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Primary progressive aphasia is a clinical syndrome that includes a group of neurodegenerative disorders characterized by progressive language impairment. Our knowledge about this disorder has evolved significantly in recent years. Notably, correlations between clinical findings and pathology have improved, and main clinical, neuroimaging, and genetic features have been described. Furthermore, primary progressive aphasia is a good model for the study of brain–behavior relationships, and has contributed to the knowledge of the neural basis of language functioning. However, there are many open questions remaining. For instance, classification into three variants (non-fluent, semantic, and logopenic) is under debate; further data about epidemiology and natural history of the diseases are needed; and, as in other neurodegenerative disorders, successful therapies are lacking. The Guest Editors expect that this book can be very useful for scholars.

Research & information: general --- Biology, life sciences --- primary progressive aphasia --- informativeness --- speech production --- assessment --- diagnosis --- cognitive approach --- dementia --- frontotemporal dementia --- Alzheimer's disease --- neuropsychology --- span --- sentence repetition --- working memory --- phonological --- visuospatial --- natural history --- mortality --- survival --- memory clinic --- graphical markers --- graphical parameters --- writing pressure --- differential diagnosis --- longitudinal assessment --- cognitive changes --- behavioural and psychological symptoms of dementia --- level of functioning --- electroencephalography --- resting-state --- biomarkers machine learning --- K-Nearest Neighbors --- graph theory --- treatment --- speech and language therapy --- intervention --- cognitive rehabilitation --- bilingualism --- semantic dementia --- semantic variant primary progressive aphasia --- word finding --- language therapy --- behavioural therapy --- electroencephalography (EEG) --- network analysis --- progressive apraxia of speech --- primary progressive aphasia --- informativeness --- speech production --- assessment --- diagnosis --- cognitive approach --- dementia --- frontotemporal dementia --- Alzheimer's disease --- neuropsychology --- span --- sentence repetition --- working memory --- phonological --- visuospatial --- natural history --- mortality --- survival --- memory clinic --- graphical markers --- graphical parameters --- writing pressure --- differential diagnosis --- longitudinal assessment --- cognitive changes --- behavioural and psychological symptoms of dementia --- level of functioning --- electroencephalography --- resting-state --- biomarkers machine learning --- K-Nearest Neighbors --- graph theory --- treatment --- speech and language therapy --- intervention --- cognitive rehabilitation --- bilingualism --- semantic dementia --- semantic variant primary progressive aphasia --- word finding --- language therapy --- behavioural therapy --- electroencephalography (EEG) --- network analysis --- progressive apraxia of speech