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Antigens, CD --- Antigens, Differentiation --- Cell Adhesion --- Cell Adhesion Molecules --- Receptors, Leukocyte-Adhesion --- physiology --- physiology --- physiology --- physiology

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Arrest chemokines are a small group of chemokines that promote leukocyte arrest from rolling by triggering rapid integrin activation. Arrest chemokines have been described for neutrophils, monocytes, eosinophils, naïve lymphocytes and effector memory T cells. Most arrest chemokines are immobilized on the endothelial surface by binding to heparan sulfate proteoglycans. Whether soluble chemokines can promote integrin activation and arrest is controversial. Many aspects of the signaling pathway from the GPCR chemokine receptor to integrin activation are the subject of active investigation. Leukocyte adhesion deficiency III is a human disease in which chemokine-triggered integrin activation is defective because of a mutation in the cytoskeletal protein kindlin-3. About 10 different such mutations have been described. The defects seen in patients with LAD-III elucidate the importance of rapid integrin activation for host defense in humans. Here we present a series of ten reports that help clarify this crucial first step in the process of leukocyte transendothelial migration.

Chemokines --- Immunologic diseases. --- Immunology. --- chemokine --- LFA-1 --- Signal Transduction --- Talin --- integrin --- leukocyte adhesion --- VLA-4 --- Kindlin-3

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Cytology. --- Proteomics. --- Biochemistry. --- Bioinformatics. --- Cell Biology. --- Protein Science. --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Molecular biology --- Proteins --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Data processing --- Composition --- Cell Adhesion. --- Cell Adhesion Molecules. --- Adhesion, Cell --- Adhesions, Cell --- Cell Adhesions --- Cell-Matrix Junctions --- Focal Adhesions --- Saccharide Mediated Cell Adhesion Molecules --- Cell Adhesion Molecule --- Intercellular Adhesion Molecule --- Intercellular Adhesion Molecules --- Leukocyte Adhesion Molecule --- Leukocyte Adhesion Molecules --- Saccharide-Mediated Cell Adhesion Molecules --- Adhesion Molecule, Cell --- Adhesion Molecule, Intercellular --- Adhesion Molecule, Leukocyte --- Adhesion Molecules, Cell --- Adhesion Molecules, Intercellular --- Adhesion Molecules, Leukocyte --- Molecule, Cell Adhesion --- Molecule, Intercellular Adhesion --- Molecule, Leukocyte Adhesion --- Molecules, Cell Adhesion --- Molecules, Intercellular Adhesion --- Molecules, Leukocyte Adhesion --- Integrins

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Pharmacology. Therapy --- Autacoids --- Immunologic Factors --- Cell Adhesion Molecules --- Cell Communication --- Cytokines --- Inflammation --- Inflammation (Pathologie) --- Mediators --- Periodicals --- Médiateurs --- Périodiques --- Biological response modifiers --- Autacoids. --- Immunologic Factors. --- Cell Adhesion Molecules. --- Cell Communication. --- Cytokines. --- Inflammation. --- Immunomodulateurs. --- Biological response modifiers. --- Médiateurs. --- Mediators. --- Inflammations --- Cell Interaction --- Cell-to-Cell Interaction --- Cell Communications --- Cell Interactions --- Cell to Cell Interaction --- Cell-to-Cell Interactions --- Communication, Cell --- Communications, Cell --- Interaction, Cell --- Interaction, Cell-to-Cell --- Interactions, Cell --- Interactions, Cell-to-Cell --- Saccharide Mediated Cell Adhesion Molecules --- Intercellular Adhesion Molecules --- Leukocyte Adhesion Molecules --- Saccharide-Mediated Cell Adhesion Molecules --- Adhesion Molecules, Cell --- Adhesion Molecules, Intercellular --- Adhesion Molecules, Leukocyte --- Molecules, Cell Adhesion --- Molecules, Intercellular Adhesion --- Molecules, Leukocyte Adhesion --- Integrins --- Biological Response Modifiers --- Biomodulators --- Factors, Immunologic --- Immune Factors --- Immunological Factors --- Modifiers, Biological Response --- Response Modifiers, Biological --- Immunomodulators --- Factors, Immune --- Factors, Immunological --- Receptors, Immunologic --- Molecular Mechanisms of Pharmacological Action --- Slow-Reacting Substances --- Slow Reacting Substances --- Substances, Slow-Reacting --- Chemistry --- Health Sciences --- Life Sciences --- Toxicology --- General and Others --- Pathology --- cellular mediators --- Immunology. --- Biological response modulators --- BRMs (Biochemistry) --- Immunoregulators --- Modifiers, Biological response --- Modulators, Biological response --- Biomolecules --- Cancer --- Cellular control mechanisms --- Immunopharmacology --- Immune response --- Inflammatory process --- Anti-inflammatory agents --- Inflammatory mediators --- Mediators of inflammation --- Immunotherapy --- Regulation --- Médiateurs. --- inflammation --- Innate Inflammatory Response --- Inflammatory Response, Innate --- Innate Inflammatory Responses --- Immunity, Innate --- farmacologie --- Cytokine --- Cell Adhesion Molecule --- Intercellular Adhesion Molecule --- Leukocyte Adhesion Molecule --- Adhesion Molecule, Cell --- Adhesion Molecule, Intercellular --- Adhesion Molecule, Leukocyte --- Molecule, Cell Adhesion --- Molecule, Intercellular Adhesion --- Molecule, Leukocyte Adhesion --- Biological Response Modifier --- Biomodulator --- Immune Factor --- Immunological Factor --- Immunomodulator --- Factor, Immune --- Factor, Immunological --- Modifier, Biological Response --- Response Modifier, Biological --- Cell adhesion molecules. --- Cell interaction. --- Inflammation Mediators --- Immunomodulateurs --- Autacoïdes. --- Molécules d'adhésion cellulaire. --- Cellules --- Interaction. --- Cellular immunity --- Cell-cell interaction --- Cell communication --- Cellular communication (Biology) --- Cellular interaction --- Intercellular communication --- Adhesion molecules (Cytology) --- Adhesion substances (Cytology) --- Cell adhesion substances --- Intercellular adhesion molecules --- Morphoregulatory molecules --- Desmosomes --- Hemidesmosomes --- Mediators of Inflammation --- Mediators, Inflammation --- Inflammasomes --- Inflamació.

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The book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior. The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, epistructural biology, centered on the interactions of water and biomolecular structures across the interface. The author introduces powerful theoretical and computational resources in order to address fundamental topics such as protein folding, the physico-chemical basis of enzyme catalysis and protein associations. On the basis of this information, a multi-disciplinary approach is used to engineer therapeutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering.

Life Sciences. --- Protein-Ligand Interactions. --- Membrane Biology. --- Molecular Medicine. --- Pharmaceutical Sciences/Technology. --- Biophysics and Biological Physics. --- Life sciences. --- Medicine. --- Pharmaceutical technology. --- RNA-ligand interactions. --- Cell membranes. --- Sciences de la vie --- Médecine --- Techniques pharmaceutiques --- Membrane cellulaire --- Antigens, Surface --- Membrane Glycoproteins --- Drug Therapy --- Drug Discovery --- Cell Physiological Processes --- Proteins --- Glycoproteins --- Chemistry, Pharmaceutical --- Amino Acids, Peptides, and Proteins --- Antigens --- Investigative Techniques --- Therapeutics --- Cell Physiological Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemistry --- Chemicals and Drugs --- Pharmacology --- Biological Factors --- Phenomena and Processes --- Natural Science Disciplines --- Biological Science Disciplines --- Disciplines and Occupations --- Cell Adhesion Molecules --- Drug Design --- Cell Adhesion --- Drug Delivery Systems --- Membrane Proteins --- Physical Sciences & Mathematics --- Biochemistry --- Integral Membrane Protein --- Membrane Protein --- Membrane-Associated Proteins --- Cell Membrane Proteins --- Cell Surface Proteins --- Integral Membrane Proteins --- Surface Proteins --- Membrane Associated Proteins --- Membrane Protein, Integral --- Membrane Proteins, Integral --- Protein, Integral Membrane --- Protein, Membrane --- Proteins, Cell Membrane --- Proteins, Cell Surface --- Proteins, Integral Membrane --- Proteins, Membrane --- Proteins, Membrane-Associated --- Proteins, Surface --- Drug Targeting --- Delivery System, Drug --- Delivery Systems, Drug --- Drug Delivery System --- Drug Targetings --- System, Drug Delivery --- Systems, Drug Delivery --- Targeting, Drug --- Targetings, Drug --- Adhesion, Cell --- Adhesions, Cell --- Cell Adhesions --- Drug Modeling --- Design, Drug --- Designs, Drug --- Drug Designs --- Drug Modelings --- Modeling, Drug --- Modelings, Drug --- Saccharide Mediated Cell Adhesion Molecules --- Intercellular Adhesion Molecules --- Leukocyte Adhesion Molecules --- Saccharide-Mediated Cell Adhesion Molecules --- Adhesion Molecules, Cell --- Adhesion Molecules, Intercellular --- Adhesion Molecules, Leukocyte --- Molecules, Cell Adhesion --- Molecules, Intercellular Adhesion --- Molecules, Leukocyte Adhesion --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Biologic Agents --- Biologic Factors --- Biological Factor --- Factor, Biologic --- Factor, Biological --- Factors, Biological --- Biological Agents --- Agents, Biologic --- Agents, Biological --- Biologic Factor --- Factors, Biologic --- Pharmacologies --- Pharmaceutical Preparations --- Cell Physiological Phenomenon --- Cell Physiological Process --- Physiology, Cell --- Cell Physiology --- Phenomena, Cell Physiological --- Phenomenon, Cell Physiological --- Physiological Process, Cell --- Physiological Processes, Cell --- Process, Cell Physiological --- Processes, Cell Physiological --- Cells --- Therapy --- Treatment --- Therapeutic --- Therapies --- Treatments --- Disease --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Antigen --- Chemistry, Pharmaceutic --- Pharmaceutic Chemistry --- Pharmaceutical Chemistry --- Medicinal Chemistry --- Chemistry, Medicinal --- Glycoprotein --- Neoglycoproteins --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Drug Prospecting --- Discovery, Drug --- Prospecting, Drug --- Therapy, Drug --- Chemotherapy --- Pharmacotherapy --- Chemotherapies --- Drug Therapies --- Pharmacotherapies --- Therapies, Drug --- Cell Surface Glycoprotein --- Membrane Glycoprotein --- Surface Glycoprotein --- Cell Surface Glycoproteins --- Surface Glycoproteins --- Glycoprotein, Cell Surface --- Glycoprotein, Membrane --- Glycoprotein, Surface --- Glycoproteins, Cell Surface --- Glycoproteins, Membrane --- Glycoproteins, Surface --- Surface Glycoprotein, Cell --- Surface Glycoproteins, Cell --- Cell Surface Antigen --- Immunologic Surface Markers --- Markers, Immunological Surface --- Surface Antigen --- Surface Markers, Immunologic --- Cell Surface Antigens --- Surface Antigens --- Surface Markers, Immunological --- Antigen, Cell Surface --- Antigen, Surface --- Antigens, Cell Surface --- Immunological Surface Markers --- Markers, Immunologic Surface --- Surface Antigen, Cell --- Surface Antigens, Cell --- pharmacology --- physiology --- therapy --- drug therapy --- therapeutic use --- Molecular biology. --- Proteins. --- Biophysics. --- Biological physics. --- Biological and Medical Physics, Biophysics. --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomolecules. --- Proteins . --- Cell membranes . --- Biological physics --- Biology --- Physics --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Biomolecules --- Systems biology --- Proteids --- Polypeptides --- Proteomics