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The emergence of H5N1 avian influenza in 1997 and of the influenza A H1N1 of swine origin in 2009 calls for new, rapid and sustainable solutions for both seasonal and pandemic influenza viruses. During the last ten years, science and technology have made enormous progress, and we are now able to monitor in real time the genetics of viruses while they spread globally, to make more powerful vaccines using novel adjuvants, and to generate viruses in the laboratory using reverse genetics. This volume not only provides state-of-the-art information on the biology of influenza viruses and on influenza vaccines, but is also designed to be a resource to face the present H1N1 pandemic and to plan for long-term global and sustainable solutions.

Influenza A virus -- Immunology. --- Influenza B virus -- Immunology. --- Influenza Vaccines -- Therapeutic use. --- Influenza vaccines. --- Influenza viruses. --- Influenza, Human. --- Influenza vaccines --- Influenza --- Influenza viruses --- Orthomyxoviridae Infections --- Influenza A virus --- Respiratory Tract Infections --- Viral Vaccines --- Respiratory Tract Diseases --- Vaccines --- RNA Virus Infections --- Influenzavirus A --- Influenza A Virus, H1N1 Subtype --- Influenza Vaccines --- Influenza, Human --- Orthomyxoviridae --- Virus Diseases --- Diseases --- Biological Products --- RNA Viruses --- Complex Mixtures --- Chemicals and Drugs --- Vertebrate Viruses --- Viruses --- Organisms --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Influenza. --- Flu --- Flu, Respiratory --- Grippe --- Respiratory flu --- Influenza virus vaccines --- Medicine. --- Virology. --- Life sciences. --- Biomedicine. --- Life Sciences, general. --- Orthomyxoviruses --- Respiratory infections --- Virus diseases --- Viral vaccines --- Medical virology. --- Biosciences --- Sciences, Life --- Science --- Medical microbiology --- Virology --- Microbiology

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Nanobodies have become outstanding tools for biomedical research, diagnostics and therapy. Recent advances in the identification and functionalization of target-specific nanobodies now make nanobody-based approaches broadly available to many researches in the field. This book provides a compilation of original research articles and comprehensive reviews covering important and up to date aspects of research on nanobodies and their applications for immunoassays, proteomics, protein crystallization and in vitro and in vivo imaging.

Medicine --- Bacillus anthracis --- immunoassay --- single-domain antibody --- genetic fusion --- Beta galactosidase --- P-type ATPase --- nanobody --- llama --- Zinc-transport --- Zinc-transporting P-ATPase --- ZntA --- TNF --- fluorescent --- nanobodies --- sensor --- anti-cytokine therapy --- autoimmune disease --- Western equine encephalitis virus --- MagPlex --- toxin --- antibody --- camelid --- vaccine --- biodefense --- hydrogen exchange-mass spectrometry --- virus --- formatting --- Fc-domain --- half-life --- ischemia --- stroke --- MCAO --- single domain antibodies --- phage display --- intrabody --- intracellular antibody --- GTPase RHO --- BRET --- RAS --- chromobodies --- live-cell imaging --- compound screening --- cellular models --- single-domain antibody fragments --- molecular imaging --- molecular therapy --- nuclear imaging --- targeted fluorescence imaging --- intraoperative imaging --- Nanobody --- Single Domain Antibody --- Cancer --- Immunotherapy --- Imaging --- influenza --- influenza B virus --- hemagglutinin --- single domain antibody --- NanobodyTM --- yeast display --- epitope mapping --- GFP --- C. elegans --- development --- drosophila --- zebrafish --- targeted photodynamic therapy --- hepatocyte growth factor receptor --- HGFR --- c-Met --- Met --- VHH --- photosensitizer --- single-domain antibodies --- neurodegenerative diseases --- brain imaging --- blood-brain barrier --- delivery --- Aids --- HIV --- Llama Antibodies --- bi-specific VHH --- pepscan --- competition studies --- co-crystallisation