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The management of colorectal liver metastases has evolved rapidly over the last decade with the introduction of newer and effective chemotherapies and a redefinition for cure. These range from the philosophical (including the greater awareness of treatment with curative intent), through the practical (more aggressive definition of respectability for cure and the use of more effective chemotherapies for both palliation and as adjuncts to surgery), to the futuristic use of biological strategies (including monoclonal antibodies and gene therapies) and lastly to the pragmatic but equally important issues of health economics (who is going to foot the bill for these increasingly expensive treatment strategies). Liver metastases addresses the contemporary multidisciplinary management of liver metastases. Throughout the text, experience from the paradigms of colorectal cancer metastases treatment strategies are used to point to new directions in the management of liver metastases from other cancers. This book overviews current understanding of the biology of liver metastases, and reviews current methods of detection and diagnosis. Chapters offer objective and systematic reviews of each of the current major treatment modalities: surgical resection; destructive therapies; chemotherapy (systemic and regional); whether there is a role for radiotherapy; biological therapies (including hormone treatment antibodies and gene therapy); and lastly the decision-making strategies that must be employed for successful multidisciplinary management. Featuring state-of-the-art reviews, key points, treatment algorithms and clear, concise illustrations this book provides the ultimate companion to anyone interested or working in the area of liver disease. This book will appeal to consultant and trainee surgeons in general surgery, hepatobiliary surgery, upper GI surgery, colorectal surgery; consultant and trainee medical and clinical oncologists with an interest in liver tumours; and consultant and trainee radiologists with an interest in liver disease.
Liver Neoplasms. --- Neoplasm Metastasis. --- Liver --- Liver metastasis --- Métastases hépatiques --- Cancer
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This book offers a complete overview on noncolorectal nonneuroendocrine (NCRNNE) liver metastases and describes in detail the currently available therapies. Each chapter focuses on the treatment of metastases from a particular primary malignancy and also provides valuable information on incidence, natural history, and diagnosis. NCRNNE metastases to the liver are rare entities compared with colorectal and neuroendocrine metastases, for which the treatments are well codified. While more publications have appeared on the topic in recent years, an in-depth study has to date been lacking. Furthermore, most published series are insufficiently comparable as they comprise patients with NCRNNE hepatic metastases from a variety of primary malignancies and consequently overlook differences in tumor behavior, frequency of isolated hepatic metastases, response to neoadjuvant or adjuvant therapy, and interval between diagnosis of the primary tumor and the liver metastases. This book, with its more specific approach, will serve not only as an up-to-date guide to diagnosis and treatment but also as a reference on which to base future studies.
Medicine & Public Health. --- Surgical Oncology. --- Minimally Invasive Surgery. --- Surgery. --- Oncology. --- Neurosurgery. --- Endocrinology. --- Medicine. --- Cancer --- Endoscopic surgery. --- Médecine --- Endocrinologie --- Cancérologie --- Chirurgie --- Chirurgie endoscopique --- Liver metastasis. --- Surgery & Anesthesiology --- Health & Biological Sciences --- Surgery - General and By Type --- Liver metastasis --- Treatment. --- Hepatic metastasis --- Minimally invasive surgery. --- Surgical oncology. --- Liver --- Metastasis --- Oncology . --- Nerves --- Neurosurgery --- Internal medicine --- Hormones --- Tumors --- Surgery, Primitive --- Medicine --- Endosurgery --- Minimal access surgery --- Minimally invasive surgery --- MIS (Minimally invasive surgery) --- Operative endoscopy --- Surgical endoscopy --- Endoscopy --- Microsurgery --- Surgery, Operative --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Surgery --- Excision --- Treatment --- Endocrinology .
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The management of colorectal liver metastases has evolved rapidly over the last decade with the introduction of newer and effective chemotherapies and a redefinition for cure. These range from the philosophical (including the greater awareness of treatment with curative intent), through the practical (more aggressive definition of respectability for cure and the use of more effective chemotherapies for both palliation and as adjuncts to surgery), to the futuristic use of biological strategies (including monoclonal antibodies and gene therapies) and lastly to the pragmatic but equally important issues of health economics (who is going to foot the bill for these increasingly expensive treatment strategies). Liver metastases addresses the contemporary multidisciplinary management of liver metastases. Throughout the text, experience from the paradigms of colorectal cancer metastases treatment strategies are used to point to new directions in the management of liver metastases from other cancers. This book overviews current understanding of the biology of liver metastases, and reviews current methods of detection and diagnosis. Chapters offer objective and systematic reviews of each of the current major treatment modalities: surgical resection; destructive therapies; chemotherapy (systemic and regional); whether there is a role for radiotherapy; biological therapies (including hormone treatment antibodies and gene therapy); and lastly the decision-making strategies that must be employed for successful multidisciplinary management. Featuring state-of-the-art reviews, key points, treatment algorithms and clear, concise illustrations this book provides the ultimate companion to anyone interested or working in the area of liver disease. This book will appeal to consultant and trainee surgeons in general surgery, hepatobiliary surgery, upper GI surgery, colorectal surgery; consultant and trainee medical and clinical oncologists with an interest in liver tumours; and consultant and trainee radiologists with an interest in liver disease.
Colorectal Neoplasms -- Pathology. --- Liver metastasis -- Treatment. --- Liver Neoplasms -- Secondary. --- Liver Neoplasms -- Therapy. --- Liver metastasis --- Colorectal Neoplasms --- Liver Neoplasms --- Pathology --- Intestinal Neoplasms --- Liver Diseases --- Rectal Diseases --- Digestive System Neoplasms --- Colonic Diseases --- Medicine --- Health Occupations --- Intestinal Diseases --- Gastrointestinal Neoplasms --- Digestive System Diseases --- Neoplasms by Site --- Diseases --- Neoplasms --- Gastrointestinal Diseases --- Disciplines and Occupations --- Oncology --- Health & Biological Sciences --- Treatment --- Liver --- Treatment. --- Cancer. --- Hepatocellular carcinoma --- Hepatic metastasis --- Medicine. --- Radiology. --- Oncology. --- Proctology. --- Surgery. --- Medicine & Public Health. --- Imaging / Radiology. --- Metastasis --- Cancer --- Oncology . --- Endocrinology. --- Radiology, Medical. --- Internal medicine --- Hormones --- Tumors --- Surgery, Primitive --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Radiological physics --- Physics --- Radiation --- Gastroenterology
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Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease. To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential. Once cancer cells enter the liver, several different scenarios may occur. The cancer cells may be immediately destroyed by local defence mechanisms, they may enter a state of dormancy as solitary cells and never produce a metastasis, initiate a short-lived process of proliferation that is aborted before a metastasis is established or actively proliferate to form macrometastases. The chapters in Part I of this book provide insight into the cellular/molecular mechanisms that determine which of these scenarios prevails. Written by experts researchers in the filed of metastasis, these chapters provide state-of-the art reviews on the cellular and molecular processes that impact the early stages of the metastatic process. The unique microenvironment of the liver, its various anatomical, cellular and molecular features and the impact they have on metastasis are highlighted. In addition, the role of inflammation (pre-existing and tumor-induced), host innate and adaptive immune responses, cytokines, chemokines, growth factors and the unique molecular signatures of metastatic tumor cells are reviewed with an underscoring of the translational implications of the current state of knowledge. Against this background, the chapters in Part II of the book provide critical reviews on major aspects of the clinical management of hepatic metastases. These include imaging strategies, surgical and chemotherapeutic treatment approaches and the use of targeted biological therapeutics such as anti-angiogenic drugs as treatment modalities. By combining information on biological and clinical aspects of liver metastasis, this volume will serve as an excellent resource for scientists, clinicians, clinician/ scientists and trainees in the domains of oncology, surgical oncology, hepatobiliary physiology and radiology.
Electronic books. -- local. --- Liver metastasis -- Treatment. --- Liver --- Digestive System Neoplasms --- Neoplastic Processes --- Liver Diseases --- Digestive System Diseases --- Neoplasms by Site --- Pathologic Processes --- Neoplasms --- Pathological Conditions, Signs and Symptoms --- Diseases --- Neoplasm Metastasis --- Liver Neoplasms --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer --- Liver metastasis --- Treatment. --- Hepatic metastasis --- Medicine. --- Cancer research. --- Immunology. --- Radiology. --- Oncology. --- Surgical oncology. --- Biomedicine. --- Cancer Research. --- Surgical Oncology. --- Imaging / Radiology. --- Metastasis --- Oncology . --- Radiology, Medical. --- Immunobiology --- Life sciences --- Serology --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Tumors --- Excision --- Treatment --- Radiological physics --- Physics --- Radiation --- Cancer research
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The field of liver tumors in children, and in particular hepatoblastoma in infants and young children, has seen tremendous therapeutic advances over recent years. This has been achieved through a much better understanding of the biology of disease, improved diagnostic procedures, refined methods of pretreatment tumor staging, the implementation of highly efficient chemotherapy and surgery, detailed monitoring of toxicity, and careful follow-up strategies. International controlled trials have played a key role in these advances, and many leading figures in the trials are among the editors and authors of this book. Their principal goal in Hepatic Tumors in Children is to provide the reader with a complete update on this complex and rapidly evolving field. All aspects of an impressive success story are covered, disclosing how the outcome of a previously devastating disease has been so dramatically improved. This book will prove essential reading for all who are involved in the care of children with liver tumors.
Liver -- Cancer -- Treatment. --- Liver metastasis -- Treatment. --- Liver Neoplasms -- Therapy. --- Age Groups --- Digestive System Neoplasms --- Liver Diseases --- Neoplasms by Site --- Digestive System Diseases --- Persons --- Diseases --- Named Groups --- Neoplasms --- Liver Neoplasms --- Child --- Medicine --- Health & Biological Sciences --- Oncology --- Liver --- Tumors in children. --- Tumors --- Treatment. --- Pediatric oncology --- Medicine. --- Oncology. --- Pediatrics. --- Medicine & Public Health. --- Children --- Abdomen --- Biliary tract --- Oncology . --- Paediatrics --- Pediatric medicine --- Health and hygiene
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This is a multi-author book on hilar cholangiocarcinoma, written by an international team of world-renowned experts covering topics in their respective areas of expertise. There are altogether 71 authors from 14 countries/regions, mainly Argentina, Australia, China, Germany, Italy, Japan, Korea, Malaysia, Thailand, the Netherlands, the United Kingdom and the United States of America. This book aims to provide an up-to-date, fully referenced text that is as succinct as possible, but as comprehensive as necessary, addressing all topics in hilar cholangiocarcinoma. It provides the latest findings in the rapidly advancing field of hilar cholangiocarcinoma. Controversial aspects are discussed by highly regarded authorities who look at the problem from different perspectives. A helpful list of references is included at the end of each chapter. The extensive use of diagrams, figures and tables makes the text easy to read. This book is primarily intended for clinicians and researchers who are interested in hilar cholangiocarcinoma, including liver surgeons, hepatologists, interventional and diagnostic radiologists, and basic researchers. General physicians, general surgeons, trainees, epidemiologists, hospital administrators, pathologists and instrument manufacturers will also find this book to be a valuable reference work. Editor Lau is currently a Professor of Surgery at the Chinese University of Hong Kong, and an Academician of Chinese Academy of Sciences, China.
Diffusion magnetic resonance imaging. --- Surgery & Anesthesiology --- Health & Biological Sciences --- Surgery - General and By Type --- Liver --- Liver metastasis. --- Tumors. --- Cancer. --- Hepatocellular carcinoma --- Hepatic metastasis --- Medicine. --- Hepatology. --- Surgery. --- Surgical oncology. --- Medicine & Public Health. --- Surgical Oncology. --- Cancer --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Surgery, Primitive --- Medicine --- Gastroenterology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Excision --- Treatment --- Metastasis --- Clinical medicine. --- Medicine, Clinical
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Gastric cancer represents one of the most frequent and lethal tumors worldwide today, finding itself in the fifth place in incidence and the third in mortality. Surgery remains the only curative treatment for localized tumors, but only 20% of patients are suitable for surgery due to the lack of specific symptoms and the late diagnosis, especially in Western countries. Additionally, even in patients who receive curative treatment, rates of locoregional relapse and distant metastasis remain high. Palliative chemotherapy is the principal treatment in cases of metastatic disease even if the prognosis of patients receiving chemotherapy is still poor. Therefore, a multidisciplinary evaluation is important in order to improve the efficacy of active treatments. In this context, there is an unmet need for a better understanding of genetic alterations and prognostic and predictive factors in order to choose the best tailored therapy for each patient. The aim of this Special Issue is to focus on the results and problems of multimodality treatment in metastatic gastric cancer, the search for prognostic and predictive factors, and the evaluation of novel strategies for individualized treatment. We are inviting relevant original research, systematic reviews, meta-analyses, and short communications covering the above-mentioned topics.
advanced gastric cancer --- precision medicine --- new drug development --- gastro-oesophageal cancer --- mutational concordance --- exome sequencing --- formalin fixed paraffin embedded --- biomarkers --- gastric cancer --- metastatic --- body composition --- sarcopenia --- visceral fat area --- subcutaneous fat area --- outcome --- toxicity --- liver metastasis --- conversion surgery --- hepatectomy --- stage iv gastric cancer --- immune checkpoint inhibitors --- Epstein Barr Virus --- tumor mutational burden --- microsatellite instability --- predictive biomarkers --- CAR T cell therapy --- vaccines --- nutritional status --- metastatic gastric cancer --- target therapy --- bone flare --- stage IV --- treatment --- RANK-L --- liquid biopsy --- circulating tumor cell --- cfDNA --- ctDNA --- epithelial–mesenchymal transition --- resistance to treatment --- HER2-inhibition --- VEGFR-inhibition --- immunotherapy --- response monitoring --- n/a --- epithelial-mesenchymal transition
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Gastric cancer represents one of the most frequent and lethal tumors worldwide today, finding itself in the fifth place in incidence and the third in mortality. Surgery remains the only curative treatment for localized tumors, but only 20% of patients are suitable for surgery due to the lack of specific symptoms and the late diagnosis, especially in Western countries. Additionally, even in patients who receive curative treatment, rates of locoregional relapse and distant metastasis remain high. Palliative chemotherapy is the principal treatment in cases of metastatic disease even if the prognosis of patients receiving chemotherapy is still poor. Therefore, a multidisciplinary evaluation is important in order to improve the efficacy of active treatments. In this context, there is an unmet need for a better understanding of genetic alterations and prognostic and predictive factors in order to choose the best tailored therapy for each patient. The aim of this Special Issue is to focus on the results and problems of multimodality treatment in metastatic gastric cancer, the search for prognostic and predictive factors, and the evaluation of novel strategies for individualized treatment. We are inviting relevant original research, systematic reviews, meta-analyses, and short communications covering the above-mentioned topics.
Medicine --- advanced gastric cancer --- precision medicine --- new drug development --- gastro-oesophageal cancer --- mutational concordance --- exome sequencing --- formalin fixed paraffin embedded --- biomarkers --- gastric cancer --- metastatic --- body composition --- sarcopenia --- visceral fat area --- subcutaneous fat area --- outcome --- toxicity --- liver metastasis --- conversion surgery --- hepatectomy --- stage iv gastric cancer --- immune checkpoint inhibitors --- Epstein Barr Virus --- tumor mutational burden --- microsatellite instability --- predictive biomarkers --- CAR T cell therapy --- vaccines --- nutritional status --- metastatic gastric cancer --- target therapy --- bone flare --- stage IV --- treatment --- RANK-L --- liquid biopsy --- circulating tumor cell --- cfDNA --- ctDNA --- epithelial-mesenchymal transition --- resistance to treatment --- HER2-inhibition --- VEGFR-inhibition --- immunotherapy --- response monitoring --- advanced gastric cancer --- precision medicine --- new drug development --- gastro-oesophageal cancer --- mutational concordance --- exome sequencing --- formalin fixed paraffin embedded --- biomarkers --- gastric cancer --- metastatic --- body composition --- sarcopenia --- visceral fat area --- subcutaneous fat area --- outcome --- toxicity --- liver metastasis --- conversion surgery --- hepatectomy --- stage iv gastric cancer --- immune checkpoint inhibitors --- Epstein Barr Virus --- tumor mutational burden --- microsatellite instability --- predictive biomarkers --- CAR T cell therapy --- vaccines --- nutritional status --- metastatic gastric cancer --- target therapy --- bone flare --- stage IV --- treatment --- RANK-L --- liquid biopsy --- circulating tumor cell --- cfDNA --- ctDNA --- epithelial-mesenchymal transition --- resistance to treatment --- HER2-inhibition --- VEGFR-inhibition --- immunotherapy --- response monitoring
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