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"The definitive social history of tuberculosis, from its origins as a haunting mystery to its modern reemergence that now threatens populations around the world. It killed novelist George Orwell, Eleanor Roosevelt, and millions of others - rich and poor. Desmond Tutu, Amitabh Bachchan, and Nelson Mandela survived it, just. For centuries, tuberculosis has ravaged cities and plagued the human body. In Phantom Plague, Vidya Krishnan, traces the history of tuberculosis from the slums of 19th-century New York to modern Mumbai. In a narrative spanning century, Krishnan shows how superstition and folk-remedies, made way for scientific understanding of TB, such that it was controlled and cured in the West. The cure was never available to black and brown nations. And the tuberculosis bacillus showed a remarkable ability to adapt -- so that at the very moment it could have been extinguished as a threat to humanity, it found a way back, aided by authoritarian governments, the toxic kindness of philanthropists, science denialism, and medical apartheid. Krishnan's original reporting paints a granular portrait of the post-antibiotic era as a new, aggressive, drug resistant strain of TB takes over. Phantom Plague is an urgent, riveting and fascinating narrative that deftly exposes the weakest links in our battle against this ancient foe."--Front jacket flap.

Tuberculosis --- Diseases and history --- Multidrug-resistant tuberculosis --- Medicine, Traditional --- Anti-Bacterial Agents --- Patents as Topic --- Tuberculosis, Multidrug-Resistant --- Latent Tuberculosis --- Humans --- Tuberculose. --- Tuberculose --- Maladies et histoire. --- Tuberculose multirésistante. --- MEDICAL / Public Health. --- History --- Treatment --- History. --- history --- Histoire. --- Traitement

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Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (MTB) and it represents a persistent public health threat for a number of complex biological and sociological reasons. According to the most recent Global Tuberculosis Report (2019) edited by the World Health Organization (WHO), TB is considered the ninth cause of death worldwide and the leading cause of mortality by a single infectious agent, with the highest rate of infections and death toll rate mostly concentrated in developing and low-income countries. We present here the editorial section to the Special Issue entitled “Mycobacterium tuberculosis Pathogenesis, Infection Prevention and Treatment” that includes 7 research articles and a review. The scientific contributions included in the Special Issue mainly focus on the characterization of MTB strains emerging in TB endemic countries as well as on multiple mechanisms adopted by the bacteria to resist and to adapt to antitubercular therapies.

Research & information: general --- Biology, life sciences --- Mycobacterium tuberculosis --- line probe assay --- second-line drugs --- drug resistance --- XDR-TB --- MDR-TB --- omics analysis --- TB treatment --- system analysis --- Beijing B0/W148 --- Mycobacterium smegmatis --- imidazo[1,2-b][1,2,4,5]tetrazine --- MmpS5-MmpL5 --- efflux --- drug discovery --- tuberculosis --- immune activation --- HLA-DR --- CD38 --- treatment response --- Mycobacterium --- macrophage --- apoptosis --- effector --- cytokine --- microRNA --- Beijing genotype --- Central Asia Outbreak --- murine infection model --- Virulence --- pre-XDR-TB --- Mycobacterium avium --- unique metabolic pathways --- subtractive genomics --- drug target --- uncharacterized proteins --- BM-MSCs --- Mtb --- bone-homing --- stem cell niche --- latent tuberculosis --- relapse --- liposomes --- M. tuberculosis --- host-pathogen interactions --- immune response --- antitubercular drug discovery --- antitubercular treatments --- IL-18 --- IL-18BP --- IL-18R --- gene expression --- Mycobacterium tuberculosis --- line probe assay --- second-line drugs --- drug resistance --- XDR-TB --- MDR-TB --- omics analysis --- TB treatment --- system analysis --- Beijing B0/W148 --- Mycobacterium smegmatis --- imidazo[1,2-b][1,2,4,5]tetrazine --- MmpS5-MmpL5 --- efflux --- drug discovery --- tuberculosis --- immune activation --- HLA-DR --- CD38 --- treatment response --- Mycobacterium --- macrophage --- apoptosis --- effector --- cytokine --- microRNA --- Beijing genotype --- Central Asia Outbreak --- murine infection model --- Virulence --- pre-XDR-TB --- Mycobacterium avium --- unique metabolic pathways --- subtractive genomics --- drug target --- uncharacterized proteins --- BM-MSCs --- Mtb --- bone-homing --- stem cell niche --- latent tuberculosis --- relapse --- liposomes --- M. tuberculosis --- host-pathogen interactions --- immune response --- antitubercular drug discovery --- antitubercular treatments --- IL-18 --- IL-18BP --- IL-18R --- gene expression