalysis --- host-guest materials --- magic-angle spinning NMR (MAS-NMR) --- nanoporous metal foam --- nanoshell --- buckling --- free vibration --- strain gradient theory --- first-order shear deformation theory --- SERS --- near-infrared --- crystal silicon photoluminescence --- porous silicon photonic crystals --- hot-spots --- mesoporous films --- direct growth --- esterification --- material formation --- porous organic polymers --- amine modification --- CO2 separation --- adsorption mechanism --- chemisorption of CO2 --- Birnessite --- nanoporous metal oxides --- impedance spectroscopy --- perovskite solar cell --- electron selective layer --- pinhole --- mesoporous TiO2 --- evaporation-induced self-assembly --- dip coating
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Nanovesicles are highly-promising systems for the delivery and/or targeting of drugs, biomolecules and contrast agents. Despite the fact that initial studies in this area were performed on phospholipid vesicles, there is an ever-increasing interest in the use of other molecules to obtain smart vesicular carriers focusing on strategies for targeted delivery. These systems can be obtained using newly synthesized smart molecules, or by intelligent design of opportune carriers to achieve specific delivery to the site of action.
n/a --- protein corona --- buspirone --- drug delivery --- Plectranthus ecklonii --- antiproliferative activity --- pancreatic ductal adenocarcinoma --- tetraethyl orthosilicate --- cancer therapy --- nanoparticles --- cationic liposomes --- Ibuprofen --- SBA-15 --- gastrointestinal stability --- mesoporous silica nanoparticles --- Parvifloron D --- anti-tumor drugs --- liposomes --- gingiva mesenchymal stromal cells --- soy lecithin liposomes --- MCM-41 --- lipophilic compound --- multifunctional liposomes --- caryophyllene sesquiterpene --- drug loading --- lamellarity --- hCMEC/D3 cells --- gold shell --- magnetic/plasmonic nanoparticles --- pH-sensitive niosomes --- hot flushes --- nasal delivery system --- andrographolide --- brain delivery --- pancreatic cancer --- Pain --- exosomes --- NSAIDs --- freeze-drying --- manganese ferrite --- surfactant --- cytotoxicity --- paclitaxel --- ovariectomized rat --- PAMPA --- uptake and safety --- nanovesicular nasal carrier --- Stober’s synthesis --- Analgesia --- protocells --- nanocochleates --- squamous cell carcinoma --- Stober's synthesis
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This book is a special collection of articles dedicated to the preparation and characterization of nanoporous materials, such as zeolitic-type materials, mesoporous silica (SBA-15, MCM-41, and KIT-6), mesoporous metallic oxides, metal–organic framework structures (MOFs), and pillared clays, and their applications in adsorption, catalysis, and separation processes. This book presents a global vision of researchers from international universities, research centers, and industries working with nanoporous materials and shares the latest results on the synthesis and characterization of such materials, which have given rise to the special interest in their applications in basic and industrial processes.
n/a --- porous silicon --- ?-zeolite --- 4-trimethylimidazolium --- silica pillared clays --- oligomerization --- hydrofluoric media --- KIT-6 --- glass --- adsorption --- synthesis parameters --- seeds --- MCM-41 --- swelling --- liquid-gas interaction --- confined environment --- ionic liquid --- aluminosilicate --- self-focusing --- zeolite --- 3 --- niobium oxyhydroxide catalysts --- kaolin --- pillaring --- surface properties --- lamellar zeolite --- antibiotics adsorption --- diffusion --- TPA --- ?-diimine --- STW zeolite --- ethanol dehydration --- paraffins --- mesoporous silica --- metal organic framework --- epoxidation --- zeolites --- layered zeolite --- liquid outflow --- Z-scan --- heterogenized --- cationic dye adsorption --- 2-ethyl-1 --- third-order nonlinearity --- gas amount --- surfactant --- nickel --- cyclohexene --- zeolite A --- mesopores --- IGC --- cubic structure --- two-dimensional zeolites --- delaminating --- MWW --- copper removal --- MCM-22 --- hierarchical zeolite --- reaction mechanism --- metakaolin --- liquid/nanoporous material system --- degassing pretreatment
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