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This Special Issue covers original and innovative basic research regarding the anti-inflammatory potential of several classes of secondary metabolites (i.e., polyphenols, phytosterols, proteoglycans, and polysaccharides) in manifestations of acute and chronic inflammation in both in vitro and in vivo experimental models.

Medicine --- laminarin --- aging --- transient cerebral ischemia --- neuroprotection --- oxidative stress --- neuroinflammation --- marine-derived fungi --- anti-inflammation --- anti-neuroinflammation --- PTP1B --- marine biocompounds --- neurodegeneration --- Alzheimer’s disease --- Parkinson’s disease --- Bacillus sp. --- proteoglycan --- macrophages --- Padina boryana --- RAW 264.7 macrophages --- Nrf2/HO-1 --- MAPK --- NF-κB --- P. oceanica --- inflammation --- pain --- CD-1 mice --- laminarin --- aging --- transient cerebral ischemia --- neuroprotection --- oxidative stress --- neuroinflammation --- marine-derived fungi --- anti-inflammation --- anti-neuroinflammation --- PTP1B --- marine biocompounds --- neurodegeneration --- Alzheimer’s disease --- Parkinson’s disease --- Bacillus sp. --- proteoglycan --- macrophages --- Padina boryana --- RAW 264.7 macrophages --- Nrf2/HO-1 --- MAPK --- NF-κB --- P. oceanica --- inflammation --- pain --- CD-1 mice

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The marine environment is considered one of the most important sources of natural bioactive compounds with extremely rich biodiversity. Marine glycans are remarkable molecules, playing a determinant role in biological processes. Marine сarbohydrate-containing substances have drawn increasing attention in the field of biomedicine for their various biological activities, such as antitumor, antivirus, hypoglycemic, immunomodulatory, and anticoagulant. These compounds obtained from marine sources, such as algae, microbes, and animals, are usually biodegradable and biocompatible, and exhibit biological properties that contribute to the discovery of a wide range of new bioactive substances with special pharmacological properties of interest to medicine. Carbohydrate-based compounds include glycans, glycoproteins, proteoglycans, glycolipids, and low-molecular and complex glycosides of differential origin. Many of the polysaccharides allow for loading lower drug dosages, which may lead to a drastic reduction of the side effects caused by the drugs. In addition, the structure of polysaccharides can be relatively easily modified in order to synthesize derivatives with desirable characteristics for drug delivery. Complexes on the basis of carbohydrates are often prepared to improve their functional properties. In this Special Issue, we seek to contribute to the discussion of various aspects of marine carbohydrate-containing compounds and provide a unique platform for a new concept for their use in medicine in order to continue to facilitate further research in this area.

chitosan-gentamicin conjugate --- antimicrobial --- anti-inflammatory --- scald repair --- sulfated polysaccharides --- galactans --- green seaweed --- NMR --- immunostimulation --- inflammatory mediators --- carrageenan --- lipopolysaccharide --- macromolecular structure --- nonspecific resistance to lipopolysaccharide --- cytokines --- enteric infections --- salmonellosis --- glyceroglycolipid metabolism --- phosphate starvation --- transcriptome --- glyceroglycolipid homeostasis --- chitosan --- polyelectrolyte complex --- cytokine --- nitric oxide --- anti-inflammatory activity --- Ulva pertusa --- polysaccharides --- colitis --- antioxidant --- exopolysaccharide --- structure --- Vibrio alginolyticus --- Epidermist --- chitosan oligosaccharides --- inflammation cytokines --- intestine --- oxidative status --- oxidative stress --- Porphyridium marinum --- high pressure homogenizer --- antibacterial activity --- anti-biofilm activity --- anti-cancer activity --- alginate lyase --- cold-adapted --- exo/endo-type --- Alteromonas portus --- oligosaccharide --- antioxidant activity --- exopolysaccharides --- scandium --- theranostic --- cancer cell lines --- proliferation --- laminarin --- fucoidan --- gastrointestinal tract --- microbiome --- swine --- post-weaning --- antibiotic alternatives --- n/a

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Brown algae comprise approx. 2040 species grown in various climatic conditions. They represent a reservoir of various bioactive compounds, including fucoidan, alginate, phlorotannins, and fucoxanthins. They have shown an array of applications in pharmaceutical and medical fields. Hence, the Guest Editor invites all interested authors to submit their contributions to the current issue in Marine Drugs entitled “Bioactive Compounds from Brown Algae”. It aims to highlight different aspects of bioactive compounds found in brown algae, in either research or review articles. Specifically, we are interested in downstream processes, chemistry, biotechnology, and applications of, for example, heteropolysaccharides and other brown algae bioactives. In addition, the structure elucidation and enzymatic modification of these components are also within the scope of the present Issue.

Medicine --- hepatic steatosis --- lipogenesis --- seaweed --- polyphenol --- fucoidans --- fucoidanases --- glycosidic linkages --- molecular masses --- NMR --- structure–activity relationships --- fucoidan --- cancer --- VEGF --- gene expression --- toxicity --- Dictyosiphon foeniculaceus --- retinal pigment epithelium --- glioblastoma --- astrocytes --- uveal melanoma --- 7-phloro-eckol --- HepG2/CYP2E1 cells --- oxidative stress --- apoptosis --- anti-lung cancer --- brown algae --- human lung carcinoma A-549 cells --- oversulfation --- Sargassum aquifolium --- phlorotannins --- antifungal --- larvicidal --- brown seaweeds --- biological activities --- anti-inflammatory --- antioxidant --- coastal area --- crude lipid extract --- Sargassum ilicifolium --- gut microbiota --- bioaccessibility --- short-chain fatty acids --- prebiotics --- gastrointestinal tract --- noise --- hearing loss --- dieckol --- PFF-A --- alginate --- laminarin --- bioactivity --- hepatic steatosis --- lipogenesis --- seaweed --- polyphenol --- fucoidans --- fucoidanases --- glycosidic linkages --- molecular masses --- NMR --- structure–activity relationships --- fucoidan --- cancer --- VEGF --- gene expression --- toxicity --- Dictyosiphon foeniculaceus --- retinal pigment epithelium --- glioblastoma --- astrocytes --- uveal melanoma --- 7-phloro-eckol --- HepG2/CYP2E1 cells --- oxidative stress --- apoptosis --- anti-lung cancer --- brown algae --- human lung carcinoma A-549 cells --- oversulfation --- Sargassum aquifolium --- phlorotannins --- antifungal --- larvicidal --- brown seaweeds --- biological activities --- anti-inflammatory --- antioxidant --- coastal area --- crude lipid extract --- Sargassum ilicifolium --- gut microbiota --- bioaccessibility --- short-chain fatty acids --- prebiotics --- gastrointestinal tract --- noise --- hearing loss --- dieckol --- PFF-A --- alginate --- laminarin --- bioactivity