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Lactoferrin --- Lactoferrin --- Congresses. --- physiology

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Tears --- Eye Proteins --- Lectins --- Lactoferrin --- chemistry --- analysis --- metabolism

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“Lactoferrin and its Role in Wound Healing” summarizes the recent advances of molecular mechanisms of wound healing. It is a complex physiological process that requires the regulation of different types of cells such as immune cells, keratinocytes, fibroblasts, and endothelial cells. Lactoferrin was first identified as an iron-binding glycoprotein abundantly found in milk. It has been considered to play important roles in host defense, since lactoferrin shows broad spectrum of anti-bacterial and anti-viral activities, arising from its iron-chelating property. Furthermore, lactoferrin can regulate the function of innate and adaptive immune cells and exhibits immuno-modulating properties. These activities of lactoferrin implicate that potential use of lactoferrin as a wound healing agent. In addition, this book shows that lactoferrin is a potent regulator of dermal fibroblasts and epidermal keratinocytes, and promotes skin or corneal epithelial wound healing by increasing their proliferation, migration or deposition of extracellular matrix (ECM) components such as collagen and hyaluronan. This book provides the scientific background on use of lactoferrin as a wound healing agent. Indeed, lactoferrin exerts its biological effects by binding to specific lactoferrin receptors on target cells. This book also covers the in-depth information on roles of lactoferrin as a signaling molecule.

Lactoferrin -- Therapeutic use. --- Wound healing. --- Wound healing --- Lactoferrin --- Lactoglobulins --- Iron-Binding Proteins --- Glycoproteins --- Regeneration --- Biological Science Disciplines --- Proteins --- Natural Science Disciplines --- Biological Processes --- Carrier Proteins --- Metalloproteins --- Globulins --- Milk Proteins --- Amino Acids, Peptides, and Proteins --- Dietary Proteins --- Biological Phenomena --- Disciplines and Occupations --- Phenomena and Processes --- Chemicals and Drugs --- Physiology --- Wound Healing --- Human Anatomy & Physiology --- Surgery & Anesthesiology --- Health & Biological Sciences --- Animal Biochemistry --- Wounds & Injuries --- Therapeutic use --- Lactoferrin. --- Healing of wounds --- Wound repair --- Lactoferrins --- Medicine. --- Human physiology. --- Proteins. --- Cell biology. --- Cell membranes. --- Biomedicine. --- Biomedicine general. --- Human Physiology. --- Cell Biology. --- Protein Science. --- Receptors. --- Membrane Biology. --- Carrier proteins --- Iron proteins --- Milk proteins --- Healing --- Regeneration (Biology) --- Cytology. --- Biochemistry. --- Cell receptors. --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Human biology --- Human body --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Composition --- Biomedicine, general. --- Health Workforce --- Proteins . --- Cell membranes . --- Proteids --- Biomolecules --- Polypeptides --- Proteomics

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Despite its limitation in terms of surface covered area, the PLD technique still gathers interest among researchers by offering endless possibilities for tuning thin film composition and enhancing their properties of interest due to: (i) the easiness of a stoichiometric transfer even for very complex target materials, (ii) high adherence of the deposited structures to the substrate, (iii) controlled degree of phase, crystallinity, and thickness of deposited coatings, (iv) versatility of the experimental set-up which allows for simultaneous ablation of multiple targets resulting in combinatorial maps or consecutive ablation of multiple targets producing multi-layered structures, and (v) adjustment of the number of laser pulses, resulting in either a spread of nanoparticles, islands of materials or a complete covering of a surface. Moreover, a variation of PLD, known as Matrix Assisted Pulsed Laser Evaporation, allows for deposition of organic materials, ranging from polymers to proteins and even living cells, otherwise difficult to transfer unaltered in the form of thin films by other techniques. Furthermore, the use of laser light as transfer agent ensures purity of films and pulse-to-pulse deposition allows for an unprecedented control of film thickness at the nm level. This Special Issue is a collection of state-of-the art research papers and reviews in which the topics of interest are devoted to thin film synthesis by PLD and MAPLE, for numerous research and industry field applications, such as bio-active coatings for medical implants and hard, protective coatings for cutting and drilling tools withstanding high friction and elevated temperatures, sensors, solar cells, lithography, magnetic devices, energy-storage and conversion devices, controlled drug delivery and in situ microstructuring for boosting of surface properties.

thin films --- matrix-assisted pulsed laser evaporation --- shellac --- enteric coatings --- PLD --- ITO --- nanoimprint lithography --- coatings --- nanostructure --- iron oxide --- pulsed laser deposition --- aluminum nitride --- nanoindentation testing --- TEM imaging --- FTIR spectroscopy --- ellipsometry --- complex refractive index --- composite coatings --- MAPLE --- Lactoferrin --- macrophage interactions --- animal-origin calcium phosphate coatings --- natural hydroxyapatite --- doping --- high adherence --- pulsed laser deposition technique --- biomimetic applications --- target preparation --- room temperature ferromagnetism --- dilute magnetic semiconductor --- Indium oxide --- (InFe)2O3 --- PLD films --- energy storage --- thin-film electrodes --- thin-film solid electrolyte --- lithium microbatteries --- calcium phosphate-based coatings --- synthetic and natural hydroxyapatite --- in vivo testing --- biomedical applications --- n/a

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The consumption of fruits, vegetables, herbs, spices, etc., is thought to be associated with reduced risk for many human diseases, including cancers. Recently, significant advances have been made in evaluating the efficacy of natural products (compounds from natural sources) against human diseases. The purpose of this Special Issue, “Natural Products and Disease Prevention, Relief and Treatment", was to collect manuscripts concerning natural products for treating human diseases. Consequently, we have collected several high-quality manuscripts that focus on the molecular mechanisms of natural products, including their anti-inflammatory, antioxidative, neuroprotective, cardioprotective, antifibrotic, and anticancer effects, as well as other health beneficial effects across a wide range of human diseases. Overall, this Special Issue is an excellent source for information on promising natural products for future preclinical and clinical research into multiple diseases.

Medicine --- Pharmacology --- Rubi Fructus --- Rubus coreanus --- lipopolysaccharide --- macrophage --- ER stress --- calcium --- chop --- STAT --- cytokine --- nitric oxide --- β-glucan --- anticancer activity --- antioxidant --- anti-inflammatory --- cyclooxygenase --- lipoxygenase --- cauliflower mushroom --- breast cancer --- Spirulina --- tocotrienol --- immunomodulatory --- synergistic --- metastasis --- YG-1 extract --- bronchodilation --- fine particulate matter (PM2.5) --- acute lung injury --- airway inflammation --- pancreatic cancer --- natural product --- traditional medicine --- apoptosis --- angiogenesis --- drug resistance --- inflammation --- interleukin-6 --- sepsis --- Dracocephalum moldavica --- NASH --- lactoferrin --- fibrosis --- hepatocarcinogenesis --- connexin --- brown algae --- Sargassum plagiophyllum --- constipation --- gastrointestinal transit --- gut microbiota --- transepithelial transport --- glaucoma --- herbs --- retinal ganglion cells --- intraocular pressure --- SLC22A12 --- quercetin --- fisetin --- uricosuric activity --- anti-hyperuricemia --- functional food --- transporter --- uric acid --- health promotion --- rooibos tea --- doxorubicin --- mokko lactone --- heart --- Mokko lactone --- Dracocephalum moldavica ethanol extract --- Sparassis crispa --- fisetin and quercetin --- Sargassum plagiophyllum extract