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"The Global Impact of Ergot Alkaloids" addresses the very broad topic of ergot alkaloids and the influence that they have on many facets of life. The content in this Special Issue pertains to research studying fungi, plants, livestock, and humans. While the perspectives of each paper may differ, the common aspect is the interest and emphasis on ergot alkaloids. These compounds cross the spectrum from feared toxins to potential pharmaceutical discoveries. The research included spans the globe and has content that will attract the interest of readers from many different backgrounds.

ergot alkaloids --- strain improvement --- UV --- EMS --- Penicillium citrinum --- response surface methodology --- PBD --- BBD --- integrative interactomics --- integrome --- metabolomics --- microbiome --- tall fescue --- Epichloë coenophiala --- fescue toxicosis --- ergot alkaloid occurrence --- sclerotia --- cereals --- LC-MS/MS --- correlation --- survey --- beef cattle --- endophyte --- ergot alkaloid --- isoflavone --- metabolites --- genetic tolerance --- cytokines --- cow productivity --- CRISPR/Cas9 --- non-transgenic engineered fungi --- genome editing --- genome sequencing --- MinION --- nanopore --- secondary metabolites --- endophyte transmission --- livestock safety --- insect testing --- quality control --- alkaloid profile --- single nucleotide polymorphism --- milk production --- calf growth --- acute ergot exposure --- ergot toxicity --- sheep --- vasoconstriction --- adrenergic receptors --- ergot --- ethnopharmacology --- abortion --- childbirth --- ergovaline --- horse pastures --- pregnant mares --- species composition --- ergot fungi --- gene divergence --- gene diversity --- indole diterpenes --- phylogeny --- Claviceps purpurea --- fungal plant pathogen --- biosynthetic gene cluster --- mycotoxins --- untargeted metabolomics --- mass spectrometry --- blood vessel --- myograph --- serotonin --- n/a --- Epichloë coenophiala