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Non-coding RNA --- Non-coding RNA. --- RNA, Untranslated. --- Noncoding RNA --- RNA, Non-Coding --- RNA, Non-Peptide-Coding --- RNA, Non-Protein-Coding --- RNA, Noncoding --- RNA, Nontranslated --- npcRNA --- Non-Coding RNA --- Non-Peptide-Coding RNA --- Non-Protein-Coding RNA --- Nontranslated RNA --- RNA, Non Coding --- RNA, Non Peptide Coding --- RNA, Non Protein Coding --- Untranslated RNA --- fRNA --- Functional RNA --- ncRNA --- nmRNA --- Non-messenger RNA --- Non-translated RNA --- Small non-messenger RNA --- Small RNA --- snmRNA --- sRNA --- RNA --- microrna --- small interfering rna --- rnai --- lincrna --- pirna --- silencing --- Genetics

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Biomarkers are measures of a biological state. The treatment of individual patients based on particular factors, such as biomarkers, distinguishes standard, generalized treatment plans from personalized medicine. Even though personalized medicine is applicable to most branches of medicine, the field of oncology is perhaps where it is most easily employed. Cancer is a heterogeneous disease; although patients may be diagnosed histologically with the same cancer type, their tumors can comprise varying tumor microenvironments and molecular characteristics that can impact treatment response and prognosis. There has been a major drive over the past decade to try and realize personalized cancer medicine through the discovery and use of disease-specific biomarkers. This book, entitled “Cancer Biomarker Research and Personalized Medicine”, encompasses 22 publications from colleagues working on a diverse range of cancers, including prostate, breast, ovarian, head and neck, liver, gastric, bladder, colorectal, and kidney. The biomarkers assessed in these studies include genes, intracellular or secreted proteins, exosomes, DNA, RNA, miRNA, circulating tumor cells, circulating immune cells, in addition to radiomic features.

Medicine --- Oncology --- clear cell renal cell carcinoma --- radiomics --- WHO/ISUP nuclear grade --- multiphasic multidetector computed tomography --- triple-negative breast cancer --- taxane --- chemotherapy --- GBP5 --- Akt/mTOR --- autophagy --- IL13Rα2 --- renal cell carcinoma --- JAK2 --- FOXO3 --- telmisartan --- ovarian cancer --- bioinformatics --- CREB1 --- drug perturbation --- lincRNA-p21 --- rectal cancer --- chemoradiotherapy --- colorectal cancer --- long non-coding RNA --- p53 --- predictive biomarker --- intestinal anastomosis --- anastomotic leak --- biomarkers --- precision medicine --- personalized medicine --- biomarker --- AmpliSeq --- DNA methylation --- epigenetics --- head and neck cancer --- saliva --- liquid biopsy --- meta-analysis --- gastric cancer --- middle-up-down --- haptoglobin --- glycopeptide --- mass spectrometry --- circulating tumor cells --- prostate cancer --- cancer vaccine --- immune response --- breast cancer --- predictive tools --- prognostic tools --- translational research --- IL6ST --- gp130 --- cytokine signalling --- tissue-based biomarkers --- liquid-based biomarkers --- radiotherapy --- radiosensitivity biomarkers --- secretome --- radioresistance --- bladder tumor --- lymphocyte-to-monocyte ratio --- peripheral blood parameters --- tumor recurrence --- transurethral resection --- lipidomics --- 1H-NMR --- LC-MS/MS --- lipoprotein subfractions --- lipoprotein lipase --- cancer biomarkers --- hepatocellular carcinoma --- p16 expression --- head and neck squamous cell carcinoma --- HPV genotyping --- exosomes --- chemoresistance --- comparative oncology --- One Health --- microRNA --- lymph node metastasis --- hormone-dependent carcinogenesis --- localized prostate cancer --- prognostic factors --- HNSCC --- n/a

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This book describes translational cancer therapeutics and the way forward from clinical and molecular diagnosis to treatment. In addition, genomics alterations, microRNAs, and long non-coding RNAs translate precision medicine for the individualistic therapy of cancer patients. It describes the involvement of various pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK) modulations of medicines. Indeed, the role of bioinformatics and biostatistics, considering the extensive data analysis serving precision medicine approaches, has also been entertained in the present book. Therefore, intended book demonstrates the successful medical evidence for the use of precision medicine in the treatment of cancer and its future clinical perspectives. It fills the gaps in cancer biology and precision medicine with its up-to-date content and well-designed chapters. It will serve as a valuable resource for science, medical students, and interdisciplinary researchers. It is a very welcome addition for the scientific community, research centers, and university-industry research collaborators to find out a complete capsular package about cancer drug targets, precision, and personalized medicine (including an introduction to cancer cell signaling, genomic alterations, miRNA targeting, pharmacogenetics, biomarkers, and metabolomics in precision medicine, etc.) at a single platform.

Precision Medicine. --- Pharmacogenetics. --- Pharmacogenomic Variants. --- MicroRNAs --- RNA, Long Noncoding. --- Biomarkers. --- Neoplasms --- Medical Oncology. --- therapy. --- Clinical Oncology --- Oncology, Medical --- Oncology, Clinical --- Biochemical Marker --- Biologic Marker --- Biologic Markers --- Clinical Marker --- Immune Marker --- Immune Markers --- Immunologic Marker --- Laboratory Marker --- Marker, Biochemical --- Marker, Biological --- Marker, Clinical --- Marker, Immunologic --- Marker, Laboratory --- Marker, Serum --- Marker, Surrogate --- Serum Marker --- Surrogate End Point --- Surrogate End Points --- Surrogate Endpoint --- Surrogate Endpoints --- Surrogate Marker --- Viral Marker --- Biochemical Markers --- Biological Markers --- Biomarker --- Clinical Markers --- Immunologic Markers --- Laboratory Markers --- Markers, Biochemical --- Markers, Biological --- Markers, Clinical --- Markers, Immunologic --- Markers, Laboratory --- Markers, Serum --- Markers, Surrogate --- Markers, Viral --- Serum Markers --- Surrogate Markers --- Viral Markers --- Biological Marker --- End Point, Surrogate --- End Points, Surrogate --- Endpoint, Surrogate --- Endpoints, Surrogate --- Marker, Biologic --- Marker, Immune --- Marker, Viral --- Markers, Biologic --- Markers, Immune --- Molecular Probes --- Endophenotypes --- LINC RNA --- LincRNAs --- Long Intergenic Non-Protein Coding RNA --- Long Non-Coding RNA --- Long Non-Protein-Coding RNA --- Long Noncoding RNA --- Long ncRNA --- Long ncRNAs --- RNA, Long Non-Translated --- lncRNA --- LincRNA --- RNA, Long Untranslated --- Long Intergenic Non Protein Coding RNA --- Long Non Coding RNA --- Long Non Protein Coding RNA --- Long Non-Translated RNA --- Long Untranslated RNA --- Non-Coding RNA, Long --- Non-Protein-Coding RNA, Long --- Non-Translated RNA, Long --- Noncoding RNA, Long --- RNA, Long Non Translated --- RNA, Long Non-Coding --- RNA, Long Non-Protein-Coding --- Untranslated RNA, Long --- ncRNA, Long --- ncRNAs, Long --- Micro RNA --- MicroRNA --- Primary MicroRNA --- Primary miRNA --- miRNAs --- pre-miRNA --- pri-miRNA --- RNA, Small Temporal --- Small Temporal RNA --- miRNA --- stRNA --- MicroRNA, Primary --- RNA, Micro --- Temporal RNA, Small --- miRNA, Primary --- pre miRNA --- pri miRNA --- RNA, Small Interfering --- Pharmacogenetic Variants --- Pharmacokinetic Genetic Variants --- Genetic Variant, Pharmacokinetic --- Genetic Variants, Pharmacokinetic --- Pharmacogenetic Variant --- Pharmacogenomic Variant --- Pharmacokinetic Genetic Variant --- Variant, Pharmacogenetic --- Variant, Pharmacogenomic --- Variants, Pharmacogenetic --- Variants, Pharmacogenomic --- Pharmacogenetics --- Precision Medicine --- P Health --- P-Health --- Personalized Medicine --- Theranostics --- Individualized Medicine --- Predictive Medicine --- Medicine, Individualized --- Medicine, Personalized --- Medicine, Precision --- Medicine, Predictive --- Theranostic --- Pharmacogenomic Variants --- Patient-Specific Modeling --- Pharmacogenomics --- Drug Resistance --- Toxicology --- Cancer. --- Cancer—Genetic aspects. --- Oncology. --- Therapeutics. --- Cancer Biology. --- Cancer Genetics and Genomics. --- Medical treatment --- Therapy --- Treatment of diseases --- Treatments for diseases --- Clinical medicine --- Tumors --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors