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This book brings together a collection of empirical case studies featuring a wide spectrum of medical innovation. While there is no unique pathway to successful medical innovation, recurring and distinctive features can be observed across different areas of clinical practice. This book examines why medical practice develops so unevenly across and within areas of disease, and how this relates to the underlying conditions of innovation across areas of practice. The contributions contained in this volume adopt a dynamic perspective on medical innovation based on the notion that scientific understanding, technology and clinical practice co-evolve along the co-ordinated search for solutions to medical problems. The chapters follow an historical approach to emphasise that the advancement of medical know-how is a contested, nuanced process, and that it involves a variety of knowledge bases whose evolutionary paths are rooted in the contexts in which they emerge. This book will be of interest to researchers and practitioners concerned with medical innovation, management studies and the economics of innovation. Chapter 5 of this book is freely available as a downloadable Open Access PDF at www.tandfebooks.com/openaccess. It has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 3.0 license.
Medical innovations. --- Medical innovations --- Innovations, Medical --- Medicine --- Medical technology --- Technological innovations --- History. --- Innovations --- clinical practice --- empirical case studies --- medical innovation
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Medical innovations --- Medicine --- Medical innovations. --- Research --- Research. --- Biomedical research --- Medical research --- Innovations, Medical --- Medical technology --- Technological innovations --- Health Workforce --- Innovations --- Medical Technology --- medical innovation --- healthcare technology --- therapeutic discovery --- clinical innovation
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"Great innovations take place within great institutions. Founded in 1819, Toronto General Hospital (TGH) is one of Canada's oldest hospitals and has created a nurturing environment for early Canadian innovations in heart surgery. The Heartbeat of Innovation tells the story of the brilliant surgeons who worked there and the hospital environment that provided an incubator to the many people--skilled perfusionists, dedicated nurses, and pioneering cardiologists--who participated in the revolution in heart surgery that took place along University Avenue in Toronto. Supported by historical records, hospital archives, personal memoirs, and interviews, this book is an extensive and descriptive account of the seemingly inexorable development of cardiac surgery at this leading academic health science centre. It pursues several themes: the complexity of this surgical specialty, its generally male-dominated nature, the trend to teamwork in practice, and the evolution and incorporation of original research into this branch of healthcare. These strands are woven together to demonstrate how the TGH has evolved into such a dominant leader in the competitive and demanding field of cardiac surgery. Canadian hearts may beat with pride at the knowledge that one of the major stories in modern medicine took place here--and continues here."--
Heart --- Surgery --- History. --- Toronto General Hospital. --- Toronto General Hospital --- Ontario --- Canadian medical history. --- Dr. Gordon Murray. --- Dr. Tirone David. --- Dr. Wilfred G. Bigelow. --- Toronto hospitals. --- cardiology. --- heart surgery. --- history of cardiac surgery. --- medical innovation.
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Biomedical Engineering. --- Biomedical Technology. --- Biomedical Technologies --- Technology, Biomedical --- Technology, Health --- Technology, Health Care --- Health Care Technology --- Health Technology --- Biomedical Engineering --- Medical Informatics --- Engineering, Biomedical --- Clinical Engineering --- Engineering, Clinical --- Biomedical Technology --- biomedical engineering --- medical devices --- medical innovation --- Biomedical engineering --- Biomedical engineering. --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine
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Medical care. --- Medical innovation. --- Obsessive-compulsive disorder. --- Cerebrovascular accident. --- Endometriosis. --- Apoplexy --- Brain --- Cerebral circulation disorders --- Cerebral vascular accident --- Cerebrovascular accident --- Cerebrovascular disorders --- Cerebrovascular syndrome --- CVA (Disease) --- Stroke --- Neglect (Neurology) --- Compulsive disorder --- Fixed ideas --- Obsession (Psychology) --- Obsessive-compulsive neuroses --- Obsessive-compulsive neurosis --- OCD (Disease) --- Neuroses --- Compulsive behavior --- Delivery of health care --- Delivery of medical care --- Health care --- Health care delivery --- Health services --- Healthcare --- Medical and health care industry --- Medical services --- Personal health services --- Public health --- Adenomyosis --- Endometrium --- Generative organs, Female --- Pelvis --- Blood-vessels --- Diseases
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As it is a goal to eliminate human African trypanosomiasis (HAT; sleeping sickness) as a public health problem by 2020 and interrupt transmission by 2030, this is a good moment to reflect on what we have achieved, what we want to achieve, and what could get in our way. HAT has a reputation for spectacular reappearances, and the latest peak of 40,000 reported and over 300,000 estimated cases only dates back to 1998. Efforts of the WHO and partners as well as the development of simpler and much better-tolerated treatments, improved diagnostics, and vector control tools made it possible to reduce this number by 95%. Case identification and confirmation remain complex and require specific skills, treatment remains error-prone and reports on long-term survivors have emerged, and the relevance of the animal reservoir for T. b. gambiense HAT needs clarification. In addition, to win the “end game” against this massively stigmatized disease, the human factor will play a key role. This Special Issue addresses many of the burning topics about disease elimination in its 12 research and 7 review articles and one case study. The papers critically reflect the approaches used, investigate the mentioned challenges, and propose novel approaches and interventions from various points of view.
Medicine --- Epidemiology & medical statistics --- (+)-spectaline --- iso-6-spectaline --- Trypanosoma brucei rhodesiense --- autophagy --- apoptosis --- cross-talk --- trypanosomosis --- iron --- transferrin --- transferrin receptor --- nutritional immunity --- flagellar pocket --- Human African Trypanosomiasis (HAT) --- mydriasis --- neurological signs --- eradication --- re-emergence --- human African trypanosomiasis --- treatment --- melarsoprol --- adverse event --- encephalopathy --- human leukocyte antigen --- association study --- disease elimination --- disease eradication --- frontline workers --- DR Congo --- mobile screening --- qualitative methods --- sequelae --- serology --- oligosymptomatic HAT --- product development partnerships --- research and development --- medical innovation --- donor policy --- African trypanosomiasis --- sleeping sickness --- trypanosoma brucei --- drugs --- drug resistance --- history --- human Africa trypanosomiasis --- fexinidazole --- home-based treatment --- patient-centred care --- Uganda --- elimination --- T. b. gambiense --- g-HAT --- T. b. rhodesiense --- r-HAT --- neglected tropical diseases --- Trypanosoma brucei --- drug discovery --- high-throughput screening --- blood-brain barrier --- brain permeability --- pharmacology --- phenotypic drug screening --- Haemoparasites --- animal reservoirs --- Trypanosoma growth inhibitors --- chemotherapy --- pafuramidine --- acoziborole --- African sleeping sickness --- development of treatment --- suramin --- medical history --- political history --- clinical research --- health system strengthening --- South Sudan --- diagnosis --- symptoms --- treatment-seeking --- case detection --- embodiment --- expertise --- serendipity --- CATT positive serological suspects --- active follow-up strategy --- (+)-spectaline --- iso-6-spectaline --- Trypanosoma brucei rhodesiense --- autophagy --- apoptosis --- cross-talk --- trypanosomosis --- iron --- transferrin --- transferrin receptor --- nutritional immunity --- flagellar pocket --- Human African Trypanosomiasis (HAT) --- mydriasis --- neurological signs --- eradication --- re-emergence --- human African trypanosomiasis --- treatment --- melarsoprol --- adverse event --- encephalopathy --- human leukocyte antigen --- association study --- disease elimination --- disease eradication --- frontline workers --- DR Congo --- mobile screening --- qualitative methods --- sequelae --- serology --- oligosymptomatic HAT --- product development partnerships --- research and development --- medical innovation --- donor policy --- African trypanosomiasis --- sleeping sickness --- trypanosoma brucei --- drugs --- drug resistance --- history --- human Africa trypanosomiasis --- fexinidazole --- home-based treatment --- patient-centred care --- Uganda --- elimination --- T. b. gambiense --- g-HAT --- T. b. rhodesiense --- r-HAT --- neglected tropical diseases --- Trypanosoma brucei --- drug discovery --- high-throughput screening --- blood-brain barrier --- brain permeability --- pharmacology --- phenotypic drug screening --- Haemoparasites --- animal reservoirs --- Trypanosoma growth inhibitors --- chemotherapy --- pafuramidine --- acoziborole --- African sleeping sickness --- development of treatment --- suramin --- medical history --- political history --- clinical research --- health system strengthening --- South Sudan --- diagnosis --- symptoms --- treatment-seeking --- case detection --- embodiment --- expertise --- serendipity --- CATT positive serological suspects --- active follow-up strategy
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Innovation in medical technology generates a remarkable supply of new drugs, devices, and diagnostics that improve health, reduce risks, and extend life. But these technologies are too often used on the wrong patient, in the wrong setting, or at an unaffordable price. The only way to moderate the growth in health care costs without undermining the dynamic of medical innovation is to improve the process of assessing, pricing, prescribing, and using new technologies. Purchasing Medical Innovation analyzes the contemporary revolution in the purchasing of health care technology, with a focus on the roles of the Food and Drug Administration (FDA), Medicare and private health insurers, physicians and hospitals, and consumers themselves. The FDA is more thoroughly assessing product performance under real-world conditions as well as in laboratory settings, accelerating the path to market for breakthroughs while imposing use controls on risky products. Insurers are improving their criteria for coverage and designing payment methods that reward efficiency in the selection of new treatments. Hospitals are aligning adoption of complex supplies and equipment more closely with physicians' preferences for the best treatment for their patients. Consumers are becoming more engaged and financially accountable for their health care choices. This book describes both the strengths and deficiencies of the current system of purchasing and highlights opportunities for buyers, sellers, and users to help improve the value of medical technology: better outcomes at lower cost.
Medical technology --- Medical innovations --- Medical care, Cost of. --- Medical care --- Health care reform. --- Health insurance. --- Health plans, Prepaid --- Insurance, Health --- Medical care, Prepaid --- Medical insurance --- Prepaid health plans --- Prepaid medical care --- Sickness insurance --- Insurance --- Ambulance service --- Health care reform --- Home care services --- Hospitals --- Medically uninsured persons --- Surgical clinics --- Health reform --- Health system reform --- Healthcare reform --- Medical care reform --- Reform of health care delivery --- Reform of medical care delivery --- Medical policy --- Health insurance --- Medical care, Cost of --- Cost of medical care --- Health care costs --- Health care expenditures --- Medical costs --- Medical expenses --- Medical service, Cost of --- Medicine --- Medical economics --- Medical savings accounts --- Innovations, Medical --- Technological innovations --- Health care technology --- Health technology --- Technology --- Cost control. --- Prospective payment --- Emergency services --- Outpatient services --- Rehabilitation services --- Costs --- Innovations --- Biomedical Technology --- Biomedical Technologies --- Technology, Biomedical --- Technology, Health --- Technology, Health Care --- Health Care Technology --- Health Technology --- Biomedical Engineering --- Medical Informatics --- Cost control --- E-books --- artificial heart valves. --- cost of medical technology. --- cost of medical treatment. --- economics of healthcare. --- health care costs. --- health care reform. --- health insurance. --- health policy. --- hip replacement. --- improving patient care. --- innovative medical care. --- insurance coverage for medical care. --- joint replacement. --- knee replacement. --- medical care. --- medical costs. --- medical economics. --- medical innovation. --- medical market access. --- medical technology industry. --- medical technology. --- patient care. --- price of medical technology.
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As it is a goal to eliminate human African trypanosomiasis (HAT; sleeping sickness) as a public health problem by 2020 and interrupt transmission by 2030, this is a good moment to reflect on what we have achieved, what we want to achieve, and what could get in our way. HAT has a reputation for spectacular reappearances, and the latest peak of 40,000 reported and over 300,000 estimated cases only dates back to 1998. Efforts of the WHO and partners as well as the development of simpler and much better-tolerated treatments, improved diagnostics, and vector control tools made it possible to reduce this number by 95%. Case identification and confirmation remain complex and require specific skills, treatment remains error-prone and reports on long-term survivors have emerged, and the relevance of the animal reservoir for T. b. gambiense HAT needs clarification. In addition, to win the “end game” against this massively stigmatized disease, the human factor will play a key role. This Special Issue addresses many of the burning topics about disease elimination in its 12 research and 7 review articles and one case study. The papers critically reflect the approaches used, investigate the mentioned challenges, and propose novel approaches and interventions from various points of view.
(+)-spectaline --- iso-6-spectaline --- Trypanosoma brucei rhodesiense --- autophagy --- apoptosis --- cross-talk --- trypanosomosis --- iron --- transferrin --- transferrin receptor --- nutritional immunity --- flagellar pocket --- Human African Trypanosomiasis (HAT) --- mydriasis --- neurological signs --- eradication --- re-emergence --- human African trypanosomiasis --- treatment --- melarsoprol --- adverse event --- encephalopathy --- human leukocyte antigen --- association study --- disease elimination --- disease eradication --- frontline workers --- DR Congo --- mobile screening --- qualitative methods --- sequelae --- serology --- oligosymptomatic HAT --- product development partnerships --- research and development --- medical innovation --- donor policy --- African trypanosomiasis --- sleeping sickness --- trypanosoma brucei --- drugs --- drug resistance --- history --- human Africa trypanosomiasis --- fexinidazole --- home-based treatment --- patient-centred care --- Uganda --- elimination --- T. b. gambiense --- g-HAT --- T. b. rhodesiense --- r-HAT --- neglected tropical diseases --- Trypanosoma brucei --- drug discovery --- high-throughput screening --- blood–brain barrier --- brain permeability --- pharmacology --- phenotypic drug screening --- Haemoparasites --- animal reservoirs --- Trypanosoma growth inhibitors --- chemotherapy --- pafuramidine --- acoziborole --- African sleeping sickness --- development of treatment --- suramin --- medical history --- political history --- clinical research --- health system strengthening --- South Sudan --- diagnosis --- symptoms --- treatment-seeking --- case detection --- embodiment --- expertise --- serendipity --- CATT positive serological suspects --- active follow-up strategy --- n/a --- blood-brain barrier
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