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This book explores the biology of the fungal pathogen Candida albicans, its interaction with the human host, and current research that seeks to identify new ways to combat the health risks posed by C. albicans infection.

Research & information: general --- Biology, life sciences --- Microbiology (non-medical) --- Candida albicans --- acridine --- antifungal --- topoisomerase --- inhibitor --- candidiasis --- 1,3,4-oxadiazole --- drug discovery --- antifungal agents --- drug resistance --- toxicity --- biofilm --- invasive Candida infections --- invasive fungal infections --- antifungal prophylaxis --- newborns --- surgery --- neonatal surgery --- multivalency --- anti-adhesion glycoconjugates --- glycomimetics --- Candida --- C. albicans --- XCL1 --- metamorphic protein --- fold-switching protein --- antifungal peptide --- polymorphism --- hyphal morphogenesis --- hyphal activation --- signal transduction pathways --- cell cycle regulation --- sphingolipids --- myriocin --- fungal infections --- epigenetic --- yeast --- chromatin --- hyphae --- human fungal pathogen --- nutrient sensing --- amino acid metabolism --- proline catabolism --- mitochondria --- SPS-sensor --- nitrogen catabolite repression --- glucose repression --- immunometabolism --- metabolism --- macrophages --- epithelial cells --- glycolysis --- glucose --- moonlighting proteins --- Candida albicans --- acridine --- antifungal --- topoisomerase --- inhibitor --- candidiasis --- 1,3,4-oxadiazole --- drug discovery --- antifungal agents --- drug resistance --- toxicity --- biofilm --- invasive Candida infections --- invasive fungal infections --- antifungal prophylaxis --- newborns --- surgery --- neonatal surgery --- multivalency --- anti-adhesion glycoconjugates --- glycomimetics --- Candida --- C. albicans --- XCL1 --- metamorphic protein --- fold-switching protein --- antifungal peptide --- polymorphism --- hyphal morphogenesis --- hyphal activation --- signal transduction pathways --- cell cycle regulation --- sphingolipids --- myriocin --- fungal infections --- epigenetic --- yeast --- chromatin --- hyphae --- human fungal pathogen --- nutrient sensing --- amino acid metabolism --- proline catabolism --- mitochondria --- SPS-sensor --- nitrogen catabolite repression --- glucose repression --- immunometabolism --- metabolism --- macrophages --- epithelial cells --- glycolysis --- glucose --- moonlighting proteins

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This book is a printed edition of the Special Issue Fungal Infections in Immunocompromised Hosts that was published in JoF

toxicity --- risk assessment --- species complex --- galactomannan --- taxonomy --- Aspergillus PCR --- candidemia --- adaptive immunity --- fungal immunity --- T2 Candida --- anti-fungal agents --- innate immunity --- antifungal stewardship --- Immunotherapy --- Candida meningoencephalitis --- liposomal amphotericin B --- anidulafungin --- liver disease --- invasive mold disease --- T2Candida --- AIDS --- (1?3)-?-d-glucan --- literature review --- yeast --- hepatic impairment --- prediction models --- IRIS --- invasive aspergillosis --- antifungal agent --- TNF inhibitors --- Aspergillus fumigatus --- fungal nomenclature --- micafungin --- non-culture-based diagnostics --- PCR --- paracoccidioidomycosis --- Candida auris --- multidrug resistance --- subcutaneous mycoses --- risk score --- mycoses of implantation --- Sporothrix brasiliensis --- antifungal resistance --- immunocompromised hosts --- Sporothrix schenckii --- Aspergillus --- fungus --- cell therapy --- MALDI-ToF MS --- lateral flow --- phylogenetics --- hematological malignancy --- candidiasis --- antifungal drug --- hematological malignancies --- mycoses --- invasive fungal infections --- lymphoma --- kidney transplant --- immune reconstitution inflammatory syndrome --- mechanisms of antifungal resistance --- fungal infections --- cytokine therapy --- sporotrichosis --- beta-d-glucan --- invasive fungal infection --- HIV --- cat-transmitted sporotrichosis --- aspergillosis --- cancer --- prognostic risk model

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This reprint describes recent advances made in the field of antifungal development, especially the discovery of new drugs and drug repurposing. The articles presented in this book provide useful information and insight for the development of new antifungal drugs or intervention strategies. The identification of new, safe molecules, and cellular targets, as well as the elucidation of their antifungal mechanisms of action, will further the effective control of fungal pathogens, especially those resistant to current therapeutic agents.

nanoparticles --- fungi --- drug delivery systems --- marine --- biological synthesis --- myconanotechnology --- canesten --- clotrimazole --- vulvovaginal --- vaginitis --- mycosis --- candidosis --- yeast infection --- candida --- candida albicans --- vaginal health --- anticandidal activity --- indazole --- pyrazole --- 3-phenyl-1H-indazole --- drug design --- acetylsalicylic acid (ASA, aspirin) --- capsule --- CAP64 --- Cryptococcus --- membrane potential (ΔΨM) --- photodynamic treatment --- photosensitiser --- ultrastructure --- drug repurposing --- antifungals --- repositioning --- yeasts --- emerging fungi --- multidrug resistance --- therapeutic alternatives --- new targets --- Candida auris --- Aspergillus spp. --- antifungal --- beta-glucan --- polycations --- Galleria mellonella model --- retinoids --- Candida spp. --- onychomycosis --- Malassezia spp. --- dermatophytes --- microbiology --- mycology --- all-trans retinoic acid --- Acanthamoeba --- free-living ameba --- Acanthamoeba keratitis --- isavuconazonium sulfate --- cyst --- drug --- drug discovery --- drug targets --- invasive aspergillosis treatment --- invasive fungal infections --- fission yeast --- cell wall --- β(1,3)-D-glucan synthase --- antifungal drugs --- echinocandin drugs --- echinocandin resistance --- Fks resistance hot spots --- cytokinesis --- septation --- cell separation --- cell integrity --- cell lysis --- sporotrichosis --- Felis catus --- quinones --- hydrazones --- zoonoses --- host-directed drug therapy --- azoles --- polyenes --- echinocandins --- viral infections --- azole --- synergy --- resistance --- Candida --- natural products --- n/a

Choose an application

• Reference Manager
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This reprint describes recent advances made in the field of antifungal development, especially the discovery of new drugs and drug repurposing. The articles presented in this book provide useful information and insight for the development of new antifungal drugs or intervention strategies. The identification of new, safe molecules, and cellular targets, as well as the elucidation of their antifungal mechanisms of action, will further the effective control of fungal pathogens, especially those resistant to current therapeutic agents.

Research & information: general --- Biology, life sciences --- nanoparticles --- fungi --- drug delivery systems --- marine --- biological synthesis --- myconanotechnology --- canesten --- clotrimazole --- vulvovaginal --- vaginitis --- mycosis --- candidosis --- yeast infection --- candida --- candida albicans --- vaginal health --- anticandidal activity --- indazole --- pyrazole --- 3-phenyl-1H-indazole --- drug design --- acetylsalicylic acid (ASA, aspirin) --- capsule --- CAP64 --- Cryptococcus --- membrane potential (ΔΨM) --- photodynamic treatment --- photosensitiser --- ultrastructure --- drug repurposing --- antifungals --- repositioning --- yeasts --- emerging fungi --- multidrug resistance --- therapeutic alternatives --- new targets --- Candida auris --- Aspergillus spp. --- antifungal --- beta-glucan --- polycations --- Galleria mellonella model --- retinoids --- Candida spp. --- onychomycosis --- Malassezia spp. --- dermatophytes --- microbiology --- mycology --- all-trans retinoic acid --- Acanthamoeba --- free-living ameba --- Acanthamoeba keratitis --- isavuconazonium sulfate --- cyst --- drug --- drug discovery --- drug targets --- invasive aspergillosis treatment --- invasive fungal infections --- fission yeast --- cell wall --- β(1,3)-D-glucan synthase --- antifungal drugs --- echinocandin drugs --- echinocandin resistance --- Fks resistance hot spots --- cytokinesis --- septation --- cell separation --- cell integrity --- cell lysis --- sporotrichosis --- Felis catus --- quinones --- hydrazones --- zoonoses --- host-directed drug therapy --- azoles --- polyenes --- echinocandins --- viral infections --- azole --- synergy --- resistance --- Candida --- natural products --- nanoparticles --- fungi --- drug delivery systems --- marine --- biological synthesis --- myconanotechnology --- canesten --- clotrimazole --- vulvovaginal --- vaginitis --- mycosis --- candidosis --- yeast infection --- candida --- candida albicans --- vaginal health --- anticandidal activity --- indazole --- pyrazole --- 3-phenyl-1H-indazole --- drug design --- acetylsalicylic acid (ASA, aspirin) --- capsule --- CAP64 --- Cryptococcus --- membrane potential (ΔΨM) --- photodynamic treatment --- photosensitiser --- ultrastructure --- drug repurposing --- antifungals --- repositioning --- yeasts --- emerging fungi --- multidrug resistance --- therapeutic alternatives --- new targets --- Candida auris --- Aspergillus spp. --- antifungal --- beta-glucan --- polycations --- Galleria mellonella model --- retinoids --- Candida spp. --- onychomycosis --- Malassezia spp. --- dermatophytes --- microbiology --- mycology --- all-trans retinoic acid --- Acanthamoeba --- free-living ameba --- Acanthamoeba keratitis --- isavuconazonium sulfate --- cyst --- drug --- drug discovery --- drug targets --- invasive aspergillosis treatment --- invasive fungal infections --- fission yeast --- cell wall --- β(1,3)-D-glucan synthase --- antifungal drugs --- echinocandin drugs --- echinocandin resistance --- Fks resistance hot spots --- cytokinesis --- septation --- cell separation --- cell integrity --- cell lysis --- sporotrichosis --- Felis catus --- quinones --- hydrazones --- zoonoses --- host-directed drug therapy --- azoles --- polyenes --- echinocandins --- viral infections --- azole --- synergy --- resistance --- Candida --- natural products