Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Return to the Sea portrays the life and evolutionary times of marine mammals-from giant whales and sea cows that originated 55 million years ago to the deep diving elephant seals and clam-eating walruses of modern times. This fascinating account of the origin of various marine mammal lineages, some extinct, others extant but threatened, is for the non-specialist. Set against a backdrop of geologic time, changing climates, and changing geography, evolution is the unifying principle that helps us to understand the present day diversity of marine mammals and their responses to environmental challenges. Annalisa Berta explains current controversies and explores patterns of change taking place today, such as shifting food webs and predator-prey relationships, habitat degradation, global warming, and the effects of humans on marine mammal communities.

SCIENCE / Life Sciences / Zoology / Mammals. --- Marine mammals --- Aquatic mammals --- Marine animals --- Evolution. --- Marine fauna --- Ocean animals --- Sea animals --- Aquatic animals --- Marine organisms --- Mammifères marins. --- bioscience books. --- climate change and animals. --- climate change and the ocean. --- elephant seals. --- evolution. --- evolutionary biologist. --- extinct mammals. --- extinct marine life. --- global warming. --- history of mammals. --- history of the sea. --- humans and marine life. --- mammal evolution. --- mammal zoology. --- marine biology students. --- marine evolution. --- marine food webs. --- marine history. --- marine life history. --- marine mammal science. --- marine species. --- natural history. --- oceanography books. --- polar bears. --- predator and prey. --- walruses. --- whales and dolphins. --- zoology.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Cancer remains one of the most significant threats to human health and one of the deadliest diseases worldwide, making it crucial to develop new drugs. Over the last few decades, natural products have become one of the key drivers in the development of innovative cancer treatments. Despite drug development from terrestrial resources, the marine environment only recently emerged as a prolific source of unparalleled structurally active metabolites. Due to their excellent scaffold diversity, structural complexity, and ability to act on multiple cell signaling networks involved in carcinogenesis, marine natural products (MNPs) are ideal candidates to inspire the development of novel anticancer medicines. This book gathers nine publications of the Special Issue "Marine Natural Products as Anticancer Agents," providing an excellent overview of the chemical richness offered by marine organisms, such as sponges, myxobacteria, fungi, and soft corals. MNPs or derived products belong to distinct chemical classes, including terpenoids, alkaloids, cyclodepsipeptides, polyketides, and hydroxyphenylacetic acid derivatives. These compounds modulate cancer cell mechanisms in in vitro and in vivo models, exhibiting high specificity and great affinity to interact with biological targets linked to specific intracellular signaling pathways, including mitochondrial dysfunction, autophagy, endoplasmic reticulum stress induction, apoptosis, inflammation, migration, and invasion. This volume provides an exciting overview of marine natural products as potential therapeutic agents for cancer treatment.

alga --- marine-derived fungus --- Penicillium chrysogenum --- polyketide --- hydroxyphenylacetic acid --- cytotoxicity --- flaccidoxide-13-acetate --- hepatocellular carcinoma --- invasion --- migration --- epithelial-mesenchymal transition --- prostate cancer --- astaxanthin --- STAT3 --- proliferation --- colony formation --- apoptosis --- Sarcophyton digitatum --- biscembranoid-type metabolites --- inflammatory factor production --- LPS-stimulated murine macrophage --- Ehlich’s tumor --- P. purpurogenum --- antitumor --- meroterpenoids --- inflammation --- T47D --- BT20 --- pontin --- mutp53 --- cancer stem cells --- Oct4 --- Nanog --- siRNA --- secondary metabolites --- epigenome --- epigenetic signaling --- bioactive compounds --- cancer therapy --- marine species --- environment --- total synthesis --- natural product --- nannocystin --- anti-cancer --- gram-scale --- aplysinopsin analogs --- indole alkaloids --- marine source --- chronic myeloid leukemia --- BH3 mimetics --- n/a --- Ehlich's tumor

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Marine organisms are a treasure trove for the discovery of novel natural products, and, thus, marine natural products have been a focus of interest for researchers for decades. Some marine bacteria are prolific producers of natural products, occurring either free-living or, as recently shown, in symbiosis with marine animals. Recent advances in DNA sequencing have led to an enormous increase in published bacterial genomes and bioinformatics tools to analyze natural product biosynthetic potential by various “genome mining” approaches. Similarly, analytical NMR and MS methods for the characterization and comparison of metabolomes of natural product producers have advanced. Novel interdisciplinary approaches combine genomics and metabolomics data for accelerated and targeted natural product discovery. This Special Issue invites articles from both genomics- and metabolomics-driven studies on marine bacteria with a focus on natural product discovery and characterization. We particularly welcome articles that combine genomics and metabolomic approaches for the dereplication and characterization of marine bacterial natural products.

Medicine --- Moorena bouillonii --- marine natural products --- chemogeography --- metabolomics --- natural products --- dereplication --- antibiotics --- marine sponges --- plant pathogen --- cyclodepsipeptides --- marine Actinobacteria --- Streptomyces spp. --- antibiotic --- sea cucumber --- HCV --- Actinobacteria --- marine --- Polar --- genomics --- specialised metabolites --- chitin --- chitinase --- chitin degradation machinery --- Pseudoalteromonas --- secondary metabolites --- bacterial natural products --- mass spectrometry --- genome mining --- paired omics --- keratinases --- keratinolytic proteases --- marine-derived Streptomyces --- genomic comparison --- cyanobacteria --- symbionts --- comparative genomics --- biosynthetic gene clusters --- Indonesia --- biodiversity --- novel antibiotics --- drug screening --- bioactivity --- gene cluster networking --- GNPS --- enterococci --- genome-wide analysis --- bacteriocins --- probiotics --- wild marine species --- Neolyngbya --- anticancer --- drug discovery --- South China Sea --- wenchangamide --- Moorea producens --- CuSO4·5H2O assisted --- differential gDNA isolation --- filamentous bacteria --- micrococcin P1 and P2 --- stalked diatoms --- Moorena bouillonii --- marine natural products --- chemogeography --- metabolomics --- natural products --- dereplication --- antibiotics --- marine sponges --- plant pathogen --- cyclodepsipeptides --- marine Actinobacteria --- Streptomyces spp. --- antibiotic --- sea cucumber --- HCV --- Actinobacteria --- marine --- Polar --- genomics --- specialised metabolites --- chitin --- chitinase --- chitin degradation machinery --- Pseudoalteromonas --- secondary metabolites --- bacterial natural products --- mass spectrometry --- genome mining --- paired omics --- keratinases --- keratinolytic proteases --- marine-derived Streptomyces --- genomic comparison --- cyanobacteria --- symbionts --- comparative genomics --- biosynthetic gene clusters --- Indonesia --- biodiversity --- novel antibiotics --- drug screening --- bioactivity --- gene cluster networking --- GNPS --- enterococci --- genome-wide analysis --- bacteriocins --- probiotics --- wild marine species --- Neolyngbya --- anticancer --- drug discovery --- South China Sea --- wenchangamide --- Moorea producens --- CuSO4·5H2O assisted --- differential gDNA isolation --- filamentous bacteria --- micrococcin P1 and P2 --- stalked diatoms